chlorhexidine gluconate / Generic mfg. - LARVOL DELTA

Enhancing CLABSI Prevention: Evaluating Enhanced Strategies in an Academic Medical Centre, Singapore. (PubMed, J Hosp Infect) - "Our experience demonstrated a statistically significant reduction in CLABSI rates following the three-year implementation of CHG dressings and IPA port protectors as part of routine hospital-wide preventive measures against CLABSI."

Journal • Infectious Disease

Oral health care during pregnancy to prevent preterm birth and low birth weight: study protocol for a randomized controlled trial. (PubMed, Trials) - "The oral health intervention is expected to improve both birth outcomes and maternal oral health. Demonstrating its effectiveness in a real-world setting may support the integration of oral health care into broader maternal, neonatal, and child health strategies, particularly in resource-limited settings."

Journal • Dental Disorders • Periodontitis

The Use of an Enhanced Recovery Bundle in Surgical Spine Patients to Reduce Opioid Requirements and Improve Patient Comfort. (PubMed, Orthop Nurs) - "Spine patients were receiving preoperative education, a consult with the pre-anesthesia testing clinic, a balanced anesthetic technique, antibiotics, and chlorhexidine gluconate wipes. A preoperative oral carbohydrate drink, and oral acetaminophen and gabapentin were added to make a complete ERAS bundle. This QI project found a statistically significant reduction in total morphine milligram equivalents required in the post-anesthesia recovery unit (PACU)...This QI ERAS bundle is evidence that the use of multimodal analgesia and oral carbohydrate combined with preexisting ERAS spine interventions reduce patients' total amount of narcotics and improve their overall comfort. Individually, these interventions do not appear impactful, but patient outcomes are positively impacted when bundled."

Journal • Anesthesia • Orthopedics

Pericyte-myofibroblast transition: a novel mechanism in peritoneal fibrosis and the effect of Asiaticoside. (PubMed, J Adv Res) - "Our findings repositioned pericytes as pivotal contributors to PF and proposed ASI as a therapeutic agent against PDGFRβ-driven PMT, which provided a new perspective for antifibrotic strategies."

Journal • Fibrosis • Immunology • FN1 • PDGFRB • TGFB1

Effect of a Chlorhexidine Gluconate-Based Oral Rinse Containing Natural Bioflavonoids on Soft Tissue Inflammation and Subgingival Porphyromonas Gingivalis Carriage in Patients With Peri-Implant Mucositis. (PubMed, Oral Health Prev Dent) - "Supplementing 0.12% CHX with bioflavonoids provides added clinical benefits when used as an adjunct to mechanical debridement (MD) in patients with peri-implant mucositis. This combined approach appears more effective than 0.12% CHX alone in reducing peri-implant soft-tissue inflammation and P. gingivalis carriage, indicating that bioflavonoid-enriched formulations may represent a valuable therapeutic option in routine clinical practice for improving peri-implant health."

Journal • Inflammation • Mucositis

Mesenchymal Stem Cell-Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation. (PubMed, Adv Sci (Weinh)) - "In a mouse model of peritoneal fibrosis induced by chlorhexidine gluconate (CG) or PD fluid, the administration of extracellular vesicles derived from human bone marrow mesenchymal stem cells (MSC-EVs) significantly ameliorates histological and functional changes in the peritoneum...Pharmacologic blockade of lactate production recapitulates the protective effects of MSC-EVs. These findings suggest that lactate-induced histone lactylation is a key driver of peritoneal fibrosis, positioning MSC-EVs as a promising cell-free therapeutic strategy for targeting metabolic-epigenetic inflammation in serosal injury."

Journal • Fibrosis • Immunology • Inflammation • CCL2

Evaluation of microbiological efficacy of 2% chlorhexidine gluconate cloths versus 4% chlorhexidine gluconate soap for preoperative preparation/shower in total joint arthroplasty: a single-centre randomised controlled trial. (PubMed, Antimicrob Resist Infect Control) - P=N/A | "The use of CHG cloths for preoperative preparation/shower seems to be a good alternative. These results must be confirmed by assessing the impact on SSI."

Clinical • Journal • Infectious Disease • Orthopedics

Effective nursing interventions for infection prevention and control in acute and critically ill patients with a peripherally inserted venous catheter: an umbrella review. (PubMed, Intensive Crit Care Nurs) - "This review underscores the need for nurses to consistently implement evidence-based interventions to prevent infections related to venous catheters, reduce complications, and improve patient outcomes. It reinforces the importance of ongoing education, institutional support, and leadership in fostering safer practices in acute and critical care environments."

Journal • Review • Cardiovascular • Critical care • Hematological Disorders • Infectious Disease • Thrombosis

The In Vitro Performance of Surgical Irrigation Solutions in Preventing Biofilm Formation on Implants. (PubMed, J Arthroplasty) - "Pretreatment with certain irrigation solutions for two minutes, reflecting clinical use, can significantly reduce biofilm formation on orthopaedic implant materials and may help prevent periprosthetic joint infections in TJA procedures."

Journal • Preclinical • Infectious Disease • Orthopedics

The Impact of Irrisept in Reducing Urinary Tract Infection During Urethral Catheter Removal. (clinicaltrials.gov) - P=N/A | N=300 | Recruiting | Sponsor: Ohio State University

New trial • Infectious Disease • Nephrology

Intraoperative 0.05% Chlorhexidine Gluconate Utilization Is Associated with an Increased Incidence of Infection in Hydrophilic Inflatable Penile Prosthesis Surgery: a Multi-institutional Cohort Study. (PubMed, J Urol) - "Use of 0.05% CHG with hydrophilic inflatable penile prostheses was associated with an elevated infection rate. For hydrophilic IPP surgery, caution with 0.05% CHG use is warranted pending additional prospective evaluation."

Journal • Erectile Dysfunction • Infectious Disease

Hands-on training for preoperative skin preparation improves compliance with manufacturer instructions for use. (PubMed, Am J Surg) - "Single hands-on training significantly improved compliance and was associated with improved SSI ratings. However, the effect was not durable, highlighting need for ongoing education and sustained surveillance to achieve lasting improvement."

Compliance • Journal • Infectious Disease

The effects of povidone-ıodine and chlorhexidine gluconate on the ocular surface after phacoemulsification cataract surgery. (PubMed, Int Ophthalmol) - "Both PI and CHG caused transient ocular surface changes after cataract surgery. However, CHG demonstrated faster recovery of tear film parameters and improved early postoperative comfort, suggesting it may be a preferable antiseptic in patients with ocular surface sensitivity."

Clinical • Journal • Cataract • Ophthalmology • Pain

Effect of Chlorhexidine Solution on the Tensile Bond Strength and Hardness of Two Soft Liners With Denture Base Resin: An In-Vitro Comparative Study. (PubMed, Cureus) - "Chlorhexidine gluconate solution, recommended as a denture cleanser, may alter these properties...Ufi Gel P showed better compatibility with chlorhexidine solution than Permasoft, under disinfectant exposure. While chemical denture cleansers are effective for oral hygiene, their impact on material properties should be carefully considered in clinical practice."

Journal • Preclinical

Non-surgical sterilization of male animals using sclerosing agents: A systematic review of intratesticular and intraepididymal injection protocols. (PubMed, Reprod Biol) - "Among sixteen substances, calcium chloride was the most frequently studied, followed by zinc gluconate, hypertonic saline, chlorhexidine gluconate, mannitol, and glycerol...Nevertheless, calcium chloride and hypertonic saline emerged as the most promising candidates, due to their robust mechanistic profiles, broad evidence base, and favorable cost-effectiveness. Therefore, researchers may prioritize these two agents in future studies to develop standardized, safe, and field-applicable protocols for large-scale population control."

Journal • Review • Infertility • Sexual Disorders

STING-Mediated Cytosolic DNA Sensing as a Novel Mechanism of Peritoneal Damage: Evidence from Transcriptomic and Functional Studies (KIDNEY WEEK 2025) - "Methods Different mouse models of peritoneal damage were done: a model of peritoneal exposure to 0.1% chlorhexidine gluconate (CHX), a S. epidermidis -induced peritonitis model, and a post-surgical intra-abdominal adhesion model...Moreover, STING overexpression was observed in human peritoneal biopsies from PD patients, highlighting its clinical relevance. Conclusion This study identifies the STING-mediated cytosolic DNA-sensing pathway as a novel pathogenic mechanism in peritoneal damage and proposes STING as a potential therapeutic target in PD-related peritoneal injury."

Fibrosis • Immunology • Inflammation • STING

Metabolic-Epigenetic Mechanism of Peritoneal Fibrosis Targeted by Mesenchymal Stem Cell-Derived Extracellular Vesicles (KIDNEY WEEK 2025) - "Methods A chlorhexidine gluconate (CG)-induced peritoneal fibrosis mouse model was treated with human bone marrow MSC-EVs...Pharmacological inhibition of lactate production mirrored the anti-fibrotic effects of MSC-EVs, further confirming the critical role of metabolic reprogramming. Conclusion These findings highlight lactate-induced histone lactylation as a key driver of peritoneal fibrosis and position MSC-EVs as a promising cell-free therapeutic strategy for targeting metabolic-epigenetic inflammation in serosal injury."

Fibrosis • Immunology • Inflammation • CCL2 • CCR2

A pH-responsive anthocyanin-based hydrogel with colorimetric infection monitoring and antibacterial properties for wound healing. (PubMed, J Mater Chem B) - "Simultaneously, it releases the antimicrobial agent chlorhexidine gluconate in a pH-dependent manner to enhance infection control...In vitro studies demonstrated excellent cytocompatibility, while in vivo evaluation using a mouse alkali burn wound model revealed significant improvement in wound healing and inflammation reduction. This work provides a promising platform for intelligent wound care by combining diagnostic and therapeutic functionalities in a single, biocompatible material."

Journal • Infectious Disease • Inflammation

Efficacy of Generic 2% Chlorhexidine Gluconate in 70% Alcohol Versus ChloraPrep for Preventing Surgical Site Infections in Orthopedic Surgery: A Scoping Review. (PubMed, Cureus) - "Early evidence suggests that generic 2% chlorhexidine in 70% alcohol may effectively reduce infection and bacterial load in orthopedic surgery. Further rigorously designed randomized comparisons are needed to guide practice and procurement."

Journal • Review • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Healthcare practitioners' perspectives on infection management, antimicrobial resistance and stewardship in wound care practice. (PubMed, J Wound Care) - "Antimicrobial dressings such as silver, iodine, polyhexamethylene biguanide, chlorhexidine gluconate and honey were reported to be used by 88.2% of participants, with 41% reporting 'just in case' use of antimicrobial dressings...The lack of consistency in AMS leadership reported within clinical settings may indicate a variation in protocols and practice across wound care. Greater integration of evidence-based guidance, education and leadership as part of wider AMS structures and teams are needed to support consistent antimicrobial use and mitigate AMR in wound care."

Journal • Infectious Disease

Perioperative Anaphylaxis And Cardiac Arrest Triggered By Chlorhexidine: A Diagnostic Challenge (ACAAI 2025) - "The day prior to surgery, she applied Chlorhexidine Gluconate (CHG) wipes to her entire body...Rocuronium testing remained negative...The delayed cutaneous reaction followed by life-threatening anaphylaxis underscores the importance of a thorough history and targeted testing, especially in the absence of common triggers. Persistent mild tryptasemia raises concern for mast cell activation despite negative genetic testing."

Cardiovascular • Dermatology • Immunology • Urticaria

Long-term efficacy of chlorhexidine-containing cutaneous dressings on ventriculostomy-related infection: a 10-year before-and-after study. (PubMed, Neurosurg Focus) - P=N/A | "The occurrence of EVDAIs was significantly reduced when using additional CHX dressings (8%), compared to silver-coated EVDs alone (19%), without extending antibiotic prophylaxis or using antibiotic-impregnated catheters as a valid alternative in terms of antibiotic stewardship. This finding should encourage the neurosurgical community to generate more awareness in using and evaluating postoperative measures that prevent this impactful complication in further research."

Clinical • Journal • Retrospective data • CNS Disorders • Infectious Disease • Ventriculomegaly

European Guideline on Pre-Operative Prevention of Surgical Site Infections Following Digestive Surgery: A Joint Update of the WHO SSI Guideline for Gastrointestinal Surgery by UEG, ESCP, EAES, and SIS-E. (PubMed, United European Gastroenterol J) - "Aqueous chlorhexidine gluconate versus aqueous povidone-iodine for surgical field preparation Pre-operative dexamethasone in single-dose versus no pre-operative dexamethasone for patients undergoing GI surgery. Discontinuing Vedolizumab preoperatively versus continuing Vedolizumab preoperatively for patients undergoing GI surgery. Discontinuing Ustekinumab preoperatively versus continuing Ustekinumab preoperatively for patients undergoing GI surgery."

Journal • Infectious Disease

Effectiveness of Preoperative Antiseptic Preparation in Transnasal Skull Base Surgery: A Randomized Three-Arm Controlled Trial. (PubMed, J Neurol Surg B Skull Base) - "Participants were randomized to either of three antiseptic preparation techniques: external 0.9% NaCl nasal preparation, external 0.05% chlorhexidine gluconate, or intranasal irrigation with 80 mg of gentamicin added to 1,000 mL of 0.9% NaCl plus external nasal preparation with chlorhexidine gluconate 0.05%. There were no clinically meaningful or significant differences in the studied intervention groups regarding postoperative infectious complications. Preoperative antiseptic techniques failed to prefer one application to prevent postoperative infectious complications in patients who underwent endoscopic transnasal skull base surgery."

Journal • Allergy • Chordoma • CNS Disorders • Immunology • Infectious Disease • Otorhinolaryngology • Pediatrics • Respiratory Diseases • Sinusitis

Incidence of local complications following implementation of alcoholic chlorhexidine for peripheral venous catheter site disinfection. (PubMed, Antimicrob Steward Healthc Epidemiol) - "A previous controlled study showed advantages of 2% Chlorhexidine Gluconate-Alcohol (CHG) over Povidone-Iodine-Alcohol in preventing infections after peripheral venous catheter placement. We applied these findings in a real-world before/after healthcare intervention and found that introduction of CHG disinfection was not associated with a major change of incidence in local skin complications."

Journal • Infectious Disease