ampicillin/sulbactam / Generic mfg. - LARVOL DELTA

Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial (ASH 2025) - P3 | "ACSseverity was defined a priori as mild (no oxygen (O2) use or RBC transfusion), moderate (O2 use ortransfusion), or severe (bilevel positive airway pressure (BiPAP) use, intubation, or pediatric intensive careunit (PICU) transfer). 271 patients enrolled (median age 15[11,18] years, 51% male; 74% HbSS/Sb°; 76% onHydroxyurea (HU)...Across all sites, 96% of patients receivedantibiotics (50% ceftriaxone, 28% ampicillin-sulbactam, 7% vancomycin, 11% other) and 82% receivedazithromycin. Site-level use ranged from 0-100% for ceftriaxone and 50-100% for azithromycin... ACS remains common in patients with SCD-VOE (20%), with 14% of ACS diagnosed duringtheir hospital stay. Two-thirds of subjects who developed ACS had a CXR done in the ED that wasnegative. ACS may have been missed in patients who did not get a CXR, and radiographic changes oftenlag behind symptoms."

Clinical • P3 data • Addiction (Opioid and Alcohol) • Cardiovascular • Cough • Genetic Disorders • Hematological Disorders • Pain • Respiratory Diseases • Sickle Cell Disease

Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in Staphylococcus aureus Isolated from Burn Wounds. (PubMed, Iran J Med Sci) - "The 50 selected isolates were resistant to cefoxitin, amoxicillin, benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, and azithromycin. No significant changes were seen in fnbA and ftsZ. Nanocurcumin inhibits S. aureus virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on fnbA and ftsZ, requiring further research."

Journal • Infectious Disease

A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test. (PubMed, Cureus) - "Outpatient urinary antigen tests for pneumococcus and Legionella were negative, and oral garenoxacin was initiated...Broad-spectrum β-lactams (sulbactam/ampicillin, followed by piperacillin/tazobactam) were ineffective...Subsequent targeted therapy with azithromycin (days 6-8 and 13-15), alongside levofloxacin, resulted in clinical improvement...This case report highlights that a single negative urinary antigen test does not rule out Legionella infection. We accordingly recommend early repeat antigen testing, ideally within one week, for postoperative pneumonia unresponsive to β-lactams, together with prompt macrolide or fluoroquinolone therapy."

Journal • Acute Kidney Injury • Cardiovascular • Diabetes • Infectious Disease • Inflammation • Lung Cancer • Metabolic Disorders • Nephrology • Oncology • Pneumococcal Infections • Pneumonia • Renal Disease • Respiratory Diseases • Solid Tumor

Antibiotic prophylaxis in trauma and orthopedic surgery : Current practices across 36 German hospitals and comparison with recently published national guidelines. (PubMed, Unfallchirurgie (Heidelb)) - "While guideline adherence is high in routine indications, significant deviations remain in open fractures and distal phalanx fractures of the fingers. Extended prophylaxis beyond 72 h in GA type III fractures and the frequent use of antibiotics in distal phalanx injuries contrast with current recommendations. Stronger implementation of national standards is essential to reduce overtreatment and support antimicrobial stewardship."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

In vitro sulbactam/avibactam synergy against carbapenem-resistant Acinetobacter baumannii from hospitals in Peru. (PubMed, JAC Antimicrob Resist) - "The presence of metallo-β-lactamase producers (all bla NDM) was observed in three isolates (1.6%). These findings demonstrate high levels of synergistic activity between ampicillin/sulbactam and ceftazidime/avibactam and their potential use as a treatment for CR-Ab."

Journal • Preclinical

Multidrug-resistant Acinetobacter baumannii meningitis and cerebellar abscess: case report and therapeutic considerations. (PubMed, Germs) - "Initial empirical therapy consisted of meropenem and vancomycin, subsequently adjusted according to the susceptibility profile to cefiderocol, intravenous and intrathecal colistin, combined with ampicillin/sulbactam and minocycline. Intrathecal administration of colistin, in combination with systemic multidrug therapy, proved decisive in controlling the infection. An interdisciplinary approach and individualized antimicrobial regimens are essential to achieving a favorable prognosis in such complex cases."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Infectious Disease • Mood Disorders • Pain

In Vitro Evaluation of the Co-Administration of Canine Blood Products and Drugs Used in Critical Illness. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "Platelet function will likely be adversely affected by the co-administration of any of the selected drugs. Co-administration of ketamine, fentanyl, and midazolam with WB resulted in significant hemolysis and is not recommended. It is reasonable to consider co-administering ampicillin, TXA, and ketamine with FDP and FFP."

