HAMS-AB / Rise Therap - LARVOL DELTA

Microbial production of short-chain fatty acids attenuates long-term neurologic impairment after traumatic brain injury. (PubMed, J Neuroinflammation) - "Diet-facilitated microbial production of acetate and butyrate attenuates behavioral deficits of LTNI after TBI and produces enduring benefits at the single-cell level on the neuro-inflammatory and neuro-progenitor responses. This therapeutic approach could have a broader potential to prevent neurodegenerative disease."

Journal • Alzheimer's Disease • CNS Disorders • Inflammation • Vascular Neurology

Study on How Nerve Signalling is Affected by a High-Fibre Supplement in Untreated Hypertensive Individuals. (ANZCTR) - P=N/A | N=29 | Not yet recruiting | Sponsor: Professor Francine Marques - Monash University

New trial • Cardiovascular • Hypertension

Safety and effects of acetylated and butyrylated high-amylose maize starch on youths recently diagnosed with type 1 diabetes: A pilot study. (PubMed, Diabetes Obes Metab) - No abstract available

Journal • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function (clinicaltrials.gov) - P1 | N=12 | Completed | Sponsor: Indiana University | Phase classification: P3 ➔ P1

Phase classification • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus • IL2RA • ISG20

HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes. (PubMed, iScience) - "Finally, SCFA increased insulin levels in human β-like cells and improved transplantation outcome in NOD/SCID mice. Our findings support the use of metabolite-based diet as attractive approach to improve glucose control in T1D."

Journal • Diabetes • Immunology • Metabolic Disorders • Obesity • Transplantation • Type 1 Diabetes Mellitus

HAMS-AB-01B: HAMS-AB in Newly Diagnosed Patients With Type 1 Diabetes (clinicaltrials.gov) - P1 | N=39 | Not yet recruiting | Sponsor: Rise Therapeutics LLC

New P1 trial • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus