BCG vaccine lyophilized / University of Antioquia - LARVOL DELTA

Tuberculosis in otherwise healthy adults with inherited TNF deficiency. (PubMed, Nature) - "These findings contrast with those for patients with inherited complete deficiency of the respiratory burst across all phagocytes, who are prone to multiple infections, including both Bacillus Calmette-Guérin disease and tuberculosis3. Human TNF is required for respiratory-burst-dependent immunity to Mycobacterium tuberculosis in macrophages but is surprisingly redundant otherwise, including for inflammation and immunity to weakly virulent mycobacteria and many other infectious agents."

Journal • Acute Myelogenous Leukemia • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CSF2 • IFNG • TNFRSF1A

Human inherited CCR2 deficiency underlies progressive polycystic lung disease. (PubMed, Cell) - "By contrast, alveolar macrophage counts are about half. Human complete CCR2 deficiency is a genetic etiology of PAP, polycystic lung disease, and recurrent infections caused by impaired CCL2-dependent monocyte migration to the lungs and infected tissues."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • CCL2 • CCR2 • CSF2