tamsulosin / Generic mfg. - LARVOL DELTA

Persistent bothersome urinary frequency following stereotactic body radiation therapy for clinically localized prostate cancer: rationale for prophylactic β3-agonist in men with elevated baseline international prostate symptom scores. (PubMed, Front Oncol) - "Answers to question 4E and tamsulosin usage were recorded at regular follow-ups to assess, and demographic factors as well as baseline prostate volume, alpha-adrenergic antagonist usage and IPSS score severity were used as modifiers. Prophylactic alpha-adrenergic antagonists do not protect against bothersome acute urinary frequency. This paper makes the case that urinary frequency may be better addressed with a prophylactic beta-3 agonist, like vibegron, which is designed to treat storage-related LUTS concerns."

Journal • Genito-urinary Cancer • Oncology • Overactive Bladder • Prostate Cancer • Solid Tumor

Delayed cardiovascular collapse in poisoning due to amlodipine, atenolol, tamsulosin and insulin. (PubMed, Clin Toxicol (Phila)) - No abstract available

Journal • Cardiovascular

Efficacy of tamsulosin 0.4 mg for the treatment in male with the international Prostate Symptom Score ≥ 20 compared with tamsulosin 0.2 mg. (PubMed, Prostate Int) - "This study demonstrates the potential superiority of tamsulosin 0.4 mg in improving IPSS and UFM parameters in Korean BPH patients with severe IPSS during the short-term follow-up. However, long-term efficacy requires further investigation."

Journal • Benign Prostatic Hyperplasia

Use of Alpha-Blockers Before RIRS: Assessment of Factors for Successful Ureteral Access Sheath Insertion. A Randomized Clinical Study (ChiCTR) - P=N/A | N=140 | Completed | Sponsor: St. Luke’s Clinical Hospital Russian Federation; St. Luke’s Clinical Hospital Russian Federation

New trial • Renal Calculi • Urolithiasis

Efficacy analysis of low intensity pulsed ultrasound combined with tamsulosin hydrochloride in the treatment of chronic prostatitis (ChiCTR) - P=N/A | N=66 | Recruiting | Sponsor: The First People's Hospital of Pinghu; The First People's Hospital of Pinghu

New trial

Exploration of peripheral blood immune cell heterogeneity and efficacy of Qianlie Xiaozhuo Formula in the treatment of type III chronic prostatitis patients based on single-cell RNA sequencing (ChiCTR) - P=N/A | N=70 | Not yet recruiting | Sponsor: Shunyi Hospital of Traditional Chinese Medicine; Shunyi Hospital of Traditional Chinese Medicine

New trial

Enhanced antiproliferative and anti-inflammatory effects of combined metformin, tadalafil, and tamsulosin in a rat model of testosterone-induced benign prostatic hyperplasia. (PubMed, Life Sci) - "although individual treatments provided benefits, their combined use enhanced therapeutic outcomes through modulation of oxidative stress, inflammation, and androgenic activity in BPH management."

Journal • Preclinical • Benign Prostatic Hyperplasia • Oncology • IGF2 • TGFB1 • TGFB2 • TNFA

Successful Treatment of Obstructive Ureterolithiasis with Medical Expulsive Therapy Including Tamsulosin in a Dog. (PubMed, Vet Sci) - "After 3 days, improvement in azotemia and resolution of ureteral obstruction were observed. Although concurrent medical treatments were administered, this case provides clinical insight into the potential role of tamsulosin as part of medical management of obstructive ureterolithiasis in a dog with small distal ureteral stones."

Journal • Anorexia • Nephrology • Renal Calculi • Renal Disease

A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate (clinicaltrials.gov) - P4 | N=136 | Recruiting | Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

New P4 trial • Benign Prostatic Hyperplasia

Effect of Celecoxib Combined With Low-Dose-Rate Brachytherapy on Long-Term Oncological Outcomes and Quality of Life in Prostate Cancer: Post Hoc Analysis of an Open-Label Controlled Randomized Trial. (PubMed, Prostate) - "Celecoxib combined with LDR-BT for prostate cancer was associated with lower cumulative incidence of BCR and metastasis, although QOL impairment was not ameliorated."

HEOR • Journal • Retrospective data • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery (clinicaltrials.gov) - P4 | N=20 | Recruiting | Sponsor: Mayo Clinic | Trial primary completion date: Dec 2027 ➔ Jan 2027

Trial primary completion date • Orthopedics

Outcome of medical treatments combined with tamsulosin for feline ureteral obstruction. (PubMed, J Vet Med Sci) - "Body weight was significantly higher in responders than in non-responders. Adverse drug reactions were rare, mild, reversible, and did not include hypotension.The response rate we report for tamsulosin may be of interest to clinicians considering its use in combination therapy where surgery is declined or delayed and for future research on feline ureteral obstruction."

