Atzumi (dihydroergotamine) / Shin Nippon Biomedical Labs - LARVOL DELTA

Spatio-temporal Evolution of Supply and Demand of Ecosystem Services and SSP-RCP Scenario Prediction in Hebei Province (PubMed, Huan Jing Ke Xue) - "The spatio-temporal patterns of supply and demand matching of four types of ecosystem services in Hebei Province from 2000 to 2070 were revealed by using the supply-demand ratio of ecosystem services， and suggestions for optimizing the balance of supply and demand of ecosystem services in Hebei Province were put forward...Between 2000 and 2020， Hebei Province exhibited spatio-temporal heterogeneity in the matching of ecosystem service provision and requirement， accompanied by a significant supply-demand mismatch. The imbalance of supply and demand matching will intensify in different scenarios in the future."

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Plant community responses to climate change in the Zayandeh-Rud Basin, Iran: Does woody plant encroachment follow global patterns? (PubMed, BMC Ecol Evol) - "In the study area, the mean (± SD) of GCMs and SSPs for the net change percentage of total woody plant communities (including Semi Steppe-Shrub, Semi Steppe-Semi Shrub, Steppe-Semi Shrub, and Semi Desert-Shrub) during the period 2050 to 2070 (over the next 60 years) was estimated at 26.86 ± 12.05%...These patterns suggest a potential trend of woody plant encroachment that may be associated with increasing temperatures and declining precipitation. Such structural changes may lead to increased dominance of woody species, shifts in community composition, biotic homogenization, and potential impacts on ecosystem functions, including carbon sequestration, nutrient cycling, soil stability, and biodiversity conservation."

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An Open-Label, 2-Period, Fixed Sequence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of STS101 (Dihydroergotamine Nasal Powder), with and without Concomitant Itraconazole in Healthy Adult Subjects. (PubMed, J Clin Pharmacol) - "No clinically significant findings of a single dose of 5.2 mg STS101 alone or with itraconazole were observed on nasal examinations, safety laboratory values, vital signs, or safety electrocardiograms. In this study, no clinically meaningful drug-drug interactions were seen when STS101 was co-administered with a strong CYP3A4 inhibiting drug."

Clinical • Journal • PK/PD data • Cardiovascular • CNS Disorders • Migraine • Pain

Ensemble Niche Modelling Projects Net Suitability Gain and Eastward Range Expansion for the Namaqua Dove (Oena capensis) in Anatolia Under Climate Change. (PubMed, Animals (Basel)) - "An ensemble niche model was fitted from occurrence and climate data, evaluated by cross-validation, and projected to 2070 and 2100 under three emission scenarios and five climate models...The projected magnitude is reported as scenario illustration rather than forecast. These results indicate that suitability for O. capensis in Türkiye is shaped jointly by precipitation and winter temperature, with colonisation tracking suitable climate rather than shifting into novel conditions."

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Refined Simulation and Analysis of Land Use Type Evolution in Heilongjiang Province (PubMed, Huan Jing Ke Xue) - "Land use changes in Heilongjiang Province from 2020 to 2070 under natural development and policy-driven scenarios were simulated using the Patch-generating Land Use Simulation （PLUS） model...DEM， population， and GDP were the dominant factors driving the expansion of various land use types， while transportation networks played a decisive role in impervious surface expansion. ④ Significant differences in projected land use changes and forest fragmentation dynamics under the two scenarios suggest that policy factors play a critical role in shaping future land use patterns in Heilongjiang Province."

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The Italian forest carbon sink: historical evolution and future projections under alternative harvest scenarios. (PubMed, Carbon Balance Manag) - "Between 2005 and 2023, the impact of harvest uncertainty on the total forest C sink averaged 11 Tg CO2 yr-1, representing about ± 23% of the C sink associated with the average harvest reported in the literature for the same period. By simulating the theoretical forest C sink dynamics under different felling rates, and by excluding any possible impacts of climate change on current growth conditions, our study provides a long-term assessment of wood production potential versus carbon storage capacity. This bottom-up modelling framework aligns with the New EU Forest Strategy and can serve as a model for other European countries."

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Periprosthetic fractures after hip and knee arthroplasty in France : national trends and future projections. (PubMed, Bone Jt Open) - "This study aimed to provide a nationwide assessment of the incidence, risk factors, morbidity, and mortality of hip and knee periprosthetic fractures in France over the past decade, and to project their future burden up to 2070 under different epidemiological scenarios...The incidence of periprosthetic fractures in France has risen steadily and is expected to increase substantially in the coming decades, driven by demographic ageing. Given their high morbidity and mortality, optimizing perioperative and post-fracture care, along with implementing measures to prevent both fractures and related complications, should be considered a public health priority."

Journal • Cardiovascular • Musculoskeletal Diseases • Orthopedics

Comparison of FDA approved intranasal acute migraine treatment adverse event profiles (AHS 2026) - "One Sentence Summary: STS101 (dihydroergotamine nasal powder) shows a low rate of local adverse events in its approved prescribing information as compared with other approved intranasal acute migraine treatments...Prescribing information dates reviewed were ATZUMI (April 2025), Migranal (September 2022), Trudhesa (May 2022), Zavzpret (August 2025), Imitrex nasal spray (December 2025), and Zomig nasal spray (May 2019)... Nasally administered products for the acute treatment of migraine are generally well tolerated. STS101 shows a favorable adverse event profile in long term prn use as compared with other FDA-approved intranasal acute migraine treatments. Most commonly reported adverse events (≥5% and occurring more frequently than placebo) as listed in the U.S. prescribing information for FDA-approved intranasal acute migraine treatments."

Adverse events • CNS Disorders • Migraine • Pain

Pharmacokinetic comparison of STS101 (Nasal DHE nasal powder) with liquid nasal spray, and injectable DHE formulations (AHS 2026) - "Cmax and early exposure levels are important for efficacy at 2 h. STS101 demonstrated greater PK values and less PK variability compared to the DHE LNSs. STS101 showed high sustained plasma concentrations, AUC0-inf comparable to the IV DHE values, and approached the IM DHE values. STS101's lower PK variability may lead to more consistent and reliable clinical performance."

PK/PD data • CNS Disorders • Migraine

Satsuma Pharmaceuticals, Inc., a biopharmaceutical company focused on advancing innovative treatments for people living with migraine, today announced that two abstracts highlighting findings from its clinical development program have been selected for presentation at the American Headache Society's (AHS) 68th Annual Scientific Meeting. (PRNewswire)

Clinical • Migraine

STS101 nasal powder as a New treatment option for acute migraine with or without aura in adults. (PubMed, Expert Rev Neurother) - "Its clinical role will likely depend on how clinicians weigh its delivery platform, DHE pharmacology, tolerability, and place relative to other available intranasal options. Comparative effectiveness trials with other intranasal therapies and real-world studies will be important for defining STS101's utilization in clinical practice."

Journal • Review • Cardiovascular • CNS Disorders • Migraine • Pain

Characterization of Groundwater Monitoring Wells in a Surficial Estuarine Aquifer: Using Non-Target Analysis to Develop a Better Understanding of the Pollution Sources in the Biscayne Bay Watershed. (PubMed, Environ Pollut) - "The concentrations of sucralose ranged from 29.3 to 2070 ng/L, with an average of 535 ± 572 ng/L...This could indicate that these contaminants are originating from the same sources. This work demonstrates the necessity of comprehensive and complementary chemical analysis to understand the impact of urban development and vulnerable wastewater systems have on groundwater quality in the Biscayne Bay Watershed."

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Synthesis of Prussian Blue-Containing Polymeric Nanocapsules via Interfacial Confined Coordination in Crosslinked Miniemulsion. (PubMed, Nanomaterials (Basel)) - "Subsequently, sequential coordination with sodium pentacyanoammine -ferroate(II) hydrate (Na3 [Fe(CN)5NH3]), followed by the addition of FeCl3, yielded a uniform PB coating, as confirmed by the appearance of a characteristic absorption peak at 780 nm in the UV-Vis spectra and a CN stretching shift from 2060 to 2070 cm-1 in FT-IR...The PB loading could be further controlled by varying the Fe3+ addition (5.0 × 10-3-4.5 × 10-2 mmol), with higher loading improving thermal stability. This rational design provides a robust and generalizable platform for engineering polymer-inorganic hybrid nanostructures with tailored functionalities."

