Alfenta (alfentanil) / Abbott - LARVOL DELTA

SED-ERCP: EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (clinicaltrials.gov) - P=N/A | N=20 | Recruiting | Sponsor: Chi Kwan Fung | Not yet recruiting ➔ Recruiting | Trial completion date: Mar 2028 ➔ Jun 2028

Enrollment open • Trial completion date • Anesthesia • Pain

Efficacy and safety of ciprofol for general anesthesia in pediatric strabismus correction surgery: a prospective, randomized, double-blind, non-inferiority study. (PubMed, Front Med (Lausanne)) - P1 | "For anesthesia induction, Group C received an intravenous injection of ciprofol 0.5 mg/kg, alfentanil 20 μg/kg, and vecuronium bromide 0.05 mg/kg; Group P received an intravenous injection of propofol 2 mg/kg, alfentanil 20 μg/kg, and vecuronium bromide 0.05 mg/kg. Ciprofol can be safely used for general anesthesia in pediatric strabismus correction surgery, with non-inferior anesthesia success rate compared with propofol and a lower incidence of adverse reactions. https://www.chictr.org.cn, identifier ChiCTR2300078654."

Clinical • Head-to-Head • Journal • Anesthesia • Ophthalmology • Pediatrics • Strabismus

The Influence of Pharmacological Agents Used During General Anesthesia on the Intensity of Postoperative Pain and the Occurrence of Post-Anesthetic Delirium-A Scoping Review. (PubMed, J Clin Med) - "Analysis of clinical trial outcomes conducted in pediatric populations undergoing various surgical procedures suggests that dexmedetomidine (administered intranasally and intravenously) and alfentanil were associated with lower incidence and severity of emergence delirium compared to standard care or other agents (e.g., midazolam)...Hydromorphone was reported in the included trials to be associated with better postoperative pain control than sufentanil, whereas remimazolam, although associated with reduced delirium incidence in some trials, did not influence the length of stay in the post-anesthesia care unit...Ketamine, while commonly used for analgesic therapy, did not demonstrate a consistent association with delirium prevention and, in some studies, was associated with increased neuropsychiatric events. Further research is required to more precisely define optimal perioperative delirium prevention protocols."

Journal • Review • Anesthesia • CNS Disorders • Cognitive Disorders • Insomnia • Pain • Pediatrics • Psychiatry • Sleep Disorder

Case Report: Esophageal balloon occlusion with a Foley catheter in high-risk sedated gastroscopy. (PubMed, Front Med (Lausanne)) - "After deepening sedation (MOAA/S score ≤ 2) with propofol and alfentanil (without endotracheal intubation), the endoscopy was performed while the esophageal balloon was gradually deflated under direct visualization...This case suggests that the use of esophageal balloon occlusion with negative-pressure suction was associated with safe, uneventful deep sedation in a patient at high risk of aspiration. The technique may serve as a simple, minimally invasive alternative to endotracheal intubation or awake endoscopy for airway protection in such high-risk patients, though further evaluation in larger studies is warranted."

Journal • Anesthesia • Gastroenterology • Gastroesophageal Reflux Disease

Effects of different doses of alfentanil on tracheal intubation stress responses in ambulatory hysteroscopic surgery: a randomized, double-blind, clinical comparative study. (PubMed, Front Med (Lausanne)) - P4 | "The low-dose alfentanil group (group AL) patients received an induction dose of 20 μg/kg alfentanil, the medium-dose alfentanil group (group AM) patients received 30 μg/kg alfentanil, the high-dose alfentanil group (group AH) received 40 μg/kg alfentanil, and the Fentanyl Group (group F) patients received an induction dose of 4 μg/kg fentanyl, with all groups additionally administered midazolam, cisatracurium, and propofol as part of the standardized induction protocol. Anesthesia maintenance was maintained with propofol and remifentanil in all groups...Secondary outcomes included plasma NE and epinephrine (E) levels at baseline (T0, before anesthesia induction), T2 (excluding NE as it was the primary measure), and 5 min post-intubation (T3), along with mean arterial pressure (MAP) and heart rate (HR) at T0, the time of the insertion of the tracheal tube (T1), T2, T3, 5 min after the removal of the tracheal tube (T4); additionally, extubation time, awakening time,..."

Clinical • Intubation • Journal • Anesthesia • Cardiovascular • Hypertension • Hypotension • Pain

22_RIPH1-08: Which is the best treatment to relieve severe acute pain in the prehospital phase : Morphine or alfentanil ? (clinicaltrialsregister.eu) - P4 | N=242 | Not yet recruiting | Sponsor: CHU De Martinique

New P4 trial • Pain

Evaluation of Therapeutic Opioids in Skin-Derived Matrices (Sweat and Sebum) of Neonatal and Pediatric Patients and Their Role in Opioid Incorporation Into Hair. (PubMed, Drug Test Anal) - "These patients had a treatment history with opioids, including fentanyl, sufentanil, remifentanil, alfentanil, morphine, methadone, and hydromorphone. In addition, a correlation was found for fentanyl between concentrations in hair and skin swab samples (r = 0.356, p = 0.0007), indicating a contribution of skin-derived matrices to opioid incorporation into the hair of children and neonates. The comprehensive and clinical nature of this study provides unique value for the generated concentration data and associated findings, providing a potential reference source for future interpretation of hair analysis results."

