tamsulosin / Generic mfg. - LARVOL DELTA

Perioperative Tamsulosin for Treating Voiding Dysfunction Following Prostate Biopsy (clinicaltrials.gov) - P4 | N=1844 | Not yet recruiting | Sponsor: Peking University First Hospital

New P4 trial

Differential Risks of Dementia, Depression, and Injury Among Common α-Blockers, with Tamsulosin as the Reference Drug: A Real-World Cohort Study in Men with Lower Urinary Tract Symptoms. (PubMed, J Clin Med) - "Patients were grouped by α-blocker type-tamsulosin, doxazosin, terazosin, alfuzosin, silodosin, or prazosin-and matched 1:1 using propensity scores to adjust for demographic, clinical, and psychosocial variables. Given its favorable profile, alfuzosin may be the preferred agent in patients at elevated risk of cognitive or psychiatric disorders. These findings highlight the need for individualized α-blocker selection and long-term pharmacovigilance in BPH management."

Journal • Real-world evidence • Alzheimer's Disease • Benign Prostatic Hyperplasia • CNS Disorders • Dementia • Depression • Mental Retardation • Oncology • Psychiatry

Tamsulosin and the Risk of Serious Adverse Events (clinicaltrials.gov) - P=N/A | N=14000 | Completed | Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Adverse events • New trial • Serious adverse event • Chronic Kidney Disease • Nephrology • Renal Disease

Distal Ureteric Stone Presenting Solely As Testicular Pain: Diagnostic Lessons From a Primary-Care Setting. (PubMed, Cureus) - "The patient was managed conservatively with oral fluids, analgesics, and tamsulosin 0.4 mg once daily...A repeat scan a week later confirmed complete resolution. This case highlights the importance of considering distal ureteric stones as a differential diagnosis for unexplained testicular pain, especially in primary-care and resource-limited environments where early imaging can prevent misdiagnosis and unnecessary interventions."

Journal • Infectious Disease • Pain

Platelet Lymphocyte Ratio and Mean Platelet Volume as Predictive Biomarkers for Spontaneous Passage of Distal Ureteric Stones in Patients Undergoing Medical Expulsive Therapy. (PubMed, Cureus) - "PLR and MPV are significant, easily measurable hematological markers that can predict spontaneous passage of distal ureteric stones, aiding clinical decision-making and potentially reducing unnecessary interventions."

Biomarker • Journal • Hematological Disorders • Renal Calculi • Urolithiasis

Silodosin in treating men With BPH-associated lower urinary tract Symptoms: A systematic review and network meta-analysis. (PubMed, Int J Surg) - "Silodosin is highly effective for BPH-LUTS, particularly for voiding symptoms, but carries a elevated risk of ejaculatory dysfunction. Combination with tadalafil may enhance urinary flow. Clinicians should weigh efficacy against adverse events; further trials are needed to confirm long-term benefits."

Journal • Retrospective data • Benign Prostatic Hyperplasia

Retrograde Intrarenal Surgery Combined with Tamsulosin Hydrochloride for Renal Calculi ≤2 cm: Single-Center Study. (PubMed, Arch Esp Urol) - "RIRS combined with tamsulosin demonstrates remarkable short-term clinical efficacy, stone clearance and renal function protection in patients with renal calculi ≤2 cm, showing promising clinical application."

Journal • Retrospective data • Oncology • Pain • Renal Calculi • B2M • CRP • IL6

Clinical effect of self-made Shireqing mixture in the treatment of chronic prostatitis with downward injection of damp-heat: A retrospective analysis. (PubMed, Medicine (Baltimore)) - "Patients in the control group received treatment with tamsulosin hydrochloride sustained release capsule in combination with levofloxacin tablets, while patients in the observation group were administered a Self-Made Shireqing Mixture. Additionally, the total effective rate in the observation group surpassed that of the control group (P  .05). The Self-Made Shireqing blend has demonstrated efficacy and safety in managing individuals suffering from CP with damp-heat descending syndrome."

Journal • Observational data • Retrospective data • Pain

Nikolavsky Urethroplasty for Distal Urethral Stricture in a Young Man With Severe Obesity and Lichen Sclerosus: A Surgical Approach to a Rare Presentation. (PubMed, Cureus) - "He presented with dysuria and incomplete bladder emptying, which mildly improved with tamsulosin...This case highlights the potential contribution of severe obesity as a risk factor for LS and urethral strictures and underscores the importance of considering LS as a possible etiology in younger patients. It also supports the efficacy of buccal mucosa grafts as a durable and effective approach for complex urethral reconstruction."

