cyclandelate / Generic mfg. - LARVOL DELTA

Synergistic Photoredox/Palladium-Catalyzed Remote Meta C-H Olefination of Mandelic Acids. (PubMed, J Org Chem) - "This method was then extended for the synthesis of meta olefinated drug derivatives such as homatropine and cyclandelate. We also successfully demonstrated this protocol for the ortho olefination of free mandelic acids without any directing groups. Finally, gram-scale synthesis, sequential diolefination, and chemical modifications of the final products were performed to showcase the synthetic utility of the method."

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KBr-Mediated Electrochemical Dihydroxylation of Alkenes Using H2O as the Hydroxyl Source. (PubMed, Org Lett) - "Both styrenes and unactivated alkenes proceed in the dihydroxylation reactions smoothly to furnish vicinal diols in good yields. The successful synthesis of Cyclandelate, DTD derivative precursors, and a key intermediate for the synthesis of herbicide Metamitron highlights its synthetic utility."

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Rongalite-Mediated Transition Metal- and Hydride-Free Chemoselective Reduction of α-Keto Esters and α-Keto Amides. (PubMed, J Org Chem) - "$0.03/1 g), mild reaction conditions, and gram-scale synthesis are some of the key features of this methodology. Also, cyclandelate, a vasodilator drug, has been synthesized in gram scale with 79% yield."

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Controlled meta-Selective C-H Mono- and Di-Olefination of Mandelic Acid Derivatives. (PubMed, Org Lett) - "The synthesis of functionalized homatropine and cyclandelate drug derivatives was demonstrated. Kinetic isotope effects revealed C-H activation as the rate-limiting step."

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