LY4175408 / Eli Lilly - LARVOL DELTA

LY4175408: Primary completion and completion of P1 trial (NCT07046923) for NSCLC in Jul 2030 (Eli Lilly) - Q3 2025 Results

Trial completion date • Trial primary completion date • Lung Cancer • Non Small Cell Lung Cancer • Oncology

A phase 1 trial of LY4175408, an antibody drug conjugate targeting protein tyrosine kinase 7-expressing tumor cells, in patients with advanced solid tumors (Trial in Progress) (AACR-NCI-EORTC 2025) - P1 | "Cofetuzumab pelidotin, a PTK7 antibody drug conjugate (ADC) with an auristatin payload, demonstrated activity across several tumor types in a phase 1 trial, however further development was discontinued.1 LY4175408 is an ADC composed of an Fc-silenced PTK7-binding antibody, a cleavable linker, and an exatecan payload. Key exclusion criteria include prior treatment with a PTK7 ADC with a topoisomerase I inhibitor as payload, unresolved toxicities from prior therapy, or known or suspected active central nervous system involvement. Key objectives are to assess safety, PK, and preliminary antitumor activity of LY4175408."

Clinical • Late-breaking abstract • Metastases • P1 data • Tumor cell • Breast Cancer • Endometrial Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • Triple Negative Breast Cancer • PTK7

A Study of LY4175408 in Participants With Advanced Cancer (clinicaltrials.gov) - P1 | N=240 | Recruiting | Sponsor: Eli Lilly and Company | Not yet recruiting ➔ Recruiting

Enrollment open • First-in-human • Breast Cancer • Endometrial Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • Triple Negative Breast Cancer

A Study of LY4175408 in Participants With Advanced Cancer (clinicaltrials.gov) - P1 | N=240 | Not yet recruiting | Sponsor: Eli Lilly and Company

New P1 trial • Breast Cancer • Endometrial Cancer • Hormone Receptor Positive Breast Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • Triple Negative Breast Cancer