fentanyl citrate / Generic mfg. - LARVOL DELTA

Acute and persistent sex-dependent disruptions of sleep-wake architecture induced by fentanyl self-administration in mice. (PubMed, Neuropharmacology) - "Together, these findings demonstrate that fentanyl self-administration induces both acute and enduring, sex-specific disruptions in sleep architecture that persist into abstinence and are associated with drug-seeking behavior. These results highlight sleep as a potential mechanistic contributor to relapse vulnerability and a promising therapeutic target in OUD."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Sleep Disorder • Substance Abuse

Dielectric barrier discharge ionization (DBDI) enables rapid analysis of new psychoactive substances with ion mobility-mass spectrometry. (PubMed, Analyst) - "Specifically, we show that IM can be used to differentiate structural isomers of synthetic cannabinoids, benzodiazepines, nitazenes, and fentanyl analogues with very minor differences in their collision cross sections (CCS)...Finally, we demonstrate the combination of ion mobility with tandem mass spectrometry (MS/MS) for mobility-aligned fragmentation that provided additional structural information for confident characterization. The coupling of DBDI with IM-MS/MS (especially high-resolution IM) constitutes a powerful approach for rapid analysis of several classes of NPS that could be used to improve throughput in the future."

Journal

Naloxone Use and Outcomes in Prehospital and Emergency Department Care. (PubMed, Cureus) - "Background Opioid toxicity remains a major public health concern in Canada, which is driven by potent synthetic opioids such as fentanyl...Conclusions Most cases were successfully reversed prior to ED arrival, and many were managed by first responders and bystanders, highlighting the importance of public education and access to intranasal naloxone. Low rates of OAT initiation underscore the need to prevent barriers to treatment following an ED visit."

Journal

Treatment Outcomes in a Specialized Opioid Maintenance Program for Prescription Opioid Use Disorder in Israel. (PubMed, Subst Abuse Rehabil) - "Overall, 42.9% used fentanyl: 44.4% of those on methadone, 42.1% on buprenorphine, and 42.9% on the injectable formulation. Positive treatment outcomes were observed in this specific population, particularly among those treated with methadone or injectable buprenorphine, but future follow-up and a larger sample are needed. Physicians' education is necessary to achieve more accurate referrals."

Journal • Addiction (Opioid and Alcohol) • Pain • Substance Abuse

STUDYING THE EFFECTIVENESS OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY IN SALVAGING DYSFUNCTIONAL HEMODIALYSIS ARTERIOVENOUS FISTULAS: INITIAL INSIGHTS FROM NORTHEAST INDIA. (ISN-WCN 2026) - "Pain relief was achieved through a combination of fentanyl and midazolam.Outcome parameters included fistula patency, defined as the time from intervention to the first occurrence of failure (including thrombosis, restenosis, or abandonment or death), as well as median time to failure and primary failure rates. The patency rate following PTA is quite satisfactory, with rates of 86.4% at 3 months and 68.9% at 6 months. Additionally, multiple lesions are common in our region.[Content of the abstract was presented at AVAATAR, India 2025, but with smaaler number patinets]"

Acute Coronary Syndrome • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Metabolic Disorders • Nephrology • Renal Disease • Systemic Lupus Erythematosus • Thrombosis

A PIONEERING STUDY OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR IMMATURE ARTERIOVENOUS FISTULA: EMPOWERING CHANGE THROUGH SINGLE-CENTRE EXPERIENCE IN NORTHEAST INDIA. (ISN-WCN 2026) - "Pain relief was achieved through a combination of fentanyl and midazolam.Outcome parameters included fistula patency, defined as the time from intervention to the first occurrence of failure (including thrombosis, restenosis, or abandonment or death), as well as median time to failure and primary failure rates. However, there is an increased risk of rupture and infection. Additionally, multiple lesions are common in our region."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Metabolic Disorders • Nephrology • Renal Disease • Systemic Lupus Erythematosus • Thrombosis

Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era. (PubMed, JAMA Netw Open) - "Compared with methadone, SROM was associated with a slightly higher risk of treatment discontinuation and lower adherence but similar mortality risk. The findings suggest either medication may be appropriate if measures are in place to support retention."