Journal • Dermatology • Genetic Disorders • Infectious Disease • Inflammation • Nephrology • Obesity • Renal Calculi • Urology

Ureteral Access Sheath Deployment: Understanding the Force Tolerance of the Human Ureter and the Development of Ureteral Injury During Endoscopic Surgery. (PubMed, J Endourol) - "Preoperative tamsulosin was not of benefit. Adherence to a force threshold of ≤6 N during UAS passage resulted in safe passage of a 16F UAS in 58% of 250 renal units; when adhering to the recommended ≤6 N force threshold, there were no PULS 3 injuries. A preexisting indwelling ureteral stent and administration of antibiotics within 6 weeks of the procedure independently favored safe passage of a 16F UAS."

Journal • Infectious Disease • Nephrology • Renal Calculi

Green HPLC-Fluorescence Method for Tamsulosin and Solifenacin in Dosage Forms Optimized by Box-Behnken Design. (PubMed, Luminescence) - "The proposed method was the only method used to assess the combined tablets content uniformity. Two greenness evaluation tools, GAPI and AGREE, were used to assess the greenness of the proposed HPLC method and the results showed a remarkable compliance with the green chemistry principles."

Journal

Management of acute urinary retention in men with benign prostatic hyperplasia: Literature review and guidelines from the French Urological Association Male LUTS Panel (CTMH). (PubMed, Fr J Urol) - "These CTMH guidelines provide evidence-based recommendations for AUR management, emphasizing alpha-blocker therapy before trial without catheter and considering patient-specific factors when selecting drainage methods. Further research is needed to optimize surgical timing and technique selection."

Clinical guideline • Journal • Review • Anesthesia • Benign Prostatic Hyperplasia

A systematic review and meta-analysis of the efficacy and safety of mirabegron vs. tamsulosin in alleviating double-J catheter related symptoms. (PubMed, Front Med (Lausanne)) - "Further large-scale, high-quality RCTs with longer follow-up periods and comprehensive safety data are needed to confirm these findings and identify patient groups who may benefit most from mirabegron treatment. https://www.crd.york.ac.uk/prospero/, CRD420251083374."

Journal • Retrospective data • Review • Hypotension • Renal Calculi

Ningmitai Capsule Facilitates Residual Fragment Clearance after Ureteroscopic Holmium Laser Lithotripsy: A Multicenter Randomized Controlled Trial. (PubMed, Urol Int) - "Conclusions NMT significantly accelerates residual fragment expulsion post-Ho:YAG-URS, with synergistic effects observed when combined with tamsulosin. This study demonstrates that patients can benefit from Ningmitai capsules alone or combined with tamsulosin, particularly for small fragments where alpha-blockers show limited efficacy."

Journal

Efficacy and Safety of Mirabegron in Males with Overactive Bladder and Lower Urinary Tract Symptoms: Analysis from an Integrated Database. (PubMed, Eur Urol Open Sci) - "The studies had four treatment arms-(1) mirabegron beginning with 25 mg and then escalated to 50 mg (25/50 mg), (2) mirabegron 50 mg, (3) mirabegron 25/50 mg + tamsulosin hydrochloride (HCl) 0.4 mg, and (4) mirabegron 50 mg + tamsulosin HCl 0.2 mg, and three cohorts-cohort 1, OAB males overall; cohort 2, OAB males with concomitant BPE taking alpha blockers; and cohort 3, OAB males with concomitant BPE taking other LUTS medications (not alpha blockers). The analyzed patients included those taking mirabegron and mirabegron combined with other medications for lower urinary tract symptoms. Our results showed that mirabegron was safe and effective in reducing the symptoms of overactive bladder."

Journal • Benign Prostatic Hyperplasia • Overactive Bladder

Cutting Costs, Not Care: New Models for Affordable Men's Health Medications. (PubMed, Urology) - "CPDC provides significant cost savings on men's health medications compared to Medicare and GoodRx."

Journal • Benign Prostatic Hyperplasia • Erectile Dysfunction • Infertility • Sexual Disorders

Crystal-Clear Consequences: Trimethoprim-Sulfamethoxazole-Induced Nephrolithiasis (KIDNEY WEEK 2025) - "He was treated conservatively with intravenous fluids and tamsulosin, resulting in the successful passage of multiple stones and return to baseline renal function. However, BPH likely contributed by promoting urinary stasis, creating an environment conducive to precipitation of the drug’s poorly soluble metabolites. This case underscores the need for heightened awareness of sulfonamide crystalluria and stone formation—even in the absence of traditional risk factors—and prompts consideration of urinary flow dynamics as a key contributor."

