ampicillin/sulbactam / Generic mfg. - LARVOL DELTA

Postoperative outcomes following institutional antibiotic protocol changes in complicated pediatric appendicitis. (PubMed, World J Pediatr Surg) - "Pediatric patients with complicated appendicitis were compared across two sequential first-line empirical antibiotic protocol periods: amikacin plus metronidazole (period 1) changed to ampicillin-sulbactam (period 2). Disease severity, particularly generalized peritonitis, was the main factor associated with intra-abdominal abscess formation. These findings support prioritizing early severity assessment and source control over modifications in empirical antibiotic selection."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pediatrics

Genomic epidemiology and antimicrobial resistance of non-typhoidal Salmonella in children in Hainan Province, China. (PubMed, Microbiol Spectr) - "The ST34 lineage demonstrated extensive multidrug resistance (23/31, 74.2%; 95% CI: 55.4%-88.1%) and accounted for the majority of resistance to ampicillin (29/31, 93.5%; 95% CI: 78.6%-99.2%) and ampicillin-sulbactam (24/31, 77.4%; 95% CI: 58.9%-90.4%). High-risk plasmids were identified, including IncHI2A-type vectors carrying the blaNDM-5 carbapenemase gene and an IncFIA/HI1 plasmid harboring the tet(X4) tigecycline resistance gene...Global phylogeny verifies the China-specific expansion of local ST34 strains with cross-regional and zoonotic potential. These findings underscore the severe threat of MDR NTS in tropical island areas, providing key epidemiological and genomic evidence for targeted surveillance, prudent antibiotic administration and One Health strategies, and offering vital references for NTS control in tropical and subtropical regions."

Journal • Infectious Disease • Pediatrics

Perioperative Antibiotic Utilisation and Infection Outcomes in Pediatric Tympanoplasty : A NSQIP-Pediatric Database Study (AAO-HNSF 2026) - "Postoperative infection rates remained zero regardless of perioperative antibiotic utilisation patterns. Differences in SAP classification between commonly used agents such as amoxicillin–clavulanate and ampicillin–sulbactam, despite similar antimicrobial spectra, highlight potential inconsistencies between guideline definitions and real-world antibiotic availability. These findings support ongoing antimicrobial stewardship efforts and suggest that SAP criteria may benefit from contextual review for paediatric otologic surgery."

Clinical • Infectious Disease • Otorhinolaryngology • Pediatrics

Impact of Intravenous Antibiotic Selection on Postoperative Head and Neck Osseous Free Flap Reconstruction Outcomes (AAO-HNSF 2026) - "They were categorized according to post-op IV antibiotic regimen, including Ampicillin-Sulbactam, Cefazolin-Metronidazole, Clindamycin, and Lexofloxacin, administered within 3, 7, or 14 days post-op...There was a higher risk of pneumonia with 14 day course of Levofloxacin and both 7 and 14 day courses of Cefazolin-Metronidazole... Unasyn was associated with a decreased overall risk of post-op complications after osseous free flap reconstruction compared to other regimens. These results emphasize the importance of evidence-based post-op antibiotic selection considering complication risks."

Cardiovascular • Infectious Disease • Nephrology • Otorhinolaryngology • Pneumonia • Respiratory Diseases

Trends of Intraoperative Antibiotic Prophylaxis for Thyroid and Parathyroid Surgery and Evaluation of Postoperative Outcomes (AAO-HNSF 2026) - "Adults (≥ 18 years) who underwent thyroid or parathyroid surgery for benign disease were grouped on whether they did or did not receive antibiotic prophylaxis with cefazolin, ampicillin/sulbactam, or piperacillin/tazobactam. Increased antibiotic use before 2019 may be associated with increased risk of C. diff infection despite low SSI risk. After 2019, intraoperative prophylaxis decreased, but antibiotic use persisted despite low SSI risk."

