tamsulosin / Generic mfg. - LARVOL DELTA

Eco-friendly spectrophotometric quantification of the potential combination of mirabegron and tamsulosin. (PubMed, Sci Rep) - "The evaluation of the environmental sustainability of the established approaches was conducted using AGREE, GAPI, MOGAPI and whiteness revealing their notable eco-friendliness. The proposed method was deemed practical after the evaluation carried out with the Blue Applicability Grade Index (BAGI) assessment."

Journal • Benign Prostatic Hyperplasia • Overactive Bladder

Efficacy and safety of drug combinations for chronic pelvic pain: a systematic review. (PubMed, Pain Rep) - "Nine studies (1,299 participants) were included and involved various different treatments including ciprofloxacin, tamsulosin, pentosan polysulfate, hyaluronic acid, chondroitin, hydroxyzine, troxerutin, carbazochrome, linzagolix, and allopurinol. None of the included studies reported a significant difference in reducing pain intensity for combination therapy vs monotherapy. If future proof-of-concept studies demonstrate that a given combination is superior to all monotherapy components, subsequent large, double-blind randomized, controlled clinical trials of such combinations for CPP are required to better elucidate the role of combination therapy in clinical settings."

Clinical • Journal • Review • Gynecology • Musculoskeletal Pain • Pain

Comparative efficacy and adverse effects of β3-agonists and antimuscarinics in overactive bladder: a network and component network meta-analysis. (PubMed, Eur J Clin Pharmacol) - "β3-agonists, especially vibegron, are effective for OAB symptoms (MF and UUI), both alone and with antimuscarinics. For short-term treatment, combination therapies seem superior to monotherapies in symptom control."

Adverse events • Journal • Retrospective data • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Overactive Bladder • Urinary Incontinence • Urology • Xerostomia

L-arginine role for stone lower ureter: A randomized controlled trial. (PubMed, Urolithiasis) - "However, a statistically significant difference was noted regarding stone density and hydronephrosis. It is concluded that L-arginine is more effective than tamsulosin in increasing the SER and reducing stone expulsion time, with better pain control, making it a safe and effective MET for ureteral stones."

Clinical • Journal • Nephrology • Pain • Renal Calculi

Use of Narrow Calibrated Side-Port Technique to Prevent Occurrence of Intraoperative Floppy Iris Syndrome During Phacoemulsification Surgery. (PubMed, Clin Ophthalmol) - "Four hundred and fifty eyes of patients using alpha-1 antagonist drug Tamsulosin were included in the study...When added to existing surgical techniques, a calibrated side-port incision significantly improves patient outcomes in managing IFIS during phacoemulsification in patients taking alpha-1 antagonist drugs. This modification helps prevent the side-port incision from becoming a focal point for IFIS, thereby enhancing surgical safety and efficacy."

Journal • Cataract • Ophthalmology

Pathophysiology of intraoperative floppy iris syndrome: An unsettled debate. (PubMed, Surv Ophthalmol) - "Initially, IFIS was thought to be a result of sympathetic signal blockage in the iris dilator muscle, since α-blockers such as tamsulosin were found to be a strong predisposing factor; however, many IFIS cases occur even in patients who discontinued α-blockers prior to cataract surgery. Several potential mechanisms through which α-blockers induces chronic changes in the iris - iris dilator atrophy, drug-melanin interaction, and loss of vascular tone - have been proposed as possible mechanisms. We address the prevailing theories on α-receptor-dependent mechanisms for IFIS and the current prophylactic measures undertaken to prevent IFIS-associated intraocular complications."

Journal • Review • Cataract • Ophthalmology

A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway. (PubMed, Nat Commun) - "Systemic and local delivery of Adra1a antagonists, including silodosin and tamsulosin, improves tear secretion and reduces corneal lesions in multiple dry eye mouse models. In addition, we identify the brain locus coeruleus as an upstream driver orchestrating sympathetic regulation of lacrimal secretion. Overall, these findings reveal a gatekeeper role of SNS in tear secretion and offer potential therapeutic strategies for dry eye disease."

Journal • Dry Eye Disease • Ophthalmology

I Know What You-TI Can-Did-a Last Summer: A Rare Scenario of Fungemia Resulting from Urinary Tract Translocation From Diabetic Neuropathy (ENDO 2025) - "Eventually blood cultures were remarkable for 2/2 candida albicans, and patient was started on fluconazole treatment with eventual transition to caspofungin due to transaminitis.Curiously enough, patient's history was not remarkable for any of the traditional niduses of candidemia...A route of disease that, while possible physiologically, is exceedingly uncommon.Patient was eventually discharged with insulin therapy, flomax, and full course of fungal treatment. Though candida UTI and candidemia are frequent concerns for patients with uncontrolled diabetes, candidemia as a result of bladder translocation is fairly novel/rare from an academic standpoint."

