Natroba (spinosad) / Royalty - LARVOL DELTA

Drugs for head lice. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Review

PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - P4 | N=50 | Recruiting | Sponsor: ParaPRO LLC | Active, not recruiting ➔ Recruiting

Enrollment open • Infectious Disease

PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - P4 | N=50 | Active, not recruiting | Sponsor: ParaPRO LLC | Trial completion date: Jun 2023 ➔ Mar 2026 | Trial primary completion date: Jun 2023 ➔ Nov 2025

Trial completion date • Trial primary completion date • Infectious Disease

In brief: OTC ivermectin for head lice. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal

PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - P4 | N=50 | Active, not recruiting | Sponsor: ParaPRO LLC | Recruiting ➔ Active, not recruiting | Trial completion date: Feb 2023 ➔ Jun 2023 | Trial primary completion date: Aug 2022 ➔ Jun 2023

Enrollment closed • Trial completion date • Trial primary completion date • Infectious Disease

Spinosad topical suspension (0.9%): a new topical treatment for scabies. (PubMed, Expert Rev Anti Infect Ther) - "There is no vaccine and for the past 30 years, the first line treatments have been topical permethrin and oral ivermectin. Here the pharmacology, clinical efficacy and tolerability of this drug are discussed. As the first single dose scabicide the formulated 0.9% topical Spinosad solution shows significant efficacy, little systemic absorption and no serious adverse reactions, making it a promising treatment for classical scabies in patients older than four years."

Journal • Dermatology • Infectious Disease

PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies (clinicaltrials.gov) - P4 | N=50 | Recruiting | Sponsor: ParaPRO LLC

New P4 trial • Infectious Disease

Spinosad 0.9% in the Treatment of Scabies: Efficacy Results from Two Multicenter, Randomized, Double-Blind, Vehicle-Controlled Studies. (PubMed, J Am Acad Dermatol) - "Spinosad 0.9% was effective in the treatment of scabies in these studies of subjects ≥ 4 years of age following 1 application of study drug."

Clinical • Journal • Dermatology • Infectious Disease • Pediatrics

[VIRTUAL] New ligands for the control of human head lice, Pediculus humanus capitis (ACS-Fall 2021) - "Natroba™ is a pediculicide for the topical treatment with 0.9 % spinosad (a 5:1 mixture of spinosyn A and spinosyn D) as the active ingredients...Dimethicone-based medical devices for the treatment of head louse infestations (e.g., Nix ULTRA, LiceMD, NYDA) are dimethylsiloxane polymers, which have high surface spreading characteristics and act as suffocants on eggs and crawling lice. Recent regulatory, legal and production actions will be discussed in terms of how they have impacted effective and sustainable head louse control in the US."

Infectious Disease • Movement Disorders

Comparative transcriptomic analysis of two Saccharopolyspora spinosa strains reveals the relationships between primary metabolism and spinosad production. (PubMed, Sci Rep) - "The addition of soybean oil in the fermentation medium activated the lipid metabolism pathway, enhancing spinosad production. Glutamic acid and aspartic acid were suggested to be the most important amino acids and might participate in spinosad biosynthesis."

Journal • Metabolic Disorders

Alteration of unfolded protein responses and autophagy signaling represented the molecular basis underlying saccharin toxicity to Drosophila (Diptera: Drosophilidae). (PubMed, Arch Insect Biochem Physiol) - "However, when saccharin was cotreated with 2.0 ppm spinosad, an additive insecticidal activity was observed at low concentrations of saccharin. Taken together, alteration of UPR and autophagy signaling represented the molecular basis underlying saccharin toxicity to Drosophila and concurrent spraying of an insecticide with saccharin could enhance the insecticidal activities."

Journal • PCR

New insights on the effects of spinosad on the development of Helicoverpa armigera. (PubMed, Ecotoxicol Environ Saf) - "These results suggested that sublethal spinosad caused hormonal disorders in larvae, which directly affect insect development. Our study serves as a reference and basis for the toxicity evaluation of spinosad on molting and pupation in insect metamorphosis, which may contribute to identifying targets for effective control of cotton bollworm."

Journal

Improving the Safety and Acceptability of Autocidal Gravid Ovitraps (AGO Traps). (PubMed, J Am Mosq Control Assoc) - "These results suggest that black, terracotta, or blue AGO traps can be used for the surveillance and control of Ae. aegypti."

Clinical • Journal

The effect of chemical insecticides on the scavenging performance of Steinernema carpocapsae: direct effects and exposure to insects killed by chemical insecticides. (PubMed, J Invertebr Pathol) - "In conclusion, we discovered that the fitness of scavenging IJs is not diminished by insecticides in insect cadavers. In fact, in some cases the exposure to chemical insecticides may enhance virulence."

