glibenclamide / Generic mfg. - LARVOL DELTA

Protective Role of Aconitum heterophyllum Ethanolic Root Extract Against Streptozotocin-induced Diabetes in Rats. (PubMed, Curr Drug Targets) - "This study found that when AHEE was administered to STZ-induced diabetic rats, both dosages exhibited antidiabetic and hypolipidemic effects."

Journal • Preclinical • Diabetes • Dyslipidemia • Inflammation • Metabolic Disorders

Repurposing of lansoprazole and nitazoxanide as NR2F2 inhibitors in the gastric cancer cell line GCIY: computational insights and siRNA-mediated in vitro tests. (PubMed, Front Chem) - "We identified lapatinib, glyburide, nitazoxanide, and lansoprazole as modulators of NR2F2-dependent reporter activity. Taken together, our data extend current evidence that NR2F2 is a ligandable orphan receptor whose transcriptional output can be pharmacologically tuned. Moreover, our findings provide new chemical tools for probing NR2F2 biology and nominate clinically used molecules as starting points for therapeutic or repurposing strategies targeting NR2F2-dependent programs."

Journal • Preclinical • Gastric Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

PolyJet 3D-printed microfluidic device that integrates hydrodynamic focusing of red blood cells and detection of ATP release. (PubMed, Anal Methods) - "Finally, the effect of inhibiting ATP release from RBCs was also determined using diamide and glibenclamide. This PolyJet 3D printing approach clearly provides a method to modulate deformation forces on RBCs and measure the subsequent ATP release in near real-time."

Journal

Genetically Prioritized Antidiabetic Drug Targets in Lung Cancer: Mendelian Randomization and Functional Validation (IASLC-WCLC 2026) - "In vitro, troglitazone inhibited A549 cell migration, whereas glibenclamide promoted migration...Conclusions : This integrated genetic and functional study prioritizes six antidiabetic drug targets with potential relevance to lung cancer biology and drug repurposing. These findings support biomarker-informed development of metabolism-directed therapeutic strategies and nominate SERPINE1 as a candidate mediator of differential response to antidiabetic drug repurposing in lung cancer."

Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CPT1A • IR • PRKAB1 • SERPINE1 • SLC29A1

Real-time Continuous Glucose Monitoring in Switching from Insulin therapy to Glibenclamide in KATPChannel-associated Neonatal Diabetes Mellitus (ESPE 2026) - No abstract available

Diabetes • Metabolic Disorders

Direct and scalable CRISPR editing in human stem cell-derived islets using enveloped delivery vehicles (EASD 2026) - "INS and NKX6.1 knockout resulted in marked reduction in insulin content (−99.1% and −90%, respectively), while ABCC8 and KCNJ11 gain-of-function variants induced increased basal insulin secretion (+3.9- fold and +4.1-fold, respectively) and abolished the potentiating effect of glibenclamide (K ATP -channel blocker) on insulin secretion... EDVs enable efficient and scalable genome editing directly in SC-islets, supporting rapid modelling of diabetes and hyperinsulinism mutations while enabling functional enhancement. This platform substantially reduces experimental timelines and provides a versatile and scalable tool to accelerate the study of beta-cell biology and the engineering of SC-islets with improved properties."

Diabetes • Metabolic Disorders • KCNJ11 • SLC16A1

Changes in circadian behaviour with onset and reversal of hyperglycaemia (EASD 2026) - "Materials and BV59M mice, which express a beta cell-specific tamoxifen-inducible KATP channel-activating mutation, were injected with tamoxifen to induce diabetes (n=16) and later implanted with a 28-day-release glibenclamide drug pellet to reverse diabetes (n=12)... Our results demonstrate that hyperglycaemia per se can disrupt sleep-wake behaviour. This disruption is proportional to the severity of hyperglycaemia and is reversible by normalisation of blood glucose. O -GlcNAc may serve as a biomarker for changes in the diabetic brain associated with disrupted sleep-wake behaviour."

Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Lifting the mist on pancreatic cell dysfunction in type 2 diabetes: lessons learnt from 1,615 organ donor pancreases handled at a single centre (EASD 2026) - "Compared to ND (n=720), T2D (n=145) islet preparations showed reduced insulin secretion to glucose (~42%), glibenclamide (~41%) and arginine (~19%)...Glucose-stimulated insulin secretion was better preserved in islets from T2D donors treated with metformin compared to insulin, despite similar insulin-positive islet areas in the two groups prior to isolation... Large numbers of well characterized ND and T2D islet preparations have allowed detailed studies of insulin secretion in response to secretagogues and its heterogeneity, mainly due to T2D and additional clinical and technical variables. Global transcriptomic comparisons identified novel genes and pathways enriched in T2D islets. Integration of these data with other datasets and omics results will point towards new islet cell targeted strategies to better prevent and treat T2D."

Clinical • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Mechanism-Targeted Therapeutic Strategies for Traumatic Brain Injury: From Molecular Pathways to Functional Recovery. (PubMed, Front Biosci (Landmark Ed)) - "Central to this synthesis is the Dual-Axis Theory, which posits that successful emerging modalities, including repurposed agents such as glibenclamide, amantadine, and statins, alongside cell-free biologics and neuromodulation, converge on two shared pathological targets: the Inflammatory Axis (M1-to-M2 microglial polarization) and the Metabolic Axis (restoration of mitochondrial bioenergetics). By integrating these biological signals with bioengineered delivery systems and artificial intelligence (AI)-driven precision phenotyping, the field can transition from acute neuroprotection toward genuine circuit-level regeneration. We conclude with a blueprint for the next generation of TBI trials, emphasizing biomarker-based stratification and multidimensional endpoints to bridge the translational gap."

Journal • Review • CNS Disorders • Inflammation • Vascular Neurology

Immune dysregulation in chronic diabetic wounds: therapeutic opportunities for healing reprogramming. (PubMed, Front Immunol) - "Emerging therapeutic strategies targeting the NLRP3 inflammasome pathway are reviewed, including pharmacological inhibitors (MCC950, glyburide, disulfiram), natural compounds (quercetin, resveratrol, tanshinone IIA), and advanced biomaterial-based approaches. The potential for macrophage phenotype reprogramming through metabolic intervention and the integration of inflammasome modulation with tissue engineering strategies are discussed. Understanding the intricate crosstalk between NLRP3 inflammasome activation and macrophage polarization provides a foundation for developing targeted therapies that can reprogram the diabetic wound microenvironment from a chronic inflammatory state toward effective healing resolution."

Journal • Review • Diabetes • Inflammation • Metabolic Disorders • IL18 • IL1B • NLRC5 • NLRP3

An Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review. (PubMed, J Korean Neurosurg Soc) - "Glibenclamide/glyburide and hypertonic sodium lactate produced preliminary imaging or physiological signals without demonstrated functional benefit. Riluzole was neutral in an adult randomized trial, whereas a small study in chronic TBI found that minocycline reduced a neuroinflammatory imaging signal but increased plasma neurofilament light. Metformin and N-acetylcysteine plus probenecid provided exploratory pharmacokinetic, biomarker, or safety data. Amantadine provided phenotype-specific clinical proof of principle in traumatic disorders of consciousness. Cerebrolysin showed mixed human evidence, including a favorable day-90 multidimensional ensemble signal that requires independent replication. Deferoxamine and clemastine remain preclinical...Module activation should require optimized foundational care, a matching phenotype, measurable target activation or engagement, and acceptable systemic safety. This framework prioritizes phenotype-enriched, single-module..."

Journal • CNS Disorders • Vascular Neurology • Plasma NfL

Design, in Vitro Biological Activities and Molecular Dynamics Simulations of Novel Chalcone and Pyrazole Derivatives Targeting α‑Glucosidase and PPAR‑γ as Antidiabetic Agents. (PubMed, ACS Omega) - "Following this strategy, acetohexamide, a compound found in the structure of glibenclamide, currently used as a second-generation antidiabetic drug and previously used as a first-generation antidiabetic drug, was selected as the starting material...Both compounds induced concentration-dependent activation of PPAR-γ, with compound 45 exhibiting moderate activity. Notably, compound 44 significantly enhanced cell migration while remaining noncytotoxic, highlighting its potential for further investigation."

Journal • Preclinical • Diabetes • Metabolic Disorders

Overcoming Drug Loading and Dosage Volume Challenges of Adsorption-Solidified SNEDDS by pH-Modulation Strategy: Atorvastatin Calcium and Glibenclamide as Model Drugs. (PubMed, Pharmaceutics) - "In vitro dissolution confirmed that pH modulation did not compromise drug dissolution despite the reduced SNEDDS content per dose. pH modulation with sodium carbonate enabled single-capsule dosing and provided a solvent-free route to boost drug loading for the two investigated model drugs."

