Maalox (aluminum hydroxide/simethicone/magnesium hydroxide) / Sanofi - LARVOL DELTA

Unique Case of Vanishing Bile Duct Syndrome Exacerbated by Noncompliance (ACG 2024) - "She was treated with cholestyramine, ursodiol, simethicone, maalox, and prednisolone. The patient was prescribed both amoxicillin and amoxicillin-clavulanic acid within a 3 month period which points to dose-dependent cause, which differs from the more documented idiosyncratic cause. This case was unique because of the exacerbated nature of disease due to noncompliance."

Clinical • Cardiovascular • Celiac Disease • Cholestasis • Fatigue • Fibrosis • Gastroenterology • Hepatology • Hypertension • Immunology • Inflammation • Liver Failure • Nephrology • Pain • Type 1 Diabetes Mellitus

Famotidine and Antacids for Treatment of Dyspepsia (clinicaltrials.gov) - P4 | N=80 | Recruiting | Sponsor: Stony Brook University

New P4 trial • Dyspepsia • Gastroesophageal Reflux Disease

Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review. (PubMed, Clin Oral Investig) - "Out of the five studies included in this systematic review, only one was able to provide some weak evidence that ACV is an effective treatment, improving healing of oral lesions and reducing duration of symptoms."

Clinical • Journal • Review • Herpes Simplex • Infectious Disease • Pain

Rare Incidence of Granular Cell Tumor in the Esophagus Causing Obstructive and Reflux Symptoms (ACG 2023) - "Symptoms were uncontrolled despite home medications including pantoprazole, famotidine, Maalox and sucralfate as well as a high fiber diet...He further reported episodes of constipation for which he was started on metoclopramide...There was sonographic evidence suggesting parenchymal invasion into the trachea (manifested by abutment). Figure 1c: Endoscopic ultrasound guided core biopsy of the esophageal lesion using H&E Stain shows diffuse proliferation of uniform epithelioid cells with abundant eosinophilic granular cytoplasm and small nuclei in muscularis propria (blue arrow), consistent with a granular cell tumor."

Anemia • Barrett Esophagus • Chronic Obstructive Pulmonary Disease • Constipation • Esophageal Cancer • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Immunology • Infectious Disease • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

"@sanofi why cannot I get maalox tablets in the USA?" (@Hollyweird_Wood)

"When my kids had - mix desatin with nystatin and Maalox and apply and leave open to air" (@SusanMaltserDO)

Results From Phase I Studies Investigating the Dose Linearity of Finerenone Tablets and the Influence of Food or pH-Modifying Comedications on its Pharmacokinetics in Healthy Male Volunteers. (PubMed, Eur J Drug Metab Pharmacokinet) - "The pharmacokinetics of the finerenone film-coated tablet were linear. High-fat, high-calorie food had no clinically relevant effect on the pharmacokinetics of finerenone. In addition, pH-modifying comedications were not found to alter the pharmacokinetics of finerenone and were deemed safe for co-administration."

Journal • P1 data • PK/PD data • Cardiovascular • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

A Study to Evaluate a New Tablet Formulation of Lu AG06466 in Healthy Participants (clinicaltrials.gov) - P1; N=16; Completed; Sponsor: H. Lundbeck A/S; Recruiting ➔ Completed

Clinical • Trial completion

"I like maalox and pepcid. Personally ive taken the lido cocktails and im not a fan of the numbness in the mouth/tongue." (@bougiemedic)

[VIRTUAL] SPONTANEOUS PNEUMOMEDIASTINUM DUE TO SUSPECTED OCCULT ESOPHAGEAL PERFORATION WITH CO-EXISTENT INTERSTITIAL LUNG DISEASE (CHEST 2021) - "In the ED she was given broad spectrum antibiotics, fluids, pepcid, lidocaine and maalox and all oral intake was then held. As with our case, spontaneous pneumomediastinum even with concomitant interstitial fibrosis, can be due to a prior esophageal microperforation etiology in an older female, and be stably managed without significant invasive interventions."

Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hypertension • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Interstitial Lung Disease • Otorhinolaryngology • Pain • Pulmonary Disease • Respiratory Diseases

[VIRTUAL] ACUTE RESPIRATORY FAILURE FROM HYPERMAGNESEMIA REQUIRING PROLONGED MECHANICAL VENTILATION (CHEST 2021) - "This was thought to be cause of his flaccid paralysis and hence was initiated on Intravenous fluids along with Lasix. N/A"

Acute Kidney Injury • Back Pain • Cardiovascular • CNS Disorders • Constipation • Diabetes • Diabetic Nephropathy • Gastroenterology • Gastrointestinal Disorder • Hypertension • Hypotension • Metabolic Disorders • Musculoskeletal Pain • Nephrology • Pain • Renal Disease • Respiratory Diseases • Vascular Neurology

A Study to Evaluate a New Tablet Formulation of Lu AG06466 in Healthy Participants (clinicaltrials.gov) - P1; N=18; Recruiting; Sponsor: H. Lundbeck A/S

Clinical • New P1 trial

"Per non sapere né leggere né scrivere, io sto comprando azioni di @sanofi considerando il boom di vendite di #Maalox" (@i_am_the_sea)

Effects of Magnesium, Calcium, and Aluminum Chelation on Fluoroquinolone Absorption Rate and Bioavailability: A Computational Study. (PubMed, Pharmaceutics) - "However, when administered orally, reduced absorption and bioavailability can occur due to chelation in the gastrointestinal tract (GIT) with multivalent metal cations acquired from diet, coadministered compounds (sucralfate, didanosine), or drug formulation. Quantum mechanical calculations elucidated FQ-metal binding energies, which were leveraged to predict the magnitude of reduced bioavailability via a quantitative structure-property relationship (QSPR). This work will help inform clinical FQ formulation design, alert to possible dietary effects, and shed light on drug-drug interactions resulting from coadministration at an earlier stage in the drug development pipeline."

Journal • Gastrointestinal Disorder • Infectious Disease

"Ma è lo stesso tizio che per mesi aveva fatto da testimonial inconsapevole al #maalox prodotto dalla casa farmaceutica francese @sanofi?" (@anticofuturo)

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness. (PubMed, Sci Rep) - "These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats."

Journal • Preclinical

[VIRTUAL] Comparing Clinical Outcomes of GI Cocktail versus Antacid alone (ASHP 2020) - "The goal of this study was to assess the efficacy of GI Cocktail (10 ml dicyclomine, 30 ml Maalox™, and 10 ml viscous lidocaine) vs. antacid (Maalox™/Mylanta). Previous clinical trials1-7 have shown the use of GI cocktail having no improvement in symptoms or pain versus antacid alone. One previous double-blinded study compared Mylanta alone, Mylanta and Donnatal, or Mylanta, Donnatal and lidocaine to assess which combination provided the most relief of dyspepsia in emergency room patients. Their results concluded that the addition of Donnatal or Donnatal plus lidocaine did not significantly relieve dyspepsia more than antacid alone4."

Clinical • Clinical data • Anesthesia • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Pain

"Meraviglioso lui...da panico il Maalox 🤮" (@tiziueb)

"Io me li immagino su Twitter sotto le foto delle ragazze: "DM per fare una partnership per il farmaco Maalox"" (@IlFuRyuzaki)

Licensing / partnership

"@Sanofi dovreste pagare la tifoseria gobba per tutte le sponsorizzazioni che fanno al Maalox" (@IlFuRyuzaki)

[VIRTUAL] Spontaneous Intramural Hematoma of the Esophagus Presenting With Chest Pain (ACG 2020) - "Her daily aspirin was discontinued due to risk of bleeding. She was started on Carafate and Maalox for symptomatic relief and discharged after resolution of her presenting symptoms...Surgery and therapeutic angiography are reserved for patients who are hemodynamically unstable. Ultimately, IHE is an important entity to identify since conservative management is appropriate in most cases and patients can be reassured of its benign nature."

Hypertension • Pain • Thrombosis

Pharmacokinetic Interaction Study Between Saxagliptin and Omeprazole, Famotidine, or Magnesium and Aluminum Hydroxides Plus Simethicone in Healthy Subjects: An Open-Label Randomized Crossover Study. (PubMed, Clin Pharmacol Drug Dev) - "Saxagliptin in combination with these medicines resulted in no unexpected safety or tolerability findings in these healthy subjects. No dose adjustment of saxagliptin or separation in the time of saxagliptin dosing is necessary with medicines that raise gastric pH when coadministered with saxagliptin."

Clinical • Journal • PK/PD data • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Caveat Medicus: Clinician experiences in publishing reports of serious oncology-associated adverse drug reactions. (PubMed, PLoS One) - "Big data, registries, Data Safety Monitoring Boards, and pharmacogenetic studies may facilitate improved pharmacovigilance efforts for oncology-associated adverse drug reactions. These initiatives overcome concerns related to complacency, indifference, ignorance, and system-level problems as barriers to documenting and reporting adverse drug events- barriers that have been previously reported for clinician reporting of serious adverse drug reactions."

Adverse drug reaction • Clinical • Journal • Oncology

"Bring back Maalox!!!" (@EyleenNad)

Biosimilar

The Effect of Antacids and Multivitamins on Raltegravir (clinicaltrials.gov) - P1; N=15; Active, not recruiting; Sponsor: Helen Reynolds; Recruiting ➔ Active, not recruiting

Enrollment closed • Biosimilar • Gene Therapies • Human Immunodeficiency Virus