erythromycin stearate / Generic mfg. - LARVOL DELTA

Antibiotic prescribing trends in primary care 2014-2022. (PubMed, Res Social Adm Pharm) - "Trends for Amoxicillin, Amoxicillin sodium, Trimethoprim, Clarithromycin, Erythromycin, Erythromycin ethylsuccinate, Erythromycin stearate, Doxycycline hyclate, Doxycycline monohydrate and Phenoxymethylpenicillin (Penicillin V) were determined. This study provides further evidence of the link between locality and poorer health outcomes (reflected in higher antibiotic prescribing). Further work is required to address antibiotic use in hot spot areas."

Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease

Mathermycin, an anti-cancer molecule that targets cell surface phospholipids. (PubMed, Toxicol Appl Pharmacol) - "Furthermore, mathermycin exhibited similar cytotoxicity toward cancer and multidrug resistant cancer cells, which could be due to its ability to inhibit mitochondrial function, as shown by our data from the Seahorse™ metabolic analyzer. This study demonstrates that mathermycin is a potentially effective class of anti-tumor chemotherapeutics that do not easily develop resistance due to a mechanism of action targeting PE."

Journal • Oncology

Antibiotic potentiation of natural products: A promising target to fight pathogenic bacteria. (PubMed, Curr Drug Targets) - "Plant-derived compounds such as gallic acid and tannic acid are effective potentiators of various antibiotics including novobiocin, chlorobiocin, coumermycin, fusidic acid, and rifampicin, resulting in a 4-fold increase in the potencies of these antibiotics. Several lines of research, as discussed in this review, have demonstrated the effectiveness of natural products in potentiating existing antibiotics. For this reason, the search for more efficient combinations should be an ongoing process with the aim to extend the life of the ones that we have and maybe preserve the life for the ones that is yet to come."

Journal • Infectious Disease • Novel Coronavirus Disease

"@bpoindexterMD @crmartin90 @sgrohwargo @TanisRD @klindermycin @NiniAlja @MandyBelfort_MD @EneFairchild @thetingting @hckap" (@neo_nutrition)

Effect of bambermycin and dietary distillers grains concentration on growth performance and carcass characteristics of finishing steers. (PubMed, Transl Anim Sci) - "Liver abscess occurrence was not affected (P ≥ 0.17) by MFA, mDGS, or their interaction. Results from this experiment indicate that including bambermycin in feedlot diets containing 30% mDGS results in increased DMI when compared with including monensin and tylosin in 30% mDGS diet without the risk for increases in liver abscess occurrence."

Journal • Hepatology

Lactoquinomycin C and D, two new medermycin derivatives from the marine-derived Streptomyces sp. SS17A. (PubMed, Nat Prod Res) - "Compounds 1 and 2 exhibited no cytotoxicity against PC-3 and HCT-116 cancer cell lines, whereas compound 3 showed stronger cytotoxicity with IC values of 0.02 and 0.04 μM, respectively. A structure-activity relationship was observed for the cytotoxicity of the medermycin derivatives with a γ-lactone unit is required for significant cytotoxicity based on compounds 1-3."

Journal • Oncology

Growth Phase Dependent Chromosome Condensation and H-NS Protein Redistribution in Escherichia coli Under Osmotic Stress. (PubMed, J Bacteriol) - "We found this behavior is related to mechanical properties of the bacterial chromosome, in particular, how tightly twisted and coiled is the chromosomal DNA. This behavior might act as a biomechanical response to stress that coordinates the expression of genes involved in adapting bacteria to a salty environment."

Journal

Structural Basis for DNA Gyrase Interaction with Coumermycin A1. (PubMed, J Med Chem) - "The inhibited dimers from different species adopt distinct sequence-dependent conformations, alternative to the ATP-bound form. These structures provide a basis for the rational development of coumermycin A1 derivatives for antibiotherapy and biotechnology applications."

Journal

Mechanism of Inhibition of Hsp90 Dimerization by Gyrase B Inhibitor Coumermycin A1 (C-A1) Revealed by Molecular Dynamics Simulations and Thermodynamic Calculations. (PubMed) - Cell Biochem Biophys - "We believe that the detailed dynamic analyses of Hsp90 presented in this study, would give an imperative insight and better understanding to the function and mechanisms of inhibition. Furthermore, information obtained from the binding mode of the inhibitor would be of great assistance in the design of more potent inhibitors against the HIV target Hsp90."

