metoprolol tartrate / Generic mfg. - LARVOL DELTA

Transient worsening of thyrotoxic myopathy following methimazole and metoprolol initiation in a 12-year-old girl: a case report and literature review. (PubMed, J Pediatr Endocrinol Metab) - "TM may show transient worsening after MMI and metoprolol tartrate administration, requiring the evaluation of TM, drug side effects, and other possible causes before continuing treatment. This case highlights the importance of recognizing TM in pediatric patients."

Journal • CNS Disorders • Endocrine Disorders • Grave’s Disease • Immunology • Muscular Atrophy • Myasthenia Gravis • Myositis • Pediatrics

FDA endorses 10 more drug products for VAT exemption (Manila Bulletin) - "The newly endorsed VAT-exempt drugs are as follows: High cholesterol: Atorvastatin (as calcium) + Fenobribrate 20 mg/160 mg; Cancer: Tegafur + Gimeracil + Oteracil Potassium 20 mg/5.8 mg/19.6 mg and Tegafur + Gimeracil + Oteracil Potassium 25 mg/7.25 mg/24.5 mg; Diabetes: Metformin Hydrochloride + Teneligliptin (as hydrobromide hydrate) 1 g/20 mg and Metformin Hydrochloride + Teneligliptin (as hydrobromide hydrate) 500 mg/20 mg; Hypertension: Metoprolol tartrate + Ivabradine (as hydrochloride) 50 mg/5 mg and Metoprolol tartrate + Ivabradine (as hydrochloride) 25 mg/5 mg; Hypertension: Metoprolol tartrate + Ivabradine (as hydrochloride) 50 mg/5 mg and Metoprolol tartrate + Ivabradine (as hydrochloride) 25 mg/5 mg; Mental illness: Lamotrigine 5 mg (dispersible/chewable tablet), Lamotrigine 25 mg (oral dispersible tablet), and Lamotrigine 25 mg (tablet)"

Commercial • FDA event • Breast Cancer • CNS Disorders • Colorectal Cancer • Diabetes • Dyslipidemia • Gastric Cancer • Hypertension • Non Small Cell Lung Cancer • Prostate Cancer • Renal Cell Carcinoma

Hyperthyroidism to Heart Failure: Armour Thyroid as a Catalyst for Takotsubo Cardiomyopathy (ENDO 2025) - "The patient was started on metoprolol tartrate, and Armour Thyroid was discontinued, replaced by Levothyroxine 75 mcg daily. This case underscores the need to recognize Armour Thyroid-induced hyperthyroidism as a potential cause of TC. A comprehensive diagnostic approach and prompt intervention are crucial for optimal patient outcomes."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Endocrine Disorders • Heart Failure • Myocardial Infarction • Pain • Psychiatry

Metastatic Pheochromocytoma and Neuroendocrine Breast Cancer in a Young Woman (ENDO 2025) - "Doxazosin 1 mg nightly and a high sodium diet were started and slowly increased to 5 mg every 12 hours over 14 days preop. Metoprolol tartrate was added after adequate alpha blockade... Cases of concurrent pheochromocytoma and neuroendocrine breast cancer remain rare. Few case studies show metastatic pheochromocytoma to the breast. Both pheochromocytoma and neuroendocrine breast cancer have been associated with several familial conditions, including Von-Hippel-Lindau, neurofibromatosis 1, and MEN2."

Clinical • Metastases • Breast Cancer • Cardiovascular • Diabetes • Endocrine Cancer • Genetic Disorders • Hormone Receptor Positive Breast Cancer • Hypertension • Neuroendocrine Tumor • Neurofibromatosis • Oncology • Pain • Solid Tumor • Von Hippel-Lindau Syndrome • PGR

Simultaneous Determination of Glibenclamide, Metoprolol Tartrate, and Phenol Red Using HPLC-PDA: Application in Rat Intestinal Permeability Studies and Its Greenness Assessment Using NEMI, Analytical Eco-Scale, GAPI, MoGAPI, AGREE, AGREEprep, RAPI, BAGI, and CACI. (PubMed, Biomed Chromatogr) - No abstract available

Journal • Preclinical

Explosive Pleuritis and Parapneumonic Effusion: A Group A Streptococcus-induced Pneumonia Crisis (ATS 2025) - "Case report: A 57-year-old male with a history of hypertension, gout, and asthma presented with worsening shortness of breath after been diagnosed with influenza and started on Tamiflu two days back...He was treated with ceftriaxone, azithromycin, clindamycin, steroids, and nebulization. During his hospital stay, he developed atrial fibrillation with rapid ventricular response, which was managed with Eliquis and Lopressor. A repeat chest x-ray showed bilateral ill-defined opacities, prompting escalation of antibiotics to Zosyn, while he completed a 3-day course of clindamycin...Explosive pleuritis may confer higher morbidity and mortality, thus early recognition and treatment is imperative. Thoracocentesis and pleural fluid analysis with early chest tube drainage is necessary with unresolved cases needing surgical interventions."

