lovastatin / Generic mfg. - LARVOL DELTA

Chromosome-Scale Genome Analysis Reveals Locus-Specific Disruption of the Citrinin-Associated Region in a Furu-Derived Monascus ruber Strain BC20. (PubMed, Foods) - "By contrast, the monacolin K (mk) locus remained syntenically conserved in BC20, supporting locus-specific structural disturbance rather than assembly-derived pseudo-absence. Additionally, its antifungal susceptibility was determined. Overall, BC20 represents a M. ruber candidate strain with undetectable citrinin, and this study provides a practical analytical framework for citrinin risk screening in food-related Monascus isolates."

Journal

A Lipid Metabolism-Related Gene Signature Stratifies Prognosis and Reflects Metabolic-Immune Heterogeneity in Head and Neck Squamous Cell Carcinoma. (PubMed, Oral Dis) - "The results validate the biological significance of the model, highlight potential associations between lipid metabolism and the immune microenvironment in HNSCC, and provide a theoretical basis for further investigating metabolism-related therapeutic strategies."

Gene Signature • Heterogeneity • IO biomarker • Journal • Head and Neck Cancer • Metabolic Disorders • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • ABCB1 • ANO1 • CDKN2A • CTLA4 • DKK1 • FABP4 • PER2 • PTX3 • TRIB3

Association of Statin Exposure With Survival and Thromboembolic Outcomes in Multiple Myeloma: A Multi-Institutional Real-World Analysis (SOHO 2026) - "In this large real-world analysis, statin exposure in MM was associated with a durable survival benefit through 5 years. Despite limitations inherent to retrospective observational studies, including residual confounding and immortal time bias, these findings support prospective investigation into the adjunctive antimyeloma role of statins. The observed reduction in thromboembolic and infectious complications further suggests pleiotropic benefits of statins beyond lipid lowering."

Clinical • Real-world • Real-world evidence • Hematological Malignancies • Multiple Myeloma • Oncology

SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes. (PubMed, Biomol Ther (Seoul)) - "These findings establish SIRT6 as a sterol-responsive nuclear regulator that converts intracellular cholesterol status into epigenetic repression of the cholesterol biosynthetic program. This SIRT6-dependent pathway complements endoplasmic reticulum-based sterol sensing and provides a mechanistic insight into hepatic cholesterol dysregulation in MASH."

Journal • Fibrosis • Hepatology • Immunology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • HMGCS1 • SIRT6

Disseminated Superficial Actinic Porokeratosis Treated with Topical Lovastatin and Cholesterol: A Case Report (EADV 2026) - No abstract available

Case report • Clinical • Dermatology

Bilateral Involvement in CHILD Syndrome Successfully Treated with Cholesterol-Lovastatin Combination (EADV 2026) - No abstract available

Clinical • Dermatology • Pediatrics

Chemical Profiling and In Vitro Cytotoxicity Assessment of Commercial Red Yeast Rice Ingredients. (PubMed, Foods) - "Red yeast rice (RYR) food supplements are widely used for cholesterol management due to their monacolin content, particularly monacolin K (MK), which shares the same chemical structure as lovastatin, a compound associated with several side effects. Exploratory proteomic profiling suggested distinct protein-abundance patterns between RYR- and simvastatin-treated cells, providing hypothesis-generating information on functional annotations associated with these patterns. These findings emphasize the importance of comprehensive chemical characterization and quality control strategies considering both monacolins and secondary metabolites to improve the safety assessment of RYR supplements."

Journal • Preclinical • Hepatocellular Cancer • Oncology • Solid Tumor

Effects of lovastatin on cortical excitability, E/I balance, and antioxidant markers in a case series of patients with drug-resistant epilepsy: a proof-of-concept study. (PubMed, Pharmacol Rep) - "This study demonstrates that a short course of lovastatin can modulate key in vivo biomarkers of E/I balance, redox state, and cortical excitability in patients with DRE. These preliminary findings provide a mechanistic rationale for further, larger studies to explore the potential of statins as a novel strategy for modifying pathological brain activity."

Journal • CNS Disorders • Epilepsy • Inflammation • TRIM33

Statins and reporting signals for amnesia: a pharmacovigilance analysis based on adverse event reporting database. (PubMed, Front Pharmacol) - "Significant positive pharmacovigilance signals were identified for atorvastatin (n = 326, ROR = 2.82, 95% CI: 2.53-3.15, P < 0.001), simvastatin (n = 600, ROR = 4.94, 95% CI: 4.55-5.35, P < 0.001), pravastatin (n = 68, ROR = 4.77, 95% CI: 3.76-6.06, P < 0.001), and lovastatin (n = 26, ROR = 6.96, 95% CI: 4.73-10.24, P < 0.001)...This study identified significant positive pharmacovigilance signals between certain statins and amnesia. The findings of this study provide preliminary disproportionality signals regarding statin-related amnesia, offering exploratory pharmacovigilance references for subsequent safety evaluation and further pharmacoepidemiological validation."

