metoprolol tartrate / Generic mfg. - LARVOL DELTA

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score (clinicaltrials.gov) - P4 | N=100 | Not yet recruiting | Sponsor: University of Michigan

New P4 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

Bimekizumab in Pityriasis Rubra Pilaris: an Innovative Therapeutic Option (AAD 2026) - "We present an 81-year-old male patient with a past medical history of hypertension and arrythmias, on lisinopril and metoprolol tartrate, with no recent lifestyle or medication changes who presented with a diffuse rash. No clear pathogenesis has been established for PRP, outside of inherited mutations of CARD14. This case demonstrates the efficacy and utility of bimekizumab as a treatment option in PRP refractory to classic therapeutic options."

Ankylosing Spondylitis • Cardiovascular • Hidradenitis Suppurativa • Hypertension • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Seronegative Spondyloarthropathies • Spondylarthritis

Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) (clinicaltrials.gov) - P4 | N=240 | Enrolling by invitation | Sponsor: Weill Medical College of Cornell University | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Cardiovascular • Congestive Heart Failure • Heart Failure

Occurrence and Ecotoxicological Risks of Pharmaceuticals and Illicit Drugs in Effluent and Unsheltered Homelessness-Impacted River Systems. (PubMed, Arch Environ Contam Toxicol) - "Several PIDs were found to be ubiquitous in the effluent-impacted sites (e.g. lidocaine, metoprolol tartrate, diclofenac acid and methamphetamine). Pharmaceuticals except sulfamethoxazole were detected at concentrations far below Predicted-no effect concentration (PNEC) values across all effluent and unsheltered homelessness-impacted river systems, indicating negligible (low) or moderate ecological risks to algae and crustaceans. However, relying solely on single-compound risk assessment might underestimate cumulative ecological risk."

Journal

Comparative Study of Treatment Strategies for Migraine in Patients with Patent Foramen Ovale (PFO): A Multicenter Randomized Controlled Trial of Transcatheter Closure versus Medical Therapy (ChiCTR) - P=N/A | N=150 | Recruiting | Sponsor: The Seventh Affiliated Hospital Sun Yat-sen University; The?Seventh?Affiliated?Hospital?Sun?Yat-sen?University

New trial • CNS Disorders • Migraine • Pain

Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) (clinicaltrials.gov) - P4 | N=240 | Not yet recruiting | Sponsor: Weill Medical College of Cornell University

New P4 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

HEART-BEAT: Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease (clinicaltrials.gov) - P2/3 | N=350 | Enrolling by invitation | Sponsor: Gødstrup Hospital | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Cardiovascular • Coronary Artery Disease • Heart Failure

HEART-BEAT: Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease (clinicaltrials.gov) - P2/3 | N=350 | Not yet recruiting | Sponsor: Gødstrup Hospital

New P2/3 trial • Cardiovascular • Coronary Artery Disease • Heart Failure

Acute Onset of Achalasia in a Patient With Metoprolol Initiation (ACG 2025) - "The patient declined repeat manometry. This case described a patient with acute onset of type III achalasia after initiation of metoprolol tartrate, with complete resolution after switching to carvedilol. Further studies are warranted to explore the effects of different BB formulations on EGJOO.Figure: Figure 1 – Repeat Barium Esophagram on day 17 with dilated esophagus and disorganized peristalsis. Figure: Figure 2 - High Resolution Manometry Performed on Day 18 Showed Elevated LES Integrated Relaxation Pressure and Shortened Distal Latency."

Clinical • Cardiovascular • Gastrointestinal Disorder • Myocardial Infarction • Rare Diseases

AORTIC DISSECTION IN AUTOIMMUNE HEPATITIS: THE INFLAMMATORY LINK TO CATASTROPHIC VASCULAR EVENTS (CHEST 2025) - "CASE PRESENTATION: A 69-year-old female with a history of MS and AIH on azathioprine presented to the emergency department (ED) with acute severe headache, confusion, and upper extremity heaviness...An esmolol drip was initiated per protocol and cardiothoracic surgery was consulted, she was then emergently transferred to a tertiary center for surgery...Intraoperative biopsy of the aorta showed hemorrhage with mixed acute and chronic inflammation.Her post-operative course was complicated by new-onset atrial fibrillation requiring amiodarone which was later transitioned to Lopressor and volume overload with hypoxic respiratory failure necessitating BiPAP and heated high-flow oxygen therapy... This case underscores a rare occurrence of aortic dissection in a patient with AIH and MS. While traditional risk factors were absent, underlying autoimmune inflammation may have contributed. Further studies are necessary to clarify the association between autoimmune diseases and..."

