Syntocinon Nasal Spray (oxytocin intranasal) / Vyera Pharma - LARVOL DELTA

OXYCAC: Experimental Study on Alcohol Use and Behavior in Young Adults (clinicaltrials.gov) - P2 | N=206 | Terminated | Sponsor: Karolinska Institutet | Trial completion date: Jan 2025 ➔ Apr 2025 | Recruiting ➔ Terminated | Trial primary completion date: Jan 2025 ➔ Apr 2025; Halted due to recruitment problems.

Trial completion date • Trial primary completion date • Trial termination • Addiction (Opioid and Alcohol)

OXY-APS: Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to Psychosocial Treatment (clinicaltrials.gov) - P2 | N=98 | Recruiting | Sponsor: Central Institute of Mental Health, Mannheim

New P2 trial • CNS Disorders • Psychiatry • Schizophrenia

OxyPLEASURE: Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls (clinicaltrials.gov) - P2 | N=42 | Not yet recruiting | Sponsor: University Hospital, Basel, Switzerland

New P2 trial • Metabolic Disorders • Type 2 Diabetes Mellitus

Effects of Intranasal Oxytocin in the Treatment of Benzodiazepine Withdrawal: A Pilot RCT (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: St. Olavs Hospital

New P2 trial

Oxytocin and Reward Processing in Women (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: International Research Training Group 2804 | Not yet recruiting ➔ Recruiting

Enrollment open

Oxytocin and Reward Processing in Women (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: International Research Training Group 2804

New trial

OXYCAC: Experimental Study on Alcohol Use and Behavior in Young Adults (clinicaltrials.gov) - P2 | N=220 | Recruiting | Sponsor: Karolinska Institutet

New P2 trial • Addiction (Opioid and Alcohol)

IN-OXT: Preventing Postpartum Depression With Intranasal Oxytocin (clinicaltrials.gov) - P2 | N=56 | Completed | Sponsor: Massachusetts General Hospital | Active, not recruiting ➔ Completed | N=110 ➔ 56

Enrollment change • Trial completion • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Post-traumatic Stress Disorder • Psychiatry

IN-OXT: Preventing Postpartum Depression With Intranasal Oxytocin (clinicaltrials.gov) - P2 | N=110 | Active, not recruiting | Sponsor: Massachusetts General Hospital | Trial completion date: Jan 2023 ➔ May 2023 | Trial primary completion date: Jan 2023 ➔ May 2023

Trial completion date • Trial primary completion date • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Post-traumatic Stress Disorder • Psychiatry

The use of oxytocin for Autism Spectrum Disorder with Intellectual Disability Het gebruik van Oxytocine neusspray bij kinderen met autismespectrumstoornis en een verstandelijke beperking (clinicaltrialsregister.eu) - P3 | N=100 | Sponsor: KU Leuven

New P3 trial • Autism Spectrum Disorder • Developmental Disorders • Genetic Disorders • Mental Retardation • Psychiatry

IN-OXT: Preventing Postpartum Depression With Intranasal Oxytocin (clinicaltrials.gov) - P2 | N=110 | Active, not recruiting | Sponsor: Massachusetts General Hospital | Trial completion date: Jun 2022 ➔ Dec 2022 | Trial primary completion date: Apr 2022 ➔ Dec 2022

Trial completion date • Trial primary completion date • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Post-traumatic Stress Disorder • Psychiatry

The Effects of Oxytocin in Obese Adults (clinicaltrials.gov) - P2 | N=61 | Completed | Sponsor: Massachusetts General Hospital | Active, not recruiting ➔ Completed | N=100 ➔ 61

Enrollment change • Trial completion • Genetic Disorders • Obesity

The Influence of Oxytocin on Socio-communicative Sensitivity (clinicaltrials.gov) - P1/2 | N=31 | Completed | Sponsor: KU Leuven | Unknown status ➔ Completed

Trial completion

Evaluation of tolerance, suckling and food intake after repeated nasals administrations of Oxytocin in PWS infants Etude de tolérance d’administrations intranasales répétées d’ocytocine selon 3 schémas d’administration chez des bébés présentant un syndrome de Prader-Willi (clinicaltrialsregister.eu) - P2 | N=18 | Sponsor: Centre Hospitalier de Toulouse

New P2 trial • Prader–Willi syndrome

The Effects of Oxytocin in Obese Adults (clinicaltrials.gov) - P2 | N=100 | Active, not recruiting | Sponsor: Massachusetts General Hospital | Recruiting ➔ Active, not recruiting | Trial completion date: Jan 2022 ➔ Jul 2022 | Trial primary completion date: Nov 2021 ➔ May 2022

Enrollment closed • Trial completion date • Trial primary completion date • Genetic Disorders • Obesity

Oxytocin and the development of attachment: Looking beyond the expected? Oxytocine en de ontwikkeling van gehechtheid: een blik voorbij de verwachting? (clinicaltrialsregister.eu) - P2 | N=200 | Sponsor: KU Leuven

New P2 trial • Psychiatry

The Effects of Oxytocin in Obese Adults (clinicaltrials.gov) - P2; N=100; Recruiting; Sponsor: Massachusetts General Hospital; Trial completion date: Apr 2021 ➔ Jan 2022; Trial primary completion date: Apr 2021 ➔ Nov 2021

Clinical • Trial completion date • Trial primary completion date • Genetic Disorders • Obesity

Oxytocin Trial Protocollo Ossitocina (clinicaltrialsregister.eu) - P2; N=30; Ongoing; Sponsor: AZIENDA OSPEDALIERA G. BROTZU

New P2 trial • Autism Spectrum Disorder • CNS Disorders • Genetic Disorders • Mental Retardation • Psychiatry

TOAD2015: Therapy With an Oxytocin Adjunct for Major Depression (clinicaltrials.gov) - P2; N=24; Completed; Sponsor: Concordia University, Montreal; Recruiting ➔ Completed

Trial completion • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

IN-OXT: Preventing Postpartum Depression With Intranasal Oxytocin (clinicaltrials.gov) - P2; N=110; Active, not recruiting; Sponsor: Massachusetts General Hospital; Completed ➔ Active, not recruiting; N=56 ➔ 110; Trial completion date: Mar 2020 ➔ Jun 2022; Trial primary completion date: Mar 2020 ➔ Apr 2022

Clinical • Enrollment change • Enrollment closed • Trial completion date • Trial primary completion date • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Post-traumatic Stress Disorder • Psychiatry

Oxytocin and Cognitive Control in Adult ADHD (clinicaltrials.gov) - P1; N=24; Completed; Sponsor: Massachusetts General Hospital; Recruiting ➔ Completed

Clinical • Trial completion • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

INOSO: The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity (clinicaltrials.gov) - P1/2; N=23; Completed; Sponsor: Sara Espinoza; Active, not recruiting ➔ Completed

Trial completion • Genetic Disorders • Obesity • Sarcopenia

Oxytocin and Cognitive Control in Adult ADHD (clinicaltrials.gov) - P1; N=24; Recruiting; Sponsor: Massachusetts General Hospital; Trial completion date: Sep 2020 ➔ Dec 2020; Trial primary completion date: Sep 2020 ➔ Dec 2020

Clinical • Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Influence of Oxytocin on Approach-avoidance Tendencies to Social and Non-social Stimuli (clinicaltrials.gov) - P=N/A; N=64; Completed; Sponsor: KU Leuven

New trial

Emotion recognition training combined with oxytocin in residential youth (clinicaltrialsregister.eu) - P2; N=60; Sponsor: Radboud University

New P2 trial • Psychiatry