ketorolac / Generic mfg. - LARVOL DELTA

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction (clinicaltrials.gov) - P2/3 | N=90 | Completed | Sponsor: Henry Ford Health System | N=62 ➔ 90

Enrollment change

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Damascus University | Recruiting ➔ Completed

Trial completion • Immunology • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology

Safety and Efficacy of Ketorolac Use After Coronary Artery Bypass Graft Surgery (SCCM 2026) - "Ketorolac administration after cardiac surgery involving CABG was associated with reduced rates of adverse clinical outcomes, except for deep-sternal wound infection in a large and complex patient population. Prospective evaluations are warranted to further evaluate this association."

Clinical • Surgery • Atrial Fibrillation • Cardiovascular • Infectious Disease

Connecting the Dots (SCCM 2026) - "We present a case of serotonin syndrome likely triggered by ondansetron and excessive supplement use of creatine.Description: A 21-year-old male with history of ankylosing spondylitis on Adalimumab for one year presented with unresponsiveness after several days of nausea, vomiting, and headache. He was evaluated at an urgent care and discharge with ketorolac and a prescription for ondansetron...He was treated with Lorazepam and Dexmedetomidine...This case illustrates the importance of thorough history-taking and exam and awareness of drug-induced neurologic syndromes in critically ill patients. Early recognition of serotonin syndrome can significantly alter outcomes."

Ankylosing Spondylitis • CNS Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Seronegative Spondyloarthropathies

A Novel Approach to Estimating the Risk of Gastrointestinal Bleeding for Patients on Oral Anticoagulants and Other Medications Including Non-Steroidal Anti-Inflammatory Drugs and Antidepressants (THSNA 2026) - " Risk of GIB for OAC products obtained from pivotal studies were: 1.99% for apixaban; 3.15% for rivaroxaban; 2.99% for dabigatran; 3.31% for edoxaban; and 2.00% for warfarin. The odds of GIB for NSAIDs ranged from 1.16 (95% CI:0.84-1.61) for celecoxib to 20.67 (95% CI:14.56-29.34) for ketorolac. Odd ratios for GIB among SSRI/SNRI ranged from 1.31 (95% CI:1.07-1.62) for paroxetine to 1.50 (95% CI:1.32-1.70) for venlafaxine. Risk of GIB for other factors included: persons over 65 years of age (OR=2.50, 95% CI:1.2–5.5); previous history of GIB (OR=5.13, 95% CI:3.95–6.67); aspirin use (OR=1.31, 95% CI:0.93-1.85); antiplatelets use (OR=1.95, 95% CI:1.68-2.27); and corticosteroids use (OR=1.68, 95% CI:1.49-1.90)... The DIOAC-GIB incorporates drug interactions with OACs and had good correlation with other bleeding risk scores. DIOAC-GIB may help identify high-risk patients that benefit from tailored prescribing. No part of this publication may be reproduced, distributed, or..."

Clinical • Gastroenterology

Unveiling a Nine-Year Enigma: Successful Treatment of a Chronic Circumferential Ulcer. (AAD 2026) - "The lesion was extensive, nearly circumferential, and severely impaired quality of life; the patient required a cane for ambulation and ingested up to ten tablets of ketorolac daily for pain control...Corticosteroid therapy was initiated with topical agents and systemic prednisone, starting at 50 mg/day and tapered to 25 mg/day...It also illustrates how timely recognition of pyoderma gangrenosum, after thorough exclusion of infection and malignancy, can dramatically alter prognosis. After nearly a decade of suffering, appropriate immunosuppressive therapy transformed this patient's clinical course and quality of life."

Diabetes • Infectious Disease • Metabolic Disorders • Pyoderma Gangrenosum • Respiratory Diseases • Tuberculosis

Adjunctive Intravenous Magnesium Sulfate for Postoperative Pain and Opioid Reduction in Lower Extremity Orthopedic Surgery: A Double-Blind Randomized Controlled Trial. (PubMed, J Clin Med) - "All patients received standard anesthesia and postoperative ketorolac with morphine PCA. Four patients (13%) in the magnesium group had transient hypotension; no serious adverse events occurred. Low-dose intravenous magnesium sulfate safely reduced pain and opioid needs in orthopedic surgery and may be considered in multimodal analgesia strategies."

