Trivax (AV0113) / Activartis - LARVOL DELTA

STAT5 activation enhances adoptive therapy combined with peptide vaccination by preventing PD-1 inhibition. (PubMed, Mol Cancer Ther) - "These findings indicate that TCR-transduced CD8 T cells can undergo antigen-dependent expansion when exposed to TriVax. Additionally, the expression of CA-STAT5 enhances T cell proliferation and persistence, partly by promoting resistance to PD-1/PD-L1-mediated inhibition in antitumor T cells."

IO biomarker • Journal • Melanoma • Oncology • Solid Tumor • CD8 • STAT5 • STAT5AWqe

""sont trivax"" (@conazole)

Melanocyte-specific CD8+ T cells demonstrate tolerance characterized by an impaired ability to differentiate into a highly proliferative population (IMMUNOLOGY 2020) - "In pre-immune mice, these cells have a naïve phenotype in both strains, and they respond similarly for the first several days after in vivo stimulation with Trp2 peptide alone or in combination with adjuvants (TriVax)...As a population, WT Trp2-specific CD8+ T cells exhibit covert anergy: despite a naïve appearance at steady state and initial acquisition of activation markers after stimulation, these self-specific cells are unable to expand productively or to efficiently mediate functional anti-melanocyte activity. These findings have implications for recently-described non-deletional CD8+ T cell tolerance in humans."

Clinical • Dermatology • Dermatopathology • Immunology • Melanoma • Oncology • Solid Tumor • Vitiligo • CD8 • Tyrosinase

Reduced T cell priming to vaccination in microbially-experienced (‘dirty’) mice (IMMUNOLOGY 2020) - "We have been using a ‘dirty’ mouse model, where SPF laboratory mice are cohoused with pet store mice to permit pathogen transfer and immune system maturation, to investigate the naive T cell response after peptide vaccination with Trivax (polyI:C and anti-CD40 mAb) or Complete Freund's Adjuvant (CFA)...One consequence of the muted T cell priming in CoH mice was reduced antitumor immunity after vaccination. Collectively, our data show the potential limitation of exclusive use of SPF mice when testing vaccine efficacy."

IO Biomarker • Preclinical • Immune Modulation • Immunology • Infectious Disease • Inflammation • Oncology

T-cells modified with CD70 as an alternative cellular vaccine for antitumor immunity (IMMUNOLOGY 2020) - "Here, antigenic peptide-loaded T-cells transfected with retrovirus encoding costimulatory ligands CD70, CD80, OX40L, or 4-1BBL were assessed for antigen-specific CD8 T-cell responses, and evaluated antitumor effects along with immunization of a mixture of synthetic peptides, poly-IC and anti-CD40 antibodies (TriVax)...Moreover, CD70-T vaccination resulted in higher expansion and migration of adoptively transferred T-cells into tumor sites, and elicits enhanced therapeutic effects with peptide-based booster immunization. These results imply that T-cells endowed with CD70 enable the design of effective vaccination strategies against solid cancer, which may overcome current limitations of DC-based vaccines."

Immune Modulation • Immunology • Inflammation • Melanoma • Oncology • Solid Tumor • CD70

T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity. (PubMed, Cancer Res Treat) - "Antigenic peptide-loaded T cells transfected with retrovirus encoding costimulatory ligands CD70, CD80, OX40L, or 4-1BBL were assessed for antigen-specific CD8 T-cell responses and evaluated antitumor effects along with immunization of a mixture of synthetic peptides, poly-IC and anti-CD40 antibodies (TriVax)...Moreover, CD70-T vaccination resulted in higher expansion and migration of adoptively transferred T cells into tumor sites and elicits enhanced therapeutic effects with peptide-based booster immunization. These results imply that T cells endowed with CD70 enable the design of effective vaccination strategies against solid cancer, which may overcome current limitations of DC-based vaccines."

Journal • CD70

"@rajdoc2005 @AnkurKalraMD @AChoiHeart @purviparwani @onco_cardiology @khurramn1 @DrJayMohan @iamritu @Drroxmehran @WomenAs1 @DrMichaelShapir @MKIttlesonMD @MichaelJBlaha @KTamirisaMD @rblument1 @trivaxheartmd @AkhilGulati @AkhilNarangMD" (@ChinnaiyanMD)

Clinical

"@trivaxheartmd @rajivxgulati @AkhilGulati @iamritu @ESHLOF @HadyLichaaMD @Dr_DanMD @DeeDeeWangMD @purviparwani @cardioPCImom @NadeenFaza @TheNarulaSeries @cardiojaydoc02 @ChinnaiyanMD @dr_chirumamilla @CardiacConsult @yuripridemd @ekgpdx @GARCIAEDINSON95 @esbrilakis" (@DrJayMohan)

"@trivaxheartmd" (@DrJayMohan)

"@TopHeartDocs @SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum" (@DrJayMohan)

The association between total lymphocyte counts after concomitant chemoradiation with overall survival in patients with newly diagnosed glioblastoma (SNO 2019) - "In addition, there was a prolonged survival of antigen-specific T cells in Trivax7 group than Trivax only group. CONCLUSION In summary, our novel combinational immunotherapy may overcome the limitations of current cell-based cancer vaccines and could be applicable for the treatment of glioblastoma patients."

Clinical • BIRC5 • IL7

"@MedEdConference @trivaxheartmd @Dr_DanMD @GARCIAEDINSON95 @RonaldWinokurMD @DrYanLiu @RonaldWinokurMD @MarquandPatton @DrAmatangelo @alaa_gabi @bchTicTocDoc @cardioPCImom @CanucksFan80 @RBP0612 @ReentrantDani @ChiznerRyan @ManualOMedicine @grepmeded @TheVeggieMD @pfarrugiamd" (@DrJayMohan)

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"@TopHeartDocs @SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum" (@DrJayMohan)

"@trivaxheartmd @CVCTForum @AbbottNews @HeartFailureTip @heartdocandcrew @HeartDocSharon @heartdoc101 @Heartdoc530 @heartdoc32 @cardioPCImom @JAMACardio @CN_publishing @CardioBot @TomLuscher @CardioMEMS @MedEdChat @CCMedEd @MedEduLab @MedEd_Journal" (@DrJayMohan)

"@MedEdConference @trivaxheartmd @Dr_DanMD @GARCIAEDINSON95 @RonaldWinokurMD @DrYanLiu @RonaldWinokurMD @MarquandPatton @DrAmatangelo @alaa_gabi @bchTicTocDoc @cardioPCImom @CanucksFan80 @RBP0612 @ReentrantDani @ChiznerRyan @ManualOMedicine @grepmeded @TheVeggieMD @pfarrugiamd" (@DrJayMohan)

"@TopHeartDocs @SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum" (@DrJayMohan)

"@ziadalinyc @GreggWStone @ajaykirtane @marok_raj @Babar_Basir @BillONeillMD @RyanMadderMD @wohnsmd @DavidFerminMD @KhandelwalMD @trivaxheartmd @rsafian @TimAFischellMD @TiberioFrisoli" (@AKassier)

"@TopHeartDocs @SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum" (@DrJayMohan)

"@SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum @AbbottNews" (@DrJayMohan)

"@SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum @AbbottNews" (@DrJayMohan)

"@ShariqShamimMD @MusaSharkawi @SureshSharmaMD @LuaySayed @mmamas1973 @DrJRicci @cardioPCImom @Pooh_Velagapudi @HeartOTXHeartMD @trivaxheartmd @agtruesdell @Almanfi_Cardio @RajTayal2 @yourheartdoc1 @evandrofilhobr @Babar_Basir @BillONeillMD @djc795 @HadyLichaaMD @DrAmirKaki" (@DrJayMohan)

"@TopHeartDocs @SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum" (@DrJayMohan)

"@TopHeartDocs @SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum" (@DrJayMohan)

"@SVM_tweets @UoMVascSurgery @AorticDissectUS @escardio @ACCinTouch @MichiganACC @EricTopol @GARCIAEDINSON95 @yourheartdoc1 @drjohnm @Medscape @JAMACardio @InvasiveCardiol @cardioPCImom @ferdikiem @keaglemd @JACCJournals @CardiacConsult @trivaxheartmd @CVCTForum @AbbottNews" (@DrJayMohan)