suplatast tosilate (ME-015) / Melius Pharma - LARVOL DELTA

Marked response to dupilumab in an elderly patient with eosinophilic annular erythema. (PubMed, JAAD Case Rep) - No abstract available

Journal • Dermatology

Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF) (clinicaltrials.gov) - P2 | N=40 | Active, not recruiting | Sponsor: Melius Pharma AB | Recruiting ➔ Active, not recruiting

Enrollment closed • Chronic Cough • Cough • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

ME015 - PrEP in Europe: current gaps and solutions (ESCMID Global 2025) - "Despite being licensed and available on prescription, the "PrEP gap" (referring to individuals eligible for but not currently on PrEP) in Europe is still too large, hindering efforts toward HIV elimination. This session will describe the current situation regarding PrEP roll-out and standards of care in Europe, as well as address missed opportunities and factors impeding its wider spread use, such as resource or cost restrictions, war, migration, and solutions to improve the situation."

Human Immunodeficiency Virus • Infectious Disease

Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF) (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: Melius Pharma AB | Not yet recruiting ➔ Recruiting | Trial completion date: Mar 2025 ➔ Sep 2025 | Trial primary completion date: Mar 2025 ➔ Aug 2025

Enrollment open • Trial completion date • Trial primary completion date • Chronic Cough • Cough • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

ON THE CORRELATION BETWEEN GASTROINTESTINAL SYMPTOMS AND SITES FOR ENDOSCOPIC BIOPSIES TO DIAGNOSE GRAFT-VERSUS-HOST DISEASE. (DDW 2024) - "Methods We analyzed the medical records of all patients hospitalized at Montefiore Medical Center (Jan 1 st 015- Jan 1 st 0 3) with diagnosed GVHD and GI symptoms who underwent both EGD and Colonoscopy with biopsies...Despite the limitation of a small cohort the anatomic distribution of GI symptoms with positive biopsies in GVHD was nearly absolute. Additional multicenter trials with larger cohorts are needed to further validate these results."

Biopsy • Bone Marrow Transplantation • Gastrointestinal Disorder • Graft versus Host Disease • Immunology • Transplantation

Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF) (clinicaltrials.gov) - P2 | N=40 | Not yet recruiting | Sponsor: Melius Pharma AB

New P2 trial • Cough • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

Inhibition of suplatast tosilate on EPSC in the single paratracheal ganglion neurons attached with presynaptic boutons. (PubMed, J Neurophysiol) - "Using single neurons of rat paratracheal ganglia (PTG) attached with presynaptic boutons, the effects of suplatast tosilate on excitatory postsynaptic currents (EPSC) were investigated with nystatin-perforated patch-clamp recording technique. Suplatast also inhibited the EPSCs potentiated by bradykinin (BK), but it did not affect the potentiation itself by BK. Thus, suplatast inhibited the EPSC of PTG neurons attached with presynaptic boutons at both of presynaptic and postsynaptic sites."

Journal

Genetic Diversity and New Sequence Types of Escherichia coli Coharboring β-Lactamases and PMQR Genes Isolated from Domestic Dogs in Central Panama. (PubMed, Genes (Basel)) - "In the intestinal strains of E. coli isolated from domestic dogs, there was a high frequency of resistance to antibiotics. The presence of genes from plasmids and chromosomal mutations that conferred antibiotic resistance, the identification of isolates previously reported in humans, and the genetic diversity of STs (including three that were newly identified) confirmed the determinants of resistance to antibiotics in the domestic dogs from central Panama."

Journal

Pharmaceutical targeting Th2-mediated immunity enhances immunotherapy response in breast cancer. (PubMed, J Transl Med) - "Our findings demonstrate that pharmaceutical inhibition of Th2 cell function improves ICB response via remodeling immune landscape of TME, which illustrates a promising combinatorial immunotherapy."

Journal • Breast Cancer • Immune Modulation • Inflammation • Oncology • Solid Tumor • CD4 • CD8 • IL4

Prevalence of Heavy Metal and Disinfectant Resistance Genes in Salmonella Enterica and Their Association with Antibiotic Resistance (ASM Microbe 2022) - "The ars(B) gene was detected only in serotypes Saint Paul (ST50) and Coeln (ST2015), while the genes merA, silA and pcoA were widely distributed across multiple serotypes and STs...In conclusion, this study demonstrates the association of HMR and DR genes in the acquisition of antimicrobial resistance genes. Moreover, the wide distribution of these genes across different STs and serotypes reflect their widespread mobility and selection due to the accumulation of metals in the environment."

Infectious Disease

Molecular Characterization of Klebsiella Pneumoniae and Enterobacter Cloacae Isolates Harboring BlaOXA-181 and BlaOXA-48 (ASM Microbe 2022) - "While EFN299 belonged to ST11, EFN262 belonged to ST5015... This study underscores the significant contribution of IncX3 and IncL in the dissemination of resistance genes. The efficient transfer of these plasmids among the bacterial species calls for regular monitoring to control the expansion of resistant strains"

Infectious Disease • Pneumonia

Successful use of montelukast in eosinophilic gastroenteritis: a case report and a literature review. (PubMed, BMC Gastroenterol) - "Montelukast may be an effective treatment for eosinophilic gastroenteritis, either alone or in combination with systemic steroids or ketotifen. Our patient is the second reported adult case of eosinophilic gastroenteritis who responded to montelukast alone as a first line therapy. Further studies and clinical trials are required to confirm efficacy compared to standard therapy."

Clinical • Journal • Review • Allergy • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Immunology • Pain • IL4 • IL5

The effect on patient life quality of prophylactic treatment to seasonal allergic rhinitis and related transcriptomics research (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "Polymerase Chain Reaction (PCR) verification of differentially expressed genes indicated that the relative expression level of HLA-G in prophylactic group was significantly lower than that in control group (0.23±0.19 vs 1.00±0.49,t=4.016, P=0.006). The prophylactic treatment of suplatast tosilate showed some benefit to the life quality of seasonal AR patients during the pollen season, and the potential mechanism might be related with the downregulation of IL-12 and IL-23 pathways and decreased expression of HLA-G."

Clinical • Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • IL12A • PCR

Suplatast tosilate in patients with interstitial cystitis: Efficacy and treatment possibilities, with suggestions for future assessments. (PubMed, Int J Urol) - "Comparison of interstitial cystitis symptom score changes suggested that the placebo effect was very small. Use of diagnostic hydrodistention was considered to be a major difference in the population characteristics of the studies and may have resulted in different observed efficacies. Diagnostic hydrodistention, which potentially influences the treatment effect, is probably not essential for trials of suplatast in interstitial cystitis patients."

Clinical • Journal • Interstitial Cystitis

Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress. (PubMed, Free Radic Biol Med) - "These findings demonstrate that suplatast tosilate could be a useful lung-protective agent that acts via suppression of oxidative stress associated with thoracic radiotherapy."

Journal • Preclinical • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Respiratory Diseases • Thoracic Cancer

Antimicrobial resistance and molecular characterization of Neisseria gonorrhoeae isolates in Fukuoka, Japan, from 1996 to 2016. (PubMed, J Glob Antimicrob Resist) - "N. gonorrhoeae isolates with decreased susceptibilities or resistance to ESC have increased over the years, in Fukuoka, Japan. Four major STs with a multi-drug resistance phenotype were identified. These isolates contained a penA mosaic allele or a non-mosaic allele in PBP2."

Journal • Complement-mediated Rare Disorders