Maalox (aluminum hydroxide/simethicone/magnesium hydroxide) / Sanofi - LARVOL DELTA

Impact of Patient and Disease Characteristics on the Effectiveness of Vonoprazan in Chinese Patients With Reflux Esophagitis: Post-Hoc Analysis of the Multicenter Prospective VIEW Study (ACG 2025) - P=N/A | "Among the 1877 patients included in the RE safety analysis population, mean (SD) age was 49.7 (13.4) years and body mass index (SD) was 24.1 (3.5) kg/m2; 64.4% were male. The mean (SD) heartburn frequency score decreased from 1.3 (1.20) at baseline to 0.5 (0.84) at week 4 (mean change: −0.8; 95% CI: −0.90, −0.78); the regurgitation frequency score decreased from 1.4 (1.16) at baseline to 0.6 (0.91) at week 4 (mean change: −0.8; 95% CI: −0.83, −0.71); difficulty getting good night's sleep due to heartburn/regurgitation decreased from 0.9 (1.09) at baseline to 0.3 (0.70) at week 4 (mean change: −0.6; 95% CI: −0.61, −0.50); and the frequency of taking additional medication for heartburn/regurgitation decreased from 0.5 (0.96) at baseline to 0.1 (0.54) at week 4 (mean change: −0.3; 95% CI: −0.38, −0.28) (Table 1). Improvements in symptom frequencies persisted across the subgroup categories by age, RE severity, and hiatal hernia size."

Clinical • Retrospective data • CNS Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Sleep Disorder

EFFECTIVENESS AND SAFETY OF VONOPRAZAN IN CHINESE PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE: POST HOC ANALYSIS OF A MULTICENTRE, PROSPECTIVE, REAL-WORLD STUDY (UEGW 2025) - P=N/A | "This real-world subgroup analysis of Chinese patients with GERD demonstrated that vonoprazan effectively relieved symptoms, improved GerdQ scores and reduced the need for additional medications while maintaining an acceptable safety profile."

Clinical • Real-world • Real-world evidence • Retrospective data • Gastroenterology • Gastroesophageal Reflux Disease

Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients (clinicaltrials.gov) - P4 | N=30 | Recruiting | Sponsor: The University of Texas Health Science Center, Houston | Not yet recruiting ➔ Recruiting

Enrollment open • Pain • Pediatrics

Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients (clinicaltrials.gov) - P4 | N=30 | Not yet recruiting | Sponsor: The University of Texas Health Science Center, Houston

New P4 trial • Pain • Pediatrics

Point spread function measurements for underwater imaging: an analysis of wavelength-specific behavior for image deconvolution. (PubMed, Opt Express) - "Image deconvolutions of a test target with correct and wrong color PSF indicate the relevance of wavelength-specific PSF consideration, especially in correcting channels of longer wavelengths. The results also indicate, that PSFs derived from models that are based on single wavelength PSF measurements can be used to effectively restore images at different wavelength when acquired over long scattering ranges and being scaled properly."

Journal

Unique Case of Vanishing Bile Duct Syndrome Exacerbated by Noncompliance (ACG 2024) - "She was treated with cholestyramine, ursodiol, simethicone, maalox, and prednisolone. The patient was prescribed both amoxicillin and amoxicillin-clavulanic acid within a 3 month period which points to dose-dependent cause, which differs from the more documented idiosyncratic cause. This case was unique because of the exacerbated nature of disease due to noncompliance."

Clinical • Cardiovascular • Celiac Disease • Cholestasis • Fatigue • Fibrosis • Gastroenterology • Hepatology • Hypertension • Immunology • Inflammation • Liver Failure • Nephrology • Pain • Type 1 Diabetes Mellitus

Famotidine and Antacids for Treatment of Dyspepsia (clinicaltrials.gov) - P4 | N=80 | Recruiting | Sponsor: Stony Brook University

New P4 trial • Dyspepsia • Gastroesophageal Reflux Disease

Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review. (PubMed, Clin Oral Investig) - "Out of the five studies included in this systematic review, only one was able to provide some weak evidence that ACV is an effective treatment, improving healing of oral lesions and reducing duration of symptoms."

Clinical • Journal • Review • Herpes Simplex • Infectious Disease • Pain

Rare Incidence of Granular Cell Tumor in the Esophagus Causing Obstructive and Reflux Symptoms (ACG 2023) - "Symptoms were uncontrolled despite home medications including pantoprazole, famotidine, Maalox and sucralfate as well as a high fiber diet...He further reported episodes of constipation for which he was started on metoclopramide...There was sonographic evidence suggesting parenchymal invasion into the trachea (manifested by abutment). Figure 1c: Endoscopic ultrasound guided core biopsy of the esophageal lesion using H&E Stain shows diffuse proliferation of uniform epithelioid cells with abundant eosinophilic granular cytoplasm and small nuclei in muscularis propria (blue arrow), consistent with a granular cell tumor."

Anemia • Barrett Esophagus • Chronic Obstructive Pulmonary Disease • Constipation • Esophageal Cancer • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Immunology • Infectious Disease • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

"@sanofi why cannot I get maalox tablets in the USA?" (@Hollyweird_Wood)

"When my kids had - mix desatin with nystatin and Maalox and apply and leave open to air" (@SusanMaltserDO)

Results From Phase I Studies Investigating the Dose Linearity of Finerenone Tablets and the Influence of Food or pH-Modifying Comedications on its Pharmacokinetics in Healthy Male Volunteers. (PubMed, Eur J Drug Metab Pharmacokinet) - "The pharmacokinetics of the finerenone film-coated tablet were linear. High-fat, high-calorie food had no clinically relevant effect on the pharmacokinetics of finerenone. In addition, pH-modifying comedications were not found to alter the pharmacokinetics of finerenone and were deemed safe for co-administration."

Journal • P1 data • PK/PD data • Cardiovascular • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

A Study to Evaluate a New Tablet Formulation of Lu AG06466 in Healthy Participants (clinicaltrials.gov) - P1; N=16; Completed; Sponsor: H. Lundbeck A/S; Recruiting ➔ Completed

Clinical • Trial completion

"I like maalox and pepcid. Personally ive taken the lido cocktails and im not a fan of the numbness in the mouth/tongue." (@bougiemedic)

[VIRTUAL] SPONTANEOUS PNEUMOMEDIASTINUM DUE TO SUSPECTED OCCULT ESOPHAGEAL PERFORATION WITH CO-EXISTENT INTERSTITIAL LUNG DISEASE (CHEST 2021) - "In the ED she was given broad spectrum antibiotics, fluids, pepcid, lidocaine and maalox and all oral intake was then held. As with our case, spontaneous pneumomediastinum even with concomitant interstitial fibrosis, can be due to a prior esophageal microperforation etiology in an older female, and be stably managed without significant invasive interventions."

Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hypertension • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Interstitial Lung Disease • Otorhinolaryngology • Pain • Pulmonary Disease • Respiratory Diseases

[VIRTUAL] ACUTE RESPIRATORY FAILURE FROM HYPERMAGNESEMIA REQUIRING PROLONGED MECHANICAL VENTILATION (CHEST 2021) - "This was thought to be cause of his flaccid paralysis and hence was initiated on Intravenous fluids along with Lasix. N/A"

Acute Kidney Injury • Back Pain • Cardiovascular • CNS Disorders • Constipation • Diabetes • Diabetic Nephropathy • Gastroenterology • Gastrointestinal Disorder • Hypertension • Hypotension • Metabolic Disorders • Musculoskeletal Pain • Nephrology • Pain • Renal Disease • Respiratory Diseases • Vascular Neurology

A Study to Evaluate a New Tablet Formulation of Lu AG06466 in Healthy Participants (clinicaltrials.gov) - P1; N=18; Recruiting; Sponsor: H. Lundbeck A/S

Clinical • New P1 trial

"Per non sapere né leggere né scrivere, io sto comprando azioni di @sanofi considerando il boom di vendite di #Maalox" (@i_am_the_sea)

Effects of Magnesium, Calcium, and Aluminum Chelation on Fluoroquinolone Absorption Rate and Bioavailability: A Computational Study. (PubMed, Pharmaceutics) - "However, when administered orally, reduced absorption and bioavailability can occur due to chelation in the gastrointestinal tract (GIT) with multivalent metal cations acquired from diet, coadministered compounds (sucralfate, didanosine), or drug formulation. Quantum mechanical calculations elucidated FQ-metal binding energies, which were leveraged to predict the magnitude of reduced bioavailability via a quantitative structure-property relationship (QSPR). This work will help inform clinical FQ formulation design, alert to possible dietary effects, and shed light on drug-drug interactions resulting from coadministration at an earlier stage in the drug development pipeline."

Journal • Gastrointestinal Disorder • Infectious Disease

"Ma è lo stesso tizio che per mesi aveva fatto da testimonial inconsapevole al #maalox prodotto dalla casa farmaceutica francese @sanofi?" (@anticofuturo)

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness. (PubMed, Sci Rep) - "These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats."

Journal • Preclinical

[VIRTUAL] Comparing Clinical Outcomes of GI Cocktail versus Antacid alone (ASHP 2020) - "The goal of this study was to assess the efficacy of GI Cocktail (10 ml dicyclomine, 30 ml Maalox™, and 10 ml viscous lidocaine) vs. antacid (Maalox™/Mylanta). Previous clinical trials1-7 have shown the use of GI cocktail having no improvement in symptoms or pain versus antacid alone. One previous double-blinded study compared Mylanta alone, Mylanta and Donnatal, or Mylanta, Donnatal and lidocaine to assess which combination provided the most relief of dyspepsia in emergency room patients. Their results concluded that the addition of Donnatal or Donnatal plus lidocaine did not significantly relieve dyspepsia more than antacid alone4."

Clinical • Clinical data • Anesthesia • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Pain

"Meraviglioso lui...da panico il Maalox 🤮" (@tiziueb)

"Io me li immagino su Twitter sotto le foto delle ragazze: "DM per fare una partnership per il farmaco Maalox"" (@IlFuRyuzaki)

Licensing / partnership

"@Sanofi dovreste pagare la tifoseria gobba per tutte le sponsorizzazioni che fanno al Maalox" (@IlFuRyuzaki)