Atherosclerosis • Atrial Fibrillation • Autoimmune Hepatitis • Cardiovascular • CNS Disorders • Hematological Disorders • Hepatology • Hypertension • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Multiple Sclerosis • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Systemic Lupus Erythematosus

SUICIDE ATTEMPT VIA OVERT FLECAINIDE OVERDOSE (CHEST 2025) - "During her stay in CCU, patient converted into AFib with RVR, uncontrolled with Metoprolol Tartrate 5mg x3 and was subsequently started on Diltiazem drip. Given how rare flecainide toxicity is in clinical practice, it is important to have a high index of suspicion anti-arrhythmogenic overdose in patients presenting with cardiac conduction abnormalities and prior atrial fibrillation, especially in those with psychiatric comorbidities. The mainstay of treatment remains supportive care, sodium bicarbonate supplementation, and where appropriate, lipid emulsion."

Atrial Fibrillation • Cardiovascular • CNS Disorders • Depression • Nephrology • Psychiatry • Renal Disease • Respiratory Diseases • Ventricular Tachycardia

FLECAINIDE FALLOUT: NAVIGATING WIDE, COMPLEX TACHYCARDIA AND PACEMAKER CAPTURE LOSS (CHEST 2025) - "CASE PRESENTATION: An 81-year-old female with a past medical history of paroxysmal atrial fibrillation (AF) on metoprolol tartrate, and flecainide, sick sinus syndrome (SSS) status post (s/p) Boston Scientific dual chamber permanent pacemaker presented with complaints of lethargy and dizziness...Additional treatments may include antiarrhythmics like amiodarone or lidocaine, intravenous fat emulsion, or pacing for bradyarrhythmias... Flecainide toxicity is diagnosed clinically, and drug levels are not necessary for diagnosis since it takes time for results to be available. Prior to starting flecainide therapy, pacemaker settings should be adjusted as the drug can improve ventricular capture. However, flecainide toxicity can increase the risk of pacemaker failure by raising the capture threshold."

Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • CNS Disorders • Epilepsy • Hepatology • Hypotension • Nephrology • Renal Disease • Ventricular Tachycardia

A NEW HURDLE: NEW-ONSET ATRIAL FIBRILLATION IN JEUNE THORACIC DYSTROPHY (CHEST 2025) - "On the second day of admission, developed new-onset atrial fibrillation (AF) with rapid ventricular response and was treated with digoxin and amiodarone...For his paroxysmal AF, the patient was discharged with Eliquis for stroke prophylaxis and metoprolol tartrate for rate control... This case highlights the potential for cardiac complications in patients with rare skeletal dysplasia that leads a restrictive lung disease. While Jeune thoracic dystrophy mainly affects his respiratory function, the complication of his chronic respiratory failure plays a part in the development of his new-onset AF. This underscores the importance of monitoring cardiac function in older patients with Jeune thoracic dystrophy."

Atrial Fibrillation • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Hepatology • Hypotension • Infectious Disease • Liver Failure • Orthopedics • Pneumonia • Psychiatry • Pulmonary Disease • Respiratory Diseases

When Pain Puts Your Heart in the Fast Lane: A Case of Ventricular Tachycardia Induced by Pain From Rib Fracture. (PubMed, Cureus) - "She was evaluated by electrophysiology, who recommended initiating metoprolol tartrate, as the working diagnosis was thought to be RMVT. She underwent cardiac catheterization, which showed non-obstructive coronary artery disease (CAD). Upon further evaluation, she was found to have right-sided rib fractures that were not seen on the initial workup...Her tachycardia was resolved with beta blockers. The patient was discharged in a stable condition with electrophysiology follow-up for considering ablation."

