remifentanil / Generic mfg. - LARVOL DELTA

Peripartum FXI replacement supports safe neuraxial anesthesia in FXI-deficient parturients (ASH 2025) - "Data collection included age, ethnicity, parity, deliverymode, type of anesthesia (NA or general anesthesia (GA), estimated blood loss, use of hemostatic agents(e.g., FXI concentrate, Fresh frozen plasma (FFP), Tranexamic acid (TXA), Red blood cells (RBC), and FXIlevels (baseline and post-treatment if available)...Of the 22 vaginal deliveries, 21 (95.4%) received NA, andone received remifentanil patient-controlled analgesia (PCA) due to personal choice...Our PPH ratewas 14%, within the previously reported 11–22% range, and did not correlate with FXI levels. No PPHoccurred in patients receiving FXI concentrate."

Anesthesia • Cardiovascular • Hematological Disorders • Hemophilia • Obstetrics • Postpartum Hemorrhage

Comparison of the safety and efficacy of desflurane versus sevoflurane on postoperative cognitive function and early recovery quality in elderly orthopedic patients: a prospective, randomized controlled trial. (PubMed, Front Med (Lausanne)) - P4 | "General anesthesia was maintained through continuous infusion of remifentanil (0.05-0.20 μg/kg/min) and a sevoflurane expiratory concentration of 1-2% or desflurane 2-5%, in combination with air containing 40% oxygen to maintain bispectral index (BIS) values 40-60. However, it demonstrated faster recovery times and higher patient satisfaction scores than sevoflurane. ChiCTR2400093852."

Clinical • Journal • Anesthesia • Orthopedics

Impact of transversus abdominis plane block plus intravenous lidocaine on rapid recovery after bariatric surgery. (PubMed, Front Med (Lausanne)) - "The CG received ultrasound-guided TAPB with ropivacaine, while the SG received ultrasound-guided TAPB with ropivacaine plus intravenous lidocaine. The two groups were compared in terms of total doses of propofol, remifentanil, and sufentanil used; pain intensity; intraoperative conditions; levels of inflammatory factors; additional use of postoperative analgesics; incidence of adverse reactions; and postoperative recovery time...Furthermore, the SG exhibited a shorter time to first flatus, first defecation, and first ambulation, as well as a shorter length of hospital stay compared to the CG (all p < 0.05). TAPB combined with intravenous lidocaine may provide effective postoperative analgesia for patients after bariatric surgery and may accelerate their rapid recovery."

Journal • Oncology • Pain • IL6 • TNFA

A Comparison of the Analgesia Nociception Index and Nociception Level Index Under General Anesthesia With Propofol and Remifentanil. (PubMed, Anesth Analg) - "The modest agreement between ANI and NOL underscores discrepancies likely stemming from their different methodological approaches. These findings suggest that a multimodal strategy integrating various monitoring modalities may enhance intraoperative analgesic management."

Journal • Anesthesia • Pain

Clinical outcomes of monitored anesthesia care vs. general anesthesia in transfemoral transcatheter aortic valve implantation: a single-center retrospective study. (PubMed, Front Cardiovasc Med) - "MAC involved administration of a combination of local anesthesia with dexmedetomidine/remifentanil sedation, whereas GA involved endotracheal intubation. The use of MAC for TAVI is comparably safe to using GA, with potential advantages in recovery speed and resource utilization. A heart team approach, including cardiac anesthesiologists, is critical for optimal patient selection."

Clinical data • Journal • Retrospective data • Anesthesia • Cardiovascular • Hypotension

Remimazolam-Based Anesthetic Management in a Patient with Severe Aortic Stenosis and Myelodysplastic Syndrome-Related Thrombocytopenia: A Case Report. (PubMed, J Clin Med) - "Transient systolic hypertension during surgical stimulation was controlled using remifentanil titration and esmolol. Recovery and the postoperative course were uneventful, and the patient was discharged in a stable condition. Remimazolam-based total intravenous anesthesia can provide hemodynamic stability without vasopressors in high-risk patients with severe AS, and a transfusion strategy adjusted step by step according to the patient's response can be effective for optimizing PLTs while minimizing the transfusion-related risks of MDS-associated thrombocytopenia."

