cefazolin / Generic mfg. - LARVOL DELTA

Prevalence and Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Effects of Antimicrobial Use in Multiple Pig Industry Sectors in Korea. (PubMed, Ann Lab Med) - "Pig-derived E. coli isolates had antimicrobial resistance (AMR) rates of 80.4%, 47.2%, 32.6%, 36.7%, 43.4%, 62.4%, and 72.1% to ampicillin, piperacillin, cefazoline, ciprofloxacin, cotrimoxazole, chloramphenicol, and tetracycline, respectively. The findings highlight the significance of elucidating AMR networks among humans, animals, and the environment. Prudent antimicrobial usage and continuous AMR monitoring in the pig industry are crucial to safeguard food safety."

Journal

Antibiotic prophylaxis in elective laparoscopic cholecystectomy: a narrative review of efficacy, safety, and antimicrobial stewardship. (PubMed, Ann Med Surg (Lond)) - "Evidence indicates that single- or multiple-dose regimens, most commonly cefazolin, reduce superficial SSI by 33-39% (relative risk 0.61-0.67; P < 0.01), equating to absolute risk reductions of 1.5-2.0% and numbers needed to treat between 30 and 50...Current guidelines from leading surgical and infectious-disease societies recommend against routine prophylaxis in healthy individuals undergoing elective procedures to support antimicrobial stewardship. While selective prophylaxis may be warranted for patients with identifiable risk factors such as intraoperative bile spillage or significant comorbidities, routine administration in otherwise low-risk elective LC is not justified by the balance of evidence."

Journal • Review • Allergy • Infectious Disease

Cefazolin pharmacokinetics during prolonged intermittent kidney replacement therapy. (PubMed, Anaesth Intensive Care) - "Optimising antimicrobial dosing in this population is essential yet challenging owing to altered pharmacokinetics in critical illness and the wide variability of prescriptions utilised in kidney replacement therapy. This case report investigates the pharmacokinetics of cefazolin in a critically ill patient receiving prolonged intermittent kidney replacement therapy, offering insights into dosing considerations in this clinical setting."

Journal • PK/PD data • Acute Kidney Injury • Nephrology • Renal Disease

Aetiopathogenesis and Treatment Evaluation of Odontogenic Cellulitis in the Maxillofacial Region: a Retrospective Study. (PubMed, J Oral Maxillofac Res) - "The most frequently detected pathogens - the streptococcus group - are characterized by a high sensitivity to penicillin and clindamycin as well as third-generation cephalosporins. The most effective empirical antibiotic therapy is a combination of cefazolin and metronidazole and cefuroxime and metronidazole. Diabetes mellitus, lung disease, alternating antibiotic therapy and complications prolong the duration of treatment."

Journal • Retrospective data • Review • Critical care • Dermatology • Diabetes • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

Community-acquired pneumonia-causing bacteria and antibiotic resistance rate among Syrian patients. (PubMed, J Infect Dev Ctries) - "These findings underscore the importance of being able to adapt the general World Health Organization recommendations according to local evidence. It is crucial to emphasize the need for continuous local monitoring, functioning and well-equipped laboratories, and well-trained specialists in infectious diseases in hospitals to be able to make these decisions."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

iPACK Block vs. Periarticular Infiltration for TKA Pain Control (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: Turgutlu State Hospital

New trial • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology

Pharmacokinetics Study of Cefazolin in Hemodialysis (CEFAZODIAL) (clinicaltrials.gov) - P4 | N=32 | Active, not recruiting | Sponsor: University Hospital, Tours | Recruiting ➔ Active, not recruiting | N=50 ➔ 32 | Trial completion date: Jul 2025 ➔ Dec 2025 | Trial primary completion date: Jul 2025 ➔ Dec 2025

Enrollment change • Enrollment closed • Trial completion date • Trial primary completion date • Infectious Disease

Antibiotic prophylaxis in trauma and orthopedic surgery : Current practices across 36 German hospitals and comparison with recently published national guidelines. (PubMed, Unfallchirurgie (Heidelb)) - "While guideline adherence is high in routine indications, significant deviations remain in open fractures and distal phalanx fractures of the fingers. Extended prophylaxis beyond 72 h in GA type III fractures and the frequent use of antibiotics in distal phalanx injuries contrast with current recommendations. Stronger implementation of national standards is essential to reduce overtreatment and support antimicrobial stewardship."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery. (PubMed, Infect Control Hosp Epidemiol) - "In a propensity-matched cohort of adult cardiac or neurosurgical procedures (n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically non-significant (-0.6%, 95% CI-2.3 to 1.1; p = 0.57). The 0% infection rate among cardiac cases receiving continuous cefazolin infusion warrants further investigation."

