TAK-227 / Zedira, Dr Falk, Takeda - LARVOL DELTA

New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review. (PubMed, Healthcare (Basel)) - "For CeD, therapies like gluten-degrading enzymes (latiglutenase, Kuma030) and zonulin inhibitors (larazotide acetate) show promise, though clinical outcomes are inconsistent...Transglutaminase 2 inhibitors like ZED-1227 could help prevent gluten-induced damage. Monoclonal antibodies targeting immune pathways, such as AMG 714 and larazotide acetate, require further validation in pediatric populations. In EoE, biologics like dupilumab, cendakimab, dectrekumab (IL-13 inhibitors), and mepolizumab, reslizumab, and benralizumab (IL-5/IL-5R inhibitors) show varying efficacy, while thymic stromal lymphopoietin (TSLP) inhibitors like tezepelumab are also being investigated...For IBD, biologics like vedolizumab, ustekinumab, and risankizumab, as well as small molecules like tofacitinib, etrasimod, and upadacitinib, are emerging treatments...Personalized therapy, integrating precision medicine, therapeutic drug monitoring, and lifestyle changes, is increasingly guiding pediatric..."

Journal • Review • Autoimmune Hepatitis • Celiac Disease • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Hepatitis B • Hepatology • Immunology • Inflammation • Inflammatory Bowel Disease • Pediatrics • Transplantation • IL13 • IL5 • TGM2 • TSLP

KI67+ INTRAEPITHELIAL LYMPHOCYTES IMPROVE PREDICTION OF THERAPEUTIC RESPONSE TO THE TRANSGLUTAMINASE INHIBITOR ZED1227 IN A CELIAC DISEASE PHASE II GLUTEN CHALLENGE TRIAL (CEC-3/CEL) (DDW 2025) - No abstract available

P2 data • Celiac Disease • Immunology

IMPACT OF TRANSGLUTAMINASE 2 INHIBITOR ZED1227 ON SYSTEMIC LIPIDOMIC RESPONSES IN CELIAC DISEASE: A GLUTEN CHALLENGE STUDY (UEGW 2024) - "This study highlights the potential of lipidomic analysis as a tool for early detection of systemic responses to gluten in CeD. The differential lipidomic profiles between the drug and placebo groups suggest that ZED1227 attenuates gluten-induced lipidomic alterations."

Celiac Disease • Immunology • PGCP • TGM2

TG2 INHIBITOR (ZED1227) SHOWS DOSE-DEPENDENT PROTECTION FROM GLUTEN-INDUCED INTESTINAL DAMAGE IN CELIAC DISEASE: TRANSCRIPTOMIC ANALYSIS FROM A PHASE 2A STUDY (UEGW 2024) - P2 | "ZED1227 effectively prevents gluten-induced mucosal damage in patients with CeD and beneficially modulates gene expression associated with mucosal integrity and the immune response, particularly of the IFN-γ pathway that is central to CD4 T cell mediated CeD pathogenesis. These data corroborate and further elucidate key pathways of intestinal damage in CeD and may suggest new biomarkers of mucosal injury."

Omic analysis • P2a data • Celiac Disease • Immunology • CD4 • IFNG • TGM2

Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease. (PubMed, Nat Immunol) - "Here, we elucidate the molecular mechanisms underlying the efficacy of the TG2 inhibitor ZED1227 by performing transcriptional analysis of duodenal biopsies from individuals with CeD on a long-term gluten-free diet before and after a 6-week gluten challenge combined with 100 mg per day ZED1227 or placebo...Moreover, data suggest that deamidated gluten-induced adaptive immunity is a sufficient step to set the stage for CeD pathogenesis. Our results, with the limited sample size, also suggest that individuals with CeD might benefit from an HLA-DQ2/HLA-DQ8 stratification based on gene doses to maximally eliminate the interferon-γ-induced mucosal damage triggered by gluten."

Journal • Celiac Disease • Immunology • Inflammation • IFNG • TGM2

Results from a phase 2a randomized trial with the transglutaminase 2 inhibitor ZED1227 in patients with MASLD (EASL-ILC 2024) - "ZED1227 was well tolerated and showed a positive trend for reducing profibrogenic PRO-C3 in phenotypic MASLD that however, did not reach statistical significance. In the subgroup of pts with higher PRO-C3 at baseline, the ZED1227 effect was more pronounced and dose dependent."

Clinical • P2a data • Cardiovascular • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Type 2 Diabetes Mellitus • TGM2

NormaliZED: Different Doses of ZED1227 vs. Placebo in NAFLD (clinicaltrials.gov) - P2 | N=186 | Completed | Sponsor: Dr. Falk Pharma GmbH | Recruiting ➔ Completed

Trial completion • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Metabolic Dysfunction-Associated Steatotic Liver Disease

Celiac disease: Hope for new treatments beyond a gluten-free diet. (PubMed, Clin Nutr) - "Despite significant efforts, no treatment has yet completed a phase III clinical trial. Future studies will likely focus on the use of supplemental drugs in conjunction to a GFD, with ALV003 and ZED-1227 currently being the most promising therapeutic options."

Journal • Review • Celiac Disease • Immunology • Inflammation

A Study of TAK-227 in Healthy Adults (clinicaltrials.gov) - P1 | N=24 | Completed | Sponsor: Takeda | Active, not recruiting ➔ Completed

Trial completion

The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment. (PubMed, Int J Mol Sci) - "Inhibition of TG2 activity by ZED1227 was demonstrated in epithelial organoids. Our findings suggest that active TG2 is present at the luminal side of the villous epithelium and that inhibition of TG2 activity by ZED1227 occurs already there before gliadin peptides enter the lamina propria."