Clinical • Journal • Anesthesia • Hypotension • Orthopedics • Pain

Safety and Efficacy of Ketorolac in the Management of Pain for Postoperative Pediatric General Surgery Patients. (PubMed, Am Surg) - "Logistic regression measured odds of opioid use in morphine equivalents 24-hour after surgery.Results5455 patients were identified. Blood transfusions were less common in patients that received Ketorolac (0.2% vs 0.7%, P = 0.005).ConclusionKetorolac does not increase the risk of bleeding requiring transfusion and decreases opioid administration. Ketorolac is efficacious in this patient population either alone or in combination with opioids and improves pain control compared to opioids alone."

Journal • Gastroenterology • Pain • Pediatrics

Fifteen-day topical ketorolac tromethamine, with and without benzalkonium chloride, alters tear function, goblet cell density, and meibomian gland integrity in healthy cats. (PubMed, Vet World) - "BACKT resulted in greater ocular discomfort, increased MG loss, and higher lipid peroxidation, indicating BAC-related cytotoxicity. Caution is advised when prescribing prolonged topical ketorolac, and concurrent ocular lubrication is recommended."

Journal • Cataract • CNS Disorders • Dry Eye Disease • Ocular Inflammation • Ophthalmology • Uveitis • CAT • MMP9

Management of Post-Operative Inflammation After Cataract Surgery with Intracanalicular Dexamethasone Implant and Topical Ketorolac. (PubMed, Clin Ophthalmol) - "To determine the safety of an intracanalicular dexamethasone ophthalmic insert (IDOI) and topical Ketorolac tromethamine 0.5% (ketorolac) versus ketorolac and topical prednisolone acetate 1% (PA) over the first month after cataract surgery (POM1). There was no difference in the rate of rebound inflammation or CME in the IDOI/ketorolac regimen compared to the PA/ketorolac regimen. IDOI can be a safe and effective dropless alternative to PA/ketorolac therapy after cataract surgery in patients susceptible to inflammation."

Journal • Cataract • Diabetic Retinopathy • Inflammation • Macular Edema • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Binimetinib and cystoid macular edema: a therapeutic dilemma in patients with metastatic melanoma. (PubMed, Arch Soc Esp Oftalmol (Engl Ed)) - "She was initially treated with Vemurafenib and Cobimetinib, achieving complete remission. However, due to cumulative toxicities, therapy was switched to Encorafenib and Binimetinib in February 2023...Management included Binimetinib dose reduction and topical ketorolac, resulting in initial improvement, although the CME recurred several months later...The patient ultimately began immunotherapy with Nivolumab and Ipilimumab, but died in February 2024 due to refractory abdominal septic shock. This case highlights the importance of early ophthalmologic monitoring and interdisciplinary collaboration in patients receiving MEK inhibitors."

IO biomarker • Journal • Diabetes • Macular Degeneration • Macular Edema • Melanoma • Metabolic Disorders • Oncology • Ophthalmology • Peritoneal Cancer • Retinal Disorders • Septic Shock • Solid Tumor • Type 1 Diabetes Mellitus • BRAF

Effective of local morphine, ketorolac, and bupivacaine in pediatric tendon surgery: a randomized controlled trial. (PubMed, Sci Rep) - "Multimodal wound infiltration using Bupivacaine, Ketorolac, and morphine did not yield any clinically important reduction in pain or opioid consumption compared with bupivacaine alone in pediatric patients who underwent lower extremities tendon surgery. TCTR20220504001 (4/5/2022)."

Journal • Anesthesia • CNS Disorders • Dermatology • Musculoskeletal Pain • Pain • Pediatrics • Pruritus

Effect of Ketorolac Administration on Operatively Treated Clavicle Fractures: A Matched Cohort Analysis (AAOS 2026) - "Ketorolac use following clavicle surgery was not associated with increased nonunion or revision surgery rates."

Musculoskeletal Diseases • Orthopedics

Nonsteroidal Anti-Inflammatory Drug Use in Orthopaedic Surgery Practice is Increasing: A Review of Medicare Part D Claims from 2013 to 2021 (AAOS 2026) - "The use of ketorolac, meloxicam, diclofenac, celecoxib, and ibuprofen significantly increased with time while the use of naproxen, nabumetone, etodolac, sulindac, piroxicam, and indomethacin significantly decreased (Table 2). Outpatient NSAID prescriptions by orthopaedic surgery providers increased between 2013 and 2021and is likely underestimated by these data as the majority of NSAIDs are available as over the counter medications. Further study is needed to identify if these practice patterns represent rising use in the setting of fracture surgery as historically this has been the subspecialty where their use was most limited."

