remifentanil / Generic mfg. - LARVOL DELTA

REMI-MEP: REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring (clinicaltrials.gov) - P4 | N=316 | Not yet recruiting | Sponsor: Mayo Clinic

Intubation • New P4 trial • Orthopedics

Effects of lidocaine bolus and infusion on neuromonitoring by bispectral index (BIS®), electroencephalogram periodic and aperiodic activity, and Surgical Pleth Index® during propofol-remifentanil anaesthesia: a single-centre prospective observational study. (PubMed, Br J Anaesth) - P | "When lidocaine is given during stable propofol-remifentanil anaesthesia, changes in spectral EEG parameters occur earlier than changes in BIS, SEF95 and SPI. The observed EEG and SPI changes are consistent with a predominant antinociceptive contribution to the anaesthetic-sparing effects of lidocaine, although the physiological interpretation of the derived parameters remains an evolving area of research."

Journal • Observational data • Anesthesia • CNS Disorders

Economic evaluations of remifentanil versus fentanyl for analgo-sedation in mechanically ventilated adult ICU patients: a systematic review. (PubMed, Intern Med J) - "This systematic review identified limited and heterogeneous evidence regarding the economic impact of remifentanil in mechanically ventilated ICU patients. Given the substantial costs of intensive care, high-quality economic evaluations using contemporary clinical practice, comprehensive cost measurement and appropriate time horizons are needed to determine whether remifentanil provides value for money."

HEOR • Journal • Review • Anesthesia • Critical care • Mood Disorders • Pain • Psychiatry

Use of Intravenous Anesthetic Combinations for Electroconvulsive Therapy Under General Anesthesia and Muscle Relaxation in Patients With Mental Illness: A Scoping Review. (PubMed, J ECT) - "Intravenous induction-agent combinations in mECT seem to offer complementary pharmacologic advantages depending on the desired clinical outcome. However, current evidence does not support the superiority of any single regimen. Future comparative trials using standardized outcome measures are needed to better inform anesthetic selection."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Epilepsy • Hypotension

Incidence and risk factors of persistent postoperative pain after cardiac surgery: a systematic review and meta-analysis. (PubMed, BMC Anesthesiol) - "The incidence of PPPCS ranged from 13.1% to 31.7%. Female sex, younger age, elevated BMI, poor wound healing, intraoperative remifentanil use, history of chronic pain, and severe acute postoperative pain were associated with higher odds of PPPCS. However, given the observational nature of the included studies, variable confounder adjustment, small numbers of studies for certain risk factors, and high heterogeneity, these associations should be interpreted cautiously and require confirmation in prospective studies with standardized definitions and more comprehensive adjustment. The identified factors may guide risk stratification but should not yet be regarded as definitively established causal determinants of PPPCS."

Clinical • Journal • Retrospective data • Review • Cardiovascular • Pain

Analgesic effect of intraoperative sufentanil on postoperative pain in patients undergoing robot-assisted urologic surgery: a retrospective propensity score-matched analysis. (PubMed, Korean J Pain) - "During the 48-hour postoperative period, the sufentanil group required significantly lower opioid rescue analgesic consumption (13.3 [5, 22.5] vs. 20 [10, 29.6] mg of morphine-equivalent dose, HL estimator -5 mg, 95% CI -6.7 to -2.5 mg; P < 0.001). Intraoperative sufentanil was associated with lower postoperative pain and analgesic consumption than was remifentanil in patients undergoing robot-assisted urologic surgery."

Journal • Retrospective data • Anesthesia • Pain

Brain Monitors to Reduce Child Confusion After Anesthesia (clinicaltrials.gov) - P=N/A | N=125 | Completed | Sponsor: Baskent University

New trial • Anesthesia • CNS Disorders

Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT) (clinicaltrials.gov) - P4 | N=24 | Not yet recruiting | Sponsor: Inonu University

New P4 trial • Anesthesia

Contact heat evoked potentials as a measure of the analgesic component of anesthesia - a patient study. (PubMed, J Clin Monit Comput) - "(1) Correlation between remifentanil-induced changes in VAS and CHEP amplitudes...The exact mechanism for the detected CHEP reduction remains to be determined. CHEPs monitoring appears unsuitable for direct assessment of the analgesic component of general anesthesia.Trial registration: German Clinical Trials Register ID DRKS00003300, Oct 24, 2011."

Journal • Anesthesia • Pain

Safety and Efficacy of Esketamine Versus Remifentanil as Adjuncts to Propofol Sedation in Children Undergoing Hematologic-Oncologic Procedures: A Randomized Crossover Controlled Trial (ChiCTR) - P=N/A | N=140 | Not yet recruiting | Sponsor: Children's Hospital of Soochow University; Children's Hospital of Soochow University | N=80 ➔ 140

Enrollment change • Acute Lymphocytic Leukemia • Anesthesia • Hematological Disorders • Hematological Malignancies

Effect of Remifentanil on Emergence Agitation after General Anesthesia (ChiCTR) - P=N/A | N=148 | Not yet recruiting | Sponsor: The First Affiliated Hospital, College of Medicine, Zhejiang University; The First Affiliated Hospital, College of Medicine, Zhejiang University | N=72 ➔ 148

Enrollment change • Anesthesia • Cognitive Disorders

Effects of inhalational versus intravenous anaesthesia on postoperative lung injury in patients with sepsis undergoing surgery: a study protocol for a single-centre, assessor-blinded, randomised controlled trial (ChiCTR) - P=N/A | N=480 | Not yet recruiting | Sponsor: The Sixth Affiliated Hospital , Sun Yat-sen University; The Sixth Affiliated Hospital , Sun Yat-sen University

New trial • Anesthesia • Infectious Disease • Respiratory Diseases • Septic Shock

The effect of remifentanil on hemodynamics during general anesthesia with double-lumen endotracheal intubation (ChiCTR) - P=N/A | N=140 | Completed | Sponsor: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Intubation • New trial • Anesthesia • Cardiovascular • Hypertension

Comparison of remifentanil and sufentanil combined with propofol in painless endoscopic variceal ligation (EVL) for liver cirrhosis: A randomized controlled trial evaluating respiratory safety and postoperative enhanced recovery after surgery (ERAS) outcomes (ChiCTR) - P=N/A | N=106 | Not yet recruiting | Sponsor: Affiliated Hospital of Guizhou Medical University; Affiliated Hospital of Guizhou Medical University

New trial • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis

Dexmedetomidine combined with sevoflurane in anesthesia maintainance: a randomized double-blind study (ChiCTR) - P=N/A | N=92 | Not yet recruiting | Sponsor: Cancer Hospital Chinese Academy of Medical Sciences; Cancer Hospital Chinese Academy of Medical Sciences

New trial • Anesthesia • Oncology

Safety and Effectiveness of Remifentanil and Sevoflurane for Maintaining General Anesthesia in Different Surgical Procedures — A Single-Center, Prospective Randomized Controlled Trial (ChiCTR) - P4 | N=500 | Not yet recruiting | Sponsor: North China University of Science and Technology Affiliated Hospital; North China University of Science and Technology Affiliated Hospital

New P4 trial • Anesthesia

A Study Assessing Heart Rate Variability During Anesthesia Induction with Remimazolam Besylate and Remifentanil Coadministration in Elderly Patients. (ChiCTR) - P=N/A | N=152 | Recruiting | Sponsor: The Affiliated Hospital of Guizhou Medical University; The Affiliated Hospital of Guizhou Medical University | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia

Determination of the Median Effective Dose of Remifentanil for Conscious Analgesic Gastroscopy with Concurrent Intravenous Lidocaine in High Aspiration-Risk Patients (ChiCTR) - P=N/A | N=35 | Not yet recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New trial

ED90 of Remifentanil during Remimazolam Sedation for Gastrointestinal Endoscopy in Elderly Patients: A Biased-Coin Up-and-Down Sequential Trial (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: The Fifth People's Hospital of Huai'an; The Fifth People's Hospital of Huai'an

New trial • Anesthesia

Remimazolam Combined with Low-Dose Propofol for Sedation in Adult Patients Undergoing Endoscopic Ultrasonography (ChiCTR) - P=N/A | N=132 | Not yet recruiting | Sponsor: Mianyang 404 Hospital; Mianyang 404 Hospital

New trial • Anesthesia • Gastrointestinal Cancer • Oncology • Solid Tumor

THE EFFECT OF CHRONIC SSRI/SNRI ANTIDEPRESSANT TREATMENT ON PROPOFOL CONSUMPTION IN ELECTIVE SPINE SURGERY (clinicaltrials.gov) - P=N/A | N=216 | Not yet recruiting | Sponsor: Kocaeli City Hospital

New trial • Orthopedics

Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=450 | Completed | Sponsor: Xijing Hospital | Recruiting ➔ Completed

Trial completion • Cardiovascular • CNS Disorders • Diabetes • Geriatric Disorders • Metabolic Disorders

Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia for Opioid Consumption in Laparoscopic Hysterectomy (clinicaltrials.gov) - P=N/A | N=45 | Recruiting | Sponsor: Andrea Saporito | Trial completion date: Apr 2026 ➔ Dec 2026 | Trial primary completion date: Apr 2026 ➔ Dec 2026

Trial completion date • Trial primary completion date • Anesthesia • Gynecology

NORELACs: "Impact of NOciception Level (NOL) Index Intraoperative Guidance of REmifentanil Administration on Opioid Consumption and QoR in Ambulatory Patients Undergoing LAparoscopic Cholecystectomy." (clinicaltrials.gov) - P=N/A | N=120 | Completed | Sponsor: Svendborg Hospital

New trial

Subcostal TAP Block and EEG Dynamics in Laparoscopic Cholecystectomy (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital

New trial • Pain