chlorhexidine gluconate / Generic mfg. - LARVOL DELTA

Establishing an ex vivo porcine skin model to investigate the effects of broad-spectrum antiseptic on viable skin microbial communities. (PubMed, mSphere) - "Compared to water-treated control skin, skin treated with the antiseptic chlorhexidine gluconate had significantly lower culturable counts and bioburden as determined by viability-qPCR...The impacts of such agents on beneficial microbes in the skin microbiome are understudied. Here, we describe an ex vivo skin model to test the impacts of antiseptics or other topical agents on the healthy skin microbiome."

Journal • Preclinical • Infectious Disease

Impact of Chemical Disinfectants on Surface Microhardness of Acrylic Resin Denture Teeth: An In Vitro Study. (PubMed, Cureus) - "Glutaraldehyde and sodium hypochlorite significantly reduced the microhardness of acrylic resin denture teeth, whereas chlorhexidine gluconate had a minimal effect, suggesting its suitability for routine denture disinfection. Careful selection of disinfectants is crucial for maintaining the integrity of denture materials."

Journal • Preclinical

Influence of irrigants on "bond strength" of "Bio-C Repair and TheraCal LC" in "perforation repair:" An in vitro study. (PubMed, J Conserv Dent Endod) - "This study assessed the effect of "2% chlorhexidine gluconate (CHX) and etidronic acid (HEBP)" on the "dislodgment resistance" of "Bio-C Repair" and "TheraCal LC." The aim of the study was to evaluate and compare the "POBS" of "Bio-C Repair and TheraCal LC" used for "furcation perforation repair" under the influence of different irrigants...HEBP enhanced the "bond strength" of "Bio-C Repair" and appears to be a compatible irrigant for use with calcium silicate-based repair materials. Further research is required to investigate the long-term chemical and structural effects of irrigants on these materials."

Journal • Preclinical

The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal (clinicaltrials.gov) - P3 | N=848 | Recruiting | Sponsor: The Cooper Health System

New P3 trial • Genetic Disorders • Infectious Disease • Oncology • Skin Cancer

Tootbrush_ICU: The Effect of an Suction Toothbrush on the Development of Ventilator-Associated Pneumonia (clinicaltrials.gov) - P=N/A | N=90 | Active, not recruiting | Sponsor: Koç University

New trial • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Comparative Efficacy of Chlorhexidine Gluconate and Povidone-Iodine for Preoperative Skin Preparation in High- and Low-Middle-Income Countries: A Systematic Review and Meta-Analysis (ACS-CLINCON 2025) - "Abstract is embargoed at this time."

Retrospective data • Review

Alterations of the oral microbiota in mild Alzheimer's disease and the appropriate application of chlorhexidine gluconate. (PubMed, JAR Life) - P=N/A | "This research was registered with the Chinese Clinical Trial Registry (ChiCTR; Reference: ChiCTR2000032876). Registered: 14th of May 2020; http://www.chictr.org.cn/showprojen.aspx?proj=53555."

Journal • Alzheimer's Disease • CNS Disorders • Diabetes • Inflammation • Metabolic Disorders

Meta-Analysis Comparing Chlorhexidine Gluconate and Povidone-Iodine for Reducing Surgical Site Infections (ACS-CLINCON 2025) - "Abstract is embargoed at this time."

Retrospective data • Infectious Disease

DECREASE SSI: Decolonization to Reduce After-Surgery Events of Surgical Site Infection (clinicaltrials.gov) - P4 | N=2700 | Recruiting | Sponsor: University of California, Irvine | Trial primary completion date: Dec 2027 ➔ Jan 2027

Trial primary completion date • Infectious Disease

Antimicrobial Efficacy of Aloe Vera, Chlorhexidine, Hyaluronic Acid, and Diode Laser Against Periodontopathogenic Bacteria: A Mixed-Methods Study. (PubMed, Cureus) - "The 980 nm diode laser exhibited superior antibacterial efficacy for acute periodontal interventions, followed by CHX, HA, and aloe vera. These findings support the tailored use of adjunctive therapies based on exposure time and clinical needs for chronic periodontitis management."

