hydroxyzine hydrochloride / Generic mfg. - LARVOL DELTA

Sertraline safety in adolescents experiencing a depressive episode during first 3 weeks: added anxiolytic matters more than CYP2C19 polymorphisms. (PubMed, Front Pharmacol) - "The use of anxiolytics (alimemazine and hydroxyzine) was significantly associated with an increased number of vegetative/somatic, and mental ADRs on day 7, as well as an increased total number of ADRs by day 21. Linear regression analysis confirmed that anxiolytics were the most significant predictors of ADR development on day 21 (Estimate = 0.86, 95% CI 0.32-1.41, p = 0.002). Polypharmacy (particularly, adding a non-benzodiazepine anxiolytic) was a more significant risk factor for ADRs when taking sertraline, compared to the carrier status of CYP2C19 gene polymorphisms."

Journal • CNS Disorders • Depression • Psychiatry • CYP2C19

Intentional Naproxen Overdose Causing Metabolic Acidosis: A Case Report. (PubMed, Cureus) - "We describe the case of a 24-year-old female who presented to the Emergency Department after an intentional multidrug overdose involving naproxen, hydroxyzine, and clonazepam. This case report aims to illustrate that large doses of naproxen may contribute to metabolic acidosis in overdose situations. In cases of intentional ingestions involving multiple substances, clinicians should consider NSAIDs as potential contributors to acid-base abnormalities, particularly when more common causes are excluded."

Journal • Metabolic Disorders

TNK-Induced Angioedema With Difficult Intubation: Risk Factors and Airway Management Strategies (SCCM 2026) - "Introduction: Tenecteplase (TNK) is increasingly used for acute ischemic stroke due to its single bolus dosing and fibrin specificity...He was sedated, intubated, treated with steroids and hydroxyzine, and extubated on hospital day 4...Following the ASA Difficult Airway Algorithm, the team escalated early while the patient remained maskable. As TNK use broadens to milder strokes, clinicians must prioritize first-pass success, airway coordination, and early OR transfer to optimize outcomes."

Clinical • Intubation • Ataxia • Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Ischemic stroke • Mood Disorders • Movement Disorders • Otorhinolaryngology

Pharmaco-EEG-Based Classification of Psychotropic Activity of a Novel Chromone-Containing Allylmorpholine in Rats. (PubMed, Adv Pharm Bull) - "Amplitude-spectral analysis using PCA resulted in 6 new principal components that accounted for 83.57% of the variance...CCAM 33a at doses of 100 and 300 mg/kg shows similar effects to hydroxyzine and sulpiride...The data obtained confirm the effectiveness of the combined use of NBC and PCA for classification tasks. The effects of the different doses of compound 33a on ECoG, as well as the abolition of the effects of apomorphine and 5-HTP in mice and rats, suggest a dopamine- and 5-HT2-blocking action of the molecule under study."

Journal • Preclinical • CNS Disorders

Crusted Scabies Beyond the Immunocompromised: A Case of Delayed Diagnosis (AAD 2026) - "Despite therapy with oral hydroxyzine and topical corticosteroids, pruritus persisted...The patient was promptly started on oral ivermectin...Delayed recognition may contribute to progression, dissemination, and risk of nosocomial outbreaks. Clinicians should maintain a high index of suspicion for atypical scabies presentations to ensure timely diagnosis and treatment."

Clinical • Contact Dermatitis • Dermatitis • Immunology • Infectious Disease • Nephrology • Pruritus

A Comparison of Oral Sedation-Related Events of Three Multi-Agent Regimens in Pediatric Patients: A Randomized Clinical Trial. (PubMed, Pediatr Dent) - "Group 1 received midazolam, meperidine, and hydroxyzine (MZ/M/H; n equals 20). Postoperative monitoring remains essential up to 24 hours. Longer postoperative monitoring may be required when a 3-medication regimen is used."