Medicare • Reimbursement • Review • Surgery • US reimbursement • Musculoskeletal Diseases • Orthopedics

Effect of Ketorolac Administration on Operatively Treated Clavicle Fractures: A Matched Cohort Analysis (AAOS 2026) - "Ketorolac use following clavicle surgery was not associated with increased nonunion or revision surgery rates. Although opioid prescription rates trended lower in the ketorolac group, the difference was not statistically significant. A small but significant increase in wound disruption was observed at 30 days in the ketorolac group; however, no differences were found in other infection-related complications."

Infectious Disease • Musculoskeletal Diseases • Orthopedics

Efficacy of Intra-Articular Tranexamic Acid in Addition to Intravenous Tranexamic Acid in Enhancing Pain Relief and Function after Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Clinical Trial (AAOS 2026) - "One hundred patients with isolated, unilateral, chronic ACL tears were randomized 1:1 to receive either an intra-articular injection containing TXA (1 g), morphine sulfate, ketorolac, lidocaine, and normal saline (intervention group) or an identical injection without TXA (control group). Intra-articular TXA did not significantly reduce early postoperative pain or opioid use when added to a multimodal analgesic regimen and intravenous TXA in arthroscopic ACL reconstruction. However, it was associated with slightly better functional outcomes at 1 and 3 months postoperatively, as measured by KOOS and Lysholm scores. Although its clinical effect is questionable."

Clinical • Immunology • Orthopedics • Osteoarthritis • Pain

Postoperative Ketorolac Administration and Pseudoarthrosis Following Lumbar Spinal Fusion: A Matched Cohort Study (AAOS 2026) - "Postoperative ketorolac may reduce short-term opioid use and thromboembolic risk without increasing pseudoarthrosis or mechanical complications. These findings support ketorolac as a potentially safe adjunct in postoperative pain management. Further randomized trials are warranted."

Cardiovascular • Infectious Disease • Osteoarthritis

Efficacy of Local Infiltration Anesthesia versus Interscalene Brachial Plexus Block for Postoperative Pain Control after Arthroscopic Rotator Cuff Surgery: A Noninferiority Trial (AAOS 2026) - " Patients undergoing arthroscopic rotator cuff surgery were randomized to receive either ISB (20 ml of 0.375% bupivacaine) or LIA administered to the subacromial space and arthroscopic portal incisions (20 ml of 0.5% bupivacaine, 1 ml of ketorolac [30 mg/ml], and 19 ml of normal saline)...Additionally, cumulative morphine consumption at 24 hours was significantly greater in the LIA group compared to the ISB group (20.2 ± 17.1 mg vs. 9.0 ± 6.3 mg; p = 0.02), as was intraoperative fentanyl requirement (171.8 ± 54.4 mcg vs. 131.3 ± 38.9 mcg; p < 0.001)... Local infiltration anesthesia (LIA) was non-inferior to interscalene brachial plexus block (ISB) for pain control at 24 hours after arthroscopic rotator cuff surgery. However, ISB provided superior analgesia during the immediate postoperative period (0–12 hours) and was associated with significantly lower intraoperative and postoperative opioid consumption."

Clinical • Head-to-Head • Surgery • Orthopedics • Pain

Intraoperative Methadone Versus Regional and Local Anesthesia in Periacetabular Osteotomy with Hip Arthroscopy: Postoperative Pain, Opioid Use, and Length of Surgery in Three Cohorts (AAOS 2026) - "This is the first study to evaluate methadone use in PAO with arthroscopy, comparing efficacy and opioid consumption of three different anesthetic regimens: (1) lumbar plexus catheter with a single shot intrathecal hydromorphone (LP+HM) (2) locally administered intraoperative soft tissue periarticular injection with ropivacaine, epinephrine, and ketorolac (arthroplasty block [AP]), and (3) AP with intraoperative methadone (AP+M)...Primary outcomes were 48-hour morphine milligram equivalents (MME) and total inpatient opioid consumption... Intraoperative methadone added to the arthroplasty block provided comparable analgesia and reduced total opioid use compared to arthroplasty block alone. These findings support methadone as an adjunct to periarticular anesthesia for improving pain control and reducing opioid use in hip preservation surgery."

Surgery • Orthopedics • Pain

A Prospective Randomized Controlled Trial Comparing Single-Shot Liposomal Bupivacaine Versus Liposomal Bupivacaine Combined with Dexamethasone for Foot and Ankle Procedures (AAOS 2026) - "Preliminary results suggest that adding dexamethasone to liposomal bupivacaine prolongs the duration of nerve block and is associated with reduced ketorolac use by POD 14. No significant differences were observed in pain scores or opioid consumption between groups. The higher incidence of altered sensation seen in the dexamethasone group may reflect an extended analgesic effect."

Clinical • Orthopedics

Safety of Ketorolac in Primary THAs: An Analysis of over 7,000 Cases (AAOS 2026) - "Perioperative ketorolac use does not elevate the risk of postoperative AKI, regardless of administration route. Risk factors for AKI include preexisting CKD, male sex, elevated BMI, need for intraoperative transfusion, and history of hypertension."

Clinical • Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Hypertension • Nephrology • Orthopedics • Renal Disease

Opioid Prescription and Refill Patterns Following Periacetabular Osteotomy: A Comparative Analysis of Postoperative Pain Control with an Epidural Catheter Versus Periarticular Injection (AAOS 2026) - "In the PI group, there were two subgroups receiving weight based ropivacaine, ketorolac and epinephrine or liposomal bupivacaine...The primary outcomes were morphine milligram equivalents (MME) of opioid prescription at discharge, total opioid exposure (MME of discharge medications plus refills within 30 days), and opioid refill within 30 days... Among patients undergoing PAO, the combination of a periarticular injection and decreased recommended number of discharge opioids was associated with significantly reduced opioids prescribed at discharge and in total compared to epidural catheter, yet had a higher incidence of early refills. These findings support the role of a PI with ropivacaine in opioid minimization strategies but highlight the need for tailored discharge planning to ensure adequate pain control."

Orthopedics • Pain

Does adding corticosteroids to the cocktail solution for Local Infiltration Analgesia in TKA minimise knee inflammation? A randomised controlled trial (AAOS 2026) - "The CF-LIA mixture consisted of 20 mL of 0.5% bupivacaine, 0.3 mL of 1:1000 adrenaline, 30 mg of ketorolac, and 0.9% saline solution, for a final volume of 40 mL. The C-LIA mixture consisted of similar agents with an additional 40 mg of Solumedrol... The significant increase in the levels of inflammatory cytokines in synovial fluid confirmed the inflammation after TKA in both C-LIA and CF-LIA groups. However, although studies have shown that adding corticosteroids to the cocktail solution decreases postoperative pain and accelerates functional recovery, the present study found that it did not minimize the level of knee inflammation."

Clinical • Inflammation • Orthopedics • Osteoarthritis • CXCL8 • IFNG • IL10 • IL1B • IL2 • IL4 • IL6 • TGFB1 • TNFA

Complications Related to Platelet-Rich Plasma Injections for the Treatment of Rotator Cuff Tendon Dysfunction: A Systematic Review and Meta-Analysis (AAOS 2026) - "The comparison groups of included studies were as follows: saline injection alone, corticosteroids alone, corticosteroid group and prolotherapy group, prolotherapy alone, collagen, and ketorolac tromethamine... This review found 102 complications across 25 RCTs that compared a PRP injection to an alternative injection for treatment of rotator cuff tendinopathy. The pooled complication rates for the PRP group were statistically similar to complication rates of saline and steroid injections. There were no reports of serious events across al l studies."

Retrospective data • Review • Cardiovascular • CNS Disorders • Infectious Disease • Insomnia • Musculoskeletal Pain • Pulmonary Arterial Hypertension • Sleep Disorder

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (clinicaltrials.gov) - P2/3 | N=100 | Suspended | Sponsor: Wake Forest University Health Sciences | Recruiting ➔ Suspended

Trial suspension • Genito-urinary Cancer • Oncology • Pain • Prostate Cancer • Solid Tumor