remdesivir / Generic mfg. - LARVOL DELTA

Treatment Interruption for Patients With Thoracic Malignancy Following Accidental COVID-19 Infection (IASLC-WCLC 2026) - "Treatment included chemoradiation in four patients (cisplatin + vinorelbine, n=3; carboplatin + paclitaxel, n=1) and chemotherapy in 13 (immune checkpoint inhibitor [ICI] + platinum doublet, n=2; platinum doublet, n=3; ICI + chemotherapy, n=1; chemotherapy + antiangiogenic therapy, n=1; ICI monotherapy, n=3; four-drug chemotherapy, n=1; single-agent chemotherapy, n=2). COVID-19 management included remdesivir in 13 patients and symptomatic treatment in four, and no long-term sequelae were observed...In the present cohort, continuation of thoracic malignancy treatment during COVID-19 infection appeared to be feasible with careful monitoring. Radiation therapy was administered without major complications in the present patients, even during active COVID-19 infection."

Clinical • Infectious Disease • Interstitial Lung Disease • Lung Cancer • NUT Midline Carcinoma • Oncology • Pneumonia • Respiratory Diseases • Thoracic Cancer • Thymic Carcinoma • Thymoma • Thymus Cancer

A case of Bundibugyo virus disease treated with monoclonal antibodies and remdesivir. (PubMed, Nat Med) - "The patient recovered and was discharged on day 22 after symptom onset. This case report provides detailed insights into the clinical course, virologic dynamics and immune responses in BDBV infection during combined antiviral treatment, while larger clinical studies are needed to assess the efficacy and clinical utility of these therapeutic approaches."

Journal • Infectious Disease

Marine phlorotannins block SARS-CoV-2 entry via ACE2 and attenuate pulmonary inflammation in K18-hACE2 transgenic mice. (PubMed, Antiviral Res) - "It also selectively downregulated the pro-inflammatory mediators interferon-gamma (IFN-γ) and monocyte chemoattractant protein-1 (MCP-1), with high-dose efficacy comparable to remdesivir. These findings identify DPHC as a well-characterized phytochemical with integrated antiviral and immunomodulatory activity, targeting viral entry, replication, and inflammation through a multi-target mechanism."

Journal • Preclinical • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • CCL2 • IFNG

Resistance Analysis of Emergent Nsp12 Substitutions Observed in Immunocompromised COVID-19 Patients Treated with Remdesivir (IDWeek 2026) - No abstract available

Clinical • Infectious Disease • Novel Coronavirus Disease

Navigating the New Norm: Shaping Contemporary COVID-19 Management through Remdesivir Restrictions (IDWeek 2026) - No abstract available

Infectious Disease • Novel Coronavirus Disease

Impact of Antimicrobial Stewardship Restrictions on Remdesivir Utilization and Hospital Costs (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Oral MDL-001 a Universal Direct Acting Antiviral for Influenza Like Illness(ILI): In Vivo Equivalence or Superiority to Oseltamivir, Nirmatrelvir and Remdesivir, In Vitro Superiority to Ribavirin (IDWeek 2026) - No abstract available

Head-to-Head • Preclinical • Infectious Disease • Influenza

Clinical Usefulness of Remdesivir on Mortality and Respiratory Outcomes in Hospitalized Adult Patients with Respiratory Syncytial Virus Infection (IDWeek 2026) - No abstract available

Clinical • Infectious Disease • Respiratory Syncytial Virus Infections

Remdesivir Maintains Antiviral Potency Against Clinically Relevant SARS-CoV-2 Nsp12 Substitutions. (PubMed, Antiviral Res) - "Using a recombinant infectious SARS-CoV-2 reporter virus, we compared susceptibility of these nsp12 substitutions to RDV and its parent nucleoside, GS-441524. Collectively, these data reinforce the high genetic barrier to RDV resistance, as reduced susceptibility is typically accompanied by substantial reductions in replication. Our findings support the continued clinical utility of RDV and highlight the complementary value of SARS-CoV-2 infectious virus and replicon systems for antiviral resistance surveillance and phenotyping."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Navigating Therapeutic Frontiers: A Meta-review and Meta-analysis of COVID-19 Treatment Options. (PubMed, J Res Pharm Pract) - "285 reviews with 152 meta-analyses were included, The analysis of systematic reviews contents indicated that most reviewed drugs were as follows: chroquine/hydroxychloroquine (n = 48), tocilizumab (n = 39), remdesivir (n = 25), corticosteroids (n = 25), JAK inhibitors (n = 12), colchicine (n = 11), ivermectin (n = 8), anakinra (n = 7), favipravir (n = 7), lopinavir/ritonavir (n = 6), ACEI/ARB (n = 6), azithromycin (n = 4), sofosbuvir (n = 4), and Vitamin D (n = 4)...lower requirement for mechanical ventilation and intensive care unit admission and a shorter hospital length of stay was observed with the tocilizumab, JAKIs, anakinra, corticosteroids and sofosbuvir Only one third of the included reviews had 70% quality based on the AMSTAR scale assessment. The results of this study have the potential to be a useful tool for the translation of health evidence and for designing the decision support systems for evidence synthesis."

