Hanferon SC (interferon alpha-2b) / Daewoong Pharma - LARVOL DELTA

Dynamic transcriptomic profiling in previously untreated patients with Hemophilia A (ISTH 2025) - "Key findings identified genes such as FCGR2B, TNFSF13, and C1QC, which played significant roles in modulating immune responses, including B and T cell interactions. Table or Figure Upload"

Clinical • Hematological Disorders • Hemophilia • Hemophilia A • Rare Diseases • FCGR2B • TNFSF13

CD47/SIRPα Expression and Potential Roles in Pulmonary Fibrosis (ATS 2025) - "Finally, Bleomycin-induced mouse lung fibrosis model was used to examine the expression of CD47 and Sirpα in fibrotic lungs, and flow cytometry was used to analyze their expression fibroblast vs. myofibroblast populations... These findings suggest that the differential expression patterns of CD47 and Sirpα in response to TGFβ in fibroblasts may play distinct roles during myofibroblast differentiation. Elevated CD47 levels in myofibroblast and sB7H3-induced Siprα expression in BM-derived macrophages may indicate impaired macrophage phagocytosis, potentially leading to the persistence of myofibroblasts via CD47/Siprα axis."

Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Oncology • Pulmonary Disease • Respiratory Diseases • CD276 • CD47 • SIRPA • TERT • TGFB1

Relationship of Fungal Translocation, Inflammation and Pulmonary Function in People With HIV (ATS 2025) - "The biomarker plasma levels of pulmonary and intestinal damage and microbial translocation are positively associated with systemic inflammatory markers and worse pulmonary function, suggesting that lung and gut damage leading to increased permeability and microbial translocation could contribute to development of pulmonary dysfunction through pulmonary and systemic inflammation in PWH."

Chronic Obstructive Pulmonary Disease • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • CCL2 • CXCL10 • IL17A • MMP1 • MMP7 • REG3A • TNFA • TNFRSF1A • TNFSF10

A Phase 1b/2a, Open-label,Randomized, Safety, Tolerability, Dose Finding, PK/PD, and Preliminary Efficacy Study of SC Hanferon™ in Combination With Ribavirin in Treatment-naïve Subjects With Genotype 1 Hepatitis C (clinicaltrials.gov) - P1/2 | N=30 | Completed | Sponsor: HanAll BioPharma Co., Ltd. | Phase classification: P1b/2a ➔ P1/2

Phase classification • Hepatitis C • Hepatology • Infectious Disease • Inflammation

Plasma free hemoglobin is associated with LDH, AST, total bilirubin, reticulocyte count, and the hemolysis score in patients with sickle cell anemia. (PubMed, Ann Hematol) - "C.J.M is supported by the NHLBI 5T32HL129974-05. P.S., and S.M. declare no conflicts and/or funding."

Journal • Anemia • Cardiovascular • Genetic Disorders • Hematological Disorders • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Sickle Cell Disease

GONADOTROPINS ARE LOWER IN WOMEN AFTER INITIATING A LIFESTYLE WEIGHT LOSS INTERVENTION (ASRM 2024) - "CONCLUSIONS Preliminary findings suggest lifestyle weight loss interventions acutely suppress reproductive hormones in women with overweight or obesity, with some rebounding over time. IMPACT STATEMENT These detailed data will be useful for providing nuanced and critical information for the treatment of both infertility and obesity in reproductive aged women."

Clinical • Endocrine Disorders • Genetic Disorders • Infertility • Obesity • Sexual Disorders

Functional preservation of human livers for days using partial freezing (TTS 2024) - "Our study demonstrated functional 10-day preservation of human livers. Perfusion metrics show comparable levels between pre- and post-freeze assessments, indicating that viability before and after partial freezing is unchanged. Further analysis will enlighten histological and mitochondrial status of livers."

High molecular kininogen cleavage in cerebral malaria (ISTH 2023) - "Immunoblot of human plasma showed 56 and 46 kDa cHK in 42% (8/19) of CM vs 17% (3/18) UM patients. HK levels of CM, as measured by CELISA patients at hospital admission (59 ± 4.1 μg/ml; mean ± SEM, n=23), were significantly lower (p < 0.001) than at discharge (70 ± 3.6 μg/ml; p< 0.0001) and compared to healthy children. Low HK levels significantly correlated (Spearman) positively with uPA, TFPI and negatively with VWF, Syndecan-4, IL-6, TNF, and IL-21 (p < 0.01)."

CNS Disorders • Infectious Disease • Malaria • IL21 • IL6 • SDC4

Epitope Mapping of the α-FXIIa Allosteric Inhibitor Monoclonal Antibody 5C12 (ISTH 2023) - "5C12 is a conformationally specific Mab. It immunoblots FXII and FXIIa only on non-reduced samples; 5C12 preferentially binds to α-FXIIa over FXII. α-FXIIa blocks 5C12 binding to α-FXIIa linked to microtiter plates with an IC50 of 11.78 nM and 5C12 inhibits α-FXIIa hydrolysis of H-D-Pro-Phe-Arg-pNA·2HCl with an IC50 of 3.5 nM."

Cardiovascular • Hematological Disorders • Thrombosis • HGFAC

Variability independent of mean blood pressure as a real-world measure of cardiovascular risk. (PubMed, EClinicalMedicine) - "The demonstrated prognostic ability of VIM derived from non-standardized BP readings indicates the utility of this measure for risk stratification in a real-world practice setting, although residual confounding from unmeasured variables cannot be excluded. This study was funded in part by National Institutes of Health grants R01-HL134168, R01-HL131532, R01-HL143227, R01-HL142983, U54-AG065141; R01-HL153382, K23-HL136853, K23-HL153888, and K99-HL157421; China Scholarship Council grant 201806260086; Academy of Finland (Grant no: 321351); Emil Aaltonen Foundation; Finnish Foundation for Cardiovascular Research."

Journal • Real-world evidence • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Myocardial Infarction

Examining Weight Status and Weight Loss on Menstrual Cycle Length and Variability Among Reproductive Aged Women. (SRI 2022) - "These data suggest that among regularly cycling women, menstrual cycle length is remarkably preserved across weight status and during energy restriction, with rather high within-woman variability on average. Cycle length does not appear to be a good indicator of the underlying hormonal or ovulatory characteristics of the menstrual cycle that are disrupted by insufficient and surplus energy stores and low energy availability."

Clinical • Genetic Disorders • Long-acting Reversible Contraceptives • Obesity

A phase 1b/2a, open-label,randomized, safety, tolerability, dose finding, PK/PD, and preliminary efficacy study of SC Hanferon in combination with ribavirin in treatment-naïve subjects with genotype 1 hepatitis C (clinicaltrials.gov) - P1/2, N=30; Sponsor: HanAll BioPharma Co; Active, not recruiting -> Completed.

Trial completion • Immunology