tamsulosin / Generic mfg. - LARVOL DELTA

Refining bladder filling strategies in MR-guided adaptive radiotherapy for rectal cancer (ESTRO 2025) - "Two patients with prostate hyperplasia reported urinary discomfort, including frequency and urgency, improving with tamsulosin. Bladder filling control via catheterization and volume monitoring maintains dosimetric accuracy in short-course rectal cancer treatments while minimizing infection risk."

Colorectal Cancer • Infectious Disease • Nephrology • Oncology • Rectal Cancer • Solid Tumor

Single Dose Versus Double Dose Tamsulosin 0.4 and Solifenacin 5 in Management of Stent Related Symptoms (clinicaltrials.gov) - P=N/A | N=64 | Completed | Sponsor: Ain Shams University

New trial

A Case of Metformin-Associated Lactic Acidosis Secondary to Obstructive Acute Kidney Injury (ATS 2025) - "Three days prior, he was seen by his primary care physician for worsening urinary hesitancy, presumed related to BPH, and was prescribed tamsulosin. This case highlights the importance of a broad diagnostic and therapeutic approach to lactic acidosis that prioritizes correction of shock and hypoxemia while also considering rare etiologies including pharmacologic toxicity. While MALA is most frequently encountered in constellation with hypovolemia-induced AKI, this case represents one of the rare descriptions of this process with acute urinary obstruction."

Clinical • Acute Kidney Injury • Benign Prostatic Hyperplasia • Diabetes • Hepatology • Liver Failure • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Bladder Retention as a Prodrome of Spinal Cord Infarction: A Diagnostic Challenge in a Patient With Atrial Fibrillation (ATS 2025) - "This case highlights the diagnostic challenges posed by atypical presentations of spinal cord infarction.Case PresentationThe patient had experienced urinary retention for three days, reporting no relief even after doubling his tamsulosin dose...ConclusionThis case highlights the importance of considering spinal cord pathology in patients with persistent urinary retention, especially in those with vascular risk factors like atrial fibrillation. Early recognition and timely intervention are essential to preventing irreversible neurological damage."

Clinical • Atrial Fibrillation • Benign Prostatic Hyperplasia • Cardiovascular • Diabetes • Hypertension • Hypotension • Metabolic Disorders • Thrombosis • Urology

Complex Critical Care Management of Vasoplegic Shock and Serotonin Syndrome Following Polysubstance Overdose: A Case Report (ATS 2025) - "This abstract is funded by: None Introduction This case report presents a complex instance of vasoplegic shock and serotonin syndrome following a suicide attempt through polysubstance overdose involving amlodipine, lisinopril, tamsulosin, and sertraline. Additionally, it underscores the need for titrating pressors to therapeutic effect rather than adhering to hospital-defined "maximal doses," as demonstrated by the effective use of high-dose norepinephrine. Protocol flexibility in pressor titration is essential, especially in complex overdoses, to optimize patient outcomes."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • CNS Disorders • Critical care • Depression • Heart Failure • Infectious Disease • Metabolic Disorders • Nephrology • Ophthalmology • Pneumonia • Psychiatry • Renal Disease • Respiratory Diseases

Calcium-channel Blocker Induced Respiratory Failure? An Unusual Phenomenon (ATS 2025) - "Home medications included Albuterol, Budesonide-Glycopyr-Formoterol, Diltiazem ER 360 mg daily, Lisinopril, Metoprolol, Ranolazine, Tamsulosin, and Torsemide.Examination revealed coarse rhonchi in the left lung and pitting edema...CT angiography chest imaging revealed mass-like consolidation in the left lower lobe, tracheobronchomalacia, and no pulmonary embolism.The patient was admitted to the medical intensive care unit (MICU) for agitation, started on a Dexmedetomidine drip, and received antibiotics for pneumonia...However, blocking HPV can exacerbate V/Q mismatch and lead to significant hypoxemia. This case underscores the need for clinicians to consider the potential adverse effects of vasodilators like Diltiazem in patients with acute pulmonary illnesses."

Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Heart Failure • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Obstructive Sleep Apnea • Pain • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Sleep Disorder • Type 2 Diabetes Mellitus

Sailing or rocky road in navigating the ureteral orifice: Does preoperative tamsulosin improve success of primary ureteroscopy in children? (PubMed, J Pediatr Urol) - "Preoperative tamsulosin was not associated with improved odds of traversing the ureteral orifice in primary flexible or semirigid URS in the unstented pediatric population."

Journal • Nephrology • Pediatrics • Renal Calculi

Comparative effectiveness of silodosin vs. tamsulosin in treating acute urinary retention in benign prostatic hyperplasia patients. (PubMed, J Pak Med Assoc) - "The efficacy of tamsulosin and silodosin in individuals with benign prostatic hyperplasia was comparable."

Clinical • HEOR • Journal • Benign Prostatic Hyperplasia • Transplantation • Urology

I Know What You-TI Can-Did-a Last Summer: A Rare Scenario of Fungemia Resulting from Urinary Tract Translocation From Diabetic Neuropathy (ENDO 2025) - "Eventually blood cultures were remarkable for 2/2 candida albicans, and patient was started on fluconazole treatment with eventual transition to caspofungin due to transaminitis.Curiously enough, patient's history was not remarkable for any of the traditional niduses of candidemia...A route of disease that, while possible physiologically, is exceedingly uncommon.Patient was eventually discharged with insulin therapy, flomax, and full course of fungal treatment... Though candida UTI and candidemia are frequent concerns for patients with uncontrolled diabetes, candidemia as a result of bladder translocation is fairly novel/rare from an academic standpoint.*. .*"

Cardiovascular • Diabetes • Diabetic Neuropathy • Genetic Disorders • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Type 2 Diabetes Mellitus • Urinary Incontinence • Urology • Uveitis

An eco-friendly HPLC method for the sustainable analysis of the newly approved combinations of Alfuzosin and Tamsulosin, with Tadalafil in organic-solvent-free mixed-micellar systems. (PubMed, Analyst) - "Greenness of the method was assessed using the Analytical GREEnness metric approach (AGREE), and the blueness was assessed using blue applicability grade index (BAGI), with scores of 0.76 and 82.5, respectively. These scores underline the superiority of the proposed procedure over previously reported methods."

Journal • Benign Prostatic Hyperplasia • Urology

Efficacy of the combination of tadalafil and tamsulosin versus tadalafil alone as a medical expulsive therapy for stone L1/3 ureter 10 mm or less: A prospective comparative placebo-controlled study. (PubMed, Curr Urol) - "The combination of PDE5Is and α-blockers effectively increases the expulsion of lower ureteric stones (5-10 mm), but with the same effect as PDE5Is alone, with the advantage of decreasing pain recurrence. Stone size did not affect the expulsion rate in patients who received MET for stones less than 1 cm in size."

Journal • Pain • Urolithiasis

RETRACTION: Investigating How Tamsulosin Combined With Levofloxacin Impacts Wound Healing in Patients With Chronic Prostatitis who May also Have Perineal or Urethral Wounds. (PubMed, Int Wound J) - "The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction."

Journal

Comparative Study of the Efficacy and Tolerability of Palmex® (Roystonea regia Lipid Extract), Saw Palmetto, Finasteride and Tamsulosin in Patients with Benign Prostatic Hyperplasia. (PubMed, Urol Res Pract) - "The treatments were well tolerated. Palmex® for 6 months demonstrated to have a comparable efficacy to saw palmetto, finasteride, and tamsulosin in patients with mild and moderate BPH, being safe and well tolerated."

Journal • Benign Prostatic Hyperplasia

Glycolysis-enhancing α1-adrenergic antagonists are neuroprotective in Alzheimer's disease. (PubMed, bioRxiv) - "Terazosin (TZ) is an α 1 -adrenergic receptor antagonist that enhances glycolysis by activating the enzyme phosphoglycerate kinase 1 (PGK1). Finally, in a large human administrative dataset, we found that patients taking TZ or related glycolysis-enhancing drugs had a lower hazard of being diagnosed with AD compared to those taking tamsulosin or 5-alpha reductase inhibitors. These data further implicate metabolism in neurodegenerative diseases and suggest that glycolysis-enhancing drugs may be neuroprotective in AD."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Lewy Body Disease • Movement Disorders • Parkinson's Disease • Solid Tumor • PGK1

Assessing the Safety of Combined Therapy, Croton membranaceus and Tamsulosin, in the Self-Prescribed Treatment Protocol for Benign Prostatic Hyperplasia. (PubMed, J Toxicol) - " The results suggest that the combination of C. membranaceus and tamsulosin does not provide additional therapeutic benefits for treating BPH. Relative organ weights provide a better evaluation metric than total organ weights."

Journal • Benign Prostatic Hyperplasia

Cataracts: A Review. (PubMed, JAMA) - "Systemic α1-adrenergic antagonists for symptomatic benign prostatic hyperplasia, such as tamsulosin, increase the risk of surgical complications and some ophthalmologists temporarily discontinue the drug preoperatively. Intraocular antibiotics, such as moxifloxacin or cefuroxime, delivered intraoperatively have reduced the rates of sight-threatening postsurgical endophthalmitis from 0.07% to 0.02%...Cataracts are common among older adults and may cause visual disability and blindness without treatment. Cataract surgery reverses and prevents progressive vision loss, and advanced technology lens implants facilitate reduced dependence on eyeglasses."

Journal • Alzheimer's Disease • Anesthesia • Benign Prostatic Hyperplasia • Cataract • CNS Disorders • Dementia • Developmental Disorders • Diabetes • Genetic Disorders • Infectious Disease • Inherited Retinal Dystrophy • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Retinitis Pigmentosa • Rubella

Effect of Preoperative Tamsulosin on Postoperative Urinary Retention Prevention After Sling Placement: A Randomized Controlled Trial. (PubMed, Int Urogynecol J) - "These results suggest that single-dose preoperative tamsulosin might not have an effect on postoperative urinary retention after MUS placement, with or without concomitant reconstructive pelvic surgery."

Clinical • Journal • Hypotension • Infectious Disease • Nephrology

Establishing a context of use for three-dimensional cardiac tissue derived from human induced pluripotent stem cell-derived cardiomyocytes using inotropes. (PubMed, Toxicol Sci) - "Both models demonstrated high predictability for negative inotropy and showed similar results for detecting non-active compounds, except for higher concentrations of phentolamine, zimelidine, and tamsulosin...The 3D ECTs captured inotropic changes more accurately and thus represented a more translatable model than the 2D hiPSC-CMs. Overall, contractility assessment using the 3D ECTs could be advantageous for profiling candidate compounds and mechanistic investigations of hemodynamic changes during in vivo or clinical studies."

Journal

IMPROVEMENT OF URINARY TRACT INFECTION-LIKE SYMPTOMS USING A STANDARDIZED TREATMENT PROGRAM OVER TWELVE MONTHS (AUA 2025) - "Behavioral modification and treatment with a combination of vaginal estradiol cream and tamsulosin, or gabapentin were associated with a significant decrease in UTILS. In this select cohort of patients with UTILS, management was achieved by avoiding antibiotics and improving antibiotic stewardship. A prospective randomized study design is necessary to further evaluate patients with LUTS and negative urinalysis."

