cefazolin / Generic mfg. - LARVOL DELTA

Antimicrobial Resistance Profiles, Resistance Genes, and Their Association with Bacteriophage Susceptibility Among Vibrio parahaemolyticus Isolates from Zhanjiang Shrimp Aquaculture Farms. (PubMed, Microorganisms) - "High resistance was observed against kanamycin (95.5%), sulfamethoxazole (94.7%), cefazolin (78.8%), imipenem (78.8%), amoxicillin (70.5%), and ampicillin (65.2%). Association analysis revealed significant links between tetA, tetB, blaOXA, and bacteriophage responses. These findings suggest that antimicrobial resistance and reduced phage susceptibility can co-occur among V. parahaemolyticus isolates recovered from shrimp farms in Zhanjiang, highlighting the need for regional resistance surveillance and careful phage selection."

Journal

Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-Susceptible Staphylococcus aureus Bone and Joint Infections: A Narrative Review. (PubMed, Antibiotics (Basel)) - "This narrative review summarizes the randomized and observational evidence with emphasis on osteoarticular populations and discusses the cefazolin inoculum effect, bone pharmacokinetics, the safety of prolonged therapy, outpatient practicality and current guidelines. We conclude that cefazolin is a rational first-line option for most patients with MSSA BJI, outline the remaining uncertainties in high-inoculum and implant-associated infection, and propose a focus-specific research agenda."

Journal • Review • Infectious Disease • Inflammation

Antibiotic-chemotherapy interaction in brain tumors: cefazolin reduces chemotherapeutic efficacy of irinotecan in glioblastoma and neuroblastoma cells. (PubMed, Med Oncol) - "These findings suggest that cefazolin may antagonize the cytotoxic effects of irinotecan in vitro. This study highlights the potential for antibiotic-chemotherapy interactions and underscores the need for further validation in in vivo and clinically relevant models."

Journal • Brain Cancer • Glioblastoma • Infectious Disease • Neuroblastoma • Oncology • Solid Tumor

A Closed-Loop Clinical Audit of Preoperative Antibiotic Prophylaxis Adherence for Surgical Procedures at Care Medical Hospital-Alrawabi in Riyadh, Saudi Arabia. (PubMed, Cureus) - "In addition, all patients in the second audit cycle received prophylactic antibiotics; cefazolin use increased substantially, and inappropriate broad-spectrum antibiotic use was eliminated...Conclusion This audit demonstrated that structured education and coordinated system-based changes can significantly improve adherence to preoperative antibiotic prophylaxis standards. Continuous auditing and stewardship efforts are essential to sustain improvements, optimize surgical care, and enhance patient safety."

Journal • Infectious Disease

Esophageal Blebs as a Clue to Occult Descending Aortic Dissection (ACG 2026) - "He received pantoprazole, octreotide, ceftriaxone, and fluids, then was transferred for EGD...Blood cultures grew MSSA, suspected from leg wounds, and cefazolin was started...Although imaging showed no compression, coexistence of esophageal submucosal discoloration and thoracic aortic intramural pathology suggests an association. Figure: Localized moderate mucosal changes characterized by congestion, erythema, erosion and altered texture were found in the lower third of the esophagus Figure: Esophageal blebbing seen on EGD"

Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Epilepsy • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Nicotine Addiction • Pneumonia • Portal Hypertension • Respiratory Diseases • Thrombosis

Efficacy of Prophylactic Antibiotics in Ambulatory ERCP Stent Removal and Exchange: A Large-Scale Propensity Score-Matched Analysis (ACG 2026) - "The antibiotic cohort received pre-procedure prophylactic antibiotics (ciprofloxacin, levofloxacin, cefazolin, ceftriaxone) on the same day as the ERCP procedure and were compared to matched controls who did not receive any antibiotics. PSM yielded 17,472 matched patients in the combined cohort (8,736 per group). At 7 days, the antibiotic group demonstrated a significantly reduced incidence of bacteremia (OR 0.66; p=0.001), cholangitis (OR 0.78; p=0.010), sepsis (OR 0.67; p< 0.001), and mortality (OR 0.58; p=0.006). In subgroup PSM analysis for stent removal only cohort (N=9,748; 4,874 per group), antibiotics reduced 7-day incidence of bacteremia (OR 0.62;p=0.046) and sepsis (OR 0.68; p=0.016), with sustained 30-day benefit for bacteremia (OR 0.68; p=0.037)."

Clinical • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Neutropenia • Primary Sclerosing Cholangitis • Septic Shock

A Silent Consequence of Deferred Cholecystectomy: Gallbladder-Associated MSSA Hepatic Abscess With Aortic Root Pseudoaneurysm (ACG 2026) - "He underwent bioprosthetic aortic valve replacement with patch repair and was discharged on intravenous cefazolin...Figure: Axial MRI demonstrating a bilobed hepatic collection with the medial component inseparable from a decompressed, thick-walled gallbladder, consistent with gallbladder-associated hepatic abscess. Figure: There is focal aneurysmal dilatation of the aortic root adjacent to the right coronary cusp of the aortic valve."