Journal • Preclinical • Hematological Disorders

Bacillus mycoides bacteremia after dog bite trauma in a patient on chronic suppressive antibiotics. (PubMed, IDCases) - "The patient, who had a chronic Left Ventricular Assist Device (LVAD) in place and was on a chronic suppressive regimen of doxycycline and cefadroxil for a preexisting driveline infection, developed B. mycoides bacteremia despite ongoing antibiotic therapy. She was successfully treated with intravenous ampicillin-sulbactam plus vancomycin, followed by oral ciprofloxacin upon discharge. The patient's recovery was uncomplicated and the final susceptibility testing confirmed pan-susceptibility to all tested agents. This case highlights the potential pathogenicity of B. mycoides in humans and raises questions on the risk factors for infection and optimal management of B. mycoides infections in the setting of relatively limited clinical data."

Journal • Cardiovascular • Infectious Disease • Mood Disorders

Prevalence and Resistance Profiles of Acinetobacter baumannii in ICU Patients in Saudi Arabia: A Systematic Review and Meta-Analysis. (PubMed, Antibiotics (Basel)) - "Colistin remained highly effective, showing 100% susceptibility in some studies. Meanwhile, resistance to carbapenems like imipenem and meropenem often exceeds 50%. Additional antibiotics with notable resistance included gentamicin, tigecycline, ampicillin/sulbactam, trimethoprim-sulfamethoxazole, ceftazidime, piperacillin/tazobactam, and third-generation cephalosporins...baumannii poses a substantial challenge in Saudi Arabian ICUs, with high prevalence and significant resistance to commonly used antibiotics. The results highlight the critical need for continuous monitoring, cautious antibiotic stewardship, and strict infection control methods to manage and lessen the effects of MDR-AB in ICUs."

Journal • Retrospective data • Review • Critical care • Infectious Disease

Occurrence and Antibiotic Resistance Risk Burden of Vibrio mimicus Isolates from Seafood and Aquatic Environments. (PubMed, Antibiotics (Basel)) - "Overall, Vm exhibited diverse antimicrobial resistance patterns across sources with high resistance concerns and high rates against penicillins, cephalosporins, macrolides, and sometimes polymyxins. Thus, it is recommended that stricter regulations on antibiotic use in aquaculture are enforced; wastewater treatment is improved, one-health surveillance is implemented; and education of stakeholders about resistance risks, use of alternatives, and proper cooking of seafood to mitigate Vm-resistant impact is promoted."

Journal • Infectious Disease

Changing Bacterial Profiles and Antibiotic Susceptibility Patterns in Spontaneous Ascites Infection: A Shift in Empiric Combination Antibiotic Therapy? (PubMed, Antibiotics (Basel)) - "According to all culture data, the rate of antibiotic susceptibility was third- and fourth-generation cephalosporins between 76.4 and 68%, 68% for ampicillin-sulbactam, 81.8% for piperacillin-tazobactam, 66% for ciprofloxacin, 71% for levofloxacin, 30% for tetracycline, and 45% for penicillin. The increase in Gram-positive infections and resistance to other antibiotic groups indicates empirical antibiotic selection based on local microbial culture results and antibiotic susceptibility. Our results are crucial to allowing for more rational and successful use of antibiotics."

Journal • Fibrosis • Immunology • Infectious Disease

Distribution and antimicrobial resistance of Acinetobacter spp. isolated from different types of clinical specimens from hospitalized patients and outpatients in Poland. (PubMed, Int J Med Microbiol) - "While AB accounted for 63.1 % of isolates, non-AB species were common, particularly in clinical specimens from genitourinary tract and from skin and wound. Emerging hospital-acquired infections by species like A. pittii underline the need for vigilant monitoring. The high resistance to ciprofloxacin and low but noticeable resistance to carbapenems and colistin highlights the importance of early detection and resistance surveillance to prevent the spread of resistant strains."