Adverse events • Journal • CNS Disorders

Fermented oats by Monascus purpureus modulates gluten network architecture and quality attributes in wheat dough and Chinese steamed bread. (PubMed, Food Res Int) - "Although the β-glucan content decreased (1.73 mg/g), the levels of the lipid-lowering component Monacolin K (0.45 mg/g) and the multifunctional Monascus pigments increased in the CSB-MOF. Overall, both textural, sensory properties and functions of CSB were enhanced by Monascus fermentation, providing a potential approach for developing nutritious and flavorful fermented cereal products."

Journal

Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. (PubMed, Endocrinol Diabetes Metab) - "Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin, pitavastatin and most notably pravastatin exert either neutral or advantageous effects with respect to glucose metabolism."

Journal • Review • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus • CDC42 • RAC1

MdSPL1-MdNF-YB4-MdCKX7 Module Positively Regulates Saline-Alkali Tolerance by Mediating Cytokinin Levels in Apple. (PubMed, Plant Cell Environ) - "Further analysis revealed that MdNF-YB4, a positive regulator of saline-alkali tolerance, interacts with MdSPL1 to facilitate its transcriptional activation of MdCKX7. Collectively, our study reveals the MdSPL1-MdNF-YB4-MdCKX7 regulatory module that orchestrates cytokinin-mediated saline-alkali tolerance in apple, providing valuable molecular tools for the breeding of saline-alkali-tolerance apple varieties."

Journal

Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway. (PubMed, Eur J Histochem) - "Rescue experiments were performed using the ferroptosis inhibitor deferoxamine and MVA supplementation...MVA supplementation restored cell viability, normalized oxidative stress and iron levels, and reversed alterations in MVA pathway enzymes and ferroptosis-associated proteins. Lovastatin suppresses prostate cancer cell growth and invasiveness by inhibiting the MVA pathway and inducing ferroptosis, highlighting the MVA-ferroptosis axis as a potential therapeutic target for PCa."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Electrochemical monitoring of early astrocytic responses underlying the synergistic effect of extracellular matrix softening and hypoxia. (PubMed, Chem Sci) - "Our work observes the in situ and early state changes of astrocytes under a combined mechanical-hypoxic microenvironment for the first time. The findings offer mechanistic insights into TBI pathogenesis and highlight promising strategies for early therapeutic intervention."

Journal • CNS Disorders • Inflammation • Vascular Neurology • HIF1A

Older Statins Reduce Metastatic Potential in ccRCC: Mechanistic Validation of SIM (Selective Inhibitor of Metastasis) Development (KCRS 2026) - "Statins were classified as older (fluvastatin, simvastatin, lovastatin) or newer (atorvastatin, pravastatin, rosuvastatin)...These findings support further development of SIMs towards achieving metastasis-preventive therapy for ccRCC. Keywords statin, cancer metastasis, ccRCC, selective inhibitor of metastasis DOD CDMRP Funding yes"

Metastases • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Renal Cell Carcinoma • Solid Tumor • HIF1A

Two novel compounds (lovastatin analog Y and lovastatin analog Z) isolated from health foods containing beni-koji (red yeast rice) with adverse events report. (PubMed, J Nat Med) - "UHPLC-HRMS and NMR analyses further showed that the absolute configurations of lovastatin analogs Y and Z isolated from the FFC samples are identical to those of the synthesized compounds. Considering that lovastatin analogs Y and Z are produced through the co-incubation of Monascus pilosus and Penicillium adametzioides, these findings are expected to contribute to biosynthetic research related to these fungal species."

Adverse events • Journal

Inhibition of PrimPol by mevalonate pyrophosphate: A metabolic link between genome integrity and cytokinesis? (PubMed, Biochim Biophys Acta Mol Cell Res) - "Competition assays and molecular modelling suggested that Mev-PP may interact with the Zinc-finger domain of PrimPol, potentially interfering with binding of the initiating nucleotide. These results allow to propose that mevalonate diphosphate accumulation contributes to the retention of stalled forks by inhibiting PrimPol re-priming activity, and suggest a novel connection between mevalonate-pathway metabolites and the replicative stress response."