Surgery • Infectious Disease • Otorhinolaryngology

Use of Ampicillin/Sulbactam and Clinical Outcomes in Carbapenem-Resistant Acinetobacter baumannii Infections: Preliminary Results from a Multicenter Cohort (IDWeek 2026) - No abstract available

Clinical • Clinical data • Infectious Disease

Comparison of Ceftriaxone and Ampicillin-sulbactam in the Treatment of Community Acquired Pneumonia in the Elderly Population (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Genomic insights into Aeromonas infections in diarrheal patients: high diversity, emerging resistance, and potential outbreak in Beijing. (PubMed, Front Microbiol) - "Resistance rates were notably high for ampicillin/ampicillin-sulbactam (78.26%), nalidixic acid (56.52%), and ertapenem (21.73%), and 65.21% of isolates were multidrug-resistant. Collectively, this study delineates high genetic diversity, emerging chromosomal colistin resistance, and species-specific virulence specialization among Aeromonas isolates from diarrheal patients in Beijing. The detection of a potential outbreak cluster and a rare clinical isolate underscores the power of genomics-based surveillance for detecting and mitigating foodborne pathogen threats."

Journal • Infectious Disease

Appropriateness of Antibiotic Dosing in Patients with Augmented Renal Clearance in Cardiovascular Surgery and Coronary Intensive Care Units. (PubMed, J Coll Physicians Surg Pak) - "Although ARC was uncommon, dosing errors were frequent. Early recognition of ARC and individualised dosing are critical to optimise therapy in ICU patients."

Journal • Cardiovascular • Critical care

A CASE OF PYOGENIC SPONDYLITIS CAUSED BY MESH INFECTION AFTER LAPAROSCOPIC SACROCOLPOPEXY (PubMed, Hinyokika Kiyo) - "We report a case involving an 81-year-old woman who developed pyogenic spondylitis following laparoscopic sacrocolpopexy (LSC) for a cystocele in November year X. During concomitant uterine resection, purulent discharge was observed, and oral levofloxacin was administered for 5 days postoperatively...She was admitted and treated with intravenous sulbactam/ampicillin for 1 week, but her symptoms did not improve...After surgery, the antibiotic regimen was switched to intravenous imipenem/cilastatin, resulting in good infection control...Oral minocycline was initiated on postoperative day 69 and continued until day 133...Although pyogenic spondylitis is recognized as a serious complication of LSC, this represents postoperative case encountered at our institution. On the basis of a review of the literature, we discuss this case and its clinical implications."

Journal • Endometriosis • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • Orthopedics • Pain • Seronegative Spondyloarthropathies

Combined Endoscopic OTSC Closure and Percutaneous n-BCA Glue Embolization for a Gastro-Subphrenic Fistula Complicating Crohn's Disease in a Surgically Hostile Abdomen (ACG 2026) - "CD had been controlled on adalimumab then guselkumab, which was held for five months during hospitalizations...He was started on ampicillin-sulbactam and fluconazole...This case highlights the value of a multidisciplinary approach for complicated CD patients at high surgical risk. Figure: Methylene blue was injected via percutaneous drain seen entering the stomach Figure: OTSC clips applied to close the tract"

Cardiovascular • Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease • Short Bowel Syndrome

Clinical use of ampicillin-sulbactam/ceftazidime-avibactam combination therapy for carbapenem-resistant Acinetobacter baumannii complex infections. (PubMed, Antimicrob Agents Chemother) - No abstract available

Journal • Infectious Disease

Phlegmonous Gastritis During Consolidation Therapy With High-Dose Cytarabine and FLT3 Inhibitor in FLT3-ITD-Mutated Acute Myeloid Leukemia. (PubMed, Cureus) - "We report a patient in his 60s with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)-mutated acute myeloid leukemia (AML) who developed PG during the consolidation therapy with high-dose cytarabine and the FLT3 inhibitor quizartinib...Intravenous piperacillin/tazobactam, followed by ampicillin/sulbactam after clinical improvement, achieved complete clinical and radiologic resolution without surgical intervention. This case highlights the importance of early suspicion, prompt contrast-enhanced CT, and endoscopic biopsy with concurrent microbiological evaluation, followed by timely broad-spectrum antimicrobial therapy in immunocompromised patients with chemotherapy-induced neutropenia in the setting of hematological malignancy."

Journal • Acute Myelogenous Leukemia • Chemotherapy-Induced Neutropenia • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology • Pain • Rare Diseases • FLT3

A DrugâDrug Interaction Gone Pancreatic: Clindamycin and Antiseizure Medication Toxicity (ACG 2026) - "Recent history was notable for treatment of a dental abscess with amoxicillin/clavulanate, transitioned to clindamycin on the day symptoms began. Home medications included lamotrigine, carbamazepine, and hydrochlorothiazide (HCTZ). Given the potential interaction between clindamycin and carbamazepine resulting in elevated carbamazepine exposure and drug-induced pancreatitis, clindamycin and HCTZ were discontinued, and ampicillin/sulbactam was initiated...This case highlights the importance of recognizing drug-drug interactions as an overlooked cause of pancreatitis and carefully evaluating new medications in patients receiving chronic pharmacotherapy to prevent avoidable adverse events. Figure: Figure 1: CT abdomen/pelvis with IV contrast findings of acute pancreatitis with ill-defined hypoenhancing pancreatic parenchyma to level of the body."