Journal • Infectious Disease

Antimicrobial susceptibility of Porphyromonas spp. isolated from dogs with periodontal disease in South Korea. (PubMed, Front Vet Sci) - "Resistance was detected in six isolates (15%) to penicillin, three (7.5%) to imipenem, three (7.5%) to meropenem, 15 (25%) to clindamycin, and seven (17.5%) to ampicillin. No resistance was observed to ampicillin/sulbactam, amoxicillin/clavulanic acid, cefotetan, cefoxitin, metronidazole, chloramphenicol, piperacillin, tetracycline, mezlocillin, or piperacillin/tazobactam. These findings provide crucial insights into the antimicrobial susceptibility patterns of canine oral Porphyromonas spp. and highlight the importance of judicious antimicrobial use in veterinary dentistry."

Journal • Dental Disorders • Periodontitis

Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study. (PubMed, BMC Oral Health) - "Ampicillin monotherapy may be insufficient for preventing SSIs in bimaxillary orthognathic surgery. Sulbactam/ampicillin demonstrated superior efficacy, whereas cefmetazole and clindamycin showed comparable effectiveness as alternative prophylactic agents. These findings underscore the importance of selecting appropriate antibiotics to minimize postoperative infection risk."

Journal • Retrospective data • Infectious Disease • Orthopedics

The Effectiveness and Safety between Colistin-Based and High-Dose Ampicillin/Sulbactam-Based Combination Antibiotic Therapy for Hospital-Acquired Pneumonia Caused by Carbapenem-Resistant Acinetobacter Baumannii pneumonia (APSR 2025) - "Notably, the incidence of acute kidney injury (AKI) on day 14 was significantly higher in the colistin group (54.3%) than in the AMP/SUL group (17.9%, p  = 0.001). Conclusion : High-dose AMP/SUL-based combination therapy may be a more favorable treatment option for HAP-CRAB due to its higher microbiological success rate and significantly lower risk of AKI, despite no statistically significant difference in 28-day mortality or clinical success."

Clinical • Acute Kidney Injury • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

Clinical impact of prophylactic antibiotics in kidney transplantation: A retrospective observational cohort study with historical comparison. (PubMed, PLoS One) - "In this study, we observed that a single dose of cefazolin as perioperative antibiotic prophylaxis may lead to higher rates of postoperative urinary tract infections, but it could potentially lower the incidence of acute rejection within six months."

Clinical • Journal • Observational data • Retrospective data • Infectious Disease • Nephrology • Transplant Rejection • Transplantation

Pediatric pneumonia involving Penicillium rolfsii isolated from sputum culture following a plunge pool near-drowning incident. (PubMed, J Mycol Med) - "Chest computed tomography confirmed severe aspiration pneumonia, and empirical treatment with ampicillin-sulbactam was initiated. Based on elevated β-D-glucan levels, voriconazole was added...This is the first reported case of P. rolfsii being detected in culture tests of a human invasive infection, particularly in an otherwise healthy child. This case highlights the need for healthcare professionals to consider environmental fungi in Japanese river water as potential causes of invasive infections, such as pneumonia, particularly after near-drowning incidents."

Journal • Critical care • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Development of a predictive model for eosinophilia in patients treated with ampicillin/sulbactam or piperacillin/tazobactam. (PubMed, Br J Clin Pharmacol) - "This study proposes a clinically applicable risk-scoring model for predicting eosinophilia in patients treated with penicillin/beta-lactamase inhibitors. Incorporating machine learning improved model accuracy, enabling more precise identification of high-risk patients. The model supports proactive risk assessment and may inform tailored monitoring and intervention strategies in clinical settings."

Journal • Cardiovascular • Eosinophilia • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Ertapenem as an Antibiotic Prophylaxis for Colectomies and Laparotomies: A Systematic Review. (PubMed, Surg Infect (Larchmt)) - "Ertapenem was compared with single-agent second-generation cephalosporins such as cefotetan, cefuroxime, and cefoxitin and to a single-agent penicillin with or without a combined β-lactamase inhibitor (i.e., ampicillin-sulbactam). However, most studies were observational. Therefore, RCTs, especially in trauma, are needed."

Journal • Review • Infectious Disease

Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-Based Model. (PubMed, J Infect Dis) - "This study highlights the potential of integrating genomic insights into MBM to optimize antibiotic regimens. The ampicillin/sulbactam and ceftazidime/avibactam combinations demonstrated promising activity against highly resistant CRAB strains, supporting their potential for clinical application in managing difficult-to-treat infections."

