DK210 (CD19) / Deka BioSci - LARVOL DELTA

Balanced Diakine™ targeted cytokines localize within the immunological synapse and augment immune response in combination with T cell engagers (SITC 2024) - "Conclusions DK210 (CD19) either alone or in combination with TCE uncouples anti-tumor activity from CRS-related cytokines; enhances the cytolytic function of CD8+ T cells; and augments both the duration and avidity of effector-to-target cell interactions. These results provide mechanistic rationale for the Diakine™ platform constructs to be combined with TCEs to potentially improve therapeutic index."

Combination therapy • Oncology • CD8 • EGFR • GZMB • IFNG • IL10 • IL1B • IL2 • IL6 • TNFA