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A century-scale dynamic modeling of demolition waste metabolism and associated global warming impact in China's urban residential sector. (PubMed, Waste Manag) - "This paper quantifies demolition waste (DW) from urban residential buildings (URB) in China from 1970 to 2070 under low, medium, and long-lifespan scenarios, as well as the associated global warming impact, quantified as global warming potential (GWP), from DW disposal and avoided through material reproduction under low, medium, and high-recycling rate scenarios...In the high-recycling rate scenario, GWP becomes negative, with net savings of 27.64 TgCO2e in the short-lifespan scenario, 18.95 TgCO2e in the medium-lifespan scenario, and 9.55 TgCO2e in the long-lifespan scenario. Extending building lifespans and increasing recycling rates markedly reduce both DW generation and associated GWP, with steel and brick offering the highest GWP reduction potential through enhanced recycling practices."

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Network Meta-analysis of Atzumi (STS101) Dihydroergotamine Nasal Powder Versus Modern Oral and Intranasal Agents for the Acute Treatment of Migraine (AAN 2026) - "In contrast, zavegepant 10 mg IN, ubrogepant 50 mg PO, and rimegepant 75 mg ODT achieved PF RRs of 1.49, 1.52, and 1.46, respectively, while sumatriptan 100 mg PO remained highest (1.88 [1.64–2.15]). Safety favored Atzumi, with mild nasal discomfort (8.3%) and dysgeusia (3.7%), and no serious adverse events, compared with higher systemic AEs for oral triptans. Conclusions Atzumi (STS101) showed sustained efficacy beyond 3 hours with excellent tolerability, offering a safe non-oral option for acute migraine; overall study quality was high with low ROB 2.0."

Retrospective data • CNS Disorders • Migraine • Pain

Assessment of climatic parameter variation and its impact on sustainable agriculture in Dir Upper Pakistan with mitigation and adaptation strategies. (PubMed, Sci Rep) - "In the subsequent period of 2041 to 2070, this warming trend is projected to accelerate significantly, with temperature increases ranging from 4 to 7 °C, and a median rise of 5.5 °C...Additionally, adaptive strategies including tunnel farming, agroforestry, construction of small dams, and efficient irrigation systems were promoted to enhance resilience. The findings emphasize the urgent need for policy-driven climate-smart agriculture, afforestation, and integrated water management strategies to sustain agricultural productivity and rural economies in the face of escalating climate risks."

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2025 New Drug Update (Part 2): Recent Approvals and Clinical Implications. (PubMed, Sr Care Pharm) - "This review synthesizes the latest evidence on recently approved medications including Atzumi™ and Brekiya® (dihydroergotamine mesylate) for migraine headaches, Attruby™ (acoramidis) for transthyretin amyloid cardiomyopathy, and Blujepa® (gepotidacin) for uncomplicated urinary tract infections. Insights are offered into prescribing considerations for these agents in older populations, potential drug-drug interactions, and administration and handling tips. This work will be of significant interest to health care professionals as they evaluate the appropriateness of these new therapeutic options."

Journal • Amyloidosis • Cardiac Amyloidosis • Cardiomyopathy • Cardiovascular • CNS Disorders • Infectious Disease • Migraine • Nephrology • Pain

Spatial-temporal Evolution of Land Use and Habitat Quality in the Hutuo River Basin Under Typical SSPs-RCPs Scenarios (PubMed, Huan Jing Ke Xue) - "Based on land use data from 2000 to 2020 in the Hutuo River Basin, this study applied the future land use simulation （FLUS）-integrated valuation of ecosystem services and tradeoffs （InVEST） model to simulate and analyze the spatial-temporal evolution characteristics of land use and habitat quality in the basin from 2030 to 2070 under typical shared socioeconomic pathway （SSPs）-representative concentration pathway （RCPs） scenarios （SSP1-2.6, SSP2-4.5, and SSP5-8.5）...The SSP1-2.6 and SSP5-8.5 scenarios primarily showed an increase in hotspots and coldspots, respectively. These findings provide valuable insights for enhancing habitat quality in the basin and promoting the synergistic development of ecological and economic systems in the future."

