Levodopa Cyclops
/ PUREIMS
- LARVOL DELTA
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September 27, 2025
An In Vitro-In Vivo Comparison of Two Levodopa Dry Powder Products for Inhalation: A Randomized Trial Comparing Inbrija and Levodopa Cyclops.
(PubMed, Pharmaceutics)
- " This suggests that the systemic absorption of levodopa via the lungs is not limited by dissolution but most likely by its permeation rate. This finding underscores the need to critically apply in vitro tests and critically interpret the results for predicting the in vivo performance of inhaled products."
Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease
July 25, 2024
DPI-6: Usability of Levodopa Cyclops™ vs INBRIJA® in Parkinson's Patients
(clinicaltrials.gov)
- P=N/A | N=16 | Completed | Sponsor: Martini Hospital Groningen | Recruiting ➔ Completed | Trial completion date: Dec 2024 ➔ Jul 2024 | Trial primary completion date: Nov 2024 ➔ Jul 2024
Trial completion • Trial completion date • Trial primary completion date • CNS Disorders • Movement Disorders • Parkinson's Disease
May 29, 2024
DPI-6: Usability of Levodopa Cyclops™ vs INBRIJA® in Parkinson's Patients
(clinicaltrials.gov)
- P=N/A | N=16 | Recruiting | Sponsor: Martini Hospital Groningen | Not yet recruiting ➔ Recruiting
Enrollment open • CNS Disorders • Movement Disorders • Parkinson's Disease
January 18, 2024
PureIMS gears up for abbreviated registration of Levodopa Cyclops DPI against OFF episodes in Parkinson's disease with the successful completion of a comparative pharmacokinetic study
(Yahoo Finance)
- P1 | N=26 | NCT06037590 | Sponsor: PureIMS B.V. | "PureIMS...this week reported it has completed a comparative pharmacokinetic study with Levodopa Cyclops. The study results show rapid pulmonary absorption of levodopa in absence of safety and tolerability issues....The study suggests a high comparability with a marketed inhaled levodopa product, which opens the path towards an abbreviated registration....This drastically improves its usability over other products for the intended, motorically impaired patient population. Pharmacodynamics of Levodopa Cyclops® were demonstrated in a phase II study in PD patients experiencing OFF episodes. A significant and clinically meaningful improvement of MDS-UPDRS-part III motor scores was already observed after 15-20 minutes."
P1 data • CNS Disorders • Parkinson's Disease
October 27, 2023
A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops™ Relative to INBRIJA®
(clinicaltrials.gov)
- P1 | N=26 | Completed | Sponsor: PureIMS B.V. | Active, not recruiting ➔ Completed
Trial completion • CNS Disorders • Movement Disorders • Parkinson's Disease
October 24, 2023
DPI-6: Usability of Levodopa Cyclops™ vs INBRIJA® in Parkinson's Patients
(clinicaltrials.gov)
- P=N/A | N=16 | Not yet recruiting | Sponsor: Martini Hospital Groningen | Trial completion date: Oct 2023 ➔ Dec 2024 | Trial primary completion date: Oct 2023 ➔ Nov 2024
Trial completion date • Trial primary completion date • CNS Disorders • Movement Disorders • Parkinson's Disease
October 01, 2023
A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops™ Relative to INBRIJA®
(clinicaltrials.gov)
- P1 | N=26 | Active, not recruiting | Sponsor: PureIMS B.V. | Not yet recruiting ➔ Active, not recruiting
Enrollment closed • CNS Disorders • Movement Disorders • Parkinson's Disease
September 15, 2023
A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops™ Relative to INBRIJA®
(clinicaltrials.gov)
- P1 | N=26 | Not yet recruiting | Sponsor: PureIMS B.V.
New P1 trial • CNS Disorders • Movement Disorders • Parkinson's Disease
April 03, 2023
PureIMS secures new investment round to develop lead inhalation product and facilitate partnering activities
(PRNewswire.co.uk)
- "PureIMS...today announced it has secured a new investment round. New investor Boost-UP Foundation has joined current shareholders (CardusoCapital venture capital fund, IMDS Medical Devices and LinesBridge Pharma Group) in this round to finance the company's ambitious growth strategy. The funds will be mainly used to develop lead program Levodopa Cyclops™ for US and EEA marketing, of which early clinical studies already demonstrated very rapid onset of action in combatting OFF-episodes in Parkinsons' disease, much faster than other inhaler and non-inhaler alternatives."
Clinical data • Financing
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