ampicillin/sulbactam / Generic mfg. - LARVOL DELTA

A CASE OF CEFTRIAXONE-ASSOCIATED ENCEPHALOPATHY IN A PATIENT UNDERGOING PERITONEAL DIALYSIS (ISN-WCN 2026) - "CTRX-associated encephalopathy was suspected, and CTRX was discontinued on day 4 and replaced with ampicillin/sulbactam. This case highlights the importance of recognizing AAE as a potential cause of acute consciousness disturbance during antibiotic therapy. Early diagnosis, discontinuation of the offending agent, and consideration of dialysis are crucial for favorable outcomes in high-risk populations."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Diabetes • Diabetic Nephropathy • Epilepsy • Hypertension • Infectious Disease • Metabolic Disorders • Movement Disorders • Nephrology • Renal Disease

INFECTIVE ENDOCARDITIS IN HEMODIALYSIS PATIENTS: A REPORT OF TWO CASES ASSOCIATED WITH HEMODIALYSIS ACCESS (ISN-WCN 2026) - "Microbiology: Culture of the catheter tip revealed Methicillin-resistant Staphylococcus epidermidis (MRSE), which was resistant to vancomycin...Management: DLC removal and administration of intravenous ampicillin-sulbactam and gentamicin.Case II: A 57-year-old man with renal failure undergoing HD was admitted with worsening shortness of breath and decreased consciousness (GCS E3V4M2) and a body temperature of 38.7°C...The first case involved a 30-year-old woman and the second a 57-year-old man. Both cases met the Modified Duke Criteria."

Clinical • Cardiovascular • Infectious Disease • Inflammation • Renal Disease

Dramatic increase in consumption of antibiotics in Colombia, 2020-2023. (PubMed, Biomedica) - "The progressive increase in consumption and spending on antimicrobials in Colombia requires a set of interventions that include promoting changes in medical prescribing behaviour and a public education campaign that leads to the adoption of a sustainable public health policy."

Journal

Ampicillin/sulbactam and ceftazidime/avibactam for the treatment of carbapenem-resistant Acinetobacter baumannii complex: correlation of genotype, phenotype, and clinical outcomes (ESCMID Global 2026) - No abstract available

Clinical • Clinical data

Acinetobacter baumannii bacteraemia: evaluation of strategies for the treatment of in-hospital acquired infection (A-BEAST study), cefiderocol vs ampicillin/sulbactam vs their combination (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease

Pharmacodynamic activity of sulbactam/durlobactam and ampicillin/sulbactam combinations against Acinetobacter baumannii (ESCMID Global 2026) - No abstract available

PK/PD data

Analysis of perioperative antibiotic usage in the operating room during the 2019 cefazolin shortage in Japan: a multicenter observational study. (PubMed, J Anesth) - "The drop in CEZ supply reduced its perioperative use and increased reliance on alternative antimicrobials. The impact was less severe at facilities with multiple suppliers, suggesting supplier diversification may help mitigate future shortages. These findings, based on actual administration data from operating rooms across Japan, provide insights for ensuring a stable antibiotic supply."

Journal • Observational data • Anesthesia

The effect of papain on some bacterial pathogens in poultry meat. (PubMed, Poult Sci) - "coli resisted ampicillin/sulbactam (65-67%); Salmonella resisted ceftriaxone (88-91%) and penicillin (82-86%). In conclusion, poultry farms, especially turkey farms, harbor multidrug-resistant E. coli and Salmonella with clinically important ESBL/carbapenemase genes. Prudent antibiotic use, strengthened biosecurity, and papain-based interventions can mitigate food-safety risks."

Journal

Longitudinal Trends in Antimicrobial Susceptibility Among ECMO Patients With Gram-Negative Rods (SCCM 2026) - "We used AI-assisted tools for statistical coding and editorial refinement. Ertapenem maintained >95% susceptibility throughout all years. Meropenem showed a transient drop in 2022 (62.9%) but recovered to 100% by 2023...Ciprofloxacin susceptibility peaked in 2020–2021 before declining in 2023. Due to inconsistent data, piperacillin-tazobactam was excluded from trend analysis. Antimicrobial susceptibility patterns among GNRs in ECMO patients have fluctuated over the past five years. Antimicrobial susceptibility patterns among GNRs in ECMO patients have fluctuated over the past five years. Carbapenems remain reliable, while recovery of susceptibility to narrower-spectrum agents such as ampicillin-sulbactam and cefepime suggests a potential role for empiric antibiotic cycling. ECMO-specific antibiograms provide critical guidance for treatment and support the role of stewardship in curbing MDRO development in this high-risk population."

Clinical • Gram negative • Infectious Disease • Pneumonia

When the Brown Recluse Strikes Back: Acute Generalized Exanthematous Pustulosis After Loxosceles Envenomation (AAD 2026) - "Treatment: In the emergency department, the patient received intravenous (IV) fluids, vancomycin, cefepime, and ondansetron. Due to lack of improvement, he was switched to IV ampicillin-sulbactam and oral linezolid. Acetaminophen and morphine sulfate were added to the medication regimen. On day eight, the patient received 40mg of oral prednisone and was discharged the following morning after significant improvement."

Hematological Disorders • Immunology • CRP • HP

Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP (clinicaltrials.gov) - P4 | N=236 | Recruiting | Sponsor: Medical College of Wisconsin | Trial completion date: May 2027 ➔ May 2028 | Trial primary completion date: May 2027 ➔ May 2028

Head-to-Head • Trial completion date • Trial primary completion date • Infectious Disease • Pneumonia • Respiratory Diseases

Minor non-fermenting Gram-negative bacilli in Europe, 2020-2024 (MINOFEu). (PubMed, Int J Antimicrob Agents) - "This study provides an updated overview of the diagnostic approaches and epidemiology of minor NFGNB across Europe, supporting future comparative analyses and improved diagnostic and antimicrobial strategies."

Journal • Infectious Disease

Left Ventricular Apical Intracardiac Mass With Embolic Stroke During Aggregatibacter segnis Bacteremia Following Acute Cholangitis: A Case Report. (PubMed, Cureus) - "An elderly woman with cholangiocarcinoma and a metallic biliary stent presented with fever and anorexia and was initially treated for acute cholangitis with biliary drainage and intravenous ampicillin/sulbactam...Follow-up TTE performed immediately after the neurological event showed the complete disappearance of the apical mass, suggesting embolization. This case highlights the importance of careful echocardiographic follow-up in patients with A. segnis bacteremia, even when initial imaging is unremarkable, particularly in the presence of apical wall-motion abnormalities that may alter intracardiac flow."

Journal • Anorexia • Biliary Cancer • Cardiomyopathy • Cardiovascular • Cholangiocarcinoma • CNS Disorders • Ischemic stroke • Oncology • Solid Tumor

Peptide-based antimicrobial effect against carbapenem-resistant Acinetobacter baumannii: preclinical drug assessment and translational potential. (PubMed, Front Pharmacol) - "In both the checkerboard method and time-kill assay, DD-S052P demonstrated in vitro synergistic activity against CRAB isolates when combined with ampicillin/sulbactam, ceftolozane/tazobactam, and colistin. Our findings indicate that DD-S052P in combination with colistin may represent a promising therapeutic option for CRAB infections. Further research is required to elucidate the mechanisms by which DD-S052P overcomes existing carbapenem resistance and validate its clinical applicability."

Journal • Preclinical • Infectious Disease

Purring pathogen: Peritoneal dialysis peritonitis caused by Pasteurella multocida in a multicat household (NKF-SCM 2026) - "Empiric intraperitoneal vancomycin and cefepime were initiated with the addition of oral nystatin prophylaxis. Cultures were ultimately positive for Pasteurella multocida, with the plan to treat with intravenous (IV) ampicillin/sulbactam, followed by a 3-week course of oral amoxicillin/clavulanate and intraperitoneal cephalosporins...The patient remains infection-free while on hemodialysis at one-month follow-up. CONCLUSION This case illustrates the improtance of patient education in preventing peritoneal dialysis associated peritonitis, emphasizing the need to address pet exposure as an important modifiable risk factor"

Infectious Disease • Nephrology • Renal Disease

Possible Antifungal-Associated Acute Tubular Necrosis in the Management of Candidemia (NKF-SCM 2026) - "He received ampicillin-sulbactam for 9 days...The improvement in renal function after stopping caspofungin strengthened the suspicion of a drug-induced component. Persistent high urine output with gradual biochemical recovery was consistent with the diuretic phase of ATN."

Diabetes • Hypotension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Septic Shock • Type 1 Diabetes Mellitus

Canine Companions and Opportunistic Threats: A Case of Capnocytophaga Induced Ventriculitis (AAN 2026) - "We report a rare case of ventriculitis caused by Capnocytophaga in a dog-owning patient with no visible wounds or reported history of bites or scratches.Design/ N/A A 78-year-old male with rheumatoid arthritis on rituximab and a history of splenectomy presented to the hospital with syncope...He was admitted for sepsis with septic shock, requiring vasopressors, and was empirically started on cefepime and vancomycin...He was switched to IV ampicillin-sulbactam and discharged on oral amoxicillin-clavulanate.Eight days after discharge, the patient was readmitted with worsening fatigue, altered mental status, and fever of 103°F... C. canimorsus bacteremia is rare but can lead to life-threatening central nervous system infections following animal exposure, even in the absence of bites or scratches. In immunocompromised individuals with a history of canine contact, differential diagnoses should be considered, as early detection and treatment is essential to reduce..."

