tamsulosin / Generic mfg. - LARVOL DELTA

Early removal of urinary catheter before extubation in robotic total mesorectal excision with perioperative tamsulosin. (PubMed, Surg Endosc) - "Immediate urinary catheter removal before extubation was feasible in this prospective service evaluation cohort managed within a predefined integrated perioperative pathway. These findings support further prospective comparative evaluation but should not be interpreted as evidence of superiority over conventional catheter management. The concentration of recatheterisation events amongst patients with pre-existing benign prostatic hyperplasia supports further investigation of individualised postoperative urinary management."

Journal • Benign Prostatic Hyperplasia • Colorectal Cancer • Infectious Disease • Nephrology • Oncology • Rectal Cancer • Solid Tumor

ASIV Attenuates Cisplatin-Induced Proximal Tubular Injury by Enhancing Mitochondrial Biogenesis and Mitophagy Through the ADRA1A/AMPK/FOXO3A Pathway. (PubMed, FASEB J) - "In contrast, the renoprotective action of ASIV against cisplatin-induced proximal tubular injury was largely abrogated by the ADRA1A antagonist tamsulosin in vivo and by ADRA1A-specific siRNA in vitro. These findings identify ASIV as a highly promising renoprotective agent that upregulates ADRA1A expression and activates the AMPK/FOXO3A axis to enhance mitochondrial biogenesis and mitophagy, thereby counteracting cisplatin-induced proximal tubular injury."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Clinical study of Tamsulosin on the recovery of voluntary urinary function after total mesorectal excision(TME) for rectal cancer (ChiCTR) - P=N/A | N=668 | Not yet recruiting | Sponsor: The Sixth Affiliated hospital of Sun Yat-sen University; The Sixth Affiliated hospital of Sun Yat-sen University

New trial • Colorectal Cancer • Oncology • Rectal Cancer • Solid Tumor

Alpha-Adrenoceptor Blockade as a Novel Pathway Toward Non-Hormonal Male Contraception: A Mechanistic and Clinical Evidence Review. (PubMed, J Clin Med) - "Agents such as tamsulosin and silodosin have been reported to induce anejaculation or markedly reduce semen volume, providing pharmacodynamic evidence of impaired seminal emission; however, these effects should not be considered equivalent to demonstrated contraceptive efficacy. α1-adrenoceptor antagonists represent a biologically plausible pharmacologic strategy for male non-hormonal contraception by interfering with seminal emission and sperm delivery without directly suppressing spermatogenesis. Further pharmacokinetic-pharmacodynamic studies and rigorously designed multicentre clinical trials are required to determine the optimal dosing strategy, completeness and consistency of seminal emission suppression, contraceptive effectiveness, safety, acceptability, and reversibility of this approach."

Clinical • Journal • Review • Cardiovascular • Sexual Disorders • ADRA1B

Retrograde Intrarenal Surgery: Analysis of Efficacy, Safety and Cost-Effectiveness of drug preparation (PubMed, Urologiia) - "Drug preparation with Omnic Ocas is not inferior to prestenting in efficacy, but superior in tolerability and economic feasibility, being a preferred alternative."

HEOR • Journal • Review • Nephrology • Pain • Renal Calculi • Urolithiasis

Tamsulosin and the Risk of Serious Adverse Events (clinicaltrials.gov) - P=N/A | N=14000 | Active, not recruiting | Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Completed ➔ Active, not recruiting | Trial completion date: Mar 2025 ➔ Dec 2027

Adverse events • Enrollment closed • Serious adverse event • Trial completion date • Chronic Kidney Disease • Nephrology • Renal Disease

Efficacy and safety of Qianlieshutong Capsules in the treatment for Type III prostatitis: A post-marketing, multicenter, randomized, double-blind, single-dummy, active-controlled, parallel-group clinical trial. (PubMed, Phytomedicine) - "The combination of QLSTCs and tamsulosin is a safe and more effective treatment than tamsulosin alone for CP/CPPS, offering superior symptom relief, particularly in pain, urinary symptoms, and quality of life. This approach may serve as a promising multimodal therapeutic option in clinical practice."

Clinical • Journal • P4 data • Gynecology • Musculoskeletal Pain • Pain

R-POUR: Prophylactic Use of Tamsulosin in the Prevention of Post-operative Urinary Retention in Men After Rectum Resection (clinicaltrials.gov) - P3 | N=220 | Recruiting | Sponsor: CHU de Quebec-Universite Laval | Not yet recruiting ➔ Recruiting | Trial completion date: Jul 2025 ➔ Jul 2028 | Trial primary completion date: Jul 2025 ➔ Jul 2027

Enrollment open • Trial completion date • Trial primary completion date

Post Operative Urinary Retention (POUR) Following Thoracic Oncological Surgery (clinicaltrials.gov) - P1 | N=46 | Recruiting | Sponsor: Hackensack Meridian Health | Trial primary completion date: Dec 2026 ➔ Jun 2027 | Trial completion date: Dec 2026 ➔ Jun 2027

Trial completion date • Trial primary completion date

Effect of Tamsulosin Combined With Flexible Ureteroscopic Holmium Laser Lithotripsy on Renal Function and Postoperative Inflammatory Response in Patients With Renal Calculi. (PubMed, Arch Esp Urol) - "In this retrospective study, perioperative tamsulosin combined with FURL was associated with shorter operation times, higher stone clearance, and lower renal function, inflammatory, and complication markers. However, due to potential selection bias, these associations require confirmation via prospective randomized controlled trials."

Journal • Retrospective data • Inflammation • Renal Calculi

Prospective Post Market Clinical Trial for the Zenflow Spring System - A Minimally Invasive Treatment for LUTS Associated With BPH. (clinicaltrials.gov) - P4 | N=110 | Not yet recruiting | Sponsor: Zenflow, Inc.

New P4 trial • Benign Prostatic Hyperplasia

The silent signal is tadalafil counterbalancing tamsulosin induced ejaculatory dysfunction. (PubMed, World J Urol) - No abstract available

Journal

Tamsulosin versus tamsulosin plus tolterodine for the treatment of distal ureteral stones. (PubMed, World J Urol) - "The combination of tamsulosin and tolterodine demonstrated superior efficacy in terms of stone expulsion rate and reduced expulsion time for distal ureteral stones compared to tamsulosin monotherapy. This combination therapy may offer a more effective medical expulsive therapy option for patients with distal ureteral calculi."

Clinical • Journal • Pain • Renal Calculi • Urology • Xerostomia

Polypharmacy and skin cancer: a new vision for skin cancer pathogenesis - photocarcinogenicity-mediated due to nitrosamine formation during telmisartan/tamsulosin intake (EADV 2026) - No abstract available

Genetic Disorders • Oncology • Skin Cancer

Lurasidone-Associated Urinary Retention in a Patient With Bipolar Affective Disorder: A Case Report. (PubMed, Case Rep Psychiatry) - "Despite dose reduction and addition of tamsulosin, symptoms of UR persisted and only resolved with cessation of lurasidone. This case underscores the need for clinicians to remain vigilant for UR in patients prescribed lurasidone, or other atypical antipsychotics, despite their generally favourable side effect profile. Early recognition and management are critical to prevent complications and ensure appropriate ongoing treatment of BPAD."

Journal • Bipolar Disorder • CNS Disorders

Bioequivalence, Food-Effect Assessment and Exploratory IVIVC of Two Extended-Release Tamsulosin 0.4 mg Formulations in Healthy Mexican Subjects. (PubMed, Pharmaceutics) - P=N/A | "Comparable dissolution and IVIVC findings further support their reliability in vivo performance and therapeutic interchangeability. ClinicalTrials.gov identifiers: NCT07698288 and NCT07698275."

