metoprolol tartrate / Generic mfg. - LARVOL DELTA

Too Big to Ignore: A 16-cm Hepatic Mass Leading to the Discovery of Neuroendocrine Malignancy (ACG 2026) - "She was started on metoprolol tartrate with improvement...Figure: Figure A: CT scan shows severe hepatomegaly with low density inferior mass. Figure B: MRI shows innumerable hepatic masses with large R hepatic lobe mass."

Cardiovascular • Colonic Polyps • Gastroenterology • Gastrointestinal Disorder • Gastrointestinal Neuroendocrine Tumor • Heart Failure • Hepatocellular Cancer • Hepatology • Liver Cancer • Neuroendocrine Tumor • Oncology • Solid Tumor

Comparison table: Some drugs for migraine prevention. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Are beta-blockers safe early after heart transplantation? (TTS 2026) - "This includes excess bradycardia and hypotension, especially if previous amiodarone was given prior to HTx. This study confirms that BB therapy used early after heart transplant must be used with caution, as exaggerated responses are experienced."

Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Transplantation

Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control (clinicaltrials.gov) - P4 | N=69 | Terminated | Sponsor: CAMC Health System | N=150 ➔ 69 | Unknown status ➔ Terminated; Low enrollment and PI retired.

Enrollment change • Trial termination • Atrial Fibrillation • Cardiovascular

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: University of Michigan | Initiation date: Jul 2026 ➔ Oct 2026

Trial initiation date • Cardiovascular • Congestive Heart Failure • Heart Failure

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users. (PubMed, Clin Transl Sci) - "Single random plasma samples were collected from 996 patients receiving metoprolol tartrate...Our study suggests that CYP2D6-inferred metabolizer status can inform on mortality risk in patients treated with metoprolol. Larger initiatives are required to confirm the association of CYP2D6 metabolizer status with clinical events beyond pharmacokinetic and hemodynamic considerations."

Journal • Cardiovascular

Beta‑blocker tapering and symptom improvement in dysautonomic dysfunction patients (ESC 2026) - "Cardioselective beta‑blockers were commonly used (metoprolol succinate 33 %, metoprolol tartrate 29 %, bisoprolol 28 %, carvedilol 11 %). Symptom improvements were observed across the full spectrum of dose reduction; this highlights the synergistic value of combining beta‑blocker tapering with multimodal rehabilitation. Prospective controlled studies are warranted to confirm these observations and to optimise pharmacological strategies in dysautonomic dysfunction management."

Clinical • Cardiovascular

Walking the tightrope: Mixed respiratory failure exacerbated by heart rate control and concurrent pneumonia in an elderly patient with new-onset atrial fibrillation: A case report. (PubMed, Medicine (Baltimore)) - "In geriatric patients, infection can present atypically and act as a silent trigger for HF decompensation, leading to mixed respiratory failure. Rate control targets should be individualized and dynamically adjusted, particularly during acute illness, to avoid potential compromise of cardiac output. This case underscores the importance of diagnostic vigilance, serial imaging, electrolyte monitoring, and flexible, pathophysiology-guided management in optimizing outcomes in this vulnerable population."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Congestive Heart Failure • Cough • Geriatric Disorders • Heart Failure • Hypertension • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Metoprolol Population Pharmacokinetics in Older Chinese Patients With CKM Syndrome: Joint Effects of rs1065852 and CKM2S2-BAG Score on Clearance. (PubMed, Clin Transl Sci) - "The PopPK analysis included sparse real-world data from 42 older adults (60-93 years) receiving immediate-release metoprolol tartrate...This study provides a model-informed framework for exposure-threshold-based dose stratification. Prospective validation with clinical outcomes and comprehensive CYP2D6 genotyping is warranted."