Clinical • Immunology • Infectious Disease • Inflammatory Arthritis • Rheumatoid Arthritis • Septic Shock • Vasculitis

Machine learning-enabled early risk stratification of β-Iactam-induced electrolyte imbalances. (PubMed, Per Med) - "We retrospectively analyzed 240 hospitalized adults treated with piperacillin - tazobactam or ampicillin - sulbactam. Electrolyte imbalances were common during β-lactam/β-lactamase inhibitor therapy. An interpretable model using routine clinical variables may support risk-informed monitoring; external validation is warranted."

Journal • Cardiovascular • Endocrine Disorders • Renal Disease • Respiratory Diseases

Actinomycetoma Caused by Gordonia rubripertincta: Case Report. (PubMed, Diagnostics (Basel)) - "Doxycycline treatment was ineffective...Although initial improvement was observed with amoxicillin-clavulanate treatment, the condition later worsened, requiring long-term penicillin therapy and eventual surgical excision...A six-week course of ampicillin-sulbactam and ciprofloxacin, along with offloading, decreased pain and stabilized radiological findings. Gordonia infections mean there is no universally established treatment protocol. This case underscores the diagnostic and therapeutic challenges associated with mycetoma, particularly in non-tropical regions."

Journal • Infectious Disease • Pain

Comparison of Two Different Doses of Ampicillin-Sulbactam as Part of Combination Therapy in the Treatment of Multidrug Resistant Acinetobacter baumannii Ventilator Associated Pneumonia: A Randomized Clinical Trial. (PubMed, Infect Drug Resist) - "This study aimed to compare the clinical outcomes of low- versus high-dose ampicillin-sulbactam in combination of meropenem and colistin in patients with MDR Acinetobacter baumannii associated VAP. However, the small sample size, short follow-up period, and use of concomitant antibiotics limit attribution of outcomes solely to ampicillin-sulbactam dosing. Larger, well-controlled studies are needed to define the optimal dosing strategy."

Clinical • Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

In reply to the Letter to Editor regarding 'Pharmacokinetics of Ampicillin, Sulbactam, and Combined Ampicillin/Sulbactam in Subcutis, Muscle, and Plasma: A Microdialysis Trial in Healthy Volunteers'. (PubMed, Int J Antimicrob Agents) - No abstract available

Journal • PK/PD data

Bacterial Pathogens and Antibiotic Resistance Patterns in Pediatric Appendicitis: Implications for Antibiotic Choice. (PubMed, Pediatr Infect Dis J) - "In our cohort, cefuroxime/metronidazole seems to be an adequate option for uncomplicated and piperacillin/tazobactam for complicated cases."

Journal • Gastroenterology • Gastrointestinal Disorder • Pediatrics • CRP

Phenotypic Resistance of Ciprofloxacin and Azithromycin Resistant Campylobacter Isolates to an Extended Panel of Antibiotics. (PubMed, bioRxiv) - "In this study we explored phenotypic resistance using traditional Kirby-Bauer methods in human and animal derived Campylobacter isolates that were concurrently resistant to both azithromycin and ciprofloxacin to an expanded panel of antimicrobials, including clindamycin, fosfomycin, ampicillin sulbactam and tigecycline. Out of 236 Campylobacter isolates, over 85% of C. jejuni and C. coli were resistant to clindamycin, over 60% were resistant to ampicillin sulbactam and over 30% to fosfomycin. Less than 2% of isolates were resistant to tigecycline and there was no observed resistance to Imipenem."

Journal

Emerging Threat of Acinetobacter radioresistens Infection in Immunocompromised Patients. (PubMed, Case Rep Infect Dis) - "Initial empiric antibiotics were vancomycin and cefepime...The patient's antibiotic regimen was de-escalated to intravenous ampicillin-sulbactam, to which he initially responded...It highlights the utility of rapid molecular diagnostics for precise pathogen identification and antimicrobial stewardship, while also illustrating the critical role of confirmatory methods like MALDI-TOF. Vigilance for less common Acinetobacter species is warranted in patients with significant comorbidities."

Journal • Alzheimer's Disease • Chronic Obstructive Pulmonary Disease • CNS Disorders • Dementia • Immunology • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pulmonary Disease • Respiratory Diseases • Septic Shock • Solid Tumor

Short-Term Outcomes of Expectant Management With Antibiotics for Preterm Subclinical Intra-Amniotic Infection. (PubMed, J Obstet Gynaecol Res) - "Expectant management with antibiotics is feasible in the short term for subclinical intra-amniotic infections caused solely by Ureaplasma spp./Mycoplasma hominis. However, for cases caused by the other bacteria, further studies are needed to determine appropriate management strategies."

Journal • Retrospective data • Infectious Disease • Inflammation • IL6