Journal • Anesthesia • Cardiovascular • Hematological Disorders • Hematological Malignancies • Hypertension • Myelodysplastic Syndrome • Oncology • Thrombocytopenia

Effects of different anesthetics on remifentanil-induced postinfusion hyperalgesia in patients undergoing percutaneous endoscopic interlaminar discectomy: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - "In this study, we investigated the effects of different anesthetics (remimazolam, propofol or sevoflurane) on RPH. The mechanical pain thresholds for the dominant inner forearm, postoperative pain intensity, sufentanil consumption, and side effects were similar among the three groups. Continuous infusion of Propofol or remimazolam attenuated RPH but not acute pain or analgesic consumption after PEID, potentially lowering the risk of chronic pain."

Journal • Anesthesia • Pain

ROCVIDEO: Remifentanil Versus Rocuronium for Optimizing Video Laryngoscopy-assisted Tracheal Intubation (clinicaltrials.gov) - P4 | N=2648 | Recruiting | Sponsor: Nordsjaellands Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Sep 2026 ➔ Apr 2027 | Trial primary completion date: Jun 2026 ➔ Apr 2027

Enrollment open • Intubation • Trial completion date • Trial primary completion date • Anesthesia

Management of a difficult airway for multispace infection of the floor of the mouth: A case report. (PubMed, Medicine (Baltimore)) - "This is the first reported case of diabetic ketoacidosis with severe trismus and multispace infection managed by ATI using an epidural catheter fixed to a channel-less fiberoptic bronchoscope for sequential topical anesthesia. The technique offers an alternative when standard devices are impossible or contraindicated."

Journal • Anesthesia • Diabetes • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Type 1 Diabetes Mellitus

Effects of Transcutaneous Electrical Acupoint Stimulation on Recovery After Gynecological Laparoscopic Surgery: A Randomized, Single-Blind, Controlled Trial. (PubMed, J Pain Res) - "Additionally, the TEAS group exhibited lower blood glucose levels 30 minutes after skin incision (P=0.045), reduced intraoperative remifentanil consumption (P=0.031), fewer total and effective PCA demands (P=0.004 and P=0.039, respectively), and earlier recovery of gastrointestinal function (all P<0.05). Perioperative TEAS effectively reduces the incidence of early postoperative nausea and vomiting and enhances recovery quality in patients undergoing gynecological laparoscopic surgery, but the improvements in QoR-30 scores were statistically significant but not clinically significant. These benefits may be attributed to attenuated stress responses, improved sleep quality, and decreased analgesic requirements."

Journal • Anesthesia • Gynecology • Pain

Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: Ataturk University

New trial • Anesthesia

Perioperative Multimodal General Anesthesia Focusing on Specific Central Nervous System Targets Does Not Reduce Postoperative Interleukin-6 and Neurofilament Light Levels in Patients Undergoing Cardiac Surgeries: A Randomized Controlled Trial. (PubMed, J Cardiothorac Vasc Anesth) - "MMGA did not reduce postoperative IL-6 or NFL levels, nor did it improve neurocognitive outcomes, compared with standard of care. The higher burst suppression in the MMGA group underscores the need for structured EEG education among cardiac anesthesiologists. Future studies should explore other EEG metrics and multimodal strategies for perioperative brain protection."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Cognitive Disorders • Pain • IL6 • NEFL

TKA: Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients (clinicaltrials.gov) - P4 | N=162 | Recruiting | Sponsor: Qianfoshan Hospital

New P4 trial • Orthopedics • Pain

Comparison of the effects of different general anesthesia methods on the quality of early postoperative recovery in patients undergoing metabolic bariatric surgery: A randomized controlled trial. (PubMed, J Physiol Pharmacol) - "In both groups, patients received propofol, remifentanil and rocuronium for induction...In Group S, anesthesia was maintained with sevoflurane and remifentanil...No significant intergroup difference in QoR-40 scores was observed at 48 h postoperatively, and NRS scores were comparable between groups at both time points. The study results indicate that propofol intravenous anesthesia is associated with better recovery quality at 24 h after metabolic bariatric surgery, while the recovery difference between the two methods diminishes by 48 h."

Clinical • Journal • Anesthesia • Genetic Disorders • Obesity • Pain

Anesthetic Management Using Remimazolam for Dental Treatment in a Pediatric Patient With Dravet Syndrome. (PubMed, Anesth Prog) - "After a slow mask induction with sevoflurane, RMZ, remifentanil, and rocuronium were administered to facilitate oral intubation, after which general anesthesia was maintained with air, oxygen, and continuous infusions of RMZ and remifentanil. Intraoperative temperature and other vital signs were stable, and no fever or convulsions were observed during the perioperative period. RMZ is an ultrashort-acting benzodiazepine that may be useful for the anesthetic management of pediatric patients with DS because of its potential to prevent seizures."

