irinotecan nano (LAUR-401) / Lauren Sciences - LARVOL DELTA

A Self-Assembled Irinotecan Nanomedicine Abrogates Steatohepatitis-Induced Liver Metastasis and Potentiates Antitumor Efficacy against Colorectal Cancer. (PubMed, ACS Nano) - "In subcutaneous and liver metastatic CRC models, NICER demonstrates potent antitumor efficacy, reducing the tumor burden by 74.6% and 96.2%, respectively, while also exhibiting good biosafety. In summary, this work synergistically abrogates the prometastatic adverse effect of irinotecan and enhances its antitumor efficacy, presenting a promising strategy to potentiate irinotecan-based chemotherapies."

Journal • Colorectal Cancer • Hepatology • Oncology • Solid Tumor • CPT1A

The Role of Nanoparticles in Therapy of Real-World Patients with Pancreatic Cancer: A Scoping Review. (PubMed, Cancers (Basel)) - "Pancreatic cancer (PC) is one of the most aggressive and fatal malignancies worldwide, posing a significant global health challenge due to its high mortality rates, late-stage diagnosis, and limited therapeutic efficacy [...]."

Journal • Real-world evidence • Review • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Solid Tumor