CNS Disorders • Dental Disorders • Depression • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Immunology • Neuralgia • Pancreatitis

A Bleed Without a Lesion: Catastrophic Gastrointestinal Hemorrhage and Solobacterium moorei Septic Shock in a Renal Transplant Recipient (ACG 2026) - "He developed septic shock requiring ICU care, vasopressors, and IV ampicillin-sulbactam plus vancomycin. Transplant recipients are uniquely vulnerable to sepsis from commensal organisms due to immunosuppression and mucosal barrier dysfunction. This case expands the recognized severity of S. moorei infection and highlights that life threatening melena in immunocompromised patients may occur concurrently with invasive anaerobic bacteremia despite unrevealing endoscopy."

Clinical • Cardiovascular • Diabetes • Diabetic Nephropathy • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Septic Shock • Transplantation

From Anorectal Surgery to Abdominal Lemierre Syndrome: Fusobacterium Necrophorum Bacteremia With Hepatic Abscesses (ACG 2026) - "Blood cultures grew Fusobacterium necrophorum resistant to clindamycin and susceptible to ampicillin-sulbactam, meropenem, and metronidazole. Recognition that pylephlebitis is a clinical pathophysiologic diagnosis is essential to ensure prompt anaerobic directed therapy, source control, and prolonged treatment duration. Figure: CT abdomen pelvis with IV contrast revealed multiple hepatic abscesses; this image highlights the largest lesion in segment VI measuring 2.5 Ã 1.8 cm."

Surgery • Acute Kidney Injury • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Nephrology • Pulmonary Disease • Renal Disease • Thrombocytopenia • Thrombosis

A Rare Gastrointestinal Catastrophe: Acute Esophageal Necrosis in DKA and Septic Shock (ACG 2026) - "Thus treated with ampicillin-sulbactam .He then developed upper gastrointestinal bleeding...Such reports remain important for improving awareness, early recognition, and future evidence synthesis of this rare but potentially life-threatening condition. Figure: Image 1 showing initial EGD demonstrating diffuse circumferential black discoloration of the distal esophageal mucosa consistent with acute esophageal necrosis Figure: Image 2 showing repeat EGD demonstrating interval mucosal healing with significant resolution of the necrotic black discoloration of the distal esophagus"

Acute Kidney Injury • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Inflammation • Metabolic Disorders • Nephrology • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Septic Shock

Colonic Perforation and Feculent Empyema Arising From an Incarcerated Morgagni Hernia Presenting as Pneumothorax (ACG 2026) - "She was started on ampicillin-sulbactam...Treatment included ceftriaxone, metronidazole, and fluconazole...This measures approximately 10 cm in axial dimension (prior study 4.8 cm). Figure: Figure 2: CT on arrival to our tertiary center showing high-density enteric contrast throughout the right pleural space, concerning for perforation of the contrast-containing herniated supradiaphragmatic bowel with partial decompression of the dilated supradiaphragmatic segment."

Cough • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock

Sigmoid Diverticulitis With Streptococcus constellatus Bacteremia, Pylephlebitis, and Hepatic Abscesses Mimicking Metastatic Malignancy (ACG 2026) - "Blood cultures were obtained, intravenous heparin was initiated, and ceftriaxone plus metronidazole were started...Antibiotics were narrowed to ampicillin-sulbactam and later transitioned to oral therapy...Figure: MRI Abdomen with and without Contrast: multiple multiloculated, rim-enhancing liver lesions. Figure: MRI Abdomen with and without Contrast: near occlusive thrombus within the left portal vein."

