M-Vax (DNP VACC) / AVAX Technologies - LARVOL DELTA

Pivoting Covid-19 Vaccination Through Mvax: A Perspective From An Lmic Setup. (PubMed, J Ayub Med Coll Abbottabad) - "Vaccine inequity and acceptance has been an issue in Pakistan owing to lack of knowledge, lack of proximity to healthcare facilities, poor socio-economic status, etc. Also, the behaviour of the populace in Pakistan varies from that of other countries in that when COVID-19 cases declined, individuals thought the virus has been abolished and they stopped following standard operating procedures (SOPs). In this context, this article introduces the notion of mobile vaccination for everyone, which may be implemented to improve vaccination coverage."

Journal • Infectious Disease • Novel Coronavirus Disease

Trends in Melanoma Phase 3 Clinical Trials since 2010: Is there Hope for Advanced Melanoma Therapies beyond Approved Treatment Mechanisms? (PubMed, Cancers (Basel)) - "Since most clinical trials focus on previously approved drug mechanisms, it is likely that paradigm-changing treatments will involve these therapies being used in new treatment contexts or combinations. Only 2 exploratory drug mechanisms studied since 2010 have achieved promising results in the phase 3 setting, though many other trials are ongoing at this time."

Journal • P3 data • Review • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor

"Agreed. I’m vaxed since March but still careful." (@DanPoyourow)

Reverse Vaccinology Approach in Constructing a Multi-Epitope Vaccine Against Cancer-Testis Antigens Expressed in Non-Small Cell Lung Cancer. (PubMed, Asian Pac J Cancer Prev) - "Overall, in silico evaluations show that Mvax is a potential immunotherapeutic agent against NSCLC."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • CD4 • CD8 • CTAG1B • MAGEA3 • MAGEA4

"It'll be like the old days- I'm vaxxed so I can go to store and get supplies, wife is not; I die and now she can't go to the store, goes hungry, and now she loses the farm since unvaxxed can't own property. Crazy, right?" (@coolhandhutch)

"I'm vaxxed, and I walk maskless while alone in Manhattan. It's a new world." (@benryanwriter)

"Not my problem. I'm vaxxed. My risk is low so I can be mask less." (@AVoiceofReason)

"Me and the boys now that I’m vaxxed up @JNJNews https://t.co/lpTe5yV9Wi" (@nealberg96)

[VIRTUAL] Trojan horse immunotherapy strategy for mycobacterial infections (ACS-Fall 2020) - "ARM delivery strategies have been developed to target various pathogens, but no strategies have been reported for delivering ARMs to mycobacteria. Here we describe a four-step synthesis and characterization of a DNP-modified trehalose monomycolate (TMM) analogue that can metabolically label mycobacteria with DNP groups in one step."

Infectious Disease • Tuberculosis

M-Vax + low dose interleukin-2 versus placebo vaccine in metastatic melanoma in patients with stage IV melanoma (clinicaltrials.gov) - P3, N=387; Sponsor: Avax; Active, not recruiting; Primary completion date: Jan 2014 -> Jan 2015.

Trial primary completion date • Melanoma

High Fib4 index in patients with suspected NASH is associated with elevation of chymase-dependent angiotensin II-forming activity in circulating mononuclear leucocytes. (PubMed, Heart Vessels) - "Many cardiovascular outpatients have a high F4I and can probably be categorized as NASH. The high F4I patients had few features of metabolic syndrome and were suspected to have elevated tissue chymase dAIIFA contributing to inflammation in the liver as well as in cardiovascular organs."

Clinical • Journal

Immunological analysis of phase II glioblastoma dendritic cell vaccine (Audencel) trial: immune system characteristics influence outcome and Audencel up-regulates Th1-related immunovariables. (PubMed, Acta Neuropathol Commun) - "Overall, these immunological considerations suggest that DC immunotherapy against glioblastoma should be studied further - with the goal of translating an apparent immunological response into a clinical response. Future research should concentrate on investigating augmentation of immune reactions through combination therapies or on developing meaningful biomarkers."

Biomarker • IO Biomarker • Journal • P2 data