Journal • Hypotension • Nephrology • Renal Calculi

Statin-Associated Headache: A Rare and Underrecognized Clinical Presentation: A Case Report. (PubMed, Reports (MDPI)) - "In this case, the patient was taking metoprolol succinate, lisinopril, simvastatin, clopidogrel, and tamsulosin. Clinicians should remain vigilant about the possibility of statin-induced headache, even in long-term users. Early recognition can prevent unnecessary diagnostic investigations, expedite symptom resolution, and support optimal management of both cardiovascular risk and treatment-related adverse effects."

Journal • Cardiovascular • Musculoskeletal Pain • Pain

The Association Between Preoperative Tamsulosin Use and Intraoperative Hypotension. (PubMed, J Cardiothorac Vasc Anesth) - "This study suggests that the use of tamsulosin prior to cardiac surgery is associated with an increased requirement for vasoactive support during CPB and upon ICU arrival. Prospective studies are warranted."

Journal • Cardiovascular • Critical care • Hypotension

Implementation of problem-based learning pedagogy with integration of tamsulosin management in traditional urology residency training under the multidisciplinary team model. (PubMed, Pak J Pharm Sci) - "Integrating a structured sequence of problem-solving learning with a focused pharmacology topic on tamsulosin, within a multidisciplinary team setting, has been shown to enhance urology residents' knowledge, problem-solving abilities, teamwork, and satisfaction compared to traditional teaching methods."

Clinical • Journal • Benign Prostatic Hyperplasia • Urology

Cardiovascular safety of 5α-reductase inhibitors in people with benign prostatic hyperplasia and type 2 diabetes: a propensity-score matched analysis. (PubMed, Eur Heart J Cardiovasc Pharmacother) - "Our retrospective data from two large cohorts suggest that the risk of MACE may be increased among patients with type 2 diabetes taking 5α-reductase inhibitors, potentially driven by increased risk of MI. This supports careful monitoring of macrovascular outcomes when prescribing 5α-reductase inhibitors in this population."

Journal • Benign Prostatic Hyperplasia • Cardiovascular • Diabetes • Metabolic Disorders • Myocardial Infarction • Type 2 Diabetes Mellitus

Prospective Trial Comparing Oxybutynin and Tamsulosin for Stent Pain in the Pediatric Population (clinicaltrials.gov) - P=N/A | N=0 | Withdrawn | Sponsor: Phoenix Children's Hospital | N=60 ➔ 0 | Unknown status ➔ Withdrawn

Enrollment change • Trial withdrawal • Pain • Pediatrics

Postoperative Urinary Retention After Hernia Repair: A Randomized Controlled Trial Identifying Patients at Risk and Assessing the Incidence After Tamsulosin Pretreatment. (PubMed, HCA Healthc J Med) - "Seven days of preoperative tamsulosin did not show a statistically significant reduction in postoperative urinary retention in men undergoing elective hernia operations. However, the subgroup analysis did reveal a statistically significant difference in the preoperative IPSS of patients who had postoperative urinary retention and those who did not, possibly indicating that the IPSS could be used as a predictive tool in the future."

Journal • Gastroenterology

Tamsulosin for Prevention of Urinary Retention After Midurethral Sling. (PubMed, Urogynecology (Phila)) - "These findings suggest that patient and procedural characteristics may play a more significant role in POUR risk than perioperative tamsulosin use for patients undergoing MUS placement."

Journal • Gynecology • Urinary Incontinence • Urology

Efficacy of alpha-blockers in medical expulsive therapy for ureteral stones: A systematic review and meta-analysis of randomized controlled trials between 2010 and 2025. (PubMed, Arab J Urol) - "Network meta-analysis revealed efficacy ranking favoring at first terazosin, followed by doxazosin then, silodosin then, tamsulosin then, alfuzosin and last the least effective was naftopidil. While tamsulosin remains the most studied agent, our network meta-analysis suggests terazosin and doxazosin may offer superior efficacy. The favorable risk-benefit profile supports routine use of alpha-blockers for appropriately selected patients with ureteral stones."

Journal • Retrospective data • Review • Pain • Renal Calculi • Urolithiasis

Therapeutic intervention for control of LUTS after TURBT: prospective comparison between tamsulosin, oxybutynin and control (EAU 2026) - No abstract available

Clinical • Bladder Cancer

Study to Evaluate the Drug-drug Interaction Between IY001 and IY002 in Healthy Adult Male Subjects. (clinicaltrials.gov) - P1 | N=43 | Completed | Sponsor: Il-Yang Pharm. Co., Ltd.

New P1 trial

Doxazosin versus tamsulosin for the treatment of male lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH): systematic literature review and network meta-analysis. (PubMed, World J Urol) - No abstract available

Journal • Retrospective data • Review • Benign Prostatic Hyperplasia

Comparison of Mirabegron and Tamsulosin for Ureteral Stone Expulsion (clinicaltrials.gov) - P4 | N=500 | Not yet recruiting | Sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

New P4 trial • Renal Calculi

ARAB: Intermittent vs Daily Tamsulosin for LUTS/BPH (clinicaltrials.gov) - P4 | N=288 | Not yet recruiting | Sponsor: Mansoura University

Head-to-Head • New P4 trial • Benign Prostatic Hyperplasia