Encevac (freeze-dried, vero cell culture-derived, inactivated Japanese encephalitis vaccine) / Meiji Seika - LARVOL DELTA

Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction. (PubMed, Immunity) - "Systemic delivery of high-dose donor H2-Kd peptides combined with CTLA4-Ig reduced the frequencies of Kd287+ CD4+ T cells and DSA formation. Thus, targeting a narrow range of donor antigens may prevent DSA formation and improve transplant outcomes."

Journal • Immunology • Transplant Rejection • Transplantation • CD4

MHC Class II Immunopeptidome Landscape Associated with Transplant Rejection in Mice and Humans: Implication for CD4 T Cell-Mediated Tolerance (ATC 2024) - "Overall, this work demonstrates computational prediction and experimental mapping of rejection-associated CD4+ T cell epitopes offer opportunities to develop peptide immunotherapy as a key component of donor-specific transplant tolerance regimens to prevent DSA."

IO biomarker • Preclinical • Immunology • Transplant Rejection • Transplantation • CD4 • HLA-DRB1 • IFNG