Journal • Biosimilar • Gene Therapies

Discovery and biosynthesis of mathermycin from marine-derived Marinactinospora thermotolerans SCSIO 00652. (PubMed) - Appl Environ Microbiol - "We report here the discovery of a new lantibiotic mathermycin from the marine-derived Marinactinospora thermotolerans strain and elucidation of its biosynthesis. We also demonstrate that mathermycin possesses antimicrobial activities towards a bacillus strain."

Journal • Biosimilar

Revisiting Aminocoumarins for the Treatment of Melioidosis. (PubMed, Int J Antimicrob Agents) - "We demonstrate that coumermycin has superior pharmacokinetic properties compared with novobiocin and report that coumermycin in L-tyrosine formulation can be used as an effective treatment for acute respiratory melioidosis in the murine model. Repurposing existing approved antibiotics offers new resources in a challenging era of drug development and antimicrobial resistance."

Journal

Induction of Antibacterial Metabolites by Co-Cultivation of Two Red-Sea-Sponge-Associated Actinomycetes Micromonospora sp. UR56 and Actinokinespora sp. EG49. (PubMed, Mar Drugs) - "Moreover, their structural differences, particularly the substitution at C-1 and C-6, played a crucial role in the determination of their inhibitory spectra and potency. In conclusion, the present study highlighted that microbial co-cultivation is an efficient tool for the discovery of new antimicrobial candidates and indicated phenazines as potential lead compounds for further development as antibiotic scaffold."

Journal

Coumarin-containing hybrids and their antibacterial activities. (PubMed, Arch Pharm (Weinheim)) - "Several coumarin-containing hybrids such as coumermycin A1, clorobiocin, and novobiocin have already been used in clinical practice for the treatment of various bacterial infections; thus, it is conceivable that hybridization of the coumarin moiety with other antibacterial pharmacophores may provide opportunities for the development of novel antibiotics. This review outlines the advances in coumarin-containing hybrids with antibacterial potential in the recent 5 years and the structure-activity relationships are also discussed."

Journal • Review

A new medermycin analog from the marine-derived actinomycetes Streptomyces sp. ZS-A45. (PubMed, J Asian Nat Prod Res) - "The structure elucidation of compound 1 was determined by the HRESIMS and extensive NMR analysis. And compound 1 exhibited significant cytotoxicity against PC3 cell lines with IC values of 0.81 ± 0.42 μm."

Journal

Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39. (PubMed, J Nat Prod) - "Bioactivity evaluations of these compounds showed that compounds 3 and 4 exhibited cytotoxicity against HCT-116 and PC-3 cancer cell lines and 4 exhibited moderate inhibition of ROCK 2 protein kinase. In addition, all of the new compounds showed antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus and antifungal activity against Candida albicans."

Journal

Studies toward the synthesis of macrotermycin C: stereoselective construction of the acyclic skeleton of the aglycon. (PubMed, Org Biomol Chem) - "The important features of this synthesis study include Evans methylation, Takai olefination, Sonogashira coupling followed by selective alkyne reduction, intermolecular Heck coupling, and Wittig olefination. Intramolecular Heck coupling has been tested for macrocyclization."

Journal

"@apc_md @martinhoenigl @jschaenman @jobadd @MicrobLog_me_uk @AlainnaJJ @DocWoc71 @DoctorRachael @TMcCarty2010 @GrysClinMicro @ElliTheelPhD @FranciscoMarty_ @First10EM @Drjulietmd @FLeeMD1 @DrLuisO @Payal_Patel @klindermycin @sean_ling @sebpoule @pukears @neleshg @dan_diekema" (@GermHunterMD)

"@BradSpellberg @CarlosdelRio7 @JenniferSpicer4 @klindermycin @Cortes_Penfield @foamid @CalderwoodMD @Darcy_ID_doc @UNMC_ID @IUIDfellowship @IDdocAdi @BSchwartzinSF @AllisonRBond @Payal_Patel @JLD_ID_Doc @prasad_prithiv @MDdreamchaser @IDPittStop @Dr_Mike_Stevens @DKopeMD" (@jdcooperid)