Metastases • Cardiovascular • Gastrointestinal Disorder • Hepatology • Oncology • Thrombosis

Hepatic Encephalopathy Masquerading as Dementia, Unmasked by Antibiotic-Associated Diarrhea (ACG 2026) - "Opioids, benzodiazepines, and gabapentin were held without improvement...Secondly, ampicillin-sulbactam may have reduced ammonia-producing gut bacteria, similar to rifaximin therapy...Diagnosis was supported by cirrhosis on CT abdomen, asterixis, prior HE, lactulose nonadherence, and lack of improvement after sedatives were held...Although AAD is not a therapeutic strategy, clinicians should recognize that cathartic diarrhea during antibiotic therapy may incidentally benefit patients with undertreated HE. This case emphasizes that in patients labeled with dementia or unexplained cognitive decline, occult or undertreated HE should remain on the differential."

Acute Kidney Injury • Alzheimer's Disease • CNS Disorders • Dementia • Fibrosis • Gastroenterology • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

Capnocytophaga SBP: A Reminder of Shifting Microbiology and the Necessity of Proactive Management (ACG 2026) - "Despite empiric ceftriaxone, his clinical status plateaued and leukocytosis worsened...Transitioning to ampicillin-sulbactam led to rapid clinical recovery and a follow-up PMN count of < 250 cells/mm³...Second, a stagnant clinical course should prompt an immediate expansion of the differential to include atypical and MDR organisms, guided by a thorough exposure history. As speciation can be delayed, proactive reassessment is vital to bridge the gap between empiric therapy and culture-directed recovery."

Alpha-1 Antitrypsin Deficiency • Fibrosis • Genetic Disorders • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Pulmonary Disease • Respiratory Diseases

Subhepatic Abscess From Dropped Gallstones Five Years After Laparoscopic Cholecystectomy With Microbiological Concordance to Original Bile Culture (ACG 2026) - "Bile fluid culture grew ESBL-producing Escherichia coli susceptible to amikacin, meropenem, and piperacillin-tazobactam with intermediate susceptibility to ampicillin-sulbactam. This finding carries implications for antibiotic choice: original bile culture data, even years old, may guide empiric therapy for dropped gallstone abscesses before new results are available. This case reinforces the importance of routine bile culture during cholecystectomy, documentation of stone spillage, and diligent follow-up of incidental post-cholecystectomy findings."

Discordant • Colon Cancer • Colorectal Cancer • Diabetes • Gastroenterology • Hepatology • Metabolic Disorders • Respiratory Diseases • Solid Tumor

Clinical Outcomes of Penicillin-Based Therapy Compared to Alternative Enterococcal Treatment in Patients With Vancomycin-Susceptible Enterococcal Bloodstream Infections: A Monocentric Cohort Study. (PubMed, Transbound Emerg Dis) - "The aim of this retrospective cohort study was to evaluate clinical outcomes of penicillin-based therapies (ampicillin, ampicillin/sulbactam, or piperacillin/tazobactam) compared with alternative therapies (glycopeptides, linezolid, or daptomycin) in patients with vancomycin-susceptible enterococcal bloodstream infections (BSIs). However, in the multivariable weighted regression model, only septic shock (aOR with 95% CI: 23.53 [1.66; 334.54]) was identified as an independent positive predictor of 30-day mortality. In conclusion, penicillin-based therapy was still an effective and safe treatment but was not associated with an improved survival in a weighted analysis of patients with enterococcal BSI."

Clinical • Clinical data • Journal • Retrospective data • Infectious Disease • Septic Shock

Tracheal Actinomycosis Presenting as a Pseudotumor: A Case Report. (PubMed, Cureus) - "Following treatment with ampicillin/sulbactam, surgical resection, and tracheostomy, the patient made a satisfactory recovery. This case highlights the importance of considering actinomycosis in the differential diagnosis of unexplained airway masses that mimic neoplasms."

Journal • Cough • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases

Canine-Associated Capnocytophaga canimorsus Bacteremia in an Older Adult Without Classical Immunosuppressive Risk Factors. (PubMed, Am J Case Rep) - "Because beta-lactamase testing results were pending at discharge, the patient was prescribed oral amoxicillin-clavulanate. Growth of gram-negative bacilli in aerobic or anaerobic blood cultures from patients with zoonotic exposure should raise clinical suspicion for this organism. When Capnocytophaga infection is suspected in a hospitalized patient, empiric treatment with ampicillin-sulbactam should be initiated while awaiting culture confirmation and susceptibility results."

Journal • Addiction (Opioid and Alcohol) • Dermatology • Fibrosis • Immunology • Infectious Disease