Atzumi (dihydroergotamine) / Shin Nippon Biomedical Labs - LARVOL DELTA

Climate sensitivity is widely but unevenly spread across zoonotic diseases. (PubMed, Proc Natl Acad Sci U S A) - "These studies were predominantly located in areas expected to have substantial increases in annual mean temperature (>1.5 °C in 97% of studies) and rainfall (>25 mm in 53% of studies) by 2041 to 2070...Our analyses provide evidence that climate sensitivity is common across zoonoses, likely leading to substantial yet complex effects of climate change on zoonotic burden. We emphasize the need for future studies to utilize biologically relevant models, apply rigorous space-time controls, consider causal perspectives, and address taxonomic and geographic biases to allow robust consensus of climate-risk relationships to emerge."

Journal • Infectious Disease

Dihydroergotamine Intranasal Powder for Acute Migraine Treatment. (PubMed, Ann Pharmacother) - "The design and pharmacokinetic properties of DHE intranasal powder appear to offer advantages over other DHE dosage forms, but current data do not support its use as a first-line agent for the treatment of migraine headaches."

Journal • Review • CNS Disorders • Migraine • Pain

From growth to green: exploring the impact of green economic indicators on carbon emission multiplier in G20 countries. (PubMed, Environ Sci Pollut Res Int) - "In addition, the Fb Prophet method is used to forecast carbon emission multiplier trajectories for each country up to 2070. The key findings of the study are as follows: (1) panel cointegration tests confirm a long-term relationship among the chosen variables; (2) renewable electricity, green trade, and environmental technology significantly reduce the carbon emission multiplier over time, while relative advantages in environmental practices tend to increase it; and (3) the Fb Prophet forecasting indicates that there is variation among countries in the timing and magnitude of decarbonization efforts. Based on these findings, this research provides key insights into the varying progress and challenges faced by G20 members in aligning with the goals of the Paris Agreement and suggests guidance for designing effective green policies."

Journal

Vaccination Strategies against HPV Infection and Cervical Cancer in China: A Transmission Modeling Study. (PubMed, Med Decis Making) - "Sensitivity analyses were conducted to assess parameter effects.ResultsWithout vaccination, HPV infection becomes endemic (R0 = 1.38), causing 2.92 million cervical cancer cases in China during 2021 to 2070...A higher vaccination rate accelerates elimination: annual rates of 0.09, 0.15, and 0.21 among females aged ≥15 y achieve elimination by 2037, 2035, and 2034, respectively, accelerating timelines by 15 to 20 y compared with strategies targeting only 15- to 26-y-olds.ConclusionsHPV vaccination is pivotal for reducing cervical cancer burden in China, with prioritizing women aged 15 to 26 y as the optimal strategy. Expanding vaccination to all women aged ≥15 y can accelerate the achievement of WHO elimination targets.HighlightsAn age-stratified model simulates HPV transmission patterns and assesses cervical cancer interventions.Without intervention, HPV remains endemic (R0 = 1.38), causing 2.92 million cervical cancer cases in China (2021-2070).Prioritizing 15- to..."

Journal • Cervical Cancer • Human Papillomavirus Infection • Infectious Disease • Oncology • Solid Tumor

Grain for green mitigates climate-driven increases in nitrogen loss from agricultural nonpoint sources and N2O emissions. (PubMed, Sci Total Environ) - "From 2020 to 2070, agricultural nitrogen loss decreased by approximately 49.31 %, whereas the proportion of nitrogen loss from N2O emissions increased from approximately 42.07 % to 63.25 %...Intensified rainfall primarily promotes ANPS nitrogen loss associated with surface runoff, while high temperatures exacerbate the N2O emission process. However, GFG could control the increase in agricultural nitrogen loss from ANPS and N2O emissions caused by high rainfall and temperature."

Journal

Study participant impression of use and satisfaction with STS101 (dihydroergotamine nasal powder): Results from the open-label ASCEND acute migraine study. (PubMed, Headache) - P3 | "Participant impression data through 12 months suggest that STS101 was generally perceived as favorable by participants on multiple attributes. Most considered STS101 easy to use and indicated they would be likely to use the product if it were available. Exploratory efficacy evaluations indicated beneficial effects."

Journal • CNS Disorders • Migraine • Pain

Atzumi for migraine: a new era of needle-free dihydroergotamine delivery. (PubMed, Ann Med Surg (Lond)) - "Atzumi, a dihydroergotamine mesylate nasal powder, recently received U.S. Food and Drug Administration approval and represents a promising alternative. Data from both early pharmacokinetic testing and a long-term safety study suggest that it works quickly and is generally well tolerated. Patients experienced meaningful relief, often without needing backup medications, and side effects were reported infrequently."

