amodiaquine hydrochloride / Generic mfg. - LARVOL DELTA

Indirect Benefits of Seasonal Malaria Chemoprevention for Non-Malarial Pediatric Infections and Routine Antibiotic Use in Real-World Programmatic Settings: A Pre-Post Study Using Positive and Negative Controls. (PubMed, medRxiv) - "To assess the benefits of Seasonal Malaria Chemoprevention (SMC), the monthly administration of sulfadoxine-pyrimethamine and amodiaquine during the high malaria season, beyond malaria prevention in real-world program settings. Reductions varied across SMC cycles and were most pronounced following the final round. SMC may have additional benefits beyond malaria prevention, including reductions in common pediatric infections and subsequent routine antibiotic use."

Journal • Real-world evidence • Infectious Disease • Malaria • Pediatrics • Pneumonia • Respiratory Diseases

Development of a new wealth index for South Sudan: association between household wealth and malaria prevention practices in the context of seasonal malaria chemoprevention in Northern Bahr el Ghazal, South Sudan. (PubMed, Infect Dis Poverty) - "The new wealth index tailored to South Sudan is a useful tool for assessing socioeconomic health determinants. While household access to SMC showed a low degree of wealth-associated disparities, reflecting the equitable coverage of the door-to-door SMC delivery model, significant inequities remain in household access to other malaria prevention practices, such as mosquito nets. These findings imply the need for strategies to enhance equity in distributing essential malaria prevention resources."

Journal • Infectious Disease • Malaria

A LC-MS/MS Assay for Quantification of Amodiaquine and Desethylamodiaquine in Dried Blood Spots on Filter Paper. (PubMed, Int J Anal Chem) - "Artesunate-amodiaquine (ARS-AQ) is a first-line antimalarial treatment recommended by the World Health Organization. The developed method was demonstrated to be reliable and accurate. This assay may be particularly useful in the context of resource limited settings and in pediatric field studies."

Journal • Infectious Disease • Malaria • Pediatrics

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents. (PubMed, Front Chem) - "and against in vivo models of eleven key antimalarials, including chloroquine, sitamaquine, amodiaquine, mefloquine, quinine, primaquine, hydroxychloroquine, tafenoquine, quinacrine and moxipraquine. Mechanistic studies and advances in clinical treatment are also discussed. This mini-review aims to show the state of the art in using antimalarial drugs to discover alternative therapies for leishmaniasis treatment."

Journal • Review • Infectious Disease

A Study on the Clinical Efficacy of Amodiaquine in the Treatment of Systemic Lupus Erythematosus (ChiCTR) - P=N/A | N=7 | Not yet recruiting | Sponsor: Ningbo Medical Centre Lihuili Hospital; Ningbo Medical Centre Lihuili Hospital

New trial • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus

"I heard at home. The leader came by to inform". The role of community leaders and community distributors in promoting uptake of seasonal malaria chemoprevention in Nampula Province, Mozambique: a qualitative study. (PubMed, BMC Public Health) - "Involving community leaders in the mobilisation and distribution of interventions, such as SMC, helps to facilitate active participation from the community and result in greater acceptability and community uptake."

Journal • Infectious Disease • Malaria • Mood Disorders • Psychiatry

Seasonal malaria chemoprevention in northern Mozambique: a cost-effectiveness analysis. (PubMed, Malar J) - "In line with existing evidence from other African countries, SMC is found to be cost-effective in Mozambique. SMC is a beneficial prevention strategy to improve under-five health in the country, at a relatively low-cost."

HEOR • Journal • Infectious Disease • Malaria

ZrS2 Nanoparticles Embedded in Chitosan-Based Hydrogel for the Electrochemical Detection of Antimalarial Drug Amodiaquine in Serum Samples. (PubMed, ACS Appl Bio Mater) - "The repeatability and reproducibility results of the ZrS2/CS hydrogel show excellent consistent results, with relative standard deviations of 3.41 and 3.46%, respectively, further affirming the reliability of the sensor. This approach opens up future research directions for detecting various analytes in point-of-care and other biomedical devices."

Journal • Infectious Disease

Plasmodium falciparum isolates: ex vivo drug response. (PubMed, J Antimicrob Chemother) - "Clinical isolates from coastal Ghana remain susceptible to artemisinin derivatives in commonly used ACTs in Ghana. However, we observed lower susceptibility to the ACT partner drugs lumefantrine and amodiaquine, suggesting the emergence of drug-tolerance phenotypes. Consistent surveillance of drug phenotype-genotype is needed to support ACT efficacy in Ghana."