Journal • Infectious Disease

Optimizing perioperative antibiotic prophylaxis: a prospective cohort study on cefazolin utilization in surgical patients with penicillin allergy labels. (PubMed, Perioper Med (Lond)) - "Antibiotic stewardship based on consensus guidelines led to a significant increase in cefazolin usage in patients with penicillin allergy labels. Employing this strategy has the potential to enhance patient safety, reduce surgical site infections, and mitigate healthcare costs."

Journal • Allergy • Immunology • Infectious Disease

Case Report: Acute methicillin-sensitive Staphylococcus aureus pericarditis in a diabetic patient. (PubMed, Front Cardiovasc Med) - "Surgical drainage was successful and the patient completed 6 weeks of intravenous cefazolin with full recovery...Invasive diagnostic strategies may be critical for achieving a microbiological diagnosis and ensuring timely source control. Multidisciplinary collaboration is essential when managing complex pericardial infections to optimize diagnostic certainty and outcomes."

Journal • Cardiomyopathy • Cardiovascular • Diabetes • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Tuberculosis • Type 2 Diabetes Mellitus

Effects of intramammary infection and dry-off treatment on the immune-metabolic profile of Alpine dairy goats. (PubMed, J Dairy Sci) - "At -61 d from kidding (DFK), goats were dried off and randomly allocated to 2 homogeneous groups either receiving no treatment (15 HEAL, 15 INFE) or being treated intramammarily with 250 mg of cefazolin per half-udder (15 HEAL, 15 INFE)...The INFE goats showed higher reactive oxygen metabolites and thiol concentrations between -57 and 8 DFK, and elevated ceruloplasmin at -7 and 8 DFK, indicating sustained systemic inflammation. Plasma analytes could serve as effective diagnostic tools to improve the detection of subclinical mastitis in dairy goats."

Journal • Dyslipidemia • Infectious Disease • Inflammation • Metabolic Disorders • HP

Plasma and Tissue Concentration of Cefazolin in Preoperative Prophylaxis in Patients Undergoing Bariatric Surgery (clinicaltrials.gov) - P=N/A | N=70 | Active, not recruiting | Sponsor: Laval University

New trial • Gastrointestinal Disorder

Oxacillin-susceptible methicillin-resistant Staphylococcus aureus septic bursitis identified following clinical failure with β-lactam therapy: A case report. (PubMed, J Assoc Med Microbiol Infect Dis Can) - "After failure to improve on cefazolin, a second aspirate was performed and sent for testing. Such methods could include a PBP2a immunoassay with high sensitivity. The patient recovered by using an antibiotic of a different class, trimethoprim-sulfamethoxazole, for which the isolate tested sensitive."

Journal • Infectious Disease

Lack of synergy between amoxicillin and cefazolin againstEnterococcus faecalis: Reassessment of a proposed empirical regimen for infective endocarditis. (PubMed, Infect Dis Now) - No abstract available

Journal • Cardiovascular

Impact of Intervertebral Disc Degeneration and Endplate Changes on Cefazolin Penetration into the Intervertebral Disc. (PubMed, Medicina (Kaunas)) - "Patient age, weight, and timing showed no significant correlations with intradisc concentrations. Ninety-four percent of disc samples exceeded the minimum inhibitory concentration for Staphylococcus aureus (>4 µg/g), but considerable variability in cefazolin levels was observed, with higher concentrations in discs showing Modic type II changes."