Journal • Anesthesia • CNS Disorders • Epilepsy • Pediatrics

Effects of electroacupuncture on the incidence of postoperative supraventricular arrhythmia and sleep quality in patients undergoing thoracoscopic surgery: a randomized controlled trial. (PubMed, Front Neurol) - P=N/A | "Dosage of remifentanil and incidence of intraoperative hypotension were significantly reduced in the EA group (911.1 vs. 1095.9, p = 0.01)...This potential impact on future treatments should inspire hope and optimism in the medical community. https://www.chictr.org.cn/indexEN.html, identifier ChiCTR2300077984."

Clinical • Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Hypotension • Lung Cancer • Oncology • Sleep Disorder • Solid Tumor • Ventricular Tachycardia

Different interventions in preventing sufentanil-induced cough: a systematic review and network meta-analysis. (PubMed, Front Pharmacol) - "Additionally, remifentanil and esketamine were effective in reducing both the overall incidence of SIC and the incidence of moderate to severe SIC...The remaining interventions indicated a trend toward reducing SIC incidence; however, this was not statistically significant. https://www.crd.york.ac.uk/PROSPERO/view/CRD42024581866 , PROSPERO (CRD42024581866)."

Journal • Retrospective data • Review • Anesthesia • Cough • Respiratory Diseases

Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery (clinicaltrials.gov) - P=N/A | N=204 | Not yet recruiting | Sponsor: Seoul National University Hospital

New trial • Anesthesia • Otorhinolaryngology

Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Fudan University

New trial • Anesthesia • Colorectal Cancer • Oncology • Solid Tumor

Effect of low-dose remifentanil infusion on emergence agitation after general anaesthesia in patients undergoing intracranial surgery: study protocol of a randomised controlled trial. (PubMed, BMJ Open) - P=N/A | "Findings will be disseminated through peer-reviewed publications and conference presentations. ChiCTR2500096691."

Clinical protocol • Journal • Anesthesia • CNS Disorders • Pain

Effective remimazolam induction dose in paediatric same-day bidirectional endoscopy: A biased coin up and down sequential trial. (PubMed, Br J Clin Pharmacol) - P=N/A | "In the induction of anaesthesia for same-day BDE, combined with 0.5 μg/kg of remifentanil, the younger the age, the higher the dose of sedative medication required. The ED90 of remimazolam was 0.67 mg/kg [90% confidence interval (CI), 0.66-0.76] in preschool children and 0.45 mg/kg (90% CI, 0.42-0.59) in school children."

Journal • Anesthesia • Pain • Pediatrics

Effect of the index of consciousness 2 on intraoperative opioid dosage in ovarian cancer patients receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial. (PubMed, BMJ Open) - P=N/A | "The experimental group will adjust the remifentanil plasma target concentration based on the IOC2 value, while the control group will adjust according to the patients' mean arterial pressure. The primary outcome will be intraoperative opioid use (calculated in morphine equivalents per hour)...The study results will be published in peer-reviewed journals and presented at relevant academic conferences. ChiCTR2400091897."

Clinical protocol • Journal • Anesthesia • Oncology • Ovarian Cancer • Pain • Solid Tumor

Remifentanil-Propofol versus Propofol Alone in Patients with Severe Traumatic Brain Injury: A Retrospective Cohort Study on Anesthesia Outcomes. (PubMed, Drug Des Devel Ther) - " For severe TBI surgery, remifentanil-propofol is associated with faster emergence, better hemodynamic control, reduced pain/agitation, attenuated neuro-inflammation, and improved long-term recovery versus propofol alone, suggesting significant clinical benefits. Prospective studies are warranted for confirmation."

Clinical • Journal • Retrospective data • Anesthesia • CNS Disorders • Inflammation • Pain • Vascular Neurology • IL6 • TNFA

Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: University of Padova

New trial • Anesthesia

Efficacy of ultrasound-guided intermediate versus superficial cervical plexus block on the quality of postoperative recovery after anterior cervical discectomy and fusion: a randomized controlled trial. (PubMed, Minerva Anestesiol) - "Compared with those who had SCPB, patients who received ICPB experienced a mild but statistically significant improvement in the quality of postoperative recovery, particularly in terms of reduced movement-related pain, decreased analgesic use, and lower incidence of nausea and vomiting."

Clinical • Journal • Anesthesia • Pain