Acute Kidney Injury • Benign Prostatic Hyperplasia • Immunology • Infectious Disease • Nephrology • Renal Calculi • Renal Disease • Steven-Johnson Syndrome • DHFR

Preoperative prediction of intraoperative complications in cataract surgery: a machine learning approach. (PubMed, Int Ophthalmol) - "This study provides a proof of concept for the feasibility of using machine learning for preoperative risk modeling of intraoperative complications in cataract surgery. While predictive performance was modest, validation on larger or external datasets is encouraged to further assess its potential role in surgical planning."

Journal • Cataract • Ophthalmology

Comparing Tamsulosin vs. Silodosin prior to Ureteroscopy: A Network Meta-Analysis of Randomized Controlled Trials. (PubMed, World J Urol) - "Silodosin and Tamsulosin are both viable options pre-URS, with Silodosin potentially yielding shorter operative time, less ureteral dilatation required and higher SAR. However, these differences are non-significant and stem from indirect estimates. Therefore, randomized head-to-head comparison trials are warranted."

Clinical • Journal • Retrospective data • Review • Renal Calculi • Urolithiasis

Efficacy of external physical vibration lithecbole combined with tamsulosin in upper ureteric stones after ESWL: a prospective randomized clinical trial. (PubMed, Sci Rep) - "The combination of EPVL and tamsulosin following ESWL significantly increased the SFR while maintaining a favorable safety profile, suggesting that this integrated approach could offer a more effective treatment pathway for stone expulsion. Further studies in larger, multi-center cohorts are needed for validation."

Clinical • Journal

A Randomized Controlled Trial on the Efficacy and Safety of Urinary Stone Relief Pills Combined with Tamsulosin in the Treatment of Upper Urinary Tract Stones (Including Postoperative Residual Stones) (ChiCTR) - P4 | N=144 | Not yet recruiting | Sponsor: Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology; Tongji Hospital, Affiliated to Tongji Medical

New P4 trial • Nephrology • Renal Calculi • Urolithiasis

Clinical Drug Study on the Efficacy and Safety of Niaoqingshu Granules in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (ChiCTR) - P4 | N=80 | Completed | Sponsor: The First Affiliated Hospital of Sun Yat sen University; The First Affiliated Hospital of Sun Yat sen University

New P4 trial • Gynecology • Musculoskeletal Pain • Pain

The Discovery of α-Adrenoceptor Antagonists as a Potential New Treatment Option for Uveal Melanoma. (PubMed, Biomolecules) - "Drug screening with UM spheroids revealed that prazosin and doxazosin dose-dependently reduced viability, whereas terazosin, alfuzosin, silodosin, tamsulosin, and phenoxybenzamine were found to be inefficient. This suggests a tumor-preventive effect through the blockade of α1A-AR. The present study highlights the responses of UM spheroids to α-AR antagonists and demonstrates that prazosin, doxazosin, or RS17053 may be a treatment option for preventing UM tumor recurrence or metastasis."

Journal • Eye Cancer • Hepatocellular Cancer • Melanoma • Ocular Melanoma • Oncology • Solid Tumor • Uveal Melanoma • AR

Impact of Fixed-Dose Combination Versus Single-Component Therapy for Benign Prostatic Hyperplasia-Related Urinary Symptoms on Persistence, Adherence, and Satisfaction in a Real-Life Setting. (PubMed, Pharmaceuticals (Basel)) - "We designed this study to assess persistence, adherence, and patient satisfaction with FDCs recently introduced to the Polish pharmaceutical market, which contain tamsulosin (an α1-adrenergic receptor antagonist) in combination with solifenacin (a muscarinic receptor antagonist) or dutasteride (a 5-α reductase inhibitor). 2. The use of FDCs increases short-term satisfaction and persistence with therapy, with a mild effect on adherence."

Journal • Benign Prostatic Hyperplasia

TURBULENCE IN DIAGNOSIS: UNCOVERING OSA AMONGST THE CLOUDS (CHEST 2025) - "Patient was diagnosed with a kidney stone in 2022, 2 days prior to the inflight event, and took one dose of tamsulosin the evening prior, with spontaneous passage of the stone that day... To mitigate the long-term sequelae of this disease, screening tools are necessary to provide appropriate testing for the subtle and uncommon manifestations of this disease. Current screening tools such as STOP-BANG remain useful to detect patients at high risk for OSA and in need of treatment. Effective treatment of OSA serves as the best option to prevent side effects during travel."

Cardiovascular • CNS Disorders • Fatigue • Hypertension • Obstructive Sleep Apnea • Renal Calculi • Respiratory Diseases • Sleep Disorder