Journal • Celiac Disease • Immunology • TGM2

A Study of TAK-227 in Healthy Adults (clinicaltrials.gov) - P1 | N=24 | Active, not recruiting | Sponsor: Takeda | Recruiting ➔ Active, not recruiting

Enrollment closed

A Study of TAK-227 in Healthy Adults (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: Takeda | Not yet recruiting ➔ Recruiting

Enrollment open

"Any news on Zed1227?" (@Hamifon)

A Study of TAK-227 in Healthy Adults (clinicaltrials.gov) - P1 | N=24 | Not yet recruiting | Sponsor: Takeda

New P1 trial

"Takeda, Zedira and Dr Falk Pharma ink pact to develop Celiac Disease therapy @TakedaPharma #Takeda #Zedira #DrFalkPharma #ZED1227 #celiacdisease #takedanews https://t.co/kTAYjkQObt" (@medicaldialogs)

Celiac Disease • Immunology

THE ORAL TISSUE TRANSGLUTAMINASE INHIBITOR ZED1227 PREVENTS GLUTEN-INDUCED ENTEROPATHY IN A HUMANIZED MOUSE MODEL OF CELIAC DISEASE (UEGW 2022) - "1.Oral ZED1227 effectively blocked TG2 activity in vivo and attenuated CeD in our transgenic NOD-DQ8 mouse model.2.The NOD-DQ8 model predicted therapeutic efficacy of ZED1227 that was later demonstrated in a phase 2a clinical trial of 160 CeD patients in remission who were challenged with gluten (Schuppan et al, NEJM 2021)."

Preclinical • Celiac Disease • Immunology • Inflammation • Inflammatory Bowel Disease • CD68 • CD8 • PTPRC

NormaliZED: Different Doses of ZED1227 vs. Placebo in NAFLD (clinicaltrials.gov) - P2 | N=160 | Recruiting | Sponsor: Dr. Falk Pharma GmbH | Not yet recruiting ➔ Recruiting | Trial completion date: Jun 2022 ➔ Jun 2023 | Trial primary completion date: Jun 2022 ➔ Jun 2023

Enrollment open • Trial completion date • Trial primary completion date • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Non-alcoholic Fatty Liver Disease

Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease. (PubMed, Cells) - "Here, we describe the specific features and profiling data of the drug candidate ZED1227. Further, we give an outlook on TG2 inhibition as a therapeutic approach in indications beyond celiac disease."

Journal • Celiac Disease • Immunology

TRANSGLUTAMINASE 2 (TG2) INHIBITOR PROTECTS GLUTEN-INDUCED INTESTINAL DAMAGE IN CELIAC DISEASE: TRANSCRIPTOMIC ANALYSIS OF A RANDOMIZED GLUTEN CHALLENGE STUDY (DDW 2022) - "Molecular histomorphometry regression model is useful tool for determination the severity of gluten-induced damage.Keywords. Celiac disease, gluten challenge, TG2 inhibitor ZED1227, molecular histomorphometry, RNA sequencing."

Clinical • Celiac Disease • Immunology • Inflammation • PGCP • TGM2

NormaliZED: Different Doses of ZED1227 vs. Placebo in NAFLD (clinicaltrials.gov) - P2 | N=160 | Not yet recruiting | Sponsor: Dr. Falk Pharma GmbH

New P2 trial • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Non-alcoholic Fatty Liver Disease

A clinical trial to evaluate ZED1227 in comparison with placebo in subjects with celiac disease experiencing symptoms despite gluten-free diet (clinicaltrialsregister.eu) - P2; N=400; Ongoing; Sponsor: Dr. Falk Pharma GmbH

Clinical • New P2 trial • Celiac Disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation

[VIRTUAL] ORAL INHIBITOR OF TISSUE TRANSGLUTAMINASE PREVENTS MUCOSAL DAMAGE IN CELIAC PATIENTS UNDERGOING GLUTEN CHALLENGE (UEGW 2021) - "Treatment of CeD patients with 3 doses of ZED1227 prevented gluten-induced mucosal damage and controlled CeD-related symptoms. All doses of ZED1227 were safe and well tolerated. . A phase 2b trial in patients with symptoms and intestinal inflammation despite a gluten free diet is planned to start in 2021."

Clinical • Late-breaking abstract • Celiac Disease • CNS Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Migraine

"Study: ZED1227 may reduce intestinal mucosal injury in CD https://t.co/GpZxRfBHMc @AmCollegeGastro @CrohnsColitisFn" (@SWexner)

Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology

A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. (PubMed, N Engl J Med) - P2 | "In a proof-of-concept trial, we assessed the efficacy and safety of a 6-week treatment with ZED1227, a selective oral transglutaminase 2 inhibitor, at three dose levels as compared with placebo, in adults with well-controlled celiac disease who underwent a daily gluten challenge...(Funded by Dr. Falk Pharma; CEC-3 EudraCT number, 2017-002241-30.)."

Clinical • Journal • Celiac Disease • Gastrointestinal Disorder • Immunology • Pain

[VIRTUAL] THE ORAL TISSUE TRANSGLUTAMINASE INHIBITOR ZED1227 PREVENTS GLUTEN-INDUCED ENTEROPATHY IN A TRANSGENIC MOUSE MODEL OF CELIAC DISEASE (DDW 2021) - "The oral TG2-specific inhibitor ZED1227 at both doses prevented gluten-induced enteropathy and immune activation in the humanized NOD-DQ8 mouse model of CeD. In view of the just concluded phase 2a clinical trial using ZED1227 in CeD patients in remission, who were challenged with gluten, this model may be a highly valuable preclinical tool to predict therapeutic efficacy in patients"

Preclinical • Celiac Disease • Immunology • Inflammation • PTPRC