Journal • Dental Disorders • Periodontitis

Antibacterial efficacy of sodium dichloroisocyanurate and 2-hydroxyisocaproic acid intracanal medicaments on Enterococcus faecalis: A comparative in-vitro study. (PubMed, J Oral Biol Craniofac Res) - "Comparative evaluation of antibacterial efficacy of intracanal medicaments such as sodium dichloroisocyanurate (NaDCC) and 2-hydroxyisocaproic acid (HICA) with a formulation of calcium hydroxide (Ca (OH)2) and 2 % chlorhexidine gluconate (CHX) against Enterococcus faecalis(E.faecalis)...HICA showed a significantly lower CFU count than Ca (OH)2 + 2 % CHX (p-value = .009) after 24 h. NaDCC and HICA demonstrate potent antimicrobial efficacy against E. faecalis, suggesting their potential as an alternative intracanal medicament for endodontic infection."

Journal • Preclinical • Gastrointestinal Disorder • Infectious Disease

Povidone-Iodine Versus Chlorhexidine Gluconate for Preoperative Skin Antisepsis in Various Surgical Procedures: A Systematic Review and Meta-Analysis (ACS-CLINCON 2025) - "Abstract is embargoed at this time."

Retrospective data • Review

Outcomes of Irrisept Irrigation as an Adjunctive Treatment in the Management of Diabetic Foot Ulcers (clinicaltrials.gov) - P=N/A | N=9 | Completed | Sponsor: Northern Illinois Foot and Ankle Specialists | Recruiting ➔ Completed | N=30 ➔ 9 | Trial completion date: Sep 2025 ➔ May 2025 | Trial primary completion date: Sep 2025 ➔ May 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date

Micro-hardness of root canal dentin using various irrigating solutions: An in vitro study. (PubMed, Bioinformation) - "The samples were divided into four groups: control (Normal Saline), 3% Sodium Hypochlorite, 17% EDTA, and 2% Chlorhexidine Gluconate, with each immersed in their respective irrigants for 15 minutes at 37°C...Notable differences were found between groups 2, 4, and 1, but not between 1 and 3. Consequently, 2% Chlorhexidine is considered a suitable irrigation solution as it did not negatively impact dentin microhardness."

Journal • Preclinical

Hydrogen sulfide ameliorates peritoneal fibrosis: inhibition of high mobility group box-1 expression to block the activation of the transforming growth factor-beta/Smad3 pathway. (PubMed, Med Gas Res) - "A peritoneal fibrosis model was established through the intraperitoneal injection of 0.1% chlorhexidine gluconate. Subsequently, the mice were administered an intraperitoneal injection of the H2S donor GYY4137. The experimental data indicate that H2S mitigates the progression of peritoneal fibrosis, potentially by inhibiting the expression of high mobility group box-1 and consequently blocking the activation of the (TGF-β)/Smad3 signaling pathway. This study provides a scientific basis for the future clinical application of H2S in the treatment of peritoneal fibrosis."

Journal • Fibrosis • Immunology • HMGB1 • SMAD3 • TGFB1

Alcoholic vs. aqueous chlorhexidine for abdominal surgery skin preparation: a randomized controlled trial. (PubMed, Sci Rep) - "Alcohol-based chlorhexidine gluconate (CHG) is widely used for preoperative skin preparation; however, aqueous CHG is being considered as a safer alternative in certain settings...Although SSI rates were similar, statistical equivalence was not demonstrated due to wide confidence intervals. Aqueous CHG may still be a suitable alternative where alcohol-based CHG is contraindicated."

Clinical • Journal • Infectious Disease

IP18-05 Characteristics of Inflatable Penile Prosthesis Infections After Intraoperative 0.05% Chlorhexidine Gluconate: Results From a Large Multi-Institutional Cohort: Erratum. (PubMed, J Urol) - No abstract available

Journal • Infectious Disease

Visualizing Antimicrobial Effects on Bacterial Surfaces by SEM: A Comparative Study of Hexamethyldisilazane (HMDS) and Freeze-Drying. (PubMed, Microsc Res Tech) - "When E. coli was treated with two types of disinfectant, benzalkonium chloride (BAC) and chlorhexidine gluconate (CHG), for 5 min, the number of viable bacteria fell below the detection limit...These morphological changes, which indicate the effectiveness of the disinfectants, were consistent with the results of observations of the freeze-dried specimens used as a control test. These results suggest that chemical drying with HMDS can quickly and efficiently provide morphological information to understand how disinfectants cause deformation and affect bacterial function."