Cardiovascular • Gastroenterology • Hepatology • Infectious Disease

Ceftriaxone versus cefazolin plus gentamicin for antibiotic prophylaxis in Gustilo-Anderson type III open lower extremity fractures. (PubMed, J Orthop Trauma) - "Ceftriaxone monotherapy demonstrated similar rate of FRI and complications compared to cefazolin plus gentamicin for Gustilo-Anderson type III open lower extremity fractures. Severity of the open fracture and time to antibiotics were independently associated with higher infection risk regardless of antibiotic regimen."

Journal • Acute Kidney Injury • Infectious Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) (clinicaltrials.gov) - P=N/A | N=300 | Recruiting | Sponsor: University Hospital, Ghent | Trial completion date: Jul 2026 ➔ Jul 2029 | Trial primary completion date: Jul 2026 ➔ Jul 2029

Trial completion date • Trial primary completion date • Pediatrics

Increased Risk of Periprosthetic Joint Infection Following Aseptic Revision Hip and Knee Arthroplasty With the Use of Non-Cefazolin Alternative Antibiotics. (PubMed, J Arthroplasty) - "Perioperative cefazolin prophylaxis is a critical modifiable risk factor, providing a substantial protective effect against PJI in aseptic revision TJA. In contrast, extended oral antibiotic prophylaxis provided no additional benefit for culture-negative patients. While UPCs occurred in 4% of cases, only one case subsequently developed PJI with a concordant microorganism. These findings reinforce the importance of standardized cefazolin prophylaxis over alternative agents in aseptic revision TJA."

Journal • Infectious Disease • Orthopedics • Pain

Optimizing Infection Risk in Primary Total Knee Arthroplasty: A Narrative Review of Current Concepts, Controversies, and Evidence Gaps. (PubMed, Cureus) - "Cefazolin remains the preferred prophylactic agent, although the optimal regimen for patients with true beta-lactam allergy or resistant-organism risk remains uncertain...Recent randomized evidence does not support routine intrawound vancomycin powder in primary TKA because it did not reduce infection and was associated with more minor wound complications...Current evidence favors systematic host optimization, microbial-burden reduction, appropriate systemic prophylaxis, standardized antisepsis, efficient high-quality surgery, and structured wound surveillance, while selective use of controversial adjuncts should be guided by patient risk and local protocols. Future research should prioritize registry-nested randomized trials, standardized definitions of high-risk patients, procedure-specific outcomes, antimicrobial-stewardship measures, cost-effectiveness, and implementation studies evaluating complete perioperative prevention bundles."

Journal • Review • Allergy • Hematological Disorders • Immunology • Infectious Disease • Orthopedics • Pain

Discovering repurposable drugs for Alzheimer's disease and related dementias: target trial emulation using decentralised real-world data. (PubMed, EBioMedicine) - "20 widely used medications may be associated with reduced progression from MCI to ADRD and represent promising candidates for clinical evaluation as repurposed therapies for dementia."

Journal • Real-world evidence • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Pain

Predictors of Prolonged Length of Stay and Perioperative Antibiotic Use Patterns in General Surgery: A Single-Centre Observational Study. (PubMed, Hosp Pharm) - "In contrast, intraoperative cefazolin use (AOR 0.08, 95% CI: 0.02-0.39) and absence of postoperative antibiotics (AOR 0.41, 95% CI: 0.21-0.79) were favourable markers associated with shorter hospitalization. Prolonged LOS in general surgery is primarily driven by disease severity and surgical complexity. Adherence to guideline-recommended surgical antimicrobial prophylaxis and the absence of need for postoperative antibiotics are favourable markers of uncomplicated recovery, supporting health system efficiency and antimicrobial stewardship goals."

Journal • Observational data • CRP

Differential risk signals of cutaneous adverse drug reactions among β-lactam antibiotics: ceftriaxone shows increased signals for SJS/TEN in clinical and real-world cohorts. (PubMed, Front Med (Lausanne)) - "Separate analyses were conducted comparing ceftriaxone with aminopenicillins, cefazolin, cefuroxime, and allopurinol, which was included as a positive control. While both datasets need to be interpreted within the context of their respective limitations, our analysis, are in line with previous studies, suggesting that ceftriaxone may have an SJS/TEN risk profile that exceeds the class-wide risk observed among cephalosporins. This underscores the importance of substance-specific, rather than purely class-based approaches in both clinical research and pharmacovigilance."

Adverse drug reaction • Journal • Real-world evidence • Steven-Johnson Syndrome

Optimization of culture read times using full microbiology laboratory automation. (PubMed, J Clin Microbiol) - "Minor and major errors were rare; however, elevated error rates were observed for specific drugs (e.g., cefazolin, piperacillin/tazobactam, nitrofurantoin, and linezolid), largely due to a limited number of susceptible isolates and breakpoint-related challenges. These findings support the use of earlier culture read time points in MLA workflows, enabling faster turnaround of clinically actionable results. Implementation of optimized incubation times has the potential to improve laboratory efficiency and accelerate patient care decisions while maintaining diagnostic reliability."

