BCY11864 / Bicycle Therap - LARVOL DELTA

[VIRTUAL] Microinjection of Nectin-4/CD137 tumor-targeted immune cell agonist (TICA™) activates the local tumor microenvironment (AACR 2021) - "Akin to our findings with transcriptional profiling of the tumor response to BT7480, BCY11864 activity was shown not to be limited to T cells but also included other CD137 positive cell populations such as myeloid and NK cells. We hypothesize that tumor targeted CD137 agonism may lead to initial myeloid cell response that enhances the cytotoxic T cell recruitment and activation in the tumor tissue."

Biomarker • IO biomarker • Tumor microenvironment • Oncology • Sarcoma • Soft Tissue Sarcoma • Solid Tumor • CD8 • NECTIN4 • TNFRSF9