Journal • Back Pain • Cardiomyopathy • Cardiovascular • Coronary Artery Disease • Heart Failure • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Ventricular Tachycardia

Antimicrobial Stability, pH, and Physical Appearance of Cardiovascular Drug Suspensions in SyrSpend® SF PH4: A Complementary Evaluation. (PubMed, Int J Pharm Compd) - "Nine oral formulations of seven cardiovascular drug suspensions were included: amlodipine (as besylate) 1.0 mg/mL, enalapril maleate 1.0 mg/mL, hydrochlorothiazide 2.0 and 5.0 mg/mL, lisinopril (as dihydrate) 1.0 mg/mL, metoprolol tartrate 10.0 mg/mL, pentoxifylline 20.0 mg/mL, and spironolactone 2.0 and 2.5 mg/mL. All formulations met USP criteria for antimicrobial effectiveness, while maintaining stable pH values and no relevant changes in physical appearance throughout the study. These results, when combined with previously demonstrated chemical stability (HPLC), confirm that SyrSpend® SF PH4 is a robust and reliable vehicle for preservative-free extemporaneous oral liquid formulations, supporting its safe use within USP-compliant BUD limits."

Journal • Cardiovascular • Pediatrics

Stability Study of Pediatric Oral Suspensions Formulated with PCCA SuspendIt Vehicle Used for the Treatment of Cardiovascular Disease. (PubMed, Int J Pharm Compd) - "The current study demonstrates that SuspendIt cardiovascular suspensions are physically, chemically and microbiologically stable for 180 days for captopril (when stored in the refrigerator) and hydrochlorothiazide and metoprolol tartrate (when stored at room temperature), retaining not less than 90% of the labeled drug concentrations. This study provides a viable compounded alternative for hydrochlorothiazide, metoprolol tartrate and captopril in a liquid dosage form with an adequate beyond-use-date to meet patient needs."

Journal • Cardiovascular • Pediatrics

Optimizing heart rate with metoprolol prior to coronary CT angiography: a dose-response analysis in a large cohort (ESC-WCC 2025) - "Patients were categorized based on the applied metoprolol preparation strategy: group 1, no metoprolol; group 2, metoprolol succinate 1-3 days before CCTA; group 3, metoprolol tartrate at the intake of CCTA; group 4, succinate and additional tartrate before CCTA. Tartrate was more effective, particularly in patients without prior succinate preparation. Doses of 100 mg are recommended for most patients with an HR >65 bpm, further guided by patient characteristics."

Cardiovascular • Coronary Artery Disease

BEACON: Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA (clinicaltrials.gov) - P4 | N=46 | Recruiting | Sponsor: VZW Cardiovascular Research Center Aalst | Initiation date: Mar 2025 ➔ Jul 2025 | Not yet recruiting ➔ Recruiting

Enrollment open • Trial initiation date • Cardiovascular • Coronary Artery Disease

Diagnostic Value of Exercise Stress Testing Combined With Beta-Blocker Therapy (Metoprolol) in Hypertensive Patients With Suspected Coronary Artery Disease. (PubMed, Cureus) - "In hypertensive patients with suspected CAD, combining EST with metoprolol provides a viable and non-invasive diagnostic strategy, offering high specificity and PPV despite moderate sensitivity."

Journal • Cardiovascular • Coronary Artery Disease • Hypertension

The impact of glidant addition on continuous blending of active pharmaceutical ingredients. (PubMed, Int J Pharm) - "Two cohesive APIs (acetaminophen micronized and metoprolol tartrate) and three different glidants (Aerosilprotect relax special {t4ht=®} 200, Aerosilprotect relax special {t4ht=®} R972 and Syloidprotect relax special {t4ht=®} 244 FP) were included...Moreover, adding higher concentrations of glidants can even increase RSDBU due to fluidization segregation and less paddle interactions. However, overall the RSDBU values obtained with the continuous blender were relatively low."