Journal • CNS Disorders • Migraine • Pain

Forecasting trends in glaucoma medication reimbursees in Finland: updated system dynamics model to 2070. (PubMed, BMJ Open Ophthalmol) - "The demand for glaucoma care in Finland will increase by 2070, necessitating proactive resource allocation and continuous monitoring using real-world data to ensure optimal care delivery. Temporary changes in the demand for glaucoma care underscore the need for adaptive forecasting methods. The updated model provides a framework for monitoring trends and informing resource allocation in national eye care systems."

Journal • Glaucoma • Ophthalmology

Rising global temperatures reduce soil microbial diversity over the long term. (PubMed, Proc Natl Acad Sci U S A) - "Under the worst-case climate warming scenario (2010 to 2070, 3.4 increase in °C), soil bacterial diversity and fungal diversity are projected to reduce by 56% and 81%, respectively, over 60 y. Importantly, in addition to the direct impact of warming on SOC, warming-induced declines in microbial diversity also contributed to SOC losses. We highlight that prolonged warming could substantially reduce soil microbial diversity and decrease SOC sequestration, accelerating future warming and underscoring the urgent need for decisive actions to mitigate global climate change."

Journal

High-Density Arrayed Spectrometer with Microlens Array Grating for Multi-Channel Parallel Spectral Analysis. (PubMed, Sensors (Basel)) - "Experimental results demonstrate that this spectrometer system can theoretically support up to 2070 independently addressable subunits...The practical spectral resolution achieved is as fine as 3.0 nm. This platform supports wafer-level spectral screening of high-density Micro-LEDs, offering a practical hardware solution for high-precision industrial inline sorting, such as Micro-LED defect inspection."

Journal

A spatial dataset on Ecuadorian cropping systems and theoretical crop residue potentials. (PubMed, Data Brief) - "Additionally, the dataset includes monthly projections of average temperature, cumulative precipitation, and estimated evapotranspiration from 2020 to 2070 under the RCP4.5 climate scenario...All variables were spatially assigned to each APCU. This open-access dataset is designed for reuse in soil carbon modeling frameworks, supports the design of biomass mobilization strategies, and informs climate-smart land-use strategies in tropical agricultural systems."

Journal

Current and future ecological niche of Dermacentor similis Lado (Acari: Ixodidae) in western North America. (PubMed, J Med Entomol) - "Future ecological suitability were similar to the current ecological suitability under both climate scenarios (2041 to 2070, SSP2-4.5 and SSP3-7.0). The results of this study will inform public and animal health messaging and awareness."

Journal

DHE plasma concentration and clinical response relationship—An in-office PK-PD study (AHS 2025) - P3 | "STS101 was well absorbed during migraine attacks. DHE plasma Cmax is a strong predictor for pain relief at 2 h after dosing with higher Cmax resulting in higher responder proportions. More severe baseline pain required higher DHE plasma concentrations to induce pain relief."

Clinical • PK/PD data • CNS Disorders • Migraine • Pain

STS101 (dihydroergotamine nasal powder) shows benefit on the resolution of cardinal migraine symptoms photophobia, phonophobia, and nausea: Results from the long-term phase 3 open-label ASCEND study (AHS 2025) - P3 | "The results of the ASCEND study show that, similar to its effects on migraine headache pain and most bothersome headache-associated symptom, STS101 showed rapid and sustained resolution of each of the cardinal migraine symptoms of photophobia, phonophobia, and nausea."

Clinical • P3 data • CNS Disorders • Migraine • Pain

STS101 use reduces migraine frequency over time (AHS 2025) - P3 | "In subjects who used STS101 over 12 months, significant reductions in treated migraine frequency were observed, especially in those who treated 5 or more attacks in month 1. This longer preventive benefit of DHE has been discussed before and may be related to its effects on multiple receptors involved in migraine pathophysiology (Tepper et al., Cephalalgia Reports 2024)."

CNS Disorders • Migraine • Pain

Strong CYP3A4 inhibitor itraconazole does not cause clinically relevant interactions with STS101 (nasal dihydroergotamine powder) (AHS 2025) - "This Phase 1 study was conducted to evaluate the PK, safety, and tolerability of single doses of 5.2 mg STS101, with and without concomitant dosing of the strong CYP3A4 inhibitor, itraconazole. The results from this study showed that DHE plasma Cmax and AUCinf were increased by approximately 14% and 19%, respectively when STS101 was administered with itraconazole. These increases were not associated with any clinical sequelae, and STS101 was well tolerated by healthy subjects when taken alone and when co-administered with itraconazole."

Clinical • CNS Disorders

The Ongoing Expansion of the Medically Important Scorpions in Southern South America. (PubMed, Ecohealth) - "We present their current suitable areas and the potential future distribution up to 2070...We conclude that, besides synanthropic capabilities, parthenogenesis is the main factor favoring the expansion of some of these species. We also conclude that interactions between invasive Tityus species may hinder their expansion process due to potential competition or exclusion mechanisms."

