BAX 555 / Takeda - LARVOL DELTA

Anti-sickling efficacy and safety of Sailin-HbS, an indigenous Ayurvedic formulation. (PubMed, Blood Cells Mol Dis) - "We compared the anti-sickling effect of Sailin-HbS with known anti-sickling agents, Niprisan, SCD 101, AES-103/5-HMF and GBT440/Voxelotor, and found it to be equally and/or more effective. Sub-acute and chronic toxicity assessments in rats reveal no adverse effects on organ function or body weight, biochemical parameters, or complete blood counts, demonstrating its safety profile with established threshold levels. Thus, Sailin-HbS exhibits considerable anti-sickling efficacy without inducing toxicity, suggesting its translational potential in SCD."

Journal • Gene Therapies • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

[VIRTUAL] AES103 - Finding Function in the Deluge of Metagenomic Data (WMF 2021) - "Collectively, this session will present (i) DRAM, a computational tool that provides critical metabolic profiling capabilities of microbial and viral genomes and (ii) how to utilize annotation outputs to decode metabolic potential harbored in microbiomes. Upon completion of this Track Hub, the participant should be able to: Explain DRAM and DRAM-v annotation workflows, as well as how to interpret their outputs Infer basic metabolic functions from genomes and auxiliary metabolic genes using computational annotation methods Apply predicted metabolic potential of genomes to ecosystem relevant processes"