chlorhexidine gluconate / Generic mfg. - LARVOL DELTA

Chlorhexidine vs Essential Oil Mouthwash for Plaque Control (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: Rehman Medical Institute - RMI

New trial • Dental Disorders • Infectious Disease

Chlorhexidine Bathing in Critically Ill Children (clinicaltrials.gov) - P=N/A | N=247 | Completed | Sponsor: Istanbul Medeniyet University | Recruiting ➔ Completed

Trial completion • Infectious Disease

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) (clinicaltrials.gov) - P2 | N=49 | Completed | Sponsor: University of North Carolina, Chapel Hill | N=37 ➔ 49

Enrollment change • Cystic Fibrosis • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases

Multifaceted infection prevention protocol is associated with reduced surgical site infection after spinal fusion: a before-and-after study. (PubMed, Spine J) - "A multifaceted SSI prevention protocol was associated with a significant reduction in SSI after spinal instrumentation surgery, supporting the adoption of standardized, multi-target prevention strategies."

Journal • Infectious Disease • Orthopedics

Genomic characterization of efflux pumps and putative small multidrug resistance (SMR)-like transporters in disinfectant-tolerant coagulase-negative staphylococci from a Vietnamese hospital. (PubMed, Microbiol Spectr) - "Here, 51 staphylococcal isolates were recovered from high-touch hospital surfaces in Hanoi, Vietnam, and 14 isolates showed elevated MICs to at least one disinfectant, including benzalkonium chloride, chlorhexidine gluconate, or hydrogen peroxide, relative to Staphylococcus aureus ATCC 25923...Genome analysis further revealed known qac genes and six putative SMR-like proteins that merit functional testing. These findings support inclusion of environmental CoNS in infection-prevention surveillance and disinfectant stewardship programs."

Journal • Infectious Disease

Chlorhexidine gluconate irrigation used at implantation lowers culture positivity in non-infected prosthesis revisions. (PubMed, J Sex Med) - No abstract available

Journal • Infectious Disease

Antimicrobial efficacy of disinfecting solutions against S. mutans on toothbrushes for school children in Uttar Pradesh, India. (PubMed, Bioinformation) - "All disinfectants significantly reduced bacterial counts compared to baseline, with the greatest reduction observed with 0.2% chlorhexidine, followed by 5% green tea. Thus, data shows that all disinfectants were effective, 0.2% chlorhexidine was the most effective and 5% green tea was a strong herbal alternative."

Journal • Dental Disorders

Constructing antimicrobial oil-in-water emulsions via spatially diffused ionic interlocking networks between chlorhexidine digluconate and polysaccharides. (PubMed, Food Res Int) - "A spatially dispersed ionic-interlocking network was constructed in a CHG/CMC/MCT oil-in-water nanoemulsion through multipoint electrostatic association between the multicationic biguanide groups of chlorhexidine gluconate (CHG) and the carboxylate groups of sodium carboxymethyl cellulose (CMC)...When applied to Gui Re Mang 82 mangoes, the optimized CGT-3 coating reduced decay incidence by 93.63% relative to the untreated control on day 12 and delayed weight loss, softening, and physicochemical deterioration without markedly interfering with normal ripening. These findings demonstrate that spatially dispersed electrostatic association can integrate emulsion stabilization, reduced CHG cytotoxicity, and sustained postharvest antimicrobial protection, providing a washable nanoemulsion coating strategy for fruit preservation."

Journal

3D-Printed poly(lactic acid)/magnesium scaffolds functionalized with chitosan-chlorhexidine gluconate microspheres for antibacterial repair of infected bone defects. (PubMed, J Mater Chem B) - "Zebrafish and rat evaluations further showed no obvious short-term abnormalities in oxidative stress-related signals, inflammatory cell-associated signals, developmental morphology, or major organ histology. In conclusion, the PLA/Mg/CTS-CHG scaffold integrated enhanced antibacterial capability with preserved osteogenic performance and represents a promising multifunctional scaffold for infected bone defect repair."

Journal • Infectious Disease

Intradiscal Cutibacterium acnes Prevalence Immediately Prior to Fusion or Total Disc Replacement Device Implantation: A Prospective Registry Study of Cervical and Lumbar Discs. (PubMed, Int J Spine Surg) - "This is the first report of disc-space swab analysis for intradiscal C acnes detection at the time of cervical and lumbar surgery. Detection prior to fusion cage or total disc replacement implantation may help characterize the microbiological environment at the implant interface and supports further investigation into strategies to reduce disc-space C acnes burden prior to implantation, particularly in total disc replacement."

Journal

Comparative evaluation of a bromelain-based endodontic irrigant versus sodium hypochlorite, chlorhexidine gluconate, and chitosan against Enterococcus faecalis - An in vitro study. (PubMed, J Conserv Dent Endod) - "BCC irrigant did not show statistically significant difference than NaOCl and chlorhexidine for antibacterial action. The novel BCC irrigant is effective in preparing dentinal surfaces for root canal without adverse effects and promising longevity."

Journal • Preclinical

Comment on 'Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial'. (PubMed, Nurs Crit Care) - No abstract available

Journal • Critical care • Infectious Disease • Pediatrics

Evaluating the efficacy of disinfecting agents against Staphylococcus aureus on external fixator devices. (PubMed, Injury) - "All disinfectants significantly reduced the bacterial load on the external fixators, supporting their safety in the sterile field. While there was no statistically significant difference in CFUs between disinfectants, the CHG + IPA group had the highest frequency of zero CFU data. In contrast, the Betadine + IPA group had the highest frequency of non-zero CFUs and the widest IQR of 0-3.8 × 102 CFUs."

Journal • Orthopedics

The Effect of Central Venous Catheter Dressings on Preventing Catheter-Related Bloodstream Infections: A Comparative Study of Patients in Intensive Care Post Abdominal Surgery. (PubMed, Cureus) - "The routine inclusion of CHG-impregnated transparent dressings in central venous catheter care protocols in intensive care units is considered a powerful strategy that can contribute to reducing the incidence of catheter-related bloodstream infections, improving patient safety, and managing care processes more effectively."

Journal • Allergy • Critical care • Immunology • Infectious Disease

A chloramine-based antiseptic polymer improves Candida auris skin decolonization compared to chlorhexidine in a murine model. (PubMed, Antimicrob Agents Chemother) - "While chlorhexidine gluconate (CHG) is widely used for general skin decolonization, it fails to reliably clear C. auris from patient skin, and no proven decolonization protocol exists...Its advantage over CHG was greater at 3 days than 7 days, likely reflecting progressive dorsal hair regrowth, a recognized limitation of the murine model. These findings support AVA-003 as a promising C. auris decolonization candidate warranting further clinical investigation."

Journal • Preclinical • Infectious Disease

Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation (clinicaltrials.gov) - P=N/A | N=120 | Completed | Sponsor: H.P. Government Dental College and Hospital Shimla

New trial • Dental Disorders • Inflammation

Chlorhexidine Gluconate as a Conducting Medium Is Noninferior to Ultrasound Gel in Ultrasound Image Quality: A Blinded, Randomized Comparative Study. (PubMed, WMJ) - "The commonly used skin antiseptic chlorhexidine gluconate with isopropyl alcohol demonstrated noninferior image quality compared with ultrasound gel and may represent a more economical alternative for ultrasound-guided interventions, with the potential to reduce infectious complications."

Clinical • Journal • Infectious Disease

In vitro analysis of antiseptic solution effects on Staphylococcus aureus biofilms on orthopedic implant materials. (PubMed, J Bone Jt Infect) - "Mature biofilms were created on stainless steel coupons using a continuous-flow reactor for 72 h, then washed for 3 min with one of six irrigation solutions: normal saline, 10 % PI (povidone-iodine), 0.35 % PI, a 10 % PI 3 % hydrogen peroxide mixture, hypochlorous acid, or 0.05 % chlorhexidine gluconate...These findings indicate that PI solutions, even at dilute concentrations, are highly effective at disrupting established biofilms on stainless steel. As an in vitro single-organism model, these findings establish a comparative efficacy baseline on a fracture-fixation-relevant surface but require validation in multispecies, multi-material, and mechanically realistic irrigation systems before clinical translation."

Journal • Preclinical • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Irrimax: Irrisept Solution for Instrumented Spine Surgery (clinicaltrials.gov) - P=N/A | N=200 | Recruiting | Sponsor: Rhode Island Hospital | Trial completion date: Sep 2026 ➔ Apr 2028 | Trial primary completion date: Sep 2026 ➔ Apr 2028

Trial completion date • Trial primary completion date • Infectious Disease • Orthopedics

Evaluating the therapeutic potential of Salacca zalacca peel ethanol extract on probing depth and gingival recession in Wistar rats with periodontitis. (PubMed, J Indian Soc Periodontol) - "On days 1, 7, and 14, the treatment group received the ethanol extract of snake fruit peel, while the positive control group received chlorhexidine gluconate...Snake fruit peel ethanol extract was associated with lower probing depth and gingival recession scores in Wistar rats with experimentally induced periodontitis. Further studies are required to confirm its biological mechanisms and therapeutic potential as an adjunctive periodontal therapy."

Journal • Preclinical • Dental Disorders • Inflammation • Periodontitis

Determining the Value of Screening and Decolonization in Burn Unit Management. (PubMed, J Burn Care Res) - "Phase 1: all patients who screened positive for MRSA received a decolonization protocol consisting of intranasal mupirocin twice daily for 5 days and daily chlorhexidine gluconate baths; Phase 2: all patients were screened but no decolonization measures were taken. No differences in length of stay, LOS/TBSA, incidence of infection by screened result or TBSA (once adjusted) or mortality were observed in either phase. The additional cost and resource utilization required for screening and decolonization did not appear to provide meaningful clinical advantage."

Journal • Infectious Disease

Using Visual Management to Improve Compliance with Chlorhexidine Gluconate Bathing and Nasal Decolonization. (PubMed, Jt Comm J Qual Patient Saf) - "This project demonstrates that visual management tools may help to improve nursing handoff communication, and CHG bathing and nasal decolonization administration and documentation."

Compliance • Journal • Infectious Disease

Exploratory Evaluation of Chlorhexidine Decolonization and Skin Colonization Dynamics of Candida auris in ICU Patients: A Prospective Pilot Study. (PubMed, Infect Drug Resist) - "Two patients (intervention group) received twice-daily 2% chlorhexidine gluconate whole-body skin decolonization; two (non-intervention group) did not, based on family consent...The small sample size, non-randomized design, baseline differences, and lack of molecular typing limit interpretation. Adequately powered, preferably randomized, studies with whole-genome sequencing are needed."

Journal • Critical care • Infectious Disease

Interpreting the evidence for chlorhexidine wound irrigation in contaminated abdominal surgery. (PubMed, World J Emerg Surg) - "recently reported a well-conducted double-blind randomized trial comparing intraoperative irrigation with 0.05% aqueous chlorhexidine gluconate (CHG) against normal saline for the prevention of surgical site infection (SSI) in abdominal surgery, concluding that CHG did not significantly reduce SSI...Third, the Discussion's suggestion of particular benefit 'in high-risk populations' is not supported by any treatment-by-subgroup interaction analysis in the manuscript. We conclude that these findings argue for a larger, stratified, culture-informed confirmatory trial rather than for adopting or abandoning CHG wound irrigation in contaminated abdominal surgery."

Journal • Infectious Disease • Orthopedics

Inhibition of Protein Arginine Methyltransferase 5 attenuates Dialysis-Related Peritoneal Fibrosis via Suppression of Angiogenesis and Inflammatory State. (PubMed, Clin Sci (Lond)) - "Genetic PRMT5 inhibition attenuated histopathological damage, extracellular matrix (ECM) deposition, angiogenesis and inflammatory infiltration induced by high-glucose PD fluid or chlorhexidine gluconate (CG), thereby improving peritoneal transport function...Furthermore, pharmacological inhibition of PRMT5 using selective PRMT5 inhibitor EPZ015666 also exhibited therapeutic efficacy in vivo. Mechanistically, our data implicates a PRMT5 mediated inflammation-angiogenesis axis in PF progression. Collectively, our findings establish PRMT5 as a pivotal, druggable epigenetic regulator in dialysis-related PF and provide a compelling rationale for clinical development of PRMT5-targeted strategies to prevent PF."

Journal • Diabetes • Fibrosis • Immunology • Inflammation • PRMT5