Journal

Empowering Indonesia's energy transition planning through long-term energy system modelling: A technoeconomic dataset. (PubMed, Data Brief) - "The dataset encompasses historical and projected data from 2010 to 2070 on key aspects such as electricity demand by sector, electricity generation, installed capacity, capacity factors, costs of energy technologies, and renewable energy potentials for solar, wind, hydro, and geothermal power. The data has been collated from Indonesian government reports, international agencies, and academic literature and harmonised using documented assumptions. While Indonesia-specific, this dataset could serve as a template for developing similar energy datasets in other countries, which may face similar challenges in developing energy transition planning."

Journal

Distribution modelling and future prediction of a threatened species - Heracleum candicans Wall. ex DC.; Within the framework of biotic and abiotic interactions. (PubMed, J Environ Manage) - "The suitable habitat of the plant is expected to show contrasting range changes from 2040 to 2070 under both SSP126 and SSP370 scenarios. By the year 2100, the range of suitable habitat is expected to expand under optimistic, and to shrink in a pessimistic scenarios, SSP126 and SSP370, respectively. The predictive modelling approach could be beneficial for assessing the conservation importance and devising the future management strategies and policies for this and number of other endemic and threatened species, especially the medicinal plants."

Journal

Demand starter data kit: Selected socio-economic and technical energy system demand modelling data for all 47 counties in Kenya. (PubMed, Data Brief) - "As a demonstration, these data were used to calibrate a demand model for Kilifi County using the Model for the Analysis of Energy Demand (MAED) for a baseline scenario from 2019 to 2070. The assumptions used and results gained are illustrated in the appendix of the article as a demonstration of what can be achieved through application of this dataset."

Journal

Transitioning to healthy and sustainable diets has higher environmental and affordability trade-offs for emerging and developing economies. (PubMed, Nat Commun) - "In this study, we project changes in water use, dietary quality, and food affordability under four dietary scenarios (including Mediterranean diet, the EAT-Lancet diet, the Healthy US-Style diet, and Vegetarian diet), assessing the potential implications at the country level from 2020 to 2070...However, in the initial phases, increased food demand escalated water use and worsened food affordability, especially in emerging and developing economies, with the maximum average deterioration being 2.62% and 13.06%, respectively. These highlight the need for long-term planning and financial support to ensure successful global transitions."

Journal

Satsuma Pharmaceuticals Announces U.S. FDA Approval for Atzumi (Dihydroergotamine) Nasal Powder for the Acute Treatment of Migraine (PRNewswire) - "Satsuma Pharmaceuticals...and its corporate parent, Shin Nippon Biomedical Laboratories...announced that the U.S. Food and Drug Administration (FDA) has approved a 505(b)(2) New Drug Application (NDA) for Atzumi (dihydroergotamine (DHE)) nasal powder for the acute treatment of migraine with or without aura in adults. Atzumi was previously known as STS101....The FDA approval for Atzumi is based on two clinical studies (Phase 1 PK trial and ASCEND Phase 3 open-label, long-term safety trial), which demonstrated fast absorption, rapid achievement of high DHE plasma concentrations, and sustained DHE plasma levels over time as well as safety and tolerability in subjects with migraine."

FDA approval • Migraine • Pain

How Long Will You Be a Widow? Determinants, Trends, and Income Gradient in Widowhood Duration. (PubMed, Demography) - "Using French life tables from 1962 to 2070 and simulations based on the Gompertz law and a bivariate Gaussian copula, we assess each determinant's relative influence...Despite converging gender life expectancies, our projections suggest that widowhood duration will remain high until 2070, at 9.2 years for females and 6.2 years for males. Notably, we identify a negative gradient in widowhood duration along the standard-of-living distribution."

Journal

Predicted impact of HPV vaccination and primary HPV screening on precancer treatment rates and adverse pregnancy outcomes in Australia 2010-2070: Modelling in a high income, high vaccination coverage country with HPV-based cervical screening. (PubMed, Vaccine) - "This analysis demonstrates that the benefits of HPV vaccination programs extend beyond prevention of HPV-related disease. HPV vaccination will reduce PTBs and LBW infants, with a further reduction with future twice-lifetime screening for HPV9 cohorts."

Adverse events • Journal • Cervical Cancer • Human Papillomavirus Infection • Infectious Disease • Obstetrics • Oncology

COMPRESSED VR EXPOSURE THERAPY HABITUATES PTSD SYMPTOMS IN A CRITICAL ILLNESS SURVIVOR (SCCM 2025) - "Her physical activity IPAQ scores improved from 1130 to 2070 but declined to 546 at 3 months after a rheumatoid disease diagnosis...Her outcomes suggest C-VRET may be useful for habituating trauma symptoms in adult critical illness survivors. Further testing with a large, diverse sample is needed."

Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Immunology • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry