tamsulosin / Generic mfg. - LARVOL DELTA

Tamsulosin for Urinary Retention in Older Women: Maximizing the Flow. (PubMed, J Gerontol Nurs) - "Tamsulosin may be considered a safe alternative option for the management of UR in older women over urinary catheterization and potentially reduces the incidence of catheter-associated complications."

Journal • Hypotension

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α1-Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents. (PubMed, J Med Chem) - "In the OVX (ovariectomy) mice, compound 10 effectively prevented OVX-induced bone loss. Collectively, these findings highlighted the therapeutic potential of 10 as a novel lead compound for antiosteoporosis by targeting ANO1."

Journal • Osteoporosis • Rheumatology • ANO1

A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin 0.4 mg Tablets, in Healthy Adult Male Subjects, Under Fed Conditions (clinicaltrials.gov) - P1 | N=46 | Recruiting | Sponsor: Berlin-Chemie AG Menarini Group

New P1 trial

Predictive CT-based parameters for successful medical expulsive therapy in unilateral ureteral calculi: A prospective observational study. (PubMed, Urologia) - "The most significant predictor of successful stone passage in MET of unilateral ureteral stones was maximal UWT, with an optimal cut-off point of 2.1 mm."

Journal • Observational data • Nephrology • Renal Calculi

Comparing Tamsulosin and Solifenacin for Relieving Double J Stent Symptoms: Using the USSQ. (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Liaquat National Hospital & Medical College

New P4 trial

Dispensing practices issue shorter prescription lengths compared to non-dispensing practices. (PubMed, BJGP Open) - "Dispensing practices are associated with shorter prescription lengths, increasing the number of prescriptions issued over time and the associated dispensing fee. The absence of clear guidance on prescription lengths likely contributes to this-central bodies should consider providing explicit recommendations to optimise prescription durations."

Journal

Updates on Pharmacological Therapy for Urolithiasis (UAA 2025) - "In primary hyperoxaluria (PH), novel RNA interference (RNAi) agents like lumasiran and nedosiran significantly lower urinary oxalate levels, offering promising alternatives for patients unresponsive to pyridoxine...Xanthine oxidase inhibitors (allopurinol, febuxostat) are reserved for hyperuricemic patients...Medical expulsive therapy (MET) with alpha-blockers (tamsulosin) remains effective for distal ureteral stones (5–10 mm), reducing time to expulsion and need for surgery...Operative times vary, with suction PCNL often being faster for large stones (47–82 min) but requiring fluoroscopy, while suction RIRS avoids tract-related risks but may necessitate staged procedures for stones >2 cm. Cost-effectiveness analyses favor suction PCNL due to fewer retreatments, though RIRS reduces radiation exposure."

Infectious Disease • Nephrology • Renal Calculi • Urolithiasis

A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin 0.4 mg Tablets, in Healthy Adult Male Subjects, Under Fed Conditions (clinicaltrials.gov) - P1 | N=46 | Active, not recruiting | Sponsor: Berlin-Chemie AG Menarini Group | Recruiting ➔ Active, not recruiting

Enrollment closed

Medical Stone Expulsive Therapy for Acutely Obstructed Ureteric Calculi (clinicaltrials.gov) - P4 | N=240 | Completed | Sponsor: Getz Pharma | Recruiting ➔ Completed | Trial completion date: Dec 2025 ➔ Jun 2025

Trial completion • Trial completion date • Renal Calculi

The Efficacy and Safety of Qianweitai (Silodosin Capsule) Versus Tamsulosin in the Treatment of BPH (clinicaltrials.gov) - P4 | N=110 | Completed | Sponsor: Shanghai Huilun Pharmaceutical Co., Ltd.

New P4 trial • Benign Prostatic Hyperplasia

Suction PCNL vs Suction RIRS? Do We Have a Winner (UAA 2025) - "In primary hyperoxaluria (PH), novel RNA interference (RNAi) agents like lumasiran and nedosiran significantly lower urinary oxalate levels, offering promising alternatives for patients unresponsive to pyridoxine...Xanthine oxidase inhibitors (allopurinol, febuxostat) are reserved for hyperuricemic patients...Medical expulsive therapy (MET) with alpha-blockers (tamsulosin) remains effective for distal ureteral stones (5–10 mm), reducing time to expulsion and need for surgery...Operative times vary, with suction PCNL often being faster for large stones (47–82 min) but requiring fluoroscopy, while suction RIRS avoids tract-related risks but may necessitate staged procedures for stones >2 cm. Cost-effectiveness analyses favor suction PCNL due to fewer retreatments, though RIRS reduces radiation exposure."

Infectious Disease • Nephrology • Renal Calculi • Urolithiasis

Prostatitis: A Review. (PubMed, JAMA) - "First-line therapy for chronic bacterial prostatitis is a minimum 4-week course of levofloxacin or ciprofloxacin...First-line oral therapy for CP/CPPS with urinary symptoms is α-blockers (eg, tamsulosin, alfuzosin; ΔNIH-CPSI score difference vs placebo = -10.8 to -4.8). Other oral therapies are associated with modest changes in NIH-CPSI score compared with placebo, including anti-inflammatory drugs (eg, ibuprofen; ΔNIH-CPSI score difference = -2.5 to -1.7), pregabalin (ΔNIH-CPSI score difference = -2.4), and pollen extract (ΔNIH-CPSI score difference = -2.49). Prostatitis includes acute bacterial prostatitis, chronic bacterial prostatitis, and CP/CPPS, each of which is diagnosed and treated differently. First-line treatments are broad-spectrum antibiotics for acute bacterial prostatitis (such as piperacillin-tazobactam, ceftriaxone, or ciprofloxacin), at least 4 weeks of fluoroquinolones for chronic bacterial prostatitis, and α-blockers for CP/CPPS with urinary symptoms."

Journal • Gynecology • Infectious Disease • Musculoskeletal Pain • Nephrology • Oncology • Pain

The influence of pre-stenting and drugs on the outcomes of ureteroscopy for kidney and ureteral stone disease: a systematic review and meta-analysis by the EAU Section of Endourology. (PubMed, World J Urol) - "Preoperative alpha blockers enhance ureteroscopy success and reduces complications. The evidence supports their use before ureteroscopy for renal and ureteral stones, improving patient outcomes and procedural efficiency. Patients pre-stented for any reason demonstrated significantly improved ureteroscopic access and stone-free rates."

Journal • Retrospective data • Review • Nephrology • Renal Calculi

Vardenafil and Tamsulosin in the Management of Ureteral Stent-Related Symptoms: A Prospective Comparative Study. (PubMed, Urol Res Pract) - "Side effects were mild, with retrograde ejaculation and hypotension in the tamsulosin group and headaches in the vardenafil group. Vardenafil showed promising results in controlling stent-related symptoms and can be considered an alternative or adjunct medication to tamsulosin in the management of stent-related symptoms; however, this needs further exploration in larger, multi-center studies to validate these findings and optimize patient outcomes in clinical practice."

Journal • Hypotension • Pain

PERSONAL: Deprescribing Tamsulosin in Older Men (clinicaltrials.gov) - P4 | N=31 | Completed | Sponsor: University of California, San Francisco | Active, not recruiting ➔ Completed

Trial completion • Benign Prostatic Hyperplasia

The Gore Test: Tackling the diagnostic challenge of intraprostatic ductal urinary reflux in men with Chronic Pelvic Pain Syndrome (UAA 2025) - "These four patients were trialled on a combination of either Extracorporeal Shockwave Therapy, Baclofen, or urethral sphincter Botox injection, with favourable outcomes. One patient with a negative test result showed improvement on Tamsulosin alone, without any need for further treatment. Our case series shows that Phenazopyridine can be a simple, non-invasive tool to suggest underlying IPUR. This allows us to gain insights into disease aetiology, and guide clinical management."

Ataxia • Gynecology • Musculoskeletal Pain • Pain

Effects of Huang'e Capsules on type IIIA prostatitis and inflammatory cytokines in the expressed prostatic secretion of the patient (PubMed, Zhonghua Nan Ke Xue) - "Huang'e Capsules has a significant clinical efficacy and safety in the treatment of type IIIA prostatitis, which can effectively relieve the pain and urination symptoms and improve the levels of the inflammatory cytokines NE, IL-8 and TGF-β1 in the patients."

Journal • Pain • CXCL8 • ELANE • TGFB1

Tamsulosin Attenuates Cardiac Hypertrophy via Integrin-Linked Kinase: Possible Mechanisms. (PubMed, Fundam Clin Pharmacol) - "The data indicate that targeting α1A adrenoceptors by inhibition offers a promising therapeutic approach for preventing cardiac hypertrophy via signal-transduction pathways, including ILK-related VEGF/eNOS/PI3K/Akt."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • CD31 • FLT1 • NOS3 • PECAM1 • PI3K

Guihuang Formula for type III prostatitis with damp-heat stasis syndrome in the essence chamber: A clinical trial (PubMed, Zhonghua Nan Ke Xue) - "Guihuang Formula is safe and effective in the treatment of type III prostatitis with the syndrome of damp-heat stasis in the essence chamber."

Clinical • Journal • Pain

Does preoperative tamsulosin facilitate semirigid ureteroscopic management of lower ureteric calculi? A prospective, randomized double-blind study. (PubMed, Curr Urol) - "It decreases operative time, the need for dilation, and the need for postoperative indwelling ureteral stenting. It also increases the success rate but does not significantly affect the complication rate."

Clinical • Journal • Nephrology • Renal Calculi • Urology

Beyond the Prostate: A Visionary Study on Ocular Impacts of Benign Prostatic Hyperplasia Drugs. (PubMed, J Ocul Pharmacol Ther) - "Notably, iridocele, macular fibrosis, corneal changes (like blepharitis), lacrimal gland changes, retinal degeneration/detachment, vitreous floaters, and retinal edema exhibited significant safety signals in both tamsulosin and finasteride, the primary contributors to reports. Significant drug safety signals in FAERS disproportionality analysis underscore the necessity for deeper exploration of the link between BPH medications and serious ocular adverse effects, including macular fibrosis, corneal pathologies, lacrimal gland changes, and macular edema."

Journal • Benign Prostatic Hyperplasia • Cataract • Dry Eye Disease • Fibrosis • Immunology • Infectious Disease • Macular Edema • Ocular Inflammation • Ophthalmology

Analysis of the positive influence of Qianlie Shutong capsule combined with tamsulosin on prostate health of patients with prostatitis. (PubMed, Pak J Pharm Sci) - "As for safety, there was no significant difference between the two groups (P>0.05). It can be seen that QLSTC combined with tamsulosin has extremely high clinical application value in the treatment of CP and is recommended to be used clinically."

Journal

Efficacy and Safety of Mirabegron and Tamsulosin Combination Therapy Compared to Tamsulosin Monotherapy for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Results of a Multicenter, Randomized, Double-Blind, Phase III Clinical Trial. (PubMed, World J Mens Health) - "Combination therapy with mirabegron and tamsulosin is more effective than monotherapy in improving LUTS in patients with BPH, particularly storage symptoms, with a comparable safety profile. A fixed-dose combination formulation in the future may further improve patient adherence and quality of life."

Clinical • Journal • Monotherapy • P3 data • Benign Prostatic Hyperplasia

An Unusual Presentation of Massive Asymptomatic Urinary Retention in a 63-Year-Old Male With Iron Deficiency Anaemia. (PubMed, Cureus) - "Management included catheterization with intermittent clamping to prevent rapid decompression, and initiation of tamsulosin and finasteride for suspected benign prostatic enlargement (BPE), with plans for transurethral resection of the prostate (TURP) as definitive management. Even without symptoms, CUR can exist and risks serious complications if not identified and managed early."

Journal • Anemia • Hematological Disorders

Tamsulosin regulates antifibrotic effects in thioacetamide-induced liver damage and ameliorates portal hypertension. (PubMed, Life Sci) - "Our results demonstrate that NE promotes hepatic stellate cell activation and fibrosis, while tamsulosin and carvedilol effectively reduce these effects in vitro and in vivo, without affecting the regenerative capacity of hepatocytes. In addition, the treatment also alleviates portal hypertension without causing systemic hypotension."

Journal • Cardiovascular • Fibrosis • Gastroenterology • Hepatology • Hypertension • Hypotension • Immunology • Liver Cirrhosis • Portal Hypertension