Journal • PK/PD data • Cardiovascular

Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation) (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Muhammad Ali Javed

New P4 trial • Atrial Fibrillation • Cardiovascular

Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial. (PubMed, Front Cardiovasc Med) - "Current Western guidelines recommend pharmacotherapy or catheter ablation, with conservative drug therapy (e.g., lidocaine, propafenone, metoprolol, amiodarone, verapamil) remaining the mainstay. Metoprolol tartrate, a first-line drug, is effective for PVCs but has single targets, limited efficacy, and potential long-term cardiovascular adverse effects...This study will provide evidence on the efficacy and safety of Guipi Mixture for PVCs (heart-spleen deficiency syndrome) and explore its impact on patients' quality of life. http://itmctr.ccebtcm.org.cn/, identifier ITMCTR2025001333."

Clinical • Journal • Cardiomyopathy • Cardiovascular

Are Betablockers Safe Early After Transplant? (ATC 2026) - "This includes excess bradycardia and hypotension, especially if previous amiodarone was given prior to HTx. This study confirms that beta-blocker therapy use early after heart transplant must be used with caution as exaggerated responses are experienced."

Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Transplantation

Recurrent bradycardia and hypotension after Oral Lacosamide during hospital boarding in the emergency department: A case report. (PubMed, Am J Emerg Med) - "We report a case of a 79-year-old woman with a history of hypertension (treated with losartan and metoprolol), restless legs syndrome (treated with ropinirole), peripheral neuropathy, and seizure disorder who presented to the emergency department with several days of intermittent confusion and generalized weakness following a recent admission for seizure-like activity, during which lacosamide had been initiated...She responded to atropine 1 mg IV and 50μg of epinephrine IV, with improvement of her vital signs and mental status. Six hours later, she received a second scheduled dose of lacosamide 150 mg along with her home medications, including metoprolol tartrate 50 mg, and again two hours later became minimally responsive with a heart rate of 49 beats per minute, blood pressure 64/32 mmHg, and a new first-degree atrioventricular block; she again responded to atropine...Emergency physicians should maintain a high index of suspicion for..."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Hypertension • Hypotension • Movement Disorders • Pain • Restless Legs Syndrome • Sleep Disorder

Effect of bucladesine calcium combined with metoprolol on heart rate variability and cardiac function prognosis in heart failure patients with chronic arrhythmias. (PubMed, Front Cardiovasc Med) - "Patients received metoprolol tartrate alone (control group, n = 41) or bucladesine calcium combined with metoprolol (observation group, n = 46) for 12 weeks...After multivariable adjustment, ΔSDNN (P = 0.037) and ΔRMSSD (P = 0.042) remained significant, while ΔLVEF became borderline (P = 0.062). Adding bucladesine calcium to metoprolol was associated with greater improvements in HRV time-domain parameters and LVEF, though effects were attenuated after covariate adjustment."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Profound Synergistic Bradycardia: Pharmacokinetic Consequences of Paxlovid-Mediated CYP3A4 and CYP2D6 Inhibition on Ranolazine, Diltiazem, and Metoprolol. (PubMed, Cureus) - "She was intubated and initiated on multi-drug inotropic support (isoproterenol, dopamine, and epinephrine). Medication reconciliation revealed a home regimen of ranolazine (1000 mg BID), diltiazem (180 mg BID), and metoprolol tartrate (25 mg BID) - all primary CYP 3A4/2D6 substrates...She maintained hemodynamic stability and was discharged the following day. This case demonstrates that the ritonavir component of Paxlovid can result in the supratherapeutic serum accumulation of ranolazine, diltiazem, and metoprolol through a dual-CYP 3A4 and 2D6 pathway inhibition, leading to a life-threatening bradycardic and hypotensive crisis."

Journal • PK/PD data • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Hypotension • Infectious Disease • Novel Coronavirus Disease • CYP3A4

Zhenyuan Solid Drink Ameliorates Inflammation and Oxidative Stress in Isoproterenol-Induced Ischemic Myocardial Infarction via TLR4/NF-κB Pathway and PI3K/AKT1/NRF2 Pathway in Rats. (PubMed, Food Sci Nutr) - "Subsequently, a multi-tiered approach integrating cardiac color Doppler ultrasound, cardiac enzyme marker analysis, inflammatory factor detection, gut microbiota profiling, network pharmacology, molecular docking, molecular dynamics (MD) simulation, and western blot analysis was employed to elucidate the effects and underlying mechanisms of ZYSD, with intervention in alleviating metoprolol tartrate as positive control...Western blot analysis results further verified that ZYSD regulates the TLR4/NF-κB pathway and PI3K/AKT1/NRF2 pathway. Collectively, our findings demonstrate that ZYSD mitigates inflammation and oxidative stress, potentially through the TLR4/NF-κB and PI3K/AKT1/NRF2 pathways, thereby providing a novel strategy for the prevention and treatment of ischemic myocardial infarction."

Journal • Preclinical • Cardiovascular • Inflammation • Myocardial Infarction

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: University of Michigan | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular • Congestive Heart Failure • Heart Failure

Design and evaluation of a novel expandable gastroretentive film for sustained Metoprolol release. (PubMed, PLoS One) - "Metoprolol tartrate, a β1-receptor blocker with a short half-life and low oral bioavailability, was selected as the model drug...Furthermore, short-term stability testing under accelerated ICH conditions confirmed the film's physical and chemical stability and sustained-release performance for 6 weeks. In conclusion, the optimized expandable film (F14) combined swelling, gastric retention, and sustained drug release, highlighting its promise as a gastroretentive platform to enhance Metoprolol bioavailability and efficacy."

Journal

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score (clinicaltrials.gov) - P4 | N=100 | Not yet recruiting | Sponsor: University of Michigan

New P4 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

Bimekizumab in Pityriasis Rubra Pilaris: an Innovative Therapeutic Option (AAD 2026) - "We present an 81-year-old male patient with a past medical history of hypertension and arrythmias, on lisinopril and metoprolol tartrate, with no recent lifestyle or medication changes who presented with a diffuse rash. No clear pathogenesis has been established for PRP, outside of inherited mutations of CARD14. This case demonstrates the efficacy and utility of bimekizumab as a treatment option in PRP refractory to classic therapeutic options."

Ankylosing Spondylitis • Cardiovascular • Hidradenitis Suppurativa • Hypertension • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Seronegative Spondyloarthropathies • Spondylarthritis

Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) (clinicaltrials.gov) - P4 | N=240 | Enrolling by invitation | Sponsor: Weill Medical College of Cornell University | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Cardiovascular • Congestive Heart Failure • Heart Failure

Occurrence and Ecotoxicological Risks of Pharmaceuticals and Illicit Drugs in Effluent and Unsheltered Homelessness-Impacted River Systems. (PubMed, Arch Environ Contam Toxicol) - "Several PIDs were found to be ubiquitous in the effluent-impacted sites (e.g. lidocaine, metoprolol tartrate, diclofenac acid and methamphetamine). Pharmaceuticals except sulfamethoxazole were detected at concentrations far below Predicted-no effect concentration (PNEC) values across all effluent and unsheltered homelessness-impacted river systems, indicating negligible (low) or moderate ecological risks to algae and crustaceans. However, relying solely on single-compound risk assessment might underestimate cumulative ecological risk."

Journal

Comparative Study of Treatment Strategies for Migraine in Patients with Patent Foramen Ovale (PFO): A Multicenter Randomized Controlled Trial of Transcatheter Closure versus Medical Therapy (ChiCTR) - P=N/A | N=150 | Recruiting | Sponsor: The Seventh Affiliated Hospital Sun Yat-sen University; The?Seventh?Affiliated?Hospital?Sun?Yat-sen?University

New trial • CNS Disorders • Migraine • Pain

Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) (clinicaltrials.gov) - P4 | N=240 | Not yet recruiting | Sponsor: Weill Medical College of Cornell University

New P4 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

HEART-BEAT: Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease (clinicaltrials.gov) - P2/3 | N=350 | Enrolling by invitation | Sponsor: Gødstrup Hospital | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Cardiovascular • Coronary Artery Disease • Heart Failure