remifentanil / Generic mfg. - LARVOL DELTA

Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (clinicaltrials.gov) - P4 | N=96 | Completed | Sponsor: Qianfoshan Hospital

New P4 trial • Otorhinolaryngology • Pain

Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (clinicaltrials.gov) - P=N/A | N=70 | Recruiting | Sponsor: Istanbul University - Cerrahpasa | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia • CNS Disorders • Pain

Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review. (PubMed, CNS Drugs) - "Current pharmacological interventions explored in disorders of consciousness target distinct molecular systems, including dopaminergic modulators (amantadine, levodopa, apomorphine, bromocriptine, selegiline, methylphenidate, and modafinil), GABAergic agents (zolpidem and baclofen), and other neuromodulatory compounds acting on glutamatergic, opioid, or serotonergic receptors (ketamine, remifentanil, and psilocin). Safety profiles associated with these treatments are also critically evaluated to guide clinical decision making. By integrating current knowledge on pharmacological modulation of key neural systems, including dopaminergic and GABAergic pathways, this article provides a comprehensive framework for understanding treatment strategies in disorders of consciousness."

Journal • Review

Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial. (PubMed, Drug Des Devel Ther) - "The OFA group received esketamine (0.5 mg·kg-1 induction, 0.4-0.5 mg·kg-1·h-1 maintenance), while the OBA group received sufentanil (0.4 μg·kg-1 induction) and remifentanil (0.1-0.2 μg·kg-1·min-1 maintenance)...Pain scores on coughing at 24 and 48 hours postoperatively were also lower in the OFA group (P=0.002 and P< 0.001, respectively). Esketamine-based OFA provided a noninferior quality of postoperative recovery compared with OBA in patients undergoing laparoscopic TAPP repair, offering a safer alternative to OFA regimens that minimizes opioid-related complications while maintaining perioperative comfort and supporting enhanced recovery."

Clinical • Head-to-Head • Journal • Anesthesia • Dermatology • Pain • Pruritus

Opioid-Free Versus Opioid-Based Anesthesia for Quality of Recovery Following Laparoscopic Hysterectomy: A Randomized Controlled Non-Inferiority Trial. (PubMed, Anaesth Crit Care Pain Med) - P4 | "Opioid-free anesthesia demonstrated non-inferiority to opioid-based anesthesia for recovery quality while reducing the incidence and severity of PONV. These findings support opioid-free protocols as effective alternatives for laparoscopic hysterectomy, particularly for patients at high PONV risk."

Head-to-Head • Journal • Anesthesia • CNS Disorders • Depression • Gynecology • Pain • Psychiatry

Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery (clinicaltrials.gov) - P=N/A | N=75 | Recruiting | Sponsor: Marmara University

New trial • Anesthesia • Musculoskeletal Diseases • Orthopedics

Closed-Loop Anesthesia: Advances in Automated Drug Delivery and Perioperative Monitoring. (PubMed, J Pharm Bioallied Sci) - "Various technologies and drugs, including propofol, remifentanil, and sevoflurane, support its function. As technology progresses, future systems may combine control of anesthesia, fluids, and blood pressure medications, working closely with electronic health records. Despite automation, human supervision remains essential for safe and effective anesthesia care."

Journal • Review • Anesthesia

SAFE-AWARENESS: Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: Ente Ospedaliero Ospedali Galliera

New trial • Anesthesia • Cognitive Disorders

TAPH: Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=500 | Recruiting | Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University | Not yet recruiting ➔ Recruiting

Enrollment open • Hypotension

Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio (clinicaltrials.gov) - P4 | N=200 | Not yet recruiting | Sponsor: Peking University First Hospital

New P4 trial • Anesthesia

Predisposing Factors for Chronic Post-Surgical Pain After Thoracic Surgery: A Scoping Review with Quantitative Synthesis. (PubMed, J Pain Res) - "Surgical determinants such as operative duration, minimally invasive approaches, tissue trauma, and postoperative complications showed variable associations, as did anesthetic factors, especially high intraoperative remifentanil doses...CPSP after thoracic and cardiothoracic surgery results from interacting nociceptive, psychological, procedural, and biological factors. Although heterogeneity across studies requires cautious interpretation, this synthesis highlights early postoperative pain control and psychological vulnerability screening as priority strategies in perioperative care, and underscores the need for standardized, prospective, biomarker-informed research."

Journal • Review • Anesthesia • Cardiovascular • CNS Disorders • Depression • Pain • Psychiatry

Sex-related differences in blood concentrations and emergence profiles following total intravenous anesthesia with remimazolam and remifentanil. (PubMed, Sci Rep) - No abstract available

Journal • Anesthesia

Commonly Used Opioids in the Orthopedic Operating Room: A Narrative Review. (PubMed, Orthop Rev (Pavia)) - "This narrative review examines the opioids most commonly used in orthopedic perioperative care, including fentanyl, morphine, remifentanil, hydromorphone, oxycodone, sufentanil, and methadone. Emphasis is placed on pharmacologic properties, clinical indications, dosing considerations, adverse effects, and comparative evidence in orthopedic populations. In addition, the evolving role of opioids within multimodal analgesia frameworks is discussed, with attention to balancing effective pain control against opioid-related risks."

Journal • Anesthesia • Inflammation • Orthopedics • Pain

GASPS: General Anaesthesia vs Spinal anaesthesia: Patient outcomes and Success in outpatient primary total knee and hip arthroplasty. (clinicaltrialsregister.eu) - P4 | N=600 | Not yet recruiting | Sponsor: Region Oerebro Laen

New P4 trial • Anesthesia • Orthopedics • Pain

Exploring the Role of Ventrolateral Periaqueductal Gray in Remifentanil-induced Postoperative Hyperalgesia. (PubMed, Neuropharmacology) - "Artificial activation of vlPAG-Glu or inhibition of vlPAG-GABA can effectively alleviate hypersensitivity behavior. This study provides new ideas and theoretical basis for clinical intervention strategies for RIH."

Journal • Immunology • Mood Disorders • Pain • FOS

Optimal Insertion Time During Remimazolam-Remifentanil Anesthesia for Painless Gastroscopy (clinicaltrials.gov) - P=N/A | N=342 | Completed | Sponsor: Huizhou First People's Hospital

New trial • Anesthesia • Pain

A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU) (clinicaltrials.gov) - P2 | N=120 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Critical care

Neuromuscular Block and Video Laryngoscope to Facilitate Intubation-A Survey of Current Practice in Denmark and Sweden. (PubMed, Acta Anaesthesiol Scand) - "NMBA use remains the standard for non-acute tracheal intubation. However, a substantial number of anaesthetists regularly employ a NMBA-free approach facilitated by high-potency opioids and video laryngoscopy, particularly in Denmark. These findings emphasise the need for further research and subsequently updated evidence-based guidance to support safe and effective intubation practices."

Intubation • Journal • Video • Anesthesia

Characteristics and effects of depth of anaesthesia on late motor responses. (PubMed, Clin Neurophysiol) - "Changing depth of anaesthesia has differential effects on late responses of different muscles."

Journal • Anesthesia

Update on total intravenous anesthesia in children. (PubMed, Curr Opin Anaesthesiol) - "Pediatric TIVA is moving toward greater precision, safety, and sustainability. Moderate effect-site targets, opioid titration, and early down-titration remain central, particularly in neonates. Propofol infusion syndrome is exceedingly rare, and organ-protective effects of TIVA are reported in major surgery. Despite clinical and environmental advantages, adoption varies globally due to limited training, variable pump availability, and regulatory barriers. Expanding structured education and pediatric-specific TCI tools is essential for broader implementation."

Journal • Anesthesia • CNS Disorders • Pediatrics

Successful anesthesia management for middle cerebral artery thrombectomy in a patient with asynchronous cardio-cerebral infarction: a case report. (PubMed, Front Pharmacol) - "Anesthesia was managed using a non-intubated general anesthesia approach, involving titration of sedation with sufentanil and remifentanil, combined with norepinephrine to maintain mean arterial pressure (MAP) within ±20% of baseline. The risk of ischemia and hemorrhage was balanced with restrictive fluid management and continuous infusion of tirofiban...Non-invasive general anesthesia was beneficial in maintaining hemodynamic stability and airway safety. The multidisciplinary individualized anesthesia plan developed in this challenging scenario may provide practical references for perioperative management of similar high-risk CCI patients, but its general applicability still needs to be verified in larger-scale studies."

Journal • Acute Kidney Injury • Anesthesia • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure • Hematological Disorders • Ischemic stroke • Myocardial Infarction • Nephrology • Renal Disease

Perioperative Challenges in a Patient With Sturge-Weber and Obesity Hypoventilation Syndromes. (PubMed, Case Rep Med) - "Premedication included intramuscular clonidine (2 μg/kg)...Anesthesia was maintained with propofol and remifentanil via target-controlled infusion...Awake fiberoptic intubation and the use of HFNO under strict ventilatory monitoring, as a rescue or bridging strategy, can facilitate safe anesthetic management in high-risk patients with SWS and OHS who are CPAP-intolerant. This case highlights the importance of multidisciplinary planning and individualized respiratory support strategies."

Journal • Anesthesia • Genetic Disorders • Obesity • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

EC50 via TCI: A Study on Median Effective Concentration of Ciprofol Combined With Remifentanil Via Target-controlled Infusion for Inhibiting Tracheal Intubation Stimulation Under qNOX Index Monitoring (clinicaltrials.gov) - P=N/A | N=70 | Active, not recruiting | Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Intubation • New trial

SYMBOL CLINICAL : Treatment of severe ocular chemical burns by subconjunctival injection of allogeneic mesenchymal stem cells:na multicentre, single-arm, open-label phase II trial (clinicaltrialsregister.eu) - P1/2 | N=21 | Not yet recruiting | Sponsor: Hopital Fondation Adolphe De Rothschild

New P1/2 trial • Thermal Injury

Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (clinicaltrials.gov) - P=N/A | N=200 | Not yet recruiting | Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

New trial • Anesthesia • Orthopedics • Pain