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A dihydroergotamine autoinjector (Brekiya) for migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Climate sensitivity is widely but unevenly spread across zoonotic diseases. (PubMed, Proc Natl Acad Sci U S A) - "These studies were predominantly located in areas expected to have substantial increases in annual mean temperature (>1.5 °C in 97% of studies) and rainfall (>25 mm in 53% of studies) by 2041 to 2070...Our analyses provide evidence that climate sensitivity is common across zoonoses, likely leading to substantial yet complex effects of climate change on zoonotic burden. We emphasize the need for future studies to utilize biologically relevant models, apply rigorous space-time controls, consider causal perspectives, and address taxonomic and geographic biases to allow robust consensus of climate-risk relationships to emerge."

Journal • Infectious Disease

Dihydroergotamine Intranasal Powder for Acute Migraine Treatment. (PubMed, Ann Pharmacother) - "The design and pharmacokinetic properties of DHE intranasal powder appear to offer advantages over other DHE dosage forms, but current data do not support its use as a first-line agent for the treatment of migraine headaches."

Journal • Review • CNS Disorders • Migraine • Pain

From growth to green: exploring the impact of green economic indicators on carbon emission multiplier in G20 countries. (PubMed, Environ Sci Pollut Res Int) - "In addition, the Fb Prophet method is used to forecast carbon emission multiplier trajectories for each country up to 2070. The key findings of the study are as follows: (1) panel cointegration tests confirm a long-term relationship among the chosen variables; (2) renewable electricity, green trade, and environmental technology significantly reduce the carbon emission multiplier over time, while relative advantages in environmental practices tend to increase it; and (3) the Fb Prophet forecasting indicates that there is variation among countries in the timing and magnitude of decarbonization efforts. Based on these findings, this research provides key insights into the varying progress and challenges faced by G20 members in aligning with the goals of the Paris Agreement and suggests guidance for designing effective green policies."

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Vaccination Strategies against HPV Infection and Cervical Cancer in China: A Transmission Modeling Study. (PubMed, Med Decis Making) - "Sensitivity analyses were conducted to assess parameter effects.ResultsWithout vaccination, HPV infection becomes endemic (R0 = 1.38), causing 2.92 million cervical cancer cases in China during 2021 to 2070...A higher vaccination rate accelerates elimination: annual rates of 0.09, 0.15, and 0.21 among females aged ≥15 y achieve elimination by 2037, 2035, and 2034, respectively, accelerating timelines by 15 to 20 y compared with strategies targeting only 15- to 26-y-olds.ConclusionsHPV vaccination is pivotal for reducing cervical cancer burden in China, with prioritizing women aged 15 to 26 y as the optimal strategy. Expanding vaccination to all women aged ≥15 y can accelerate the achievement of WHO elimination targets.HighlightsAn age-stratified model simulates HPV transmission patterns and assesses cervical cancer interventions.Without intervention, HPV remains endemic (R0 = 1.38), causing 2.92 million cervical cancer cases in China (2021-2070).Prioritizing 15- to..."

Journal • Cervical Cancer • Human Papillomavirus Infection • Infectious Disease • Oncology • Solid Tumor

Grain for green mitigates climate-driven increases in nitrogen loss from agricultural nonpoint sources and N2O emissions. (PubMed, Sci Total Environ) - "From 2020 to 2070, agricultural nitrogen loss decreased by approximately 49.31 %, whereas the proportion of nitrogen loss from N2O emissions increased from approximately 42.07 % to 63.25 %...Intensified rainfall primarily promotes ANPS nitrogen loss associated with surface runoff, while high temperatures exacerbate the N2O emission process. However, GFG could control the increase in agricultural nitrogen loss from ANPS and N2O emissions caused by high rainfall and temperature."

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Study participant impression of use and satisfaction with STS101 (dihydroergotamine nasal powder): Results from the open-label ASCEND acute migraine study. (PubMed, Headache) - P3 | "Participant impression data through 12 months suggest that STS101 was generally perceived as favorable by participants on multiple attributes. Most considered STS101 easy to use and indicated they would be likely to use the product if it were available. Exploratory efficacy evaluations indicated beneficial effects."

Journal • CNS Disorders • Migraine • Pain