Clinical • Journal • Anesthesia • Musculoskeletal Diseases • Pediatrics

Synthetic Tetrahydrocannabinol (THC) is a Safe Adjunct to the Treatment of Postoperative Pain after Arthroscopic Knee Surgery: A Pilot Randomized Safety Trial (AAOS 2026) - "Exclusion criteria included patients under the age of 18, patients unable to provide consent, patients who are pregnant, breastfeeding, or trying to become pregnant, patients with an allergy to any of the study drugs, patients undergoing revision surgery or open surgery, patients with a history of mania, depression, or schizophrenia, patients currently diagnosed with alcohol or drug abuse, patients who cannot or will not abide by the medication regimen, or patients taking any of the following drugs: anticholinergic agents, benzodiazepines, central nervous system depressants, droperidol, hydroxyzine, levomepromazine, methotrimeprazine, monoamine oxidase inhibitors, ritonavir, selective serotonin reuptake inhibitors, sympathomimetics, St...Primary outcome for this pilot study was safety of the test drug with the secondary outcome being pain control and number of opioid tablets (hydrocodone-acetaminophen 5-325mg) consumed at 3 different time intervals: 24 hours, 48 hours,..."

Clinical • Surgery • Addiction (Opioid and Alcohol) • Bipolar Disorder • Depression • Immunology • Orthopedics • Pain • Schizophrenia • Xerostomia

NATIONAL TRENDS IN OPIOID, BENZODIAZEPINE AND ANTICHOLINERGIC ORDERS IN LONG-TERM CARE (ISPOR 2026) - "The most common drugs ordered for the 657,915 residents with OB use were lorazepam (66.4%) and morphine (47.0%), which was the most common medication combination (28.5%). The most common orders for the 333,264 residents with ACH use were hydroxyzine (29.1%), diphenhydramine (23.6%), and oxybutynin (20.8%)... High-risk prescribing and significant geographic variation underscore the need for accurate documentation, targeted deprescribing, and monitoring. Leveraging regional data enables focused quality improvement and resource allocation. Proactive, data-driven strategies tailored to local trends are critical for safer medication management and achieving Star Ratings success."

Nitrous Oxide and Oral Sedation for Managing Dental Anxiety in Children: A Systematic Review. (PubMed, Cureus) - "This systematic review examines nitrous oxide-oxygen (N₂O/O₂) and oral sedation (e.g., midazolam, hydroxyzine) as minimally invasive options for children aged 2-12 years, using the Patient/Population, Intervention, Comparison, and Outcome (PICO) framework to guide analysis. Future RCTs should standardize metrics and explore adjuncts like dexmedetomidine. In practice, integrating with behavioral techniques fosters better cooperation and lifelong oral health."

Journal • Review • Anesthesia • CNS Disorders • Mood Disorders • Pediatrics • Psychiatry

Effect of promethazine and hydroxyzine, two inhibitors of Tumor Controlled Translational Protein (TCTP), on the growth of in vitro culture of Trypanosoma brucei gambiense and Trypanosoma congolense. (PubMed, Exp Parasitol) - "The results, which were obtained in vitro, show that TCTP is involved in the development/multiplication of both trypanosome species, one of which, Tbg, being pathogenic for humans. The next step will be to verify the possible effect of treatment with TCTP inhibitors on infection of mice with trypanosomes."

Journal • Preclinical • Infectious Disease • Oncology

Improving Use of Oral Antihistamines in a Children's Hospital. (PubMed, Pediatrics) - "Using the Model for Improvement, we reduced FGA use and increased cetirizine use in the PED and inpatient setting."

Journal • Pediatrics

Nemolizumab as an Alternative Therapeutic Option for Indolent Systemic Mastocytosis. (PubMed, Cureus) - "Treatment options are limited when symptoms remain refractory, and avapritinib is contraindicated or declined. We describe the case of a 62-year-old female with an 11-year history of ISM who developed worsening pruritus and urticaria despite extensive conservative and biologic therapies, including topical corticosteroids, hydroxyzine, montelukast, omalizumab, and dupilumab...After 12 doses, she achieved complete resolution of pruritus. This report suggests that nemolizumab may represent a potential therapeutic option for refractory ISM when standard therapies fail or targeted KIT inhibition is not feasible."

