MK-3281
/ Merck (MSD)
- LARVOL DELTA
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July 04, 2011
Genotypic and phenotypic characterizations of natural and acquired reductions in susceptibility to the HCV nonnucleoside inhibitor MK-3281
(International Workshop on Hepatitis C)
- P1, N=60; GT1 viruses exhibit variable susceptibility to MK-3281; Treatment with MK-3281 was associated with substitutions in NS5B (P495S/L/A) that conferred reductions in MK-3281 susceptibility & replication capacity; Individual clones within pt virus population exhibited variable MK-3281 susceptibilities in absence & presence of resistance associated mutations at P495
Biomarker data • P1 data • Hepatitis C Virus
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