NP1867
/ NeoPhore
- LARVOL DELTA
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October 03, 2025
A Cell-Based MSI Reporter Platform Identifies QHT025: A First-in-Class MMRd-Inducing Compound Sensitizing MMRp Tumors to Immunotherapy
(SITC 2025)
- "QHT025 showed superior potency in driving MSI-H and converting MMRp→MMRd versus reference compounds (NP1867, TMZ).Conclusions This platform establishes an innovative cell-based assay for assessing MSI activity...Acting as an immune-priming agent, it remodels the TME to convert 'cold' tumors to 'hot' lesions. The platform and compound pioneer a novel therapeutic approach to sensitize MMRp tumors to immunotherapy."
dMMR • IO biomarker • Tumor mutational burden • Colorectal Cancer • Microsatellite Instability • Oncology • Solid Tumor • MSI • TMB
March 06, 2024
Pharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo
(AACR 2024)
- "In conclusion, small molecule NP1867 functionally inhibits DNA MMR by targeting PMS2, enriches gained mutations with MMR-d COSMIC signatures, elicits MSI-H status, and enhances immune surveillance in preclinical models. These findings pave the way for the development of orally bioavailable compounds suitable for long-term dosing in animal models."
IO biomarker • Preclinical • Tumor mutational burden • Colorectal Cancer • Gastrointestinal Cancer • Microsatellite Instability • Oncology • Solid Tumor • MSI • PMS2 • TMB
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