Journal • Cardiovascular • Dermatology • Immunology • Pruritus • Urticaria

Phosphated maltodextrin as an anionic chiral selector for capillary electrophoresis: Application to the enantiomeric separation of basic drugs. (PubMed, J Chromatogr A) - "Its chiral recognition capability in CE was systematically assessed using five model drugs: tramadol, citalopram, hydroxyzine, amlodipine, and fluoxetine. PMD is a new anionic chiral selector combining affordability, solubility, and enhanced selectivity. Major resolution gains without longer analysis times demonstrate PMD's promising potential for routine pharmaceutical applications, with broader chiral separations to be explored in future studies."

Journal

Respiratory drugs and psychiatric adverse events in children and adolescents: a pharmacovigilance study based on the FAERS database. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "The highest mortality rates were observed with hydroxyzine (50.94%) and caffeine (50.00%), while oxytetracycline (4/4, 100%) showed the highest proportions of life-threatening events...This study identifies statistical associations between RDs and pAEs in pediatric patients, particularly with montelukast and promethazine. The highest mortality rates were observed with hydroxyzine. These findings provide a foundation for further research but require confirmation through large-scale prospective studies."

Adverse events • Journal • CNS Disorders • Depression • Pediatrics • Psychiatry • Suicidal Ideation

Domestic Abuse of Codeine: A Case Study of Non-Medical Use Leading to Fatal Outcome. (PubMed, Toxics) - "Post-mortem LC-MS/MS analysis revealed the presence of codeine (0.66 µg/mL), morphine (0.02 µg/mL), hydroxyzine (2.52 µg/mL), alprazolam (0.15 µg/mL), paracetamol (30.64 µg/mL), and additional substances in blood samples. Concentrations of codeine and hydroxyzine exceeded therapeutic ranges and were consistent with values reported in fatal intoxications, confirming a poly-drug poisoning. This case highlights the danger associated with non-medical codeine use, particularly when combined with central nervous system (CNS) depressants, and underscores the need for stricter regulation of OTC codeine-containing products as well as improved public awareness of the risks associated with domestic extraction methods."

Journal • Pain

Prescription Analysis of Antihistamines' Use in Patients with Moderate to Severe Burns. (PubMed, J Burn Care Res) - "Over 70% received antihistamines, with hydroxyzine as the most common first-line therapy, followed by diphenhydramine. These findings underscore the importance of vigilant post-burn assessment, stepwise escalation based on response, and complementary strategies to optimize PBP management. Frequent switching and prolonged durations suggest a need for more effective and tailored therapeutic approaches to improve recovery outcomes for burn patients."

Journal • Dermatology • Pruritus • Thermal Injury

Medication use in Poland for children and adolescents with neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data. (PubMed, Front Pharmacol) - "The most substantial increases occurred for sedative and anxiolytic agents (hydroxyzine, diazepam, alprazolam, lorazepam) and antipsychotics (olanzapine, aripiprazole, risperidone, chlorprothixene, haloperidol, levomepromazine), consistent with pandemic related stress, limited access to non-pharmacological care, and possible stockpiling. The COVID-19 pandemic induced broad but temporary increases in pediatric psychotropic drug dispensing, except for ADHD pharmacotherapies, which demonstrated a persistent upward trend. These findings suggest lasting shifts in diagnostic and therapeutic practices and underscore the need for continued monitoring of stimulant use and prescribing appropriateness in pediatric neurodevelopmental care."

Journal • Reimbursement • Retrospective data • US reimbursement • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Infectious Disease • Mental Retardation • Novel Coronavirus Disease • Pediatrics • Psychiatry

First-Generation Antihistamine Use in Geriatric Emergency Department Patients: Retrospective Review. (PubMed, West J Emerg Med) - "Emergency department use of first-generation antihistamines in older adults, especially those ≥ 85 years of age and with prior cognitive impairment, was associated with infrequent but clinically significant harm. Most use was potentially inappropriate. Prophylactic use of diphenhydramine for patients with a prior reaction to iodinated contrast media emerged as a common indication."

Journal • Retrospective data • Allergy • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Mood Disorders • Pain • Psychiatry

Efficacy and safety of AVIANDR in the treatment of panic disorder: results of the first stage of the multicenter, randomized, placebo-controlled study (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "Aviandr demonstrated statistically significant superiority over placebo, rapid onset of action, and a favorable safety profile, making it a promising treatment option for panic disorder."

Clinical • Journal • CNS Disorders • Mood Disorders • Psychiatry

Drug-Induced Bullous Pemphigoid Triggered by Immune Checkpoint Inhibitor Opdualag in an Elderly Patient With Recurrent Metastatic Melanoma: A Case Report and Treatment Course With Dupilumab. (PubMed, Cureus) - "We present the case of an 81-year-old male with a history of recurrent metastatic melanoma previously treated with nivolumab and relatlimab (Opdualag), who developed a persistent pruritic eruption following initiation of dual PD-1/LAG-3 blockade. Despite discontinuation of immunotherapy six months before dermatologic evaluation and use of multiple topical corticosteroids and oral antihistamines, symptoms persisted...At follow-up, the patient reported persistent activity, receiving intramuscular triamcinolone acetonide and adjunctive therapies, including hydroxyzine, hydrocortisone 2.5% cream (for groin), and triamcinolone 0.1% ointment...This case illustrates the diagnostic and therapeutic challenges in managing ICI-induced BP and highlights the early course of dupilumab therapy, which had not yet produced clinical improvement at the time of last follow-up. Continued therapy was planned, and no adverse effects were reported."

Checkpoint inhibition • Journal • Bullous Pemphigoid • Dermatology • Dermatopathology • Immunology • Melanoma • Oncology • Solid Tumor • Urticaria • LAG3

Evaluation of Pediatric Patients Receiving Intravenous Hydroxyzine (ASHP 2025) - No abstract available

Clinical • Pediatrics

APHYPAP: Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms (clinicaltrials.gov) - P3 | N=63 | Completed | Sponsor: University Hospital, Brest | Recruiting ➔ Completed

Trial completion • Dermatology • Myeloproliferative Neoplasm • Oncology • Pruritus

Post-lanosterol inhibition profile based classification of commonly used prescription medications. (PubMed, Transl Psychiatry) - "Using LC-MS/MS we measured 13 post-lanosterol intermediates in control, DHCR7 +/- and DHCR7-/- human dermal fibroblasts exposed to cariprazine, nebivolol, rotigotine, buspirone, lurasidone, fluoxetine, hydroxyzine, amiodarone, spiroxamine, vilazodone and ziprasidone. In addition, DHCR7 +/- fibroblasts responded with greater sterol profile disruptions to all medications, while DHCR7 fibroblasts from patients with Smith-Lemli-Opitz syndrome showed generally a more plateaued response. Knowing the inhibition profile-based classification of medications that have a sterol inhibiting side effect might ultimately translate into safety recommendations during pregnancy and could be critical for new drug development."

Journal • DHCR7

Impact of atropine and hydroxyzine pretreatment in contemporary bronchoscopy. (PubMed, Respir Investig) - "Anticholinergic pretreatment may reduce procedural discomfort, particularly that associated with secretions and airway reflexes, without evident adverse effects. Further randomized controlled trials are required to validate the role of pretreatment in contemporary bronchoscopy."

Journal • Cough • Respiratory Diseases

Treatment-Resistant Eosinophilic Spongiosis Dermatitis in a Patient With Various Comorbidities: A Case Report. (PubMed, Cureus) - "Alongside receiving a thorough cardiovascular exam workup, the patient tried numerous treatments for his rash and the pruritus, including topical triamcinolone, tacrolimus ointment, steroid injections, hydroxyzine, amitriptyline, and, most recently, dupilumab therapy. This case report highlights the complexity of ongoing assessment and treatment, offering guidance for the care of patients with similar presentations. Educational insights obtained from this report include maintaining broad differential diagnoses, the influence of neuropsychiatry and cardiology in dermatology, and the importance of multidisciplinary care."

Journal • Atopic Dermatitis • Cardiovascular • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Mood Disorders • Pain • Pruritus • Psychiatry • Pulmonary Disease • Venous Ulcer