Asthma • Atrial Fibrillation • Cardiovascular • Gout • Heart Failure • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Influenza • Pneumonia • Respiratory Diseases • Rheumatology

Metoprolol removal and mineralization by TiO2 and iron pillared clay nanocomposite: Impact of operating parameters, water matrices, and solar light. (PubMed, J Environ Manage) - "This study investigates the photocatalytic degradation of metoprolol tartrate (MET) using TiO2 nanostructures supported on Fe pillared activated bentonite (FeAB) under UV, visible, and solar irradiation...Total Organic Carbon (TOC) measurement showed 73 %, 100 %, and 76 % mineralization after 10 h under UV, visible, and solar light, respectively. The TiO2/FeAB composite exhibited excellent stability and reusability, highlighting its potential as a clean technology for pharmaceutical removal from diverse water sources."

Journal

Predicting Conversion From Unipolar Depression to Bipolar Disorder and Schizophrenia: A 10-Year Retrospective Cohort Study on 12,182 Inpatients. (PubMed, Depress Anxiety) - "Higher risk factors for BD progression included being female, having severe depression, being prescribed mood stabilizers, β receptor blockers (e.g., metoprolol tartrate and propranolol hydrochloride), and antipsychotics (e.g., sulpiride and quetiapine). Higher risk factors for SCZ progression included being male, exhibiting psychotic symptoms, being prescribed antipsychotics (e.g., risperidone and sulpiride), antiside effects drugs (e.g., trihexyphenidyl and hemp seed pill), and undergoing psychotherapy...A key finding is that individuals with refractory (particularly psychotic) UD had an elevated risk of transitioning to BD and SCZ, with social-demographic factors, lifestyle behaviors, vital signs, and blood markers becoming significant risk factors over follow-up. Upon further validation, these models could provide clinicians with dynamic information regarding a patient's risk of disease conversion."

Journal • Retrospective data • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • Schizophrenia

SAM STRIKES BACKWARDS: MAVACAMTEN'S ROLE IN POSTERIOR LEAFLET SYSTOLIC ANTERIOR MOTION OF THE MITRAL VALVE - Sri Nuvvula (ACC 2025) - "Despite beta-blockade (metoprolol tartrate 50 mg twice daily), LVOT gradient remained elevated (74 mmHg with Valsalva) on echocardiography (Figure 1A, 1B). This case highlights mavacamten's efficacy in reducing dynamic LVOT obstruction in HoCM in the setting of posterior leaflet SAM."

Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy • Obstructive Hypertrophic Cardiomyopathy • Pulmonary Disease

BEACON: Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study (clinicaltrials.gov) - P4 | N=46 | Not yet recruiting | Sponsor: VZW Cardiovascular Research Center Aalst

New P4 trial • Cardiovascular • Coronary Artery Disease

Profound hypotension following concomitant administration of tizanidine and lisinopril. (PubMed, BMJ Case Rep) - "Pertinent medication history included metoprolol tartrate, lisinopril, hydralazine, hydrochlorothiazide and tizanidine and was continued. This reaction scored a 4 on the Naranjo Adverse Drug Reaction Probability Scale and Drug Interaction Probability Scale. Providers should be aware of this potential adverse reaction from the combination of medications."

Journal • Back Pain • Cardiovascular • Hypertension • Hypotension • Musculoskeletal Pain • Pain

ORION: Metoprolol to Reduce Perioperative Myocardial Injury (clinicaltrials.gov) - P3 | N=72 | Completed | Sponsor: University of Chicago | N=170 ➔ 72

Enrollment change • Cardiovascular • Heart Failure

The impact of glidant addition on the loss-in-weight feeding of active pharmaceutical ingredients. (PubMed, Int J Pharm) - "Three challenging APIs (acetaminophen micronized (APAPμ), metoprolol tartrate (MPT) and spray dried placebo (SD)) and four different glidants (Aerosil® 200, Aerosil® R972, Syloid® 244FP and TRI-CAFOS® 200-7) were selected...Both the fumed silica grades (Aerosil® 200 and Aerosil® R972) and Syloid 244FP lowered the deviation on all label claim % (LC (%)) profiles of the cohesive APIs. In contrast to the volumetric trails, blends with excess fumed silica resulted in low AE10 values which are efficiently dosed by the CF during the gravimetric feeding."

Journal

Intravenous Metoprolol in Septic Shock (clinicaltrials.gov) - P2 | N=100 | Completed | Sponsor: Alexandria University | Active, not recruiting ➔ Completed

Trial completion • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock

Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis (clinicaltrials.gov) - P1 | N=21 | Completed | Sponsor: Amgen | Active, not recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

The impact of glidants on the rheological properties of active pharmaceutical ingredients: A study of conventional and alternative flow enhancers. (PubMed, Int J Pharm) - "Three challenging powders were included: two extremely cohesive APIs (acetaminophen micronized (APAPμ) and metoprolol tartrate (MPT)) which previously have shown processing issues during different stages of the continuous direct compression (CDC)-line and a spray dried placebo (SD) powder containing hydroxypropylmethyl cellulose (HPMC), known for its sub-optimal flow with a high specific surface area (SSA) and low density...Finally, to determine the appropriate concentration of the different classes of glidants, SAC calculations, an understanding of the glidant's working mechanism, and knowledge about the API's characteristics (i.e., morphology, compressibility, flowability, aeration, density, and wall friction) are required. This study confirmed the necessity of including various material characterization techniques to assess the impact of glidants on the bulk characteristics of APIs."

Journal

Development and validation of a RP-HPLC method for simultaneous determination of cimetidine, metoprolol tartrate and phenol red for intestinal perfusion studies. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "The applicability of the method was demonstrated by preliminary in-situ intestinal perfusion studies. In conclusion, samples obtained from in-situ intestinal perfusion studies performed to examine the absorption/permeability of CIM, MT, and PR can be analyzed with the developed HPLC method."

Journal

Bridge from Arrest to Recovery: Sudden Cardiac Arrest in a Young Patient with Concomitant Myocardial Bridge and Hypertrophic Cardiomyopathy (AHA 2024) - "Metoprolol tartrate was started for management of hypertrophic cardiomyopathy (HCM) and MB...However, the existing literature is inconclusive regarding the exact association between MBs and cardiovascular mortality in HCM. Here, we highlight the potentially increased risk of sudden cardiac arrest conferred by MB in HCM and the need for further studies to delineate this association."

Clinical • Atherosclerosis • Cardiomyopathy • Cardiovascular • Dyslipidemia • Fibrosis • Hypertrophic Cardiomyopathy • Immunology

Enhancing ventricular remodeling and cardiac function in post-acute myocardial infarction with sacubitril/valsartan. (PubMed, Am J Transl Res) - P=N/A | "Our findings indicate that sacubitril/valsartan (LCZ696) Sodium Tablets effectively enhance ventricular remodeling and cardiac function in patients with HF post-AMI, following a short-term treatment regimen. This therapeutic approach holds promise for improving clinical outcomes in this patient population."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

THE YOUNG AND HYPERTENSIVE: SDHB-RELATED PHEOCHROMOCYTOMA (CHEST 2024) - "Prior to the surgery, she was placed on doxazosin 10 mg daily for alpha blockade, metoprolol tartrate 100 mg daily for beta-blockade, amlodipine 2.5 mg daily, high salt diet to suppress RASS and IV fluids for volume expansion. PGL can present significant morbidity and mortality if left undiagnosed and untreated. This case highlights the importance of early recognition and management. Furthermore, the identification of a deleterious SDHB germline mutation underscores the need for genetic testing and family screening in patients with suspected PGL, allowing for early detection and intervention in at-risk relatives."

Cardiovascular • CNS Tumor • Endocrine Cancer • Hypertension • Oncology • Pain • Solid Tumor • SDHB

A DEADLY COCKTAIL: BRASH SYNDROME IN THE SETTING OF POLYPHARMACY (CHEST 2024) - "Home medications included losartan, metoprolol tartrate, metformin, and amlodipine. BRASH Syndrome remains under-diagnosed; clues such as bradycardia with sinus arrest, AV nodal blocker use, and mild hyperkalemia with renal failure should raise concern. Prompt recognition is crucial, as treatment can differ from competing etiologies of shock."

Cardiovascular • Chronic Kidney Disease • CNS Disorders • Depression • Diabetes • Diabetic Nephropathy • Hypertension • Hypotension • Metabolic Disorders • Nephrology • Psychiatry • Renal Disease • Respiratory Diseases • Type 2 Diabetes Mellitus

HAPPY HOUR TURNS SOUR: TYPE B AORTIC DISSECTION COMPLICATED BY ALCOHOL WITHDRAWAL (CHEST 2024) - "Patient was admitted to the intensive care unit and started on on esmolol drip (gtt), nicardipine gtt, cardizem and metoprolol tartrate...He was treated with phenobarbital for two days...Patient was continued on esmolol gtt and nicardipine gtt with addition of nitroprusside gtt...He was discharged on chlorthalidone 50mg, nifedipine 90mg, spironolactone 50mg, valsartan 320mg, minoxidil 5mg twice daily, and carvedilol 50mg twice daily... This is a 39 year old male with history of poor compliance to medications and alcohol abuse who required an extended stay in the intensive care unit due to refractory hypertension which was likely multifactorial, involving endothelial damage and genetic predisposition. He will require strict adherence to his new medication regimen, alcohol abstinence and follow up with vascular surgery to ensure a fair prognosis. We conclude that history of alcohol abuse may be a risk factor for complications of Type B aortic dissection."

Cardiovascular • Fibrosis • Hepatology • Hypertension • Immunology • Inflammation • Inflammatory Bowel Disease • Movement Disorders • Myositis • Pain • Psychiatry

FATAL CASE OF THEOPHYLLINE TOXICITY (CHEST 2024) - "He was given 3 doses of adenosine (6 mg, 12 mg, 12 mg), and amiodarone 150 mg bolus, and 5mg metoprolol tartrate IV...Esmolol infusion was attempted for reversal of peripheral dilation however it led to profound hypotension and was discontinued... Theophylline toxicity is rare; however, upon presentations providers must act swiftly to manage patients safely. Early activated charcoal may have prevented the rapid decline, so in our case it should have been the first step in management for theophylline toxicity."

Clinical • Asthma • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • CNS Disorders • Epilepsy • Hematological Disorders • Hypotension • Immunology • Pulmonary Disease • Respiratory Diseases

A STRANGE CASE OF VIBRIO VULNIFICUS (CHEST 2024) - "Home medications included aspirin, atorvastatin, citalopram, tiotropium bromide, ipratropium/albuterol inhaler, lisinopril, metoprolol tartrate, and pramipexole.Laboratory results showed notable abnormalities: sodium 131, BUN 77, creatinine 3.5, and WBC 20.2. Vibrio vulnificus, a rare and potent bacterium, may cause septicemia or severe cellulitis, progressing swiftly to necrotizing fasciitis. Exposure through open wounds and water contact is not always required. Swift identification and detailed history are crucial for effectively managing Vibrio vulnificus infections."

Clinical • Beta-Thalassemia • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Dermatology • Diabetes • Diabetic Nephropathy • Dyslipidemia • Genetic Disorders • Heart Failure • Hematological Disorders • Hepatology • Hypotension • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Movement Disorders • Obstructive Sleep Apnea • Osteoarthritis • Pain • Renal Disease • Respiratory Diseases • Restless Legs Syndrome • Rheumatoid Arthritis • Rheumatology • Septic Shock • Sleep Disorder

UNRAVELING THE RHYTHM: A CASE REPORT OF NEW-ONSET ATRIAL FIBRILLATION WITH ANAPLASMOSIS (CHEST 2024) - "The patient was initiated on a course of doxycycline for 13 days...Atrial fibrillation was managed with Lopressor initially and then transitioned to metoprolol 12.5 mg twice daily along with Eliquis... Through this report, we aim to underscore the importance of considering infectious etiologies in the differential diagnosis of AF, particularly in regions endemic to tick-borne illnesses, and to elucidate potential mechanisms underlying the association between anaplasmosis and cardiac dysrhythmias."

Case report • Clinical • Atrial Fibrillation • Cardiovascular • Diabetes • Dyslipidemia • Gastroenterology • Gastroesophageal Reflux Disease • Heart Failure • Hematological Disorders • Infectious Disease • Metabolic Disorders • Obstructive Sleep Apnea • Oncology • Pain • Respiratory Diseases • Sleep Disorder • Type 2 Diabetes Mellitus • IL1B • IL6 • TNFA