oxytocin inhaled (GR-121619) / Monash University - LARVOL DELTA

Pharmacokinetics and safety of inhaled oxytocin compared with intramuscular oxytocin in women in the third stage of labour: a randomised open-label study. (PubMed, Br J Clin Pharmacol) - P1 | "Inhaled and intramuscular oxytocin had similar safety profiles in third stage of labour women (phase 1 study)."

Journal • PK/PD data • Obstetrics

Form 6-K GlaxoSmithKline plc for: Apr 29 (Streetinsider.com) - "Pipeline news flow highlights since Q4 2019....GR121619 rights for postpartum haemorrhage were returned to Monash University."

Licensing / partnership • Obstetrics • Postpartum Hemorrhage

Comparison of Inhaled Oxytocin (IH) With Intramuscular (IM) Oxytocin in Pregnant Women and With Intravenous (IV) Oxytocin in Healthy Non-pregnant Women (clinicaltrials.gov) - P1; N=35; Terminated; Sponsor: GlaxoSmithKline; Recruiting ➔ Terminated; Inability to reliably measure plasma oxytocin levels during third stage labour, regardless of administration method (intramuscular or inhaled).

Clinical • Trial termination

Comparison of Inhaled Oxytocin (IH) With Intramuscular (IM) Oxytocin in Pregnant Women and With Intravenous (IV) Oxytocin in Healthy Non-pregnant Women (clinicaltrials.gov) - P1; N=30; Recruiting; Sponsor: GlaxoSmithKline; Trial completion date: Dec 2018 ➔ May 2019; Trial primary completion date: Dec 2018 ➔ May 2019

Clinical • Trial completion date • Trial primary completion date