Innovicort (peg-liposomal triamcinolone acetonide phosphate) / Enceladus - LARVOL DELTA

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis. (PubMed, Sci Rep) - "Rabbits that received subconjunctival liposomal triamcinolone acetonide phosphate (LTAP) or liposomal prednisolone phosphate (LPP) had significantly lower mean inflammatory scores than untreated controls on Day 4 after induction of uveitis (LPP vs controls, p = 0.049) and 8 (LPP vs controls, p = 0.007; LTAP vs controls, p = 0.019), and lower scores than rabbits given topical PredForte1% 4 times a day on Day 8 (p = 0.03). Localization of liposomes in inflamed ocular tissue was confirmed by histology and immunostaining, and persisted in the eye for at least one month. Our study demonstrates that a single subconjunctival injection of liposomal steroids induces effective and sustained anti-inflammatory action."

Journal

Evaluation of a liposomal steroid sustained drug delivery system for the treatment of experimental anterior uveitis (ESCRS 2019) - " Eyes treated with liposomal triamcinolone acetonide (LTA) or liposomal prednisolone phosphate (LPP) had significantly lower mean inflammatory scores than untreated controls after induction of uveitis (LPP vs controls, p = 0.049) and 8 (LPP vs controls, p = 0.007; LTA vs controls, p = 0.019), and lower scores than the topical PredForte1% group (p = 0.03)... A single subconjunctival injection of liposomal steroids induced an effective and sustained anti-inflammatory action compared to topical steroids. Liposomal steroid sustained delivery system had a greater suppression in the inflammatory response compared to topical steroids following an antigen rechallenge which simulated a clinical relapse."