Journal

Dulaglutide markedly prevents peritoneal fibrosis in a rodent model of chronic kidney disease: Insights into the pathogenesis. (PubMed, Int J Mol Med) - "In vitro Met-5A cells showed significant upregulation of inflammatory, oxidative stress, intracellular and mitochondrial reactive oxygen species (ROS), fibrotic, intracellular cytoskeletal, apoptotic and epithelial-mesenchymal transition (EMT) biomarkers, and dipeptidyl peptidase 4 (DPP4), following stimulation with a uremic toxin (p-Cresol), PF inducer [chlorhexidine gluconate (CG)] or endotoxin [lipopolysaccharide (LPS)]. At this time point, flow cytometry revealed significantly increased levels of inflammatory cells (CD11b/c+, myeloperoxidase+ and Ly6G+ cells) in the circulation and abdominal fluid, and increased peritoneal permeability in the LPS-induced peritonitis group compared with those in the SC group; these levels were significantly reversed in the LPS-induced peritonitis + dulaglutide group. In conclusion, dulaglutide may effectively maintain peritoneal integrity primarily by suppressing inflammation, oxidative stress, EMT and fibrosis."

Journal • Preclinical • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease • CD31 • CDH2 • CTNNB1 • ITGAM • MPO • PECAM1 • SMAD3 • TGFB1 • TNFA • VIM

Chlorhexidine gluconate bathing to reduce hospital-acquired infections in adult intensive care units: a best practice implementation project. (PubMed, JBI Evid Implement) - "The implementation of best practices significantly reduced HAIs in adult ICUs across the hospital. Key success factors included information technology, flat-structure communication, a top-down strategy, accountable management, and a centralized materials supply. These factors facilitated adoption of the project simultaneously across multiple units."

Journal • Allergy • Critical care • Immunology • Infectious Disease

Microbial safety of vapocoolant spray on sites for arterial line and epidural placement. (PubMed, Br J Nurs) - "There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317)...These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures."

Journal • Anesthesia

Antimicrobial efficacy of on-label vs. hand-mixed irrigation solutions against S. aureus biofilms. (PubMed, Biofilm) - "An off-label, hand-mixed 0.472 % w/v chlorhexidine gluconate solution reduced the greatest bioburden overall, with a 1.43 ± 0.20 log10 reduction...Musculoskeletal infections remain a significant clinical challenge and contribute to increasing healthcare costs. The antimicrobial efficacy of irrigation products should be assessed using clinically relevant models."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

REAGIR: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction (clinicaltrials.gov) - P3 | N=330 | Completed | Sponsor: University of California, San Francisco | Active, not recruiting ➔ Completed

Trial completion • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Patient Profile and Perioperative Care Practices Associated With the Absence of Deep Surgical Site Infections in Patients Following Coronary Artery Bypass Graft Surgery. (PubMed, J Nurs Care Qual) - "This study's findings highlight the potential effect of rigorous protocol adherence and the critical role of standardized nursing care in SSI prevention. Future research to optimize patient care and outcomes during and after CABG surgery is recommended."

Journal • Cardiovascular • Infectious Disease

The Effect of Different Cavity Disinfectants on the Bond Strength of Restorative Materials in Primary Teeth. (PubMed, J Pharm Bioallied Sci) - "This in vitro study examined the effects of three cavity disinfectants on the bond strength of restorative materials in primary teeth: 38% silver diamine fluoride (SDF), 5.25% sodium hypochlorite, and 2% chlorhexidine gluconate...Despite the decreased binding strength, SDF's antibacterial qualities point to possible therapeutic uses that merit more research. When choosing a cavity disinfectant, one should carefully consider both the product's antibacterial properties and its impact on bond strength."

Journal