Cardiovascular • Diabetes • Diabetic Neuropathy • Genetic Disorders • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Type 2 Diabetes Mellitus • Urinary Incontinence • Urology • Uveitis

Comparing efficacy and safety of monotherapy and combination therapy with tadalafil, tamsulosin, and silodosin for distal ureteral stones: A systematic review and meta-analysis. (PubMed, Asian J Urol) - "It appears that tadalafil and silodosin have similar efficacy in SET and SER. All medical expulsive therapies had comparable safety."

Journal • Monotherapy • Retrospective data • Review • Pain • Renal Calculi

A Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes. (PubMed, Urol Pract) - "Multivariate analysis identified pathway utilization as a significant predictor for each intervention (ketorolac 15 mg dose: OR 1.37, 95% CI 1.10-1.71, p = 0.004; IV lidocaine: OR 6.54, 95% CI 4.09-10.46, p < 0.001; tamsulosin: OR 3.78, 95% CI 2.97-4.79, p < 0.001). The electronic health record-integrated nephrolithiasis pathway effectively promoted evidence-based pain management promoting non-opioid pain control, and appropriate medical expulsive therapy."

Journal • Nephrology • Pain • Renal Calculi • Urology

Comparison of Silodosin and Tamsulosin for Medical Expulsive Therapy in Patients With Ureteral Stones (clinicaltrials.gov) - P=N/A | N=200 | Completed | Sponsor: Fatima Jinnah Medical University

New trial • Renal Calculi

Navigating methodological Pitfalls: A critical review of preoperative tamsulosin in pediatric ureteroscopy. (PubMed, J Pediatr Urol) - No abstract available

Journal • Pediatrics

Case report: Case series of urinary retention in young adults with severe autism hospitalized for behavioral crisis. (PubMed, Front Psychiatry) - "As the usual guidelines for screening, management, and follow-up of urinary retentions are irrelevant in this population, we provide and discuss some recommendations: limitation of anticholinergic burden, strict application of the protocol for going to the toilet with training protocol, regularization of intestinal transit, daily bladder-scan control, and eventually use of Tamsulosin hydrochloride. These recommendations significantly improved the urinary status of our patients. We conclude that chronic urinary retention is probably a recurrent and unrecognized feature in many young adults with autism and challenging behaviors, reflecting the long-term impact of iatrogenic medication and requiring a specific attention."

Journal • Autism Spectrum Disorder • Genetic Disorders

Response to: Letter to the Editor re: "Smooth sailing or rocky road in navigating the ureteral orifice: Does preoperative tamsulosin improve success of primary ureteroscopy in children?". (PubMed, J Pediatr Urol) - No abstract available

Journal

A Case of Metformin-Associated Lactic Acidosis Secondary to Obstructive Acute Kidney Injury (ATS 2025) - "Three days prior, he was seen by his primary care physician for worsening urinary hesitancy, presumed related to BPH, and was prescribed tamsulosin. This case highlights the importance of a broad diagnostic and therapeutic approach to lactic acidosis that prioritizes correction of shock and hypoxemia while also considering rare etiologies including pharmacologic toxicity. While MALA is most frequently encountered in constellation with hypovolemia-induced AKI, this case represents one of the rare descriptions of this process with acute urinary obstruction."

Clinical • Acute Kidney Injury • Benign Prostatic Hyperplasia • Diabetes • Hepatology • Liver Failure • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Bladder Retention as a Prodrome of Spinal Cord Infarction: A Diagnostic Challenge in a Patient With Atrial Fibrillation (ATS 2025) - "This case highlights the diagnostic challenges posed by atypical presentations of spinal cord infarction.Case PresentationThe patient had experienced urinary retention for three days, reporting no relief even after doubling his tamsulosin dose...ConclusionThis case highlights the importance of considering spinal cord pathology in patients with persistent urinary retention, especially in those with vascular risk factors like atrial fibrillation. Early recognition and timely intervention are essential to preventing irreversible neurological damage."

Clinical • Atrial Fibrillation • Benign Prostatic Hyperplasia • Cardiovascular • Diabetes • Hypertension • Hypotension • Metabolic Disorders • Thrombosis • Urology

Complex Critical Care Management of Vasoplegic Shock and Serotonin Syndrome Following Polysubstance Overdose: A Case Report (ATS 2025) - "This abstract is funded by: None Introduction This case report presents a complex instance of vasoplegic shock and serotonin syndrome following a suicide attempt through polysubstance overdose involving amlodipine, lisinopril, tamsulosin, and sertraline. Additionally, it underscores the need for titrating pressors to therapeutic effect rather than adhering to hospital-defined "maximal doses," as demonstrated by the effective use of high-dose norepinephrine. Protocol flexibility in pressor titration is essential, especially in complex overdoses, to optimize patient outcomes."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • CNS Disorders • Critical care • Depression • Heart Failure • Infectious Disease • Metabolic Disorders • Nephrology • Ophthalmology • Pneumonia • Psychiatry • Renal Disease • Respiratory Diseases

Calcium-channel Blocker Induced Respiratory Failure? An Unusual Phenomenon (ATS 2025) - "Home medications included Albuterol, Budesonide-Glycopyr-Formoterol, Diltiazem ER 360 mg daily, Lisinopril, Metoprolol, Ranolazine, Tamsulosin, and Torsemide.Examination revealed coarse rhonchi in the left lung and pitting edema...CT angiography chest imaging revealed mass-like consolidation in the left lower lobe, tracheobronchomalacia, and no pulmonary embolism.The patient was admitted to the medical intensive care unit (MICU) for agitation, started on a Dexmedetomidine drip, and received antibiotics for pneumonia...However, blocking HPV can exacerbate V/Q mismatch and lead to significant hypoxemia. This case underscores the need for clinicians to consider the potential adverse effects of vasodilators like Diltiazem in patients with acute pulmonary illnesses."

Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Heart Failure • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Obstructive Sleep Apnea • Pain • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Sleep Disorder • Type 2 Diabetes Mellitus

Acute dual therapeutic effects of the BKCa channel opener LDD175 on erectile dysfunction and lower urinary tract symptoms in chronic pelvic ischemia: a preliminary study. (PubMed, Asian J Androl) - "This study evaluated the effectiveness of LDD175 compared to standard treatments, such as sildenafil for ED and tamsulosin for LUTS. LDD175 administration showed promising results, with dose-dependent improvements in ICP and IUP, and therapeutic effects comparable to those of established treatments. Our findings suggest a novel therapeutic approach that can simultaneously address ED and LUTS, opening new possibilities for clinical application in the treatment of these interconnected conditions."

Journal • Atherosclerosis • Cardiovascular • Erectile Dysfunction • HIF1A • TGFB1

Preoperative Tamsulosin to Prevent Postoperative Urinary Retention After Surgery For Pelvic Floor Disorders (clinicaltrials.gov) - P1 | N=100 | Active, not recruiting | Sponsor: The Cleveland Clinic | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Oct 2024 ➔ Oct 2025

Trial completion date • Trial primary completion date • Women's Health

Prospective randomized study on the efficacy of tamsulosin, solifenacin, and their combination in relieving lower urinary tract symptoms in ureteric stent patients: insights from the brief-form Chinese USSQ. (PubMed, World J Urol) - "The brief-form USSQ is a useful, reliable substitute for evaluating stent-related symptoms. Our findings support the notion that tamsulosin/solifenacin combinations have considerably reduced LUTS linked to the placement of ureteral stents."

Clinical • Journal • Urology

The study Peptide-ALPHA: a role of bladder regulatory peptides and alpha-blockers in combination therapy for LUTS (PubMed, Urologiia) - "The addition of Vesusten to alpha-blockers in patients with LUTS and OAB caused by BPH significantly reduced irritative symptoms according to questionnaires, uroflowmetry and postvoid residual volume. Only mild local AEs were observed that did not require discontinuation of therapy."

Clinical • Journal • Benign Prostatic Hyperplasia • Overactive Bladder

Use of a combined form of prostate extract and alpha-adrenoblocker in patients after transurethral resection of the prostate (PubMed, Urologiia) - "Our data allow to recommend this drug in the combined treatment of patients with benign prostatic hyperplasia (BPH) after transurethral resection of the prostate to restore urination function and improve quality of life."

Clinical • Journal • Benign Prostatic Hyperplasia • CNS Disorders

A multicenter, randomized, parallel, controlled, prospective, open-label study of the efficiency and safety of bovhyaluronidase azoximer in combination therapy in patients with lower urinary tract symptoms due to benign prostatic hyperplasia (PubMed, Urologiia) - "Our results indicate greater efficiency and safety of combination therapy with Longidaza and tamsulosin in patients with LUTS due to BPH compared to monotherapy with tamsulosin."

Clinical • Journal • Benign Prostatic Hyperplasia

TRAM: Comparison of Alpha Blockers (Terazosin and Tamsulosin) in Reducing Ureteral Stent Related Symptoms (clinicaltrials.gov) - P3 | N=150 | Not yet recruiting | Sponsor: Penang Hospital, Malaysia

New P3 trial