Journal • Benign Prostatic Hyperplasia • Hypotension

A retrospective cohort study on the improvement of urodynamic parameters and NIH-CPSI scores with Relin granules in BPH patients with high prostatitis-like symptom scores. (PubMed, Am J Transl Res) - "In BPH patients with high prostatitis-like symptoms, adding Relin Granules to conventional therapy was associated with alleviation of pain, improvement in quality of life and lower urinary tract symptoms (LUTS), potentially through anti-inflammatory mechanisms, with good safety."

Journal • Retrospective data • Benign Prostatic Hyperplasia • Inflammation • Oncology • Pain • IL10 • TNFA

NQTIPS: The Efficacy and Safety of Silodosin in the Treatment of Benign Prostatic Hyperplasia (clinicaltrials.gov) - P4 | N=110 | Completed | Sponsor: Xintian Pharmaceutical | N=312 ➔ 110 | Recruiting ➔ Completed

Enrollment change • Trial completion • Benign Prostatic Hyperplasia

Refractory Vasoplegia in Outpatient Microdirect Laryngoscopy: Response to Hydroxocobalamin (ASA 2026) - "We present a case of refractory vasoplegia during outpatient microdirect laryngoscopy in a patient who had taken both tamsulosin and olmesartan-hydrochlorothiazide on the day of surgery. Despite high-dose vasopressors, hypotension persisted but improved following hydroxocobalamin administration. This case highlights a potential role for hydroxocobalamin in managing vasoplegia in non-cardiac, ambulatory surgical settings."

Clinical • Hypotension

Preventing Postoperative Cognitive Dysfunction in a patient on Alpha Blockade with Microvascular Cerebral Disease (ASA 2026) - "Since he was taking tamsulosin, vasopressin was used to rapidly reverse hypotension during this procedure...Furthermore, alpha-blockade not only causes intraoperative hypotension but also makes regular vasopressors ineffective. This constellation made our patient extremely vulnerable to POCD."

Clinical • Cognitive Disorders • Dyslipidemia • Hypotension

SAFETY OF TAMSULOSIN ALONE OR IN COMBINATION WITH 5Α-REDUCTASE INHIBITORS ON LIPID PROFILE, RENAL FUNCTION, AND LIVER PARAMETERS. (PubMed, Georgian Med News) - "Tamsulosin administered alone or in combination with finasteride or dutasteride for more than three months demonstrated non-significant differences in the measured biochemical parameters among the studied groups represented by no adverse effects on lipid metabolism, renal function, liver enzymes, or bilirubin homeostasis. These findings support the safe use of these therapeutic regimens in elderly BPH patients, including those with underlying metabolic or organ function concerns. Further prospective longitudinal studies with larger sample sizes are warranted to confirm these observations."

Journal • Benign Prostatic Hyperplasia • Metabolic Disorders

Incidence of type 2 diabetes mellitus in men receiving finasteride and tamsulosin: a cross-validation cohort study using data from China and UK populations. (PubMed, Diabetes Res Clin Pract) - "These findings suggest potential benefits of tamsulosin against T2DM and underscore the need for careful monitoring of T2DM risk in finasteride users."

Journal • Benign Prostatic Hyperplasia • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Absence of Interaction Between 5α-Reductase Inhibitors and Glucocorticoids on Incidence of Myocardial Infarction in People With Type 2 Diabetes. (PubMed, Diabetes Obes Metab) - "People with Type 2 diabetes exposed to 5α-reductase inhibitors or glucocorticoids are at an increased risk of myocardial infarction, although a multiplicative interaction between the use of the two drugs was not found."

Journal • Cardiovascular • Diabetes • Metabolic Disorders • Myocardial Infarction • Type 2 Diabetes Mellitus

Pupil Size and Choroidal Thickness Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients (clinicaltrials.gov) - P4 | N=40 | Not yet recruiting | Sponsor: Mohsen Pourazizi

New P4 trial • Benign Prostatic Hyperplasia • Ophthalmology

Iris Structural Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients (clinicaltrials.gov) - P4 | N=40 | Not yet recruiting | Sponsor: Mohsen Pourazizi

New P4 trial • Benign Prostatic Hyperplasia