Eporon (epoetin alfa biosimilar) / Dong-A - LARVOL DELTA

NIMBUS: Neovascularization Induced by Mechanical Barrier disrUption and Systemic Erythropoietin in Patients With Cerebral Perfusion Deficits (clinicaltrials.gov) - P2; N=44; Completed; Sponsor: Ajou University School of Medicine; Not yet recruiting ➔ Completed; N=22 ➔ 44

Clinical • Enrollment change • Trial completion • Anesthesia • Cardiovascular • Ischemic stroke

Effects of intrathecal verapamil on cerebral vasopasm in experimental rat study. (PubMed, World Neurosurg) - "Our findings suggest that intrathecal verapamil can prevent vasospasm, oxidative stress, and apoptosis after experimental subarachnoid hemorrhage."

Journal • Preclinical

To Evaluate the Efficacy, Safety, and Immunogenicity of Subcutaneous Eporon Versus Epoetin Alfa (Eprex) (clinicaltrials.gov) - P3; N=214; Recruiting; Sponsor: Dong-A ST Co., Ltd.; Trial completion date: Dec 2019 ➔ Mar 2021; Trial primary completion date: Jun 2019 ➔ Sep 2020

Clinical • Trial completion date • Trial primary completion date

Efficacy and safety of CKD-11101 (darbepoetin-alfa proposed biosimilar) compared with Darbepoetin alfa in patient on hemodialysis (KSN 2019) - "The difference in change of the level of Hb, dose of EPO, and achievement rate to target Hb during study period was comparable between two groups. CKD-11101 has an equivalent therapeutic efficacy compared with the darbepoetin-alfa in patient undergoing hemodialysis."

Clinical