Journal

Corosolic Acid Induces Endothelium-Dependent Vasorelaxation in Isolated Rat Aortic Rings. (PubMed, Molecules) - "Possible mechanisms were examined using L-NAME, ODQ, methylene blue, indomethacin, atropine, propranolol, and potassium channel blockers (glibenclamide, TEA, BaCl2, and 4-AP). CA did not significantly inhibit VOCC-mediated CaCl2-induced contraction but partially reduced PE-induced contraction under calcium-free conditions. The mechanisms for CA treating hypertension may involve NO/cGMP signalling, COX-related prostanoid pathways, GPCR-related mechanisms, potassium channel modulation, and partial inhibition of IP3R-mediated calcium release."

Journal • Preclinical • Cardiovascular • Hypertension

Lichen-derived secondary metabolites and endophytic fungi as novel antidiabetic leads: Xylaria curta extract preserves β-cell viability and SUR1-mediated glucose sensing. (PubMed, 3 Biotech) - "Molecular docking revealed that anthracen-9-one (from Ramalina conduplicans) and 2-methylresorcinol from Parmotrema reticulatum exhibited superior binding affinities (total energy: -96.64 and - 67.93 kcal/mol, respectively) compared to glibenclamide (-85.02 kcal/mol)...Consequently, DNA sequences of X. curta and M. fragilis were deposited in NCBI with accession numbers for reference and future studies. The online version contains supplementary material available at 10.1007/s13205-026-05031-3."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Effects of diazepam on contractility in a human umbilical artery model: Underlying mechanisms of vasoactivity. (PubMed, Placenta) - "Diazepam elicits near-complete relaxation in serotonin-precontracted HUA through endothelium-independent mechanisms that likely involve potassium channel activation, calcium channel inhibition, a component sensitive to ODQ suggesting possible involvement of the sGC-cGMP pathway, and interaction with TSPO. These results emphasize the remarkable vasoactivity of diazepam and its importance in the regulation of umbilical vascular tone."

Journal • NOS3

Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs. (PubMed, Int J Neuropsychopharmacol) - "These results demonstrate that chronic stress drives a hypoglycemic shift accompanied by depression-related behaviors, and that the development of both metabolic and behavioral alterations can be prevented by antidiabetic drugs with distinct primary mechanisms administered during the stress period. Thus, this study supports metabolically targeted interventions as a potential preventive strategy for stress-related mental illnesses, whereas their efficacy against an already established phenotype remains to be tested."

Journal • CNS Disorders • Cognitive Disorders • Depression • Diabetes • Hypoglycemia • Mood Disorders • Psychiatry

Dielectrophoresis and ζ-potential as potential low-cost complements to patch clamp for measurement of cell electrophysiology. (PubMed, PLoS One) - "In this paper we use DEP and ELS to examine the electrophysiology of human bladder carcinoma cell line HTB-9 following treatment with ATP, glibenclamide and tetraethylammonium, and compare the results to published data obtained by patch clamp. Results indicate that DEP yields Vm and membrane conductance values that are highly comparable to data from patch clamp, at high speed and low cost, demonstrating the usefulness of techniques such as DEP and ELS for electrophysiological study."

Journal • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor

Phenolic-rich aqueous extract of connarus suberosus improves hyperglycaemia and metabolic alterations in streptozotocin-induced diabetic rats. (PubMed, Biomed Pharmacother) - "The phenolic-rich aqueous extract of C. suberosus attenuated hyperglycaemia and improved several biochemical and histopathological alterations associated with STZ-induced diabetes. These findings support its potential as a source of bioactive compounds with antihyperglycaemic and organ-protective properties. However, because insulin secretion, insulin sensitivity, long-term glycaemic control, and molecular signaling pathways were not investigated, the underlying mechanisms remain to be elucidated in future studies."

Journal • Preclinical • Diabetes • Metabolic Disorders

Chaetocarpus castanocarpus Bark Extract Alleviates Pain, Pyrexia, Diarrhea, Hyperglycemia, and Oxidative Stress: Evidence From Integrated In Vitro and In Vivo Studies. (PubMed, Food Sci Nutr) - "The fast drop in glucose levels (Δ = 6.5 mmol/L) caused by hypoglycemia was comparable to the effects of glibenclamide...MECCB's potential as a natural medication is supported by its positive effects on pain relief, fever reduction, diarrhea treatment, and glucose regulation. Additional research is needed to identify active compounds and elucidate their mechanisms."