Journal • Infectious Disease

Antimicrobial prophylaxis for medical (local anaesthetic) thoracoscopy: a review of literature (ERS 2026) - "Only one randomised controlled trial (n=100) compared prophylactic cefazolin with placebo and demonstrated no difference in infective complications, with no cases of empyema or wound infection in either group...Current evidence does not robustly support routine prophylactic antibiotic use in medical thoracoscopy. Infection rates appear low irrespective of prophylaxis, though data are limited and largely observational."

Review • Infectious Disease • Respiratory Diseases

Impact of Intravenous Antibiotic Selection on Postoperative Head and Neck Osseous Free Flap Reconstruction Outcomes (AAO-HNSF 2026) - "They were categorized according to post-op IV antibiotic regimen, including Ampicillin-Sulbactam, Cefazolin-Metronidazole, Clindamycin, and Lexofloxacin, administered within 3, 7, or 14 days post-op...There was a higher risk of pneumonia with 14 day course of Levofloxacin and both 7 and 14 day courses of Cefazolin-Metronidazole... Unasyn was associated with a decreased overall risk of post-op complications after osseous free flap reconstruction compared to other regimens. These results emphasize the importance of evidence-based post-op antibiotic selection considering complication risks."

Cardiovascular • Infectious Disease • Nephrology • Otorhinolaryngology • Pneumonia • Respiratory Diseases

Trends of Intraoperative Antibiotic Prophylaxis for Thyroid and Parathyroid Surgery and Evaluation of Postoperative Outcomes (AAO-HNSF 2026) - "Adults (≥ 18 years) who underwent thyroid or parathyroid surgery for benign disease were grouped on whether they did or did not receive antibiotic prophylaxis with cefazolin, ampicillin/sulbactam, or piperacillin/tazobactam. Increased antibiotic use before 2019 may be associated with increased risk of C. diff infection despite low SSI risk. After 2019, intraoperative prophylaxis decreased, but antibiotic use persisted despite low SSI risk."

Surgery • Infectious Disease • Otorhinolaryngology

Interspinous Bursitis due to Staphylococcus aureus in an Adolescent. (PubMed, Case Rep Pediatr) - "Cefazolin IV (10 days) followed by oral ciprofloxacin (4 weeks), a lumbar brace, and rehabilitation yielded complete recovery...Conservative management with early antibiotic switch is effective when imaging excludes bone/disc involvement. This case highlights distinguishing features and optimal management of this rare pediatric entity."

Journal • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Pediatrics

Cefazolin versus Cefmetazole for Surgical Antibiotic Prophylaxis in Total Hip Arthroplasty: Impact on Postoperative Infection Rates. (PubMed, J Infect Chemother) - "No significant difference existed in postoperative infection rates between first- and second-generation cephems prophylaxis in primary THA. Given that supply constraints and other issues may affect CEZ availability, CMZ may be considered as an alternative."

Journal • Immunology • Infectious Disease • Orthopedics • Osteoarthritis • Pain • Rheumatology

Perioperative antibiotic prophylaxis in trauma surgery and orthopedics (PubMed, Unfallchirurgie (Heidelb)) - "The standard is cefazolin 2 g i.v. or cefuroxime 1.5 g i.v., administered approximately 30 min before skin incision. Prolonged antibiotic administration should be avoided."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

RECURRENT PERIOPERATIVE CEFAZOLIN ANAPHYLAXIS PRESENTING AS INTRAOPERATIVE PEA ARREST (CHEST 2026) - No abstract available

Cardiovascular • Respiratory Diseases

PROPHYLAXIS TURNED PERILOUS, TOXIC EPIDERMAL NECROLYSIS SECONDARY TO CEFAZOLIN (CHEST 2026) - No abstract available

Steven-Johnson Syndrome

Screening and Characterization of a Probiotic Fish-Derived Enterococcus faecium and Its Co-Fermentation with Acanthopanax senticosus Extract Modulate Growth and Immunity in Crucian Carp(Carassius auratus). (PubMed, Microb Pathog) - "Antimicrobial susceptibility testing revealed that it was sensitive to 16 tested antibiotics, with resistance only to cefazolin...Although the present study was conducted under laboratory conditions, these findings have confirmed its practical value as a green feed additive for aquaculture. Nevertheless, further validation is still required regarding its specific application effects under actual farming conditions."

Journal • Hematological Disorders • CAT • IL1B • TNFA

A new era in the treatment ofStaphylococcus aureusbacteremia: cefazolin becomes first choice (PubMed, Ned Tijdschr Geneeskd) - "Cefazolin is non-inferior to flucloxacillin in the treatment of MSSA bacteremia and is associated with less AKI."

Journal • Acute Kidney Injury • Nephrology • Renal Disease