Journal

Hyperthyroidism to Heart Failure: Armour Thyroid as a Catalyst for Takotsubo Cardiomyopathy (ENDO 2025) - "The patient was started on metoprolol tartrate, and Armour Thyroid was discontinued, replaced by Levothyroxine 75 mcg daily. This case underscores the need to recognize Armour Thyroid-induced hyperthyroidism as a potential cause of TC. A comprehensive diagnostic approach and prompt intervention are crucial for optimal patient outcomes."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Endocrine Disorders • Heart Failure • Myocardial Infarction • Pain • Psychiatry

Metastatic Pheochromocytoma and Neuroendocrine Breast Cancer in a Young Woman (ENDO 2025) - "Doxazosin 1 mg nightly and a high sodium diet were started and slowly increased to 5 mg every 12 hours over 14 days preop. Metoprolol tartrate was added after adequate alpha blockade... Cases of concurrent pheochromocytoma and neuroendocrine breast cancer remain rare. Few case studies show metastatic pheochromocytoma to the breast. Both pheochromocytoma and neuroendocrine breast cancer have been associated with several familial conditions, including Von-Hippel-Lindau, neurofibromatosis 1, and MEN2."

Clinical • Metastases • Breast Cancer • Cardiovascular • Diabetes • Endocrine Cancer • Genetic Disorders • Hormone Receptor Positive Breast Cancer • Hypertension • Neuroendocrine Carcinoma • Neuroendocrine Tumor • Neurofibromatosis • Oncology • Pain • Solid Tumor • Von Hippel-Lindau Syndrome • PGR

Transient worsening of thyrotoxic myopathy following methimazole and metoprolol initiation in a 12-year-old girl: a case report and literature review. (PubMed, J Pediatr Endocrinol Metab) - "TM may show transient worsening after MMI and metoprolol tartrate administration, requiring the evaluation of TM, drug side effects, and other possible causes before continuing treatment. This case highlights the importance of recognizing TM in pediatric patients."

Journal • CNS Disorders • Endocrine Disorders • Grave’s Disease • Immunology • Muscular Atrophy • Myasthenia Gravis • Myositis • Pediatrics

FDA endorses 10 more drug products for VAT exemption (Manila Bulletin) - "The newly endorsed VAT-exempt drugs are as follows: High cholesterol: Atorvastatin (as calcium) + Fenobribrate 20 mg/160 mg; Cancer: Tegafur + Gimeracil + Oteracil Potassium 20 mg/5.8 mg/19.6 mg and Tegafur + Gimeracil + Oteracil Potassium 25 mg/7.25 mg/24.5 mg; Diabetes: Metformin Hydrochloride + Teneligliptin (as hydrobromide hydrate) 1 g/20 mg and Metformin Hydrochloride + Teneligliptin (as hydrobromide hydrate) 500 mg/20 mg; Hypertension: Metoprolol tartrate + Ivabradine (as hydrochloride) 50 mg/5 mg and Metoprolol tartrate + Ivabradine (as hydrochloride) 25 mg/5 mg; Hypertension: Metoprolol tartrate + Ivabradine (as hydrochloride) 50 mg/5 mg and Metoprolol tartrate + Ivabradine (as hydrochloride) 25 mg/5 mg; Mental illness: Lamotrigine 5 mg (dispersible/chewable tablet), Lamotrigine 25 mg (oral dispersible tablet), and Lamotrigine 25 mg (tablet)"

Commercial • FDA event • Breast Cancer • CNS Disorders • Colorectal Cancer • Diabetes • Dyslipidemia • Gastric Cancer • Hypertension • Non Small Cell Lung Cancer • Prostate Cancer • Renal Cell Carcinoma

Simultaneous Determination of Glibenclamide, Metoprolol Tartrate, and Phenol Red Using HPLC-PDA: Application in Rat Intestinal Permeability Studies and Its Greenness Assessment Using NEMI, Analytical Eco-Scale, GAPI, MoGAPI, AGREE, AGREEprep, RAPI, BAGI, and CACI. (PubMed, Biomed Chromatogr) - No abstract available

Journal • Preclinical