Journal • Preclinical • Infectious Disease • Malaria • ABCB1

A well-characterized mechanistic Model for exploring known or hypothesized T cell -mediated drug induced liver injury: current capabilities and challenges for future predictivity. (PubMed, Expert Opin Drug Metab Toxicol) - "To overcome deficits in quantitative data characterizing CD8+ T cell-mediated DILI, a translational strategy leveraged a well-defined mouse ovalbumin (OVA) antigen model and adapted it to represent mouse amodiaquine (AQ)-specific CD8+ T cell-mediated DILI, with further adaptations to represent human AQ-specific CD8+ T cell-mediated DILI...The DILIsym CD8+ T cell sub-model is well-positioned for systematic testing to improve our understanding of CD8+ T cell-mediated DILI. It is not yet predictive but indicates a promising direction to reduce DILI events in drug development."

Journal • Hepatology • Liver Failure • CD8

Molecular Docking, Toxicity Study and In Vitro Antimalarial Evaluation of Pyrazole Substituted 1,3,5-Triazine Derivatives. (PubMed, Exp Parasitol) - "The development of resistance to antimalarial drugs such as chloroquine, amodiaquine, artemisinin, and antifolates is a major health concern, prompting more research into new antimalarial therapies. Compounds 7j and 7i exhibited considerable antimalarial efficacy against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) strains of P. falciparum, with IC50 values ranging from 23.78 to 83.36 μM and 30.89 to 64.24 μM, respectively. These pyrazole-substituted 1,3,5-triazine derivatives could be utilized to find a novel class of Pf-DHFR-TS inhibitors."

Journal • Preclinical • Infectious Disease • DHFR

Design, Synthesis, and Anti-SARS-CoV-2 Activity of Amodiaquine Analogs. (PubMed, Chem Pharm Bull (Tokyo)) - "In this study, we designed and synthesized new anti-SARS-CoV-2 drugs based on the chemical structure of amodiaquine, which is known as an antimalarial drug. Consequently, we have identified amodiaquine analogs functionalized with dialkylamino-pendant aminophenol moieties that possess a high level of anti-SARS-CoV-2 activity with a low level of toxicity."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Ab-initio Molecular Dynamics and Density Functional Theory Study of Amodiaquine Analogues as Potential Inhibitors of β-haematin Crystallization. (PubMed, Curr Med Chem) - "The findings from this study are valuable because they can aid the design and understanding of new therapeutic molecules that could be used to treat drug-resistant malaria, a global threat of today."

Journal • Infectious Disease • Malaria

Evaluation of seasonal malaria chemoprevention implementation in the Upper East region of Northern Ghana. (PubMed, Malar J) - "Despite achieving an average coverage of 87% per cycle, it falls short of the national target of 90%. Notable reasons for drop-outs and non-adherence were, the caregiver being unavailable during the distribution, highlighting the need for diversified approaches in SMC campaigns to enhance coverage, and adherence, and maximize intervention benefits."

Journal • Infectious Disease • Malaria

Impact of variation in CYP3A and CYP2C8 on tucatinib metabolic clearance in human liver microsomes. (PubMed, Drug Metab Dispos) - "CYP2C8 and CYP3A activities were quantitated by liquid chromatography-tandem mass spectrometry analysis using the following marker reactions: amodiaquine N-deethylation and midazolam 1'-hydroxylation, respectively. By elucidating how variability in CYP2C8 and CYP3A phenotypes influence tucatinib pharmacokinetics, this study has the potential to provide the framework for future studies that could inform dosing to minimize adverse events and improve therapeutic outcomes. Ultimately, understanding how individual cytochrome P450 phenotypes influence the clearance of cancer therapeutics will aid in the development of tailored regimens for diverse patient populations."

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor • CYP3A4 • CYP3A5 • HER-2

THE ROLE OF STRIATAL NURR1 IN THE SOCIAL BEHAVIOR OF PRENATALLY VALPROIC ACID -EXPOSED AUTISM SPECTRUM DISORDERS MODEL MICE (ADPD 2025) - "In addition, treatment with amodiaquine, which is a kn own ligand for Nurr1, mimicked the social deficits and synaptic abnormalities in saline -exposed mice as observed in prenatally VPA-exposed mice. Taken together, our results suggest that the increase in Nurr1 expression in the striatum is a mechanism related to the changes in synaptic deficits and behavioral phenotypes of the VPA -induced ASD mouse model."

Preclinical • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Psychiatry • NR4A2

High incidence of clinical malaria among asymptomatic Plasmodium falciparum infected children receiving SMC with sulfadoxine-pyrimethamine and amodiaquine (SP + AQ) in Koulikoro, Mali. (PubMed, Malar J) - "These findings demonstrate an elevated risk of clinical malaria in asymptomatic infected children during SMC implementation. Screening and treating P. falciparum infections prior to SMC administration could substantially enhance the effectiveness of this strategy in reducing malaria morbidity in endemic areas."