Bladder Cancer • Infectious Disease • Nephrology • Oncology • Pain • Urology

A prospective randomized trial of LUTS treatment with bioregulatory peptides and alpha-blockers. (AUA 2025) - "Baseline characteristics of the groups were comparable, all the patients received selective alpha-blockers (silodosin or tamsulosin) before enrollment. Vesusten, when added to alpha blockers in patients with LUTS due to BPH, allowed to improve significantly symptoms according to questionnaires, uroflowmethry, and PVR. This therapy did not influence BPH volume. Only mild local AE were noted that did not require additional treatment or stopping treatment with investigational drug."

Clinical • Benign Prostatic Hyperplasia • Overactive Bladder • Pain

Patients Dissatisfied with BPH Medication in the IMPACT RCT Demonstrate Worse Patient Experience and Sleep Quality Before Crossing Over to Urolift PUL (AUA 2025) - " The IMPACT trial is a prospective, multicenter RCT comparing efficacy, safety, and patient experience in BPH patients treated with medication (tamsulosin 0.4 mg daily) or MIST (UroLift PUL); patients initially randomized to medication could elect to cross over to PUL treatment after their 3-month follow-up visit... Medical therapy fails to provide adequate patient experience and sleep quality improvements for most BPH patients in the IMPACT trial, while improvements after PUL are consistently more robust than medication. BPH patients dissatisfied with medical therapy may experience worse quality-of-life and be offered a MIST (UroLift PUL)."

Clinical • Benign Prostatic Hyperplasia • CNS Disorders • Depression • Mood Disorders • Psychiatry

Utilization of Medication to Treat Lower Urinary Tract Symptoms After Prostate Cancer Therapy (AUA 2025) - "Our findings indicate that patients treated with RT have a significantly higher reliance on voiding dysfunction medications. For patients who received RT, tamsulosin is often prescribed twice daily, despite limited evidence for added benefit. These results highlight the need for careful prescribing and patient counseling."

Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Enhancing stone expulsion: The efficacy of combined medical therapy with tamsulosin and dexamethasone in renal colic patients. (PubMed, J Res Med Sci) - "This study aimed to assess the efficacy of combined medical expulsive therapy (MET) with intravenous dexamethasone and oral tamsulosin compared to tamsulosin alone in the frequency and duration of distal ureteral stone expulsion. However, it is noteworthy that the variability in the time to stone expulsion in the tamsulosin + dexamethasone group was considerably smaller than that in the control group, as indicated by the smaller standard deviation in the former (1.0 vs. 3.8 days, respectively). Adding dexamethasone to standard MET with tamsulosin for distal ureterolithiasis appears to increase the stone expulsion rate, although it did not significantly shorten the expulsion time."

Journal • Renal Calculi • Urology

In vitro-in vivo scaling of cytochrome P450-mediated metabolic clearance using a relative activity factor approach. (PubMed, Drug Metab Dispos) - "We selected multiple probe substrates for CYP1A2 (caffeine, tizanidine, phenacetin), CYP2C9 ((S)-acenocoumarol, glimepiride, lornoxicam, tolbutamide, (S)-warfarin), CYP2C19 ((S)-lansoprazole, omeprazole, pantoprazole), CYP2D6 (desipramine, metoprolol, nebivolol, tolterodine), and CYP3A4 (alprazolam, felodipine, midazolam, nisoldipine, sildenafil, triazolam) to calculate the representative RAF value for each P450 isoform based on the in vivo-to-in vitro clearance ratio of the multiple probe substrates...The fm values of the responsible P450 isoform(s) could be well predicted for mexiletine, tamsulosin, risperidone, celecoxib, and glibenclamide...By applying relative activity factor values obtained from multiple probe substrates, this study was able to quantitatively predict the in vivo clearances mediated by CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. This simple, practical method will help optimize metabolic clearances via the major cytochrome P450..."

Journal • Preclinical • CYP1A2 • CYP2C19 • CYP2C9 • CYP3A4

A multicenter randomized controlled study of hot steam ablation in treatment of type III prostatitis (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Shanghai Tongji Hospital; Shanghai Tongji Hospital

New trial