Journal • Infectious Disease

Lelliottia amnigena bacteremia in a patient with sigmoid colon cancer and schizophrenia: a case report. (PubMed, J Infect Chemother) - "Antimicrobial therapy was initiated with piperacillin/tazobactam, which was later de-escalated to ampicillin/sulbactam according to the results of antimicrobial susceptibility testing, resulting in a total of 14 days of antimicrobial treatment. L. amnigena can cause bacteremia and sometimes lead to serious conditions in patients."

Journal • CNS Disorders • Colon Cancer • Colorectal Cancer • Hypotension • Infectious Disease • Inflammatory Bowel Disease • Oncology • Psychiatry • Schizophrenia • Solid Tumor • CRP

Co-occurrence of Actinomyces israelii Infection and Squamous-Cell Carcinoma of the Jaw in a Kidney Transplant Patient (KIDNEY WEEK 2025) - "Case Description We present a 67-year-old male with End-Stage Kidney Disease secondary to hypertension, who underwent kidney transplantation in 2021 and was on immunosuppression with mycophenolic acid, prednisone, and tacrolimus...Empiric antibiotics were started and later transitioned to ampicillin-sulbactam once pathology revealed squamous cell carcinoma, osteonecrosis of the jaw, and actinomycosis...Luckily, this patient was already scheduled for mass resection and margins were negative for necrosis which helped with antibiotics length of therapy. Clinicians must remain vigilant for infections like A. israelii alongside malignancy in immunosuppressed patients after kidney transplant."

Clinical • Cardiovascular • Fibrosis • Hypertension • Immunology • Infectious Disease • Nephrology • Oncology • Pneumonia • Renal Disease • Squamous Cell Carcinoma • Transplantation

Paws for Concern: A Case of Pasteurella Peritonitis and Exit Site Infection in a Patient on Automated Peritoneal Dialysis (KIDNEY WEEK 2025) - "Patient was admitted and started on IV vancomycin and piperacillin/tazobactam...Antibiotics were narrowed to IV ampicillin/sulbactam and she was discharged on a course of intraperitoneal Ceftazidime to complete a 2-week course...Recently, the ISPD guidelines outlined management of PD peritonitis and catheter related infections, noting that infections are more likely to occur in APD as opposed to manual PD probably due to longer tubing. Although having pets is not an absolute contraindication to doing PD, educating patients to maintain a clean home environment and keeping pets away from the PD tubing are keys to preventing infection."

Clinical • Cardiovascular • Dermatology • Hypertension • Infectious Disease • Nephrology • Renal Disease

Evaluation and Management of Patient Referred for "Normal Saline Allergy" (ACAAI 2025) - "With recent NS infusion, he developed urticaria, abdominal pain and hypoxia to SpO2 70%, only resolving after epinephrine administration. He also endorses prior anaphylaxis to azithromycin, ceftriaxone, piperacillin/tazobactam, clindamycin, levofloxacin, and ampicillin/sulbactam...The reproducibility of symptoms with NS and tolerance of other fluids prompted evaluation. Testing identified chlorhexidine as the likely culprit, which poses a logistical challenge as chlorhexidine is a standard component of peripheral intravenous line placement kits."

Clinical • Allergy • Anemia • Cardiovascular • Dermatology • Genetic Disorders • Hematological Disorders • Immunology • Sickle Cell Disease • Urticaria • Vascular Neurology

Suspected Tazobactam Allergy in A Case of Anaphylaxis in Multiple Drug Allergy (ACAAI 2025) - "The patient's listed allergies included: penicillin, piperacillin-tazobactam, and multiple cephalosporin. Penicillin resulted in anaphylaxis 9 years prior, as well as anaphylaxis to ceftriaxone and cefepime. Penicillin skin testing was negative and he passed 2-step amoxicillin challenge. He subsequently tolerated Ampicillin-sulbactam. Based off susceptibilities, the primary team requested to change therapy to ceftolozane-tazobactam...He was treated for anaphylaxis with intramuscular epinephrine. Tryptase during event was 13.4μg/L. Discussion This case highlights the importance of history in drug allergy evaluation, as well as consideration of tazobactam as a separate allergenic agent."

Clinical • Allergy • Asthma • Immunology • Inflammation • Pruritus • Respiratory Diseases