Journal • Infectious Disease • Malaria

Structural and Functional Implications of MIT2 and NT2 Mutations in Amodiaquine and Piperaquine Resistant Plasmodium berghei Parasites. (PubMed, Exp Parasitol) - "These findings suggest that selection pressure from AQ and PQ leads to mutations in MIT2 and NT2. Further investigation is required to understand how these mutations affect drug susceptibility on a functional level."

Journal • Infectious Disease • Malaria • ABCG2

Phase one of a hybrid effectiveness-implementation study to assess the feasibility, acceptability and effectiveness of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique. (PubMed, Malar J) - "Results suggest that SMC was effective at preventing clinical malaria, did not significantly impact resistance profile, and was feasible and acceptable in the context. Phase two will assess SMC impact in reducing malaria incidence and if chemoprevention efficacy of SPAQ is impacted by drug resistance and drug concentrations."

Journal • Infectious Disease • Malaria

Dose-Optimization of a Novel Co-Formulated Triple Combination Antimalarial Therapy: Artemether-Lumefantrine-Amodiaquine. (PubMed, Clin Pharmacol Ther) - "Based on simulated total exposure and peak concentrations, an optimal dose regimen was developed resulting in an extension of the current 4 weight bands to a total of 5 weight bands to generate equivalent exposures in all body weight groups and minimize the fluctuation in exposure between patients. The proposed drug-to-drug ratio of artemether-lumefantrine-amodiaquine (20:120:40 mg) was kept constant throughout the dosing bands in order to simplify manufacturing, implementation, and further development of a fixed-dose co-formulated product."

Journal • Infectious Disease • Malaria • Pediatrics

Prevalence of Plasmodium falciparum drug resistance markers pfcrt K76T and pfaat1 S258L in southern Rwanda, 2010 to 2023. (PubMed, J Infect Dis) - "The persistence of pfcrt K76T 20 years after abolishing chloroquine indicates ongoing drug selection or importation. The fixation of pfaat1 S258L argues against a major fitness cost of this variant in Huye. Partial artemisinin resistance increases in Rwanda, and molecular markers indicate compromised lumefantrine efficacy. The observed pfcrt and pfaat1 signatures in the study area might guide artemisinin partner drug alternatives."

Journal • Infectious Disease • Malaria

PBPK-Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population. (PubMed, CPT Pharmacometrics Syst Pharmacol) - "Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk-to-plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five antimalarials with clinical lactation data (chloroquine, pyrimethamine, piperaquine, mefloquine and primaquine)...RID was  10% for lumefantrine and tafenoquine. For atovaquone, RID was > 10% with Model 1 but not Model 2...These prediction methodologies can be used, alongside any licensed dosing information for < 1 year-olds, to evaluate whether a clinical lactation study is necessary and to inform drug label or policy recommendations. The ultimate goal is to better inform optimal treatment for lactating women supporting malaria eradication."

Journal • Infectious Disease • Malaria

Worldwide study of the taste of bitter medicines and their modifiers. (PubMed, Chem Senses) - "The taste solutions were five medicines, tenofovir alafenamide (TAF), moxifloxacin, praziquantel, amodiaquine, and propylthiouracil (PROP), and four other solutions, TAF mixed with sucralose (sweet, reduces bitterness) or 6-methylflavone (tasteless, reduces bitterness), sucralose alone, and sodium chloride alone. Genetic analysis showed that people with variants in one bitter receptor variant gene (TAS2R38) reported PROP was more bitter than did those with a different variant (p= 7.6e-19) and that people with either an RIMS2 or a THSD4 genotype found sucralose more bitter than did others (p=2.6e-8, p=7.9e-11, resp.). Our findings may help guide the formulation of bad-tasting medicines to meet the needs of those most sensitive to them."

Journal • THSD4

Low-Cost and Portable Biosensor Based on Monitoring Impedance Changes in Aptamer-Functionalized Nanoporous Anodized Aluminum Oxide Membrane. (PubMed, Micromachines (Basel)) - "The specificity of the sensor response is characterized by exposure to varying concentrations of chloroquine, which is similar in structure to amodiaquine but does not bind to the OR7 aptamer. The sensing response measured using both the portable impedance reader and the commercial potentiostat showed a similar dynamic response and detection threshold. The specific and sensitive sensing results for amodiaquine demonstrate the efficacy of the low-cost and portable biosensor."

Journal • Infectious Disease • Malaria

Assessing the Acceptability and Feasibility of Five Cycles of Seasonal Malaria Chemoprevention in Côte d'Ivoire. (PubMed, Trop Med Infect Dis) - "Seasonal malaria chemoprevention with sulfadoxine-pyrimethamine + amodiaquine (SP + AQ) was administered monthly to eligible children over five months. A qualitative approach and quantitative surveys were used to assess the strategy acceptability and feasibility in the study area. Overall, there was a positive perception, attitude, and adherence towards the seasonal malaria chemoprevention in this study area."

Journal • Infectious Disease • Malaria