Journal

Integrated in silico pharmacology of Pleurotus ostreatus-derived bioactive compounds targeting EGFR using network pharmacology and molecular. (PubMed, In Silico Pharmacol) - "However, these findings are based on computational predictions and require further experimental validation to confirm their biological and therapeutic relevance. The online version contains supplementary material available at 10.1007/s40203-026-00690-9."

Journal • Colorectal Cancer • Lung Cancer • Oncology • Solid Tumor • CASP3 • CDC37 • EGFR • ER • HSP90AA1 • JAK2 • PACERR • PARP1 • PIK3CA • PIK3R1 • PPARG • PTGS2 • RELA • TLR4

LD-associated signatures identified by perilipin-based proximity labeling proteomics reveal GNA14 as a therapeutic and prognostic target in renal cell carcinoma. (PubMed, Cancer Gene Ther) - "Drug sensitivity analysis suggested differential responses to Sorafenib, Cediranib, and Saracatinib...Excitingly, lovastatin can partially block the detrimental pathway by which GNA14 promotes lipid accumulation. Therefore, combining lovastatin with GNA14 overexpression yields a more effective suppression of RCC."

Journal • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Kidney Cancer • Metabolic Disorders • Oncology • Renal Cell Carcinoma • Solid Tumor • PLIN2

Cholesterol in amyotrophic lateral sclerosis: a bystander, a biomarker, or a target? (PubMed, Atheroscler Plus) - "While statins are generally not associated with increased ALS risk in clinical studies, preclinical models show divergent effects: some statins accelerate disease progression, while others like lovastatin may be protective. Other lipid-lowering drugs, including fibrates and PCSK9 inhibitors, may also influence ALS-related pathways beyond cholesterol lowering, although their potential role remains to be clarified."

Biomarker • Journal • Review • Amyotrophic Lateral Sclerosis • Cardiovascular • CNS Disorders • Dyslipidemia • Metabolic Disorders

Clinical outcomes of ferroptosis-inducing agents in glioblastoma: A systematic review of clinical trials. (PubMed, J Clin Neurosci) - "Ferroptosis-inducing agents demonstrate variable efficacy and safety in GBM, reflecting the heterogeneity of treatment regimens and patient populations. Clinical benefits, including efficacy and toxicity profiles, appear context-dependent, while the predominance of early-phase, nonrandomized study designs limits definitive conclusions. Further validation through standardized trial designs and improved drug delivery strategies will be essential to clarify the role of ferroptosis-inducing agents."

Clinical data • Journal • Review • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • High Grade Glioma • Oncology • Solid Tumor

Clinical characteristics, diagnosis and prognosis of statin-induced acute pancreatitis. (PubMed, Intern Emerg Med) - "Statin-induced pancreatitis has a class effect that may be independent of duration or dosage. Clinicians should be aware of the possibility of statin-induced acute pancreatitis in order to facilitate early diagnosis and management."

Journal • Pain • Pancreatitis

Disproportionality analysis of drug-associated tinnitus safety signals: a 43-year pharmacovigilance study. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "The strongest signal was diphenhydramine citrate/ibuprofen (ROR 10.71), followed by chloroquine phosphate (9.28)...This 43-year analysis identifies 74 positive drug-associated tinnitus signals, including novel immunobiologic (guselkumab, lifitegrast) and cardiovascular (lovastatin, terazosin) associations without current audiological labelling warnings. The delayed onset profile implicates cumulative cochlear injury mechanisms. These findings provide an actionable basis for regulatory prioritisation and prospective audiological safety research for drug classes where audiological monitoring protocols are currently absent."

Adverse events • Journal • Cardiovascular • Otorhinolaryngology • ROR1

A cholesterol-dependent LRRC8A-caveolin-1 axis sustains KRAS/EGFR signaling, ribosome biogenesis and growth in pancreatic ductal adenocarcinoma. (PubMed, Oncogene) - "Furthermore, disruption of LRRC8A-CAV1 axis through LRRC8A inhibition or cholesterol depletion potently suppressed PDO growth in vitro. Collectively, our work establishes the LRRC8A-CAV1 complex as a key coordinator of biosynthetic expansion and a promising therapeutic target in pancreatic cancer."

Journal • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CAV1 • KRAS • LRRC8A

Targeting Biofilm Formation in Acinetobacter baumannii: In Silico Discovery of Novel Candidate Inhibitors for Acyl-Homoserine Lactone Synthase. (PubMed, Curr Drug Discov Technol) - "These findings suggest that Lovastatin may be a promising drug candidate for AHLS targeting the QS pathway of A. baumannii. The results warrant further experimental validation to explore its potential as an anti-bacterial therapeutic agent."

Journal • Infectious Disease