ketorolac / Generic mfg. - LARVOL DELTA

Comparing cryotherapy and ketorolac tromethamine against room-temperature saline irrigation using interleukin-8 levels and post-operative pain within single-visit endodontic treatment of symptomatic irreversible pulpitis superimposed by apical periodontitis; a comparative randomized controlled trial. (PubMed, BMC Oral Health) - No abstract available

Journal • Dental Disorders • Pain • Periodontitis

Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy (clinicaltrials.gov) - P4 | N=300 | Not yet recruiting | Sponsor: University of South Alabama

Head-to-Head • New P4 trial • Pain • Pediatrics

Comparison of the effect of Apotel and Ketorolac before surgery on pain and the need for narcotics after abdominal surgery. (PubMed, Pain Manag) - "The mean intake of narcotics was also in the group receiving Apotel (51.1 mg) and in the ketorolac group (62.8 mg, p = 0.009). The administration of Apotel before surgery was associated with more pain relief and less narcotic consumption in patients, and it seems that the use of this drug combination is more effective than the administration of Ketorolac in patients who are candidates for abdominal surgery for postoperative control.Clinical trial registration: Iranian Registry of Clinical Trials identifier is IRCT20230911059408N1."

Journal • Pain

Rimegepant for acute treatment of atypical headache syndromes: A case series (EHF-EHC 2025) - "The migralepsy patient became resistant to NSAIDs; the FHM patient had limited, inconsistent response to prochlorperazine and ketorolac, and no benefit from NSAIDs, dexamethasone, acetazolamide, or IV magnesium sulfate. Further studies are needed to confirm these findings. Patients gave their consent to publish their details in an open access journal."

Clinical • CNS Disorders • Migraine • Mood Disorders • Pain

Computational and experimental design of L-amino acid-based alternatives to ketorolac. (PubMed, Sci Rep) - "Based on these results, we selected and synthesized the best structure compared to ketorolac. We predict that this new structure, designed using a natural product and showing similar chemical effects, will be a potential alternative to ketorolac."

Journal • Pain

Synthesis of pH-sensitive hydrogel beads for controlled delivery of ketorolac tromethamine: computational evaluation and in vivo pharmacokinetic study. (PubMed, Int J Pharm X) - "An in vivo pharmacokinetic study in rabbits further demonstrated that the drug-loaded hydrogel beads achieved higher plasma concentrations of ketorolac tromethamine compared to the drug solution, supporting their potential for improved bioavailability. Hence, the developed SA/Aa-based hydrogel beads exhibited favorable physicochemical, biocompatibility, and pharmacokinetic profiles, making them promising candidates for controlled drug delivery systems."

Journal • PK/PD data • Preclinical

Comparing outcomes of one-way Heimlich valve with conventional chest tube drainage for primary spontaneous pneumothorax: a randomized clinical trial. (PubMed, Surg Pract Sci) - "Primary outcomes included length of hospital stay, time to return to normal activities other outcomes included pain scores (Visual Analog Scale - VAS), dyspnea score (0-10), ease of getting out of bed (0-10), need for ketorolac analgesia, treatment failure (requiring VATS within 7 days), 30-day rehospitalization, and complications...The Heimlich valve appears to be a safe and effective alternative, offering potential patient comfort and recovery benefits. Iranian Registry of Clinical Trials (IRCT): IRCT20230208057359N1."

Clinical • Journal • Pain • Pulmonary Disease • Respiratory Diseases

Enantioseparation by Thin-Layer Chromatography. (PubMed, Methods Mol Biol) - "Both pre-coated and custom-prepared TLC plates have been used. (-)-Quinine, (-)-erythromycin, L-(+)-tartaric acid, (S)-naproxen, bovine serum albumin (BSA), and L-amino acids were used as chiral reagents/selectors in different manners for the enantioseparations of (±)-ketamine, (RS)-ketorolac, certain β-adrenergic drugs, and DL-dansyl amino acids, as examples."

Journal

R.E.C.K vs Exparel in Robotic Nephrectomy (clinicaltrials.gov) - P3 | N=170 | Recruiting | Sponsor: Wake Forest University Health Sciences | Not yet recruiting ➔ Recruiting

Enrollment open • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor

Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection (clinicaltrials.gov) - P3 | N=360 | Recruiting | Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Not yet recruiting ➔ Recruiting

Enrollment open • Inflammation

Plasma Pharmacokinetics of Topical 0.1% Diclofenac Sodium and 0.5% Ketorolac Tromethamine in Dogs. (PubMed, Vet Ophthalmol) - "Diclofenac and ketorolac were rapidly absorbed systemically after ophthalmic administration. The half-life of topical ketorolac is six times longer than that of diclofenac."

Journal • PK/PD data • Ophthalmology

Refractory Hypokalemia in a Middle-Aged Woman: Unraveling the Mystery (KIDNEY WEEK 2025) - "She denied diarrhea, autoimmune history or diuretic use, stopped using Topamax and Ketorolac for the migraine, denied recent change in dietary habits...Started on KCL 40 mEq twice daily, and Lisinopril switched to Spironolactone 12.5 mg daily to be titrated as tolerated. The rheumatology considered Early Rheumatoid arthritis and started on Methotrexate 10 mg weekly...Discussion Our patient presented with debilitating symptoms of hypokalemia, posing significant challenges in the management, this case highlights the importance of investigating the autoimmune and genetic causes mainly in refractory hypokalemia cases, although genetically not fulfilling the criteria of Autosomal recessive disease, or classic RTA 1-Linked to patients with Rheumatoid Arthritis, It is hard to conclude the coexistence of a heterozygous SLC12A3 variant and Rheumatoid Arthritis played synergistic role or confounded one another in our patient leading to resistant hypokalemia case. Further research..."

Clinical • CNS Disorders • Fatigue • Immunology • Inflammatory Arthritis • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Rheumatoid Arthritis • Rheumatology • SLC2A3

Perioperative Ketorolac Administration and AKI (KIDNEY WEEK 2025) - "In the primary analysis, patients who received ketorolac had a similar risk of AKI compared to those who did not (adjusted odds ratio 0.95 [95% CI, 0.76–1.18) ( Figure 1D ). Conclusion In this multicenter cohort study of adult cardiac surgical patients, the risk of AKI was similar in those who received ketorolac postoperatively compared to those who did not."

Cardiovascular

Efficacy and Safety of Nalbuphine Compared With Analgesics for Moderate to Severe Postoperative Pain: A Systematic Review and Network Meta-Analysis (ISPOR-EU 2025) - "The 0 to 8 hours postoperative interval included the most studies (n = 12), where nalbuphine showed moderate analgesic efficacy, ranking below morphine and above sufentanil and ketorolac. Nalbuphine provides moderate efficacy in postoperative pain control with a favorable safety profile, particularly in surgeries associated with visceral pain. Although it is less potent than morphine, nalbuphine may be a valuable clinical alternative when minimizing opioid-related adverse effects is an important consideration."

Retrospective data • Review • Dermatology • Orthopedics • Pain • Pruritus

Efficacy and Safety of Nalbuphine Compared With Analgesics for Moderate to Severe Postoperative Pain: A Systematic Review and Network Meta-Analysis (ISPOR-EU 2025) - "The 0 to 8 hours postoperative interval included the most studies (n = 12), where nalbuphine showed moderate analgesic efficacy, ranking below morphine and above sufentanil and ketorolac. Nalbuphine provides moderate efficacy in postoperative pain control with a favorable safety profile, particularly in surgeries associated with visceral pain. Although it is less potent than morphine, nalbuphine may be a valuable clinical alternative when minimizing opioid-related adverse effects is an important consideration."

Retrospective data • Review • Dermatology • Orthopedics • Pain • Pruritus

Paralyzed by Relief: A Rare Case of Transient Quadriplegia Following Cervical Epidural Injection (ASRA-FALL 2025) - "•Intralaminar and transforaminal are the most common approaches Case Presentation •Patient: 45-year-old female •Relevant Medical History: •Hypertension, morbid obesity, migraines, myofascial pain syndrome, fibromyalgia •Cervical spinal stenosis with radiculopathy confirmed by EMG and prior ACDF (C5–C6) and posterior discectomy (C6–C7) •Remote CVA at age 15 (thrombotic, no residual deficits) •Psychiatric History: •Acute grief after death of son → panic attacks and insomnia •Medications: trazodone, lorazepam, buspirone •Prior Workup: •Hospitalized for visual changes; lumbar puncture (r/o MS) → post-dural puncture headache treated with blood patch •Presentation: •Persistent cervical radiculopathy with bilateral forearm burning pain and left-hand weakness •Prior treatments (gabapentin, ibuprofen, trigger point injections) minimally effective •Four prior CESIs provided significant improvement •Current Procedure: •CESI at C7–T1 under fluoroscopic guidance using..."

Clinical • Cardiovascular • CNS Disorders • Fibromyalgia • Genetic Disorders • Hypertension • Inflammation • Insomnia • Metabolic Disorders • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Obesity • Orthopedics • Psychiatry • Psychosomatic Disorders • Rheumatology • Sleep Disorder

Brief topical application of TRPV3 channel agonist carvacrol mediates skin vasodilation via NOS, COX, and K+ channel pathways in young adults. (PubMed, Eur J Pharmacol) - "In experiment 1 (n = 10), cutaneous vascular conductance (CVC) was measured for 90-min at four forearm sites treated with: 1) lactated Ringer's serving as a control, 2) 20 mM L-NAME, a nitric oxide synthase (NOS) inhibitor, 3) 10 mM ketorolac, a cyclooxygenase (COX) inhibitor, or 4) both inhibitors combined. In experiment 2 (n = 10), CVC was assessed at four forearm sites for 90-min treated with: 1) lactated Ringer's, 2) 50 mM tetraethylammonium, a Ca2+-activated K+ (KCa) channel blocker, 3) 10 mM 4-Aminopyridine, a voltage-gated K+ (Kv) channel blocker, and 4) 50 mM BaCl2, a non-selective K+ channel blocker...Kv blockade augmented carvacrol-induced increases in CVC during early stage (10-20 min). We showed that a brief, one-minute topical activation of TRPV3 channels with 10% carvacrol induced a moderate and prolonged cutaneous vasodilation in young adults, mediated through NOS-, COX-, and K+-channel dependent pathways."

Journal

Postoperative Ketorolac Administration and Pseudoarthrosis Following Multilevel Posterior Cervical Decompression and Fusion: A Retrospective Cohort Study (ACRM 2025) - "• Describe the need for non-addictive pain management in spine surgery. • Compare the pros and cons of using the TriNetX database."

Retrospective data • Addiction (Opioid and Alcohol) • Orthopedics • Osteoarthritis

Optimizing Peri-Operative Pain Management in Children With Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia Undergoing Left Cardiac Sympathetic Denervation: A Case Series on Continuous Erector Spinae Plane Block and Serratus Plane Block. (PubMed, Paediatr Anaesth) - "Our results support the use of a combined regional anesthesia protocol for peri-operative pain management in pediatric channelopathy patients undergoing VATS-LCSD. This approach may improve overall quality of care for this vulnerable population."

Journal • Anesthesia • Cardiovascular • Neuralgia • Pain • Pediatrics • Ventricular Tachycardia

OPTIMIZING PAIN CONTROL FOLLOWING OOCYTE RETRIEVAL - A RANDOMIZED BLINDED PLACEBO CONTROLLED TRIAL ASSESSING KETOROLAC EFFICACY AND FRESH EMBRYO TRANSFER OUTCOMES (ASRM 2025) - No abstract available

Clinical • Pain

Which Analgesic Should We Use to Relieve Pain After Knee or Hip Arthroplasty? A Systematic Review and Network Meta-analysis of RCTs. (PubMed, Clin Orthop Relat Res) - "For knee arthroplasty, local levobupivacaine appeared to be the most effective option. For hip arthroplasty, local ropivacaine combined with ketorolac and adrenaline appeared the best. In terms of functional improvement, nerve-block levobupivacaine combined with dexmedetomidine (used under monitored conditions) appeared the most effective after knee arthroplasty. Although most interventions had similar safety profiles, intravenous tramadol combined with metoclopramide decreased the risk of nausea. Clinicians should integrate these results with known safety profiles and patient-specific factors to guide individualized postoperative pain management after knee and hip arthroplasties."

Journal • Retrospective data • Musculoskeletal Pain • Orthopedics • Pain

Sulopenem etzadroxil/probenecid (Orlynvah) for uncomplicated UTIs. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease • Nephrology

The Efficacy and Safety of Ketamine or Ketorolac Compared to Opioids in Painful Vaso-Occlusive Crisis: A Systematic Review and Meta-Analysis. (PubMed, Ann Pharmacother) - "Ketamine or ketorolac may not only reduce opioid requirements but may also serve as nonopioid treatment options, supporting safer and individualized pain-management strategies in painful VOC."

Journal • Retrospective data • Pain

Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: Icahn School of Medicine at Mount Sinai | N=44 ➔ 60 | Trial completion date: Sep 2025 ➔ Sep 2026 | Trial primary completion date: Sep 2025 ➔ Sep 2026

Enrollment change • Trial completion date • Trial primary completion date • Gynecology • Women's Health

KETAMINE BASED MULTIMODAL PAIN MANAGEMENT FOR DINUTUXIMAB INDUCED PAIN: A CASE SERIES (SIOP 2025) - "A recently published case series reported average daily morphine dosing of 0.448 mg/kg/day...Our institution has adopted a multimodal analgesia regimen utilizing a ketamine infusion with scheduled acetaminophen, ketorolac, gabapentin and hydromorphone as needed... Our mulitmodal pain regimen allows for much lower doses of opioids in pediatric patients undergoing dinutuximab infusions. There have been minimal side effects with our ketamine based protocol and we have not observed any adverse effects requiring discontinuation of the ketamine infusion. A randomized trial designed to directly compare pain scores and opioid consumption could further help to guide treatment of dinutuximab infusion related pain in pediatric patients."

Clinical • Anesthesia • Neuralgia • Neuroblastoma • Pain • Pediatrics • Solid Tumor