Clinical • Journal • Observational data • Addiction (Opioid and Alcohol) • Substance Abuse

A mu-opioid receptor positive allosteric modulator provides opioid-sparing antinociception without enhancing opioid side effects. (PubMed, J Pharmacol Exp Ther) - "However, the effects of positive allosteric modulators of MOR on the behavioral actions of opioid drugs such as morphine and fentanyl have not been studied. SIGNIFICANCE STATEMENT: The undertreatment of pain and the addiction liability of opioids necessitate new strategies to improve pain management. Here, we demonstrate that the mu-opioid receptor modulator 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl) sulfonyl]-thiazolidine enhances opioid drug-mediated analgesia in mice without enhancing constipation, reward, or respiratory depression."

Adverse events • Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Constipation • Depression • Gastroenterology • Gastrointestinal Disorder • Pain • Psychiatry

Methadone Dose and Patient-Directed Discharge in Hospitalized Patients With Opioid Use Disorder. (PubMed, JAMA Netw Open) - "In this study, higher cumulative doses of methadone during the first 48 hours of care were associated with substantial reductions in the incidence of PDD. These findings suggest that early and adequate treatment of withdrawal with methadone may be associated with reduced PDD among hospitalized patients with OUD in the fentanyl era."

Journal • Observational data • Retrospective data • Addiction (Opioid and Alcohol) • Substance Abuse

Cell-type specific impact of opioid use disorder and HIV on the human forebrain and cerebellum. (PubMed, bioRxiv) - "Using a cerebellar organoid model, fentanyl treatment reduced metabolic activity while increasing neuronal activity...Cerebellum-specific Bergmann glia, in addition to forebrain microglia and astrocytes, showed expansion of reactive state identity in HIV. These results highlight shared and specific changes to immune, synaptic, and metabolic processes in OUD and HIV across brain regions and reveal that cerebellar cell types are distinctly affected by opioid abuse."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Psychiatry • Substance Abuse

Sex-related pharmacokinetic and pharmacological responses to 4F-furanylfentanyl. (PubMed, Front Pharmacol) - "Novel synthetic opioids (NSOs), including a variety of fentanyl analogs (FAs) and emerging non-fentanyl compounds, have increasingly been implicated in overdose fatalities worldwide...The findings demonstrate marked sex-specific differences in the behavioral and physiological changes and pharmacokinetics of 4F-FUF. These results underscore the importance of considering sex-specific differences in assessing the toxicity and risk profiles of novel synthetic opioids."

Journal • PK/PD data • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Psychiatry

Stenotrophomonas maltophilia Bloodstream Infection Outbreak in Acute Care Hospital, California, USA, 2022-20231. (PubMed, Emerg Infect Dis) - "Among 13 case-patients and 39 control-patients, patients exposed to iodinated contrast (odds ratio [OR] 12.0; 95% CI 2.1-∞), injectable propofol (OR 12.2; 95% CI 1.5-101.4), or fentanyl (OR 9.2; 95% CI 1.8-∞) had increased odds of S. maltophilia bloodstream infection. Although we did not have culture confirmation of a source, we suspect S. maltophilia was transmitted by exposure to nonsterile water from a common source. We recommended infection prevention and control practices to reduce risk for contamination from nonsterile water."

Journal • Review • Critical care • Infectious Disease

Xylazine exacerbates fentanyl-induced respiratory depression and prevents rescue by naloxone in mice. (PubMed, Psychopharmacology (Berl)) - No abstract available

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Mood Disorders • Psychiatry

Drug positivity, co-detection patterns, and demographic predictors in patients seeking substance use disorder treatment, United States, 2023. (PubMed, Addict Behav) - "This study highlights variations in substance presence and co-detection across 14 drug categories in SUD treatment patients, underscoring the need for tailored prevention and treatment strategies."