Journal • Preclinical • Diabetes • Hypoglycemia • Pain

Comparative Evaluation of the Antihyperglycemic Potential of Coccinia cordifolia and Gynura procumbens Leaf Extracts: Integrated Phytochemical, In Vivo, Molecular Docking, and DFT Investigations. (PubMed, Food Sci Nutr) - "At 2 g/kg body weight, the extracts of G. procumbens and C. cordifolia lowered the blood glucose by 55.74% and 52.68%, respectively, while glibenclamide, the standard drug, exhibited 61.96% reduction in blood glucose...In addition, favorable electronic stability and reactivity were found after conducting the DFT calculations. Overall, it can be concluded that the two plant extracts, especially G. procumbens, have promising antihyperglycemic effects and thus can act as good sources of bioactive compounds to be used as novel plant-based antidiabetic drugs."

Journal • Preclinical • Diabetes • Metabolic Disorders

Catestatin improves cardiac function during ischemia/reperfusion via activation of ATP-sensitive potassium channel in rats. (PubMed, Life Sci) - "CST protects against myocardial I/R injury and arrhythmias by activating KATP channels. These findings identify that myocyte KATP channels mediate CST-induced cardioprotection and may serve as a promising translational target for ischemic heart disease treatment."

Journal • Preclinical • Cardiovascular • Coronary Artery Disease • Heart Failure • Reperfusion Injury

KATP channel functional remodeling is associated with neuroinflammatory and dopaminergic alterations under metabolic stress in female mice. (PubMed, Brain Behav Immun) - "Peripheral KATP channel modulation was achieved by interscapular brown adipose tissue infusion of glibenclamide, and dopaminergic neuron-specific Kir6.2 conditional knockout mice were used to assess the contribution of neuronal KATP channel signaling...Kir6.2 deletion attenuated stress-associated behavioral alterations and reduced nucleus accumbens Iba1-positive cell accumulation, whereas effects on ventral tegmental area tyrosine hydroxylase-positive cell density were more modest. Together, these findings support KATP channel functional state as a candidate link between metabolic stress, neuroimmune alterations, and dopaminergic circuit adaptations in female mice, and suggest KATP channel modulation as a potential therapeutic strategy for metabolic-associated depression."

Journal • Preclinical • CNS Disorders • Depression • Diabetes • Genetic Disorders • Inflammation • Metabolic Disorders • Obesity • Psychiatry

Antihyperalgesic effects of ACE2 activation in a neuropathic pain model involve spinal MAS1 receptor signaling and ATP-sensitive potassium channels. (PubMed, Biochem Pharmacol) - "Pharmacological ATP-sensitive potassium (KATP) channel opening with diazoxide attenuated CCI-induced hyperalgesia, whereas blockade of these channels with glibenclamide induced mechanical and thermal hyperalgesia in naïve mice...Furthermore, MAS1 receptor immunoreactivity overlapped with that of KATP channel subunits, including SUR1, SUR2A, and Kir6.1, in the spinal dorsal horn. These findings suggest that DIZE attenuates neuropathic pain-related hyperalgesia through activation of the spinal ACE2/MAS1 receptor axis and the involvement of KATP channels."

Journal • Neuralgia • Pain • ACE2 • ANG

Integrative GC-MS, FT-IR, and Molecular Docking Analysis of Drimycarpus racemosus (Roxb.) Hook.f ex Marchand: In Vivo Analgesic and Antidiabetic Potential. (PubMed, Food Sci Nutr) - "In silico, 4-methoxybenzoic acid, methyl ester showed the strongest affinity for COX-2 (-8.3 kcal/mol), outperforming diclofenac (-6.4 kcal/mol), while 4-methoxybenzoic acid, methyl ester demonstrated higher binding with SUR-1 (-9.0 kcal/mol) compared to Glibenclamide (-8.5 kcal/mol). D. racemosus extract has substantial analgesic and hypoglycemic properties, and its phytoconstituents show promise as new medicinal research possibilities."

Journal • Preclinical • Inflammation • Metabolic Disorders • Pain