Tenafet (cefetamet pivoxil) / Incepta Pharma - LARVOL DELTA

Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study. (PubMed, Lancet Microbe) - "Cephalosporins and oxazolidinones are potential candidates for expanding the current therapeutic repertoire for syphilis. Our findings warrant testing efficacy in animal models and, if successful, clinical assessment of efficacy."

Journal • Preclinical • Infectious Disease

Predicting efficacy of fecal microbiota transplantation for crohn’s disease based on clinical factors and metabolomics (IDDF 2021) - "Specially, two clinical factors (Behavior B3, B1) and seven metabolites (MMSucc; 4-(1-Methylethyl)-2,6-dinitro-N,N-dipropylbenzenamine; cefetamet; N-phenylacetylglutamine (pos); diisodecyl phthalate; N-phenylacetylglutamine (neg); eucommin a) were commonly selected features across the three models.(IDDF2021-ABS-0091 Figure 1...Comparison of the most discriminatory metabolites at baseline between the remission and non-remission groups) Conclusions In this study, the constructed RF models using serum metabolites, clinical characteristics have a good predictive performance of FMT efficacy in CD. The combination of them will better serve the clinical decision-making."

Clinical • Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease • Transplantation

Clinical Trial to Reconfirm the Efficacy and Safety of Cefetamet Pivoxil Treatment in Sinusitis Patients: A Double-Blind, Randomized, Parallel Designed, Multicenter, Active Comparator Study (CASIS Study). (PubMed, Ear Nose Throat J) - "The overall adverse reaction rates of both drugs were 10.56% in the cefetamet pivoxil group and 15.49% in the cefdinir group, without serious adverse events or drug reactions. Cefetamet pivoxil twice a day was as efficacious and safe as cefdinir 3 times a day for the treatment of acute bacterial rhinosinusitis, which suggested that cefetamet pivoxil may be a suitable alternative to cefdinir."

Clinical • Journal • Otorhinolaryngology • Respiratory Diseases • Sinusitis

CASIS: Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis (clinicaltrials.gov) - P4; N=284; Terminated; Sponsor: Korea United Pharm. Inc.

Clinical • New P4 trial • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Extrapolation of Drug Clearance in Children ≤ 2 Years of Age from Empirical Models Using Data from Children (> 2 Years) and Adults. (PubMed, Drugs R D) - "The study indicated that simple empirical models can provide more accurate results than complex empirical models."

Clinical • Journal

Machine Learning Approach for Determining the Formation of β-Lactam Antibiotic Complexes with Cyclodextrins Using Multispectral Analysis. (PubMed, Molecules) - "Complexes of β-lactam antibiotics, including cefuroxime axetil, cefetamet pivoxil, and pivampicillin, as well as CDs, including αCD, βCD, γCD, hydroxypropyl-αCD, methyl-βCD, hydroxypropyl-βCD, and hydroxypropyl-γCD, were prepared in all combinations. Analysis of the contribution of spectral bands to the model indicated interactions of ester groups of β-lactam antibiotics with CDs, as well as some interactions of cephem ring in cefetamet pivoxil and penam moiety in pivampicillin. Molecular modeling with PM7 helped to explain experimental results and allowed to propose possible binding modes."

Journal