Journal

Levamisole in opioid overdose patients: An evolving adulterant landscape. (PubMed, Addict Behav) - "More than one in eight patients presenting with an opioid overdose were exposed to levamisole. These findings provide potential new evidence for levamisole adulteration alongside fentanyl and its analogues."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders

Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study. (PubMed, Addiction) - "Varieties of sleep deficiency compared with normal sleep appear to be associated with more severe psychological symptoms and pain interference with sleep among patients receiving methadone treatment and may serve as risk factors for substance use."

Journal • Observational data • CNS Disorders • Insomnia • Movement Disorders • Obstructive Sleep Apnea • Pain • Respiratory Diseases • Restless Legs Syndrome • Sleep Disorder • Substance Abuse

Comparison of naloxone, naltrexone, nalmefene, and methocinnamox for preventing and reversing the discriminative stimulus effects of buprenorphine and carfentanil in rats discriminating fentanyl from saline. (PubMed, J Pharmacol Exp Ther) - "MOR agonist medications for treating opioid use disorder include methadone and buprenorphine. SIGNIFICANCE STATEMENT: Buprenorphine, a μ opioid receptor (MOR) agonist used to treat opioid use disorder, can produce adverse effects that are reportedly more difficult to reverse with naloxone, compared with reversal of the effects of other MOR agonists. This study provides evidence for the potential utility of the MOR antagonist methocinnamox to reverse the adverse effects of buprenorphine by demonstrating the relatively greater potency of methocinnamox, compared with currently available MOR antagonists, to reverse the discriminative stimulus effects of buprenorphine and carfentanil."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Psychiatry • Substance Abuse

What Is Known about Substance Use in Hawai'i: A Scoping Review. (PubMed, Hawaii J Health Soc Welf) - "The granularity of geographical data was found to be at island-level and the 3 most common substances reported were alcohol, marijuana, and methamphetamine. Most documents used national datasets for reporting substance use in Hawai'i. The findings identified gaps in the literature that can be filled by future research such as focusing on the rise of substance use among older adults, disaggregating data on Pacific Islander populations in Hawai'i, reporting substance use data in geographical areas smaller than island-level, increasing the collection of data on groups that have a high risk for health problems or are underserved by health services, and intensifying collection of data about fentanyl use in Hawai'i."

Journal • Substance Abuse

Outcomes with intrathecal 2-chloroprocaine 3% 60 mg and fentanyl 15 μg for cervical cerclage: a retrospective quality assurance study (2021 - 2023). (PubMed, Int J Obstet Anesth) - "Intrathecal 2-chloroprocaine 3% 60 mg with fentanyl showed fewer anesthetic failures (but this was not statistically significant) and a modestly longer discharge time than 50 mg."

Journal • Retrospective data • Anesthesia • Back Pain • Musculoskeletal Pain • Pain

Xylazine-Induced Skin Necrosis: A Systematic Review (AAD 2026) - "Introduction: Xylazine is a veterinary non-opioid tranquilizer that has gained popularity as an illicit drug additive, often mixed with fentanyl, cocaine, or heroin... Due to its diagnostic ambiguity and frequent lack of confirmatory testing, it is essential to have a high index of suspicion for xylazine-induced skin necrosis when evaluating chronic, non-healing ulcers in patients who inject drugs."

Review

Safety and Efficacy of Intranasal Fentanyl Use in Early Infancy: A Single-Center Experience (PAS 2026) - No abstract available

Clinical

Variable association of fetal fentanyl and substance exposure with congenital anomalies and syndromes in neonates < 34 weeks gestation (PAS 2026) - No abstract available

Acceptability of a Fentanyl Vaccine to Protect Against Overdose for Adolescents and Young Adults (PAS 2026) - No abstract available

Clinical

Clinical Characteristics and Harm Reduction Interventions in Adolescent Illicitly Manufactured Fentanyl Overdoses at a Quaternary Children’s Hospital (PAS 2026) - No abstract available

Clinical

“Sharing and Borrowing”: Understanding the Language Used by Youth to Describe Pill-Taking Behaviors That May Lead to Fentanyl Exposure (PAS 2026) - No abstract available