Journal

Population structure and insecticide resistance status of Tuta absoluta populations from Turkey. (PubMed, Pest Manag Sci) - "The results will contribute to design area-wide resistance management programs in T. absoluta control in Turkey. However, more monitoring studies are needed to implement evidence-based IRM strategies in the frame of integrated pest management (IPM)."

Clinical • Journal

Field and Laboratory Testing of Feeding Stimulants to Enhance Insecticide Efficacy Against Spotted-Wing Drosophila, Drosophila suzukii (Matsumura). (PubMed, J Econ Entomol) - "Similarly, infestation in field plots and a semifield bioassay showed no significant decreases in infestation with the inclusion of feeding stimulants for the insecticides tested in these trials. We discuss the implications of these findings for managing D. suzukii in fruit crops to help ensure the harvest of marketable fruit."

Clinical • Journal

Sublethal concentration of insecticide amplifies interference competition in a tortrix moth. (PubMed, Ecotoxicol Environ Saf) - "Many organisms (pest and non-target species) compete through interference and theory predicts that a change in interference can substantially change dynamics. Our finding therefore reveals the importance of assessing the effect of insecticides on the mechanisms of competition when predicting their impact on populations."

Journal

Transcriptomic identification and characterization of genes commonly responding to sublethal concentrations of six different insecticides in the common fruit fly, Drosophila melanogaster. (PubMed, Pestic Biochem Physiol) - "Furthermore, genes related to eggshell formation and motion were also under-transcribed, which may indicate a possible energy trade-off for xenobiotic stress. In summary, most of the differentially expressed genes were not directly related to well-known detoxification genes, suggesting that the roles of commonly expressed tolerance-related genes are not likely related to direct metabolic detoxification, but rather are associated with restoration of homeostasis."

Journal

Knockin of the G275E mutation of the nicotinic acetylcholine receptor (nAChR) α6 confers high levels of resistance to spinosyns in Spodoptera exigua. (PubMed, Insect Sci) - "Inheritance analysis showed that the resistance trait is autosomal and incompletely recessive. This study employs a reverse genetics approach to validate the functional role played by the G275E mutation in nAChR α6 of S. exigua in spinosyns resistance and provides another example of the use of CRISPR/Cas9 gene-editing technology to confirm the role played by candidate target site mutations in insecticide resistance."

Journal • PCR

"Aber Bienensterben mit Spinosad ist OK?" (@HellwegBernhard)

High level field-evolved resistance to spinosad in Colorado potato beetle, Leptinotarsa decemlineata, in organically managed fields. (PubMed, Pest Manag Sci) - "This is the first report of high-level resistance to spinosad in Coleopterans. Strength of selection due to the number of years used and applications per season appear to have been the primary factors driving the evolution of resistance to spinosad, highlighting the need for resistance management in organic production, where fewer alternative active ingredients for resistance management are available."

Journal

Mutation (G275E) of nAChR subunit Foα6 associated with spinetoram resistance in Australian western flower thrips, Frankliniella occidentalis (Pergande). (PubMed, Mol Biol Rep) - "We speculate resistance may relate to extensive chemical use in crops nearby such as horticulture where thrips are often targeted for control. Our molecular diagnostic assay can provide timely and precise resistance frequency information that can support sustainable chemical use including spinetoram based IPM."

Journal

Effects of insecticides on mortality, growth and bioaccumulation in black soldier fly (Hermetia illucens) larvae. (PubMed, PLoS One) - "However, we conclude that insecticides present in substrates may affect growth and survival of BSFL. More research on a larger variety of substances and insect species is recommended."

Journal

Management of Onion Thrips (Thrips tabaci) in Organic Onion Production Using Multiple IPM Tactics. (PubMed, Insects) - "While spinosad + neem oil reduced thrips numbers and increased yield alone, none of the treatment combinations were effective at suppressing populations of thrips. Future T. tabaci management in organic onions will require optimization of the available effective biopesticides."

Journal

SELECTIVE ACTIONS OF INSECTICIDES ON DESENSITIZING and NON-DESENSITIZING NICOTINIC ACETYLCHOLINE RECEPTORS IN COCKROACH (Periplaneta americana) NEURONS. (PubMed, Pest Manag Sci) - "Nicotinic acetylcholine receptor competitive modulators (IRAC Group 4) and nicotinic acetylcholine receptor allosteric modulators, site II (hexatoxins, IRAC Group 32) are selective for nAChD receptors, while nicotinic acetylcholine receptor allosteric modulators, site I (spinosyns, IRAC Group 5) are selective for nAChN receptors. It is proposed that IRAC Groups 5 and 32 be re-named non-desensitizing nicotinic acetylcholine receptor allosteric modulators and desensitizing nicotinic acetylcholine receptor allosteric modulators, respectively."

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