Journal • Critical care • Pediatrics

Remimazolam for Bronchoscopy in High-Risk Patients (clinicaltrials.gov) - P4 | N=360 | Recruiting | Sponsor: First Affiliated Hospital of Zhejiang University | Enrolling by invitation ➔ Recruiting

Enrollment status • Infectious Disease • Oncology • Pain • Respiratory Diseases

Optimizing sedation in elderly patients: advantages and challenges of alfentanil-ciprofol for painless gastroscopy. (PubMed, Am J Transl Res) - "The use of the traditional narcotic sedation guidelines like fentanyl and propofol is linked to respiratory and circulatory suppression in this at-risk group. Furthermore, we address the challenges inherent to its use in this age group, such as dose individualization and respiratory management, and propose potential solutions. Lastly, we outline future research directions, emphasizing that individualized dosing strategies based on the principles of precision anesthesia will be central to optimizing outcomes for elderly patients."

Journal • Review • Anesthesia • Pain

A clinical study on the safety and efficacy of anesthesia with target-controlled infusion of remimazolam or propofol in endobronchial ultrasound diagnosis and treatment (ChiCTR) - P1 | N=110 | Not yet recruiting | Sponsor: Affiliated Hospital of Jiangsu University; Affiliated Hospital of Jiangsu University

New P1 trial • Anesthesia

Comparison of the efficacy and safety of equivalent doses of ciprofol versus propofol in elderly patients undergoing gastroscopy. (ChiCTR) - P1 | N=180 | Recruiting | Sponsor: Liaoning Cancer Hospital & Institute; Liaoning Cancer Hospital

New P1 trial • Anesthesia • Geriatric Disorders

Exploration of the ED50 value and appropriate administration time of alfentanil for preventing rocuronium-induced limb withdrawal movements in children: an age-stratified study (ChiCTR) - P=N/A | N=100 | Not yet recruiting | Sponsor: Taizhou Hospital of Zhejiang Province; Taizhou Hospital of Zhejiang Province

New trial • Pain

Comparison of Alfentanil and Sufentanil for General Anesthesia in Complex Impacted Tooth Extraction (ChiCTR) - P=N/A | N=180 | Completed | Sponsor: School and Hospital of Stomatology, Hebei Medical University; School and Hospital of Stomatology, Hebei Medical University

New trial • Anesthesia

ED50 of Ciprofol Combined with Alfentanil for Suppression of Laryngeal Mask Airway Insertion Responses in Patients Undergoing Gynecological Laparoscopic Surgery (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Tai'an Central Hospital (Qingdao University Affiliated Tai'an Central Hospital, Taishan Medical Care Center); Tai'an Central Hospital (Qingdao Univers

New trial • Gynecology • Women's Health

Analgesic Efficacy and Adverse Effects of Epidural Ropivacaine Combined with Equipotent Alfentanil or Sufentanil for Labor Analgesia: A Multicenter Randomized Controlled Single-Blind Trial. (PubMed, Pain Ther) - P4 | "Both alfentanil and sufentanil, when combined with 0.075% ropivacaine, provide effective and safe epidural labor analgesia. However, alfentanil offers the advantage of a faster onset of analgesia, making it a valuable alternative to sufentanil in clinical practice."

Adverse events • Journal • Dermatology • Obstetrics • Pain • Pruritus

Dose-response relationship of remimazolam and afentanil for tympanostomy in children: based on the Dixon up-and-down sequential method (ChiCTR) - P=N/A | N=70 | Not yet recruiting | Sponsor: Affiliated Shunde Hospital of Jinan University; Affiliated Shunde Hospital of Jinan University

New trial • Otorhinolaryngology

Study on the Efficacy and Safety of Remimazolam Besylate Combined with Alfentanil in Elderly Patients Undergoing Flexible Bronchoscopy (ChiCTR) - P=N/A | N=146 | Not yet recruiting | Sponsor: Inner Mongolia Autonomous Region People's Hospital; Inner Mongolia Autonomous Region People's Hospital

New trial

The Effect and Safety of Alfentanil on Postoperative Vomiting in Children Aged 1-3 Years Undergoing Laparoscopic Herniorrhaphy：a randomized clinical trial (ChiCTR) - P4 | N=440 | Not yet recruiting | Sponsor: Children's Hospital of Chongqing Medical University; Children's Hospital of Chongqing Medical University

New P4 trial • Gastroenterology

Different doses of Afentanil combined EP mixture for painless gastrointestinal endoscopy application. (ChiCTR) - P=N/A | N=135 | Recruiting | Sponsor: Yanan University Affiliated Hospital; Yanan University Affiliated Hospital

New trial • Pain

Evaluation of the Hemodynamic Effects of Ciprofol Combined with Alfentanil in Patients Undergoing Painless Gastroenteroscopy via Echocardiography (ChiCTR) - P=N/A | N=84 | Not yet recruiting | Sponsor: Chongqing Red Cross Hospital; Chongqing Red Cross Hospital

New trial • Pain

A Comparative Study of Oliceridine versus Alfentanil and Sