remifentanil / Generic mfg. - LARVOL DELTA

Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery (clinicaltrials.gov) - P=N/A | N=1228 | Completed | Sponsor: Peking University First Hospital | Active, not recruiting ➔ Completed

Trial completion • Anesthesia • Oncology

Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality With Mechanical Ventilation (clinicaltrials.gov) - P4 | N=174 | Completed | Sponsor: Peking University First Hospital | Recruiting ➔ Completed

Trial completion • Critical care

Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer (clinicaltrials.gov) - P=N/A | N=106 | Completed | Sponsor: Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,

New trial • Anesthesia • Cognitive Disorders • Liver Cancer • Oncology • Pain • Solid Tumor

Minimal Flow Anesthesia and Infection Risk (clinicaltrials.gov) - P=N/A | N=140 | Active, not recruiting | Sponsor: Ankara City Hospital Bilkent

New trial • Anesthesia • Infectious Disease

Intraoperative Methadone Versus Other Opioids: A Retrospective Review of Postoperative Outcomes in Pediatric Surgeries. (PubMed, Anesth Analg) - "In this large, single-center retrospective study, intraoperative methadone administered to pediatric patients was found to be associated with reduced postoperative pain scores, opioid consumption, and emergence delirium. Larger studies are needed to achieve the necessary power to assess adverse events in pediatric surgical patients who receive methadone versus other opioids."

Journal • Retrospective data • Anesthesia • CNS Disorders • Gastrointestinal Disorder • Pain • Pediatrics

The Effects of Dexmedetomidine and Remifentanil on Kidney Injury After Muscle Compression Injury in Rats (clinicaltrials.gov) - P=N/A | N=28 | Completed | Sponsor: Ankara City Hospital Bilkent

New trial • Acute Kidney Injury • Nephrology • Renal Disease

Impact of Remimazolam on Prognosis After Bladder Cancer Surgery (clinicaltrials.gov) - P4 | N=1128 | Recruiting | Sponsor: Peking University First Hospital | Trial completion date: Oct 2025 ➔ Oct 2026 | Trial primary completion date: Oct 2024 ➔ Oct 2025

Trial completion date • Trial primary completion date • Anesthesia • Bladder Cancer • CNS Disorders • Genito-urinary Cancer • Oncology • Solid Tumor

Impact of Interscalene Block Combined With General Anesthesia on Burst Suppression in Shoulder Surgery Patients (clinicaltrials.gov) - P=N/A | N=50 | Completed | Sponsor: Bezmialem Vakif University | Recruiting ➔ Completed

Trial completion • Anesthesia • CNS Disorders

MCTR1 alleviates remifentanil-induced hyperalgesia by regulating mitochondrial fission protein DRP1 in rats. (PubMed, Neuroreport) - "MCTR1 exerts a preventive effect on RIH by modulating NR2B activity through the DRP1-mitochondrial-ROS pathway."

Journal • Preclinical • Pain

Living Liver Donor Intra-operative Analgesia and Day 1 Pain - Insights from the International LDLT Registry (WTC 2025) - "Donor demographics are shown in table 1 with a summary of surgical approach, systemic analgesia and regional techniques used shown in table 2.Multivariable analysis demonstrated an association between a reduced pain and robotic hepatectomy, and use of remifentanil and dexmedetomidine...Ketamine and regional blocks did not show a statistically significant effect on day 1 pain scores, though an interaction between ketamine used and open hepatectomy was statistically significant (see figure 1).* This analysis highlights modifiable factors influencing early post-operative pain, with surgical techniques demonstrating significant impact. This analysis highlights modifiable factors influencing early post-operative pain, with surgical techniques demonstrating significant impact. These findings encourage further investigation as LDLTregistry.org continues to expand its data collection and improve completeness. Additional data (e.g., dosing of systemic and neuraxial drugs) and..."

Late-breaking abstract • Anesthesia • Pain

Effect of Remifentanil on Pruritus and Paresthesia of Fospropofol Disodium Anesthesia (clinicaltrials.gov) - P=N/A | N=265 | Not yet recruiting | Sponsor: Tongji Hospital

New trial • Anesthesia • Dermatology • Pruritus

Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients. (PubMed, Drug Test Anal) - "These patients were treated with medically approved novel synthetic opioids (fentanyl, remifentanil, sufentanil, or alfentanil) and traditional opioids (morphine, methadone, and hydromorphone) during their clinical treatment. The metabolite ratio of β-hydroxyfentanyl to fentanyl was particularly well suited for children and neonatal patients. In conclusion, concentration ranges, metabolite ratios, and dose correlations of the studied opioids in pediatric hair were established, providing insights into opioid incorporation pathways."

Journal • Pediatrics

Analgesic Efficacy of Remifentanil Versus Dexmedetomidine in Patients Undergoing Bariatric and Metabolic Surgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, Cureus) - "However, the incidence of PONV was significantly lower in the dexmedetomidine group. Further studies are warranted to identify the most suitable adjunct to GA in this high-risk patient population."

Journal • Retrospective data • Review • Anesthesia • Obesity • Pain

The Effect-site Concentration of Remifentanil Blunting Endotracheal Intubation Responses During Anesthesia Induction With Lidocaine or Sufentanil Combined With Etomidate (clinicaltrials.gov) - P=N/A | N=99 | Not yet recruiting | Sponsor: Peking University Shenzhen Hospital

Intubation • New trial • Anesthesia

Impact of Interscalene Block Combined With General Anesthesia on Burst Suppression in Shoulder Surgery Patients (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Bezmialem Vakif University

New trial • Anesthesia • CNS Disorders

Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy (clinicaltrials.gov) - P4 | N=79 | Completed | Sponsor: West Virginia University | Recruiting ➔ Completed

Trial completion

OFA VS OBA1: OFA vs OBA in Bariatric Surgery (clinicaltrials.gov) - P=N/A | N=70 | Completed | Sponsor: Hospital HM Nou Delfos

New trial • Anesthesia • Genetic Disorders • Obesity • Pain

NOL-Guided vs Conventional Intraoperative Opioid Infusion on Outcomes in Geriatric Patients (clinicaltrials.gov) - P=N/A | N=80 | Not yet recruiting | Sponsor: Saglik Bilimleri Universitesi

New trial • Anesthesia • Geriatric Disorders • Pain

Anesthesia Management Involving Remimazolam in a Patient With Pulmonary Hypertension and Right Ventricular Failure: A Case Report. (PubMed, Cureus) - "Total intravenous anesthesia was administered using remifentanil and remimazolam. The patient's postoperative course was also uneventful, and she was discharged without any serious complications. Anesthesia management using remimazolam might be beneficial in patients with PH, as it provides stable hemodynamics and allows for safe perioperative care."

Journal • Anesthesia • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Immunology • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis

Remifentanil enhances the sedative effect of remimazolam during anesthesia induction in patients undergoing hysteroscopy: a randomized controlled trial. (PubMed, Ann Med) - P4 | "Remifentanil enhances the sedative effect of remimazolam during anesthesia induction in patients undergoing hysteroscopy. The trial was registered at http://www.chictr.org.cn (ChiCTR2200062983)."

Clinical • Journal • Anesthesia • Gynecology

Successful Anesthetic Management of Video-Assisted Thoracic Surgery in a Patient With Cardiac Complications After Arterial Switch Operation. (PubMed, Cureus) - "During left isolated ventilation in the lateral decubitus position, the patient's hemodynamics and oxygenation were both well maintained, and a right thoracoscopic bullectomy was performed uneventfully under total intravenous anesthesia with propofol and remifentanil. Vital signs were also stable postoperatively, and the patient was discharged on the fifth postoperative day without adverse cardiovascular events. In the present case, the non-stenotic left pulmonary artery was considered to have played a vital role in successful one-lung ventilation, highlighting the importance of multimodal evaluation for long-term cardiac complications in a patient who underwent an arterial switch operation."

Journal • Video • Anesthesia • Cardiovascular • Heart Failure • Respiratory Diseases

Effect of low-dose esketamine on postoperative quality of recovery in total laparoscopic hysterectomy: a randomized controlled trial. (PubMed, Perioper Med (Lond)) - "In patients undergoing total laparoscopic hysterectomy, one injection of low-dose esketamine at anesthesia induction did not affect QoR-40 scores. However, esketamine stabilized intraoperative hemodynamics, decreased intraoperative opioid requirements, and shortened postoperative extubation time and PACU stay. It also alleviated postoperative inflammatory response and pain without causing adverse effects."

Journal • Anesthesia • CNS Disorders • Depression • Gynecology • Hypotension • Inflammation • Pain • Psychiatry

RETRACTION: The Impact of Sufentanil versus Remifentanil on Surgical Site Wound Healing in Caesarean Section Primiparas Undergoing Epidural Anaesthesia: A Systematic Meta-Analysis. (PubMed, Int Wound J) - "The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction."

Journal • Retrospective data • Anesthesia

Physiological pattern differences in non-intubated vs. intubated thoracic anesthesia based on time series analysis. (PubMed, J Thorac Dis) - "The protocol of both non-intubated SubL and Lob reduced the use of sevoflurane, sufentanil, remifentanil, and cisatracurium (P<0.01). This approach, tolerating mild hypercapnia, permissive lower mean artery pressure, notably results in postoperative outcomes comparable to intubated anesthesia. Non-intubated anesthesia accelerates postoperative recovery in the PACU, particularly for Lob patients."

Journal • Anesthesia

Anesthetic Considerations and Intraoperative Management of a Patient with Brugada Syndrome (ASA 2025) - "Induction was achieved with midazolam, fentanyl, lidocaine, and etomidate; maintenance with remifentanil aimed to suppress sympathetic surges...Neuromuscular blockade was achieved with rocuronium and reversed with sugammadex...The case remained uneventful. This case highlights strategic perioperative planning in Brugada syndrome patients."

Clinical • Anesthesia • Bipolar Disorder • Cardiovascular • CNS Disorders • Genetic Disorders • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Mood Disorders • Psychiatry • Pulmonary Embolism • Respiratory Diseases