CPT31
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October 30, 2024
Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues.
(PubMed, J Virol)
- "The findings of trapped HIV-1 virions in all tissues examined demonstrate a wide distribution of the CPT31 inhibitor, a desirable property for a potential therapeutic. In addition, the presence of virions trapped by spokes, particularly in vascular endothelial cells, demonstrates that the fusion inhibitors can be used as markers for potential HIV-1-target cells within tissues, facilitating the mapping of HIV-1 target cells within the complex cellular milieu of infected tissues."
Journal • Human Immunodeficiency Virus • Infectious Disease • CD4 • CXCR4
September 04, 2024
Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues.
(PubMed, bioRxiv)
- "The finding of trapped HIV-1 virions in all tissues examined demonstrates a wide distribution of the CPT31 inhibitor, a desirable property for a potential therapeutic. In addition, the presence of virions trapped by spokes, particularly in vascular endothelial cells, demonstrates that fusion inhibitors can be used as markers for potential HIV-1-target cells within tissues, facilitating the mapping of HIV-1 target cells within the complex cellular milieu of infected tissues."
Journal • Human Immunodeficiency Virus • Infectious Disease • CD4 • CXCR4
March 25, 2022
A Clinical Study of the HIV Drug CPT31 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=32 | Completed | Sponsor: Navigen, Inc. | Enrolling by invitation ➔ Completed | Trial completion date: Dec 2022 ➔ Apr 2021
Trial completion • Trial completion date • Human Immunodeficiency Virus • Infectious Disease
March 10, 2022
A Clinical Study of the HIV Drug CPT31 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=32 | Enrolling by invitation | Sponsor: Navigen, Inc. | Trial completion date: Apr 2021 ➔ Dec 2022
Trial completion date • Human Immunodeficiency Virus • Infectious Disease
December 17, 2020
A Clinical Study of the HIV Drug CPT31 in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=32; Enrolling by invitation; Sponsor: Navigen, Inc.
Clinical • New P1 trial • Human Immunodeficiency Virus • Infectious Disease
August 22, 2020
Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent d-peptide HIV entry inhibitor.
(PubMed, Proc Natl Acad Sci U S A)
- "In chronically infected animals with viremia initially controlled by combination antiretroviral therapy (cART), CPT31 monotherapy prevented viral rebound after discontinuation of cART. These data establish CPT31 as a promising candidate for HIV prevention and treatment."
Journal • Human Immunodeficiency Virus • Infectious Disease
September 03, 2020
New long-acting injectable drug might soon be a key HIV treatment
(Health-e)
- "A group of scientists have developed an injectable HIV drug that blocks the virus from entering cells over a longer term. The drug has been tested on non-human primates...'This is an exciting new HIV therapeutic option for both prevention and treatment, with a unique mechanism of action compared to other approved drugs,' says Professor Michael Kay, of the University of Utah. The treatment could help those struggling with drug resistance, he adds....'As a D-peptide, our hope is that CPT31 will provide extended viral suppression with a lower dose and reduced side effects,' says Welch."
Preclinical • Human Immunodeficiency Virus
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