Journal • Musculoskeletal Diseases • Orthopedics

Piper nigrum Extract as an Adjuvant in a Collagen System for Infected Wound Healing: Therapeutic Synergy and Biocompatibility. (PubMed, Antibiotics (Basel)) - "This study focused on developing a collagen-based composite enriched with P. nigrum extract in powder form, designed to enhance the efficacy of the antibiotic cefazolin while promoting the healing of chronic wounds...Tests on keratinocytes confirmed biocompatibility, and hemocompatibility demonstrated an excellent safety profile, with protection against AAPH-induced oxidative stress. Overall, collagen powders with P. nigrum extract at moderate/low concentrations combine stability, antibiotic-enhanced activity, and cellular compatibility, making them promising adjuvants for the topical treatment of chronically infected wounds."

Journal

A Retrospective Study on the Use of Daptomycin and Linezolid in Singapore General Hospital. (PubMed, Antibiotics (Basel)) - "The primary reason for inappropriate linezolid use was overly broad empirical therapy where first-line options like cefazolin and vancomycin could have been prescribed. Nevertheless, our findings suggest the need to re-evaluate the empirical treatment strategies especially in VRE-colonized patients. Implementation of robust risk-based criteria as well as in-house hospital guidelines or protocols on the initiation of VRE-active agents may help support more judicious prescribing practices of these agents."

Journal • Retrospective data • Infectious Disease

Cefazolin-induced coagulopathy: a case report. (PubMed, J Med Case Rep) - "Cefazolin-induced coagulopathy is a potentially life-threatening complication that may present with or without overt bleeding a few days after initiating intravenous cefazolin therapy. Owing to its rarity, this adverse effect requires heightened awareness and familiarity with predisposing risk factors to ensure timely recognition and management."

Journal • Chronic Obstructive Pulmonary Disease • Critical care • Genetic Disorders • Hematological Disorders • Immunology • Nephrology • Obesity • Pulmonary Disease • Renal Disease • Respiratory Diseases

Perioperative Antibiotic Administration Review: An Analysis of Outpatient Surgeries at OhioHealth Doctors Hospital. (PubMed, Cureus) - "Adherence to perioperative timing standards was concerningly inadequate, even though antibiotic selection and dosage were generally suitable. The findings point to a substantial workflow and protocol enforcement gap at the system level. Operational adjustments like real-time warnings, checklists integrated with electronic health records (EHRs), and simpler delivery techniques may increase adherence and reduce preventable SSIs. Future research is required to assess how these strategies influence patient outcomes."

Journal • Anesthesia • Infectious Disease • Orthopedics

Surgical antibiotic prophylaxis in women undergoing caesarean delivery: a systematic review of clinical practice guidelines. (PubMed, J Hosp Infect) - "CPG development should be a rigorous process, with all information about development made easily accessible for the users and recipients of the practice recommendations."

Clinical guideline • Journal • Review • Obstetrics

Are We on the Same Page? Defining Consensus for Pediatric Open Fracture Management Among Level 1 Pediatric Trauma Centers. (PubMed, J Pediatr Orthop) - "While most surveyed Level-1 Pediatric Trauma Centers have formal protocols for timing and GA-type-dependent antibiotic selection, there is substantial variation among centers in success rates of prompt antibiotic administration and in selection of antibiotics for GA-type 3 open fractures. This variability highlights the need for pediatric-specific research to establish standardized evidence-based protocols, especially for severe injuries that carry a greater morbidity risk."

Journal • Allergy • Immunology • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pediatrics

Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL) (clinicaltrials.gov) - P3 | N=506 | Recruiting | Sponsor: Assistance Publique - Hôpitaux de Paris | Trial completion date: Jan 2025 ➔ Jul 2026 | Trial primary completion date: Oct 2024 ➔ Apr 2026

Trial completion date • Trial primary completion date • Thermal Injury

Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial (clinicaltrials.gov) - P4 | N=1770 | Active, not recruiting | Sponsor: Duke University | Trial completion date: Aug 2025 ➔ Dec 2025

Trial completion date • Orthopedics • Pain • Rheumatology

CLOCEBA: Non-inferiority Trial Comparing Cloxacillin vs Cefazolin in Methicillin-susceptible Staphylococcus Aureus Bacteremia (clinicaltrials.gov) - P=N/A | N=315 | Completed | Sponsor: Assistance Publique - Hôpitaux de Paris | Active, not recruiting ➔ Completed | Trial completion date: Dec 2024 ➔ Mar 2025

Head-to-Head • Trial completion • Trial completion date