Journal • Retrospective data • Review • Critical care • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Remdesivir for Adenovirus After Hematopoietic Stem Cell Transplant. (PubMed, Pediatr Blood Cancer) - No abstract available

Journal • Bone Marrow Transplantation • Transplantation

From supportive galenic compounding to advanced clinical pharmacy: A decade of excellence and safety in the Antiblastic Drugs Unit in Southern Italy (2014-2025). (PubMed, J Oncol Pharm Pract) - "ObjectivesAntiblastic Drugs Units (ADUs) ensure safety, appropriateness and sustainability of oncology treatments...During COVID-19, the unit served as central hub for vaccine and remdesivir management. Despite a 1194% increase in pharmaceutical expenditure (€2.54 M to €32.87 M), systematic reimbursement management generated €8.92 M in recoveries and savings in 2025 (27.1% of expenditure).ConclusionsThe experience of this ADU illustrates how a structured, quality-driven approach can support the transformation of aseptic compounding into advanced clinical pharmacy. The integration of pharmacists into multidisciplinary oncology teams was associated with strengthened medication safety processes, expanded access to innovation and improved economic sustainability, suggesting a potential reference model for comparable settings."

Journal • Infectious Disease • Novel Coronavirus Disease • Oncology

Enabling the Synthesis of the 4'-Thioremdesivir Core. (PubMed, Chemistry) - "In this study, we report the first successful synthesis of the parent 4'-thionucleoside core of remdesivir...Computational and NMR reaction monitoring studies provide mechanistic insight into thioribose reactivity and establish a framework for controlling anomeric stereochemistry in C-linked 4'-thionucleoside synthesis. These results establish a foundation for future C-linked 4'-thionucleoside antiviral development."

Journal • Oncology

Comprehensive Chemical Profile and Anti-Infective Properties of Cymbopogon schoenanthus L.: Phytochemical Analysis, In Silico Investigations, and Evaluation of Anti-SARS-CoV-2, Antimicrobial, and Antibiofilm Activities. (PubMed, An Acad Bras Cienc) - "The essential oil demonstrated a marked antiviral effect against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), with a selectivity index (18.6) superior to that of remdesivir (15.11). Molecular docking revealed strong binding affinities of major constituents to key enzymatic targets, including SARS-CoV-2's receptor-binding domain, and bacterial PBP2a and Gyrase B, with sesquiterpenes showing higher binding energies than monoterpenes. These results scientifically validated the traditional uses of C. schoenanthus and highlighted its potential as a source of natural anti-infective agent."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The effect of intravenous remdesivir on endometrial receptivity in female mice. (PubMed, Clin Exp Reprod Med) - "In pregnant mice, remdesivir reduced serum estradiol levels, decreased the number of endometrial pinopodes, and suppressed interleukin-6 expression. These findings suggest that remdesivir may adversely affect the endometrium and potentially compromise implantation; however, direct functional validation is required."

Journal • Preclinical • Critical care • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IL1B • IL6

Assessing the pandemic potential of Nipah virus: From molecular pathogenesis to ecological spillover risks. (PubMed, Infect Med (Beijing)) - "Current medical countermeasures (mRNA vaccines, m102.4 antibody, remdesivir) and deployment challenges (genetic diversity, biosafety level 4 constraints, regulatory dependence on the "Animal Rule") are evaluated. The conclusion calls for a "One Health"‑informed global defense system anchored on four pillars: intelligent forecasting that integrates ecological data; a broadly protective countermeasure repository; democratized rapid diagnostics; and translational bridges linking molecular insights to actionable interventions. Strengthening global collaboration is imperative to prevent Nipah virus from escalating into a pandemic."

Journal • Review

Retrospective Cohort Study Assessing Remdesivir Effectiveness in Hospitalized COVID-19 Patients With Renal or Hepatic Comorbidities. (PubMed, Clin Infect Dis) - "Early RDV initiation was associated with improved survival among patients with renal or hepatic disease who were hospitalized for COVID-19."

Journal • Hepatology • Infectious Disease • Novel Coronavirus Disease

Measles: A Narrative Review of Current Therapeutic Options and Implications for the Future. (PubMed, Viruses) - "Despite the availability of a safe and effective measles vaccine for several decades, measles remains a significant cause of morbidity and mortality worldwide, causing 95,000 deaths in 2024 alone...There are few reports indicating that repeated remdesivir courses, as well as intraventricular or intrathecal ribavirin or IFN, may temporarily stabilize the neurologic status of patients with subacute sclerosing panencephalitis...Overall, the development of antiviral agents against measles has been extremely slow. Therapeutic agents against measles are urgently needed."

Clinical • Journal • Review • CNS Disorders • Infectious Disease • Measles

Computational Identification of Potential RSV L-RdRp Inhibitors with Predicted Superior Activity and Safety Profiles over Remdesivir Using QSAR Modeling, Molecular Docking and Molecular Dynamics Simulations. (PubMed, Pharmaceuticals (Basel)) - " Ultimately, five candidate compounds were selected, all of which demonstrated predicted higher inhibitory activity, lower predicted cytotoxicity, a stable predicted binding mode, and favorable oral bioavailability compared with the reference drug remdesivir. These findings provide valuable in silico-derived lead candidates and a reliable computational workflow for identifying experimental L-RdRp inhibitors targeting RSV."

Journal • Respiratory Diseases

Wastewater-Based Genomic Surveillance of SARS-CoV-2 Antiviral Resistance Determinants in Ontario: Towards a Scalable Framework for Population-Level Antiviral Resistance Monitoring. (PubMed, Viruses) - "These findings demonstrate that wastewater surveillance enables population-scale monitoring of antiviral resistance and immune escape-associated mutations and offers a scalable model for broader surveillance."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

Activated Sludge in the Bioremediation of Water Containing SARS-CoV-2 Antivirals. (PubMed, J Xenobiot) - "This study evaluates the removal percentages, kinetic mechanisms, and toxicity profiles of six SASs, daclatasvir (DCV), darunavir (DRV), favipiravir (FAV), lopinavir (LOP), remdesivir (REM), and ritonavir (RIT), using activated sludge. Perturbation analysis showed that all tested factors have a distinct influence on process performance. These established kinetic trends should support further investigations into advanced biological wastewater treatment methods and precise ecotoxicity profiling of emerging biotransformation products."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Synthesis and antitumoral evaluation of 3',4'-unsaturated nucleoside analogues bearing a chlorinated remdesivir-like base. (PubMed, Bioorg Chem) - "Among the synthesized compounds, 17k, a C-nucleoside bearing both a 3',4'-unsaturated sugar moiety and a chlorinated remdesivir-like base, exhibited potent antiproliferative activity against HepG2 cells, with an IC₅₀ value of 2.27 ± 0.36 μM, lower than that of gemcitabine under the same assay conditions. Compound 17k also suppressed colony formation and wound closure, induced apoptosis, and caused S-phase accumulation in HepG2 cells. These findings identify 17k as a nucleoside analogue with unanticipated antiproliferative activity and suggest that kinase modulation may contribute to its cellular effects."

Journal • Oncology • CDK12 • CDK13 • CDK9 • KDR

Whole body fluorine-18 fluorodeoxyglucose parametric PET/computed tomography in people with long coronavirus disease: the ERASE-LC trial protocol. (PubMed, Nucl Med Commun) - "The early experiences of performing this protocol demonstrated that participants were able to tolerate the scan duration and positioning. In conclusion, this protocol demonstrates a novel use of parametric PET/computed tomography fluorine-18 fluorodeoxyglucose whole body scans for the assessment of long COVID and response to remdesivir."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

DABPU-DE targeting host adipose triglyceride lipase provides broad-spectrum anti-coronavirus effects in vitro. (PubMed, Front Pharmacol) - "The antiviral effect of DABPU-DE with remdesivir against SARS-CoV-2, either alone or in combination, was evaluated by IFA, and their synergistic effect was analyzed using SynergyFinder 3.0...Our findings indicate that the broad-spectrum anti-coronaviral activity of these compounds, particularly DABPU-DE, provides a promising preclinical foundation. This study underscores the potential of ATGL-targeted interventions as a viable strategy for managing current SARS-CoV-2 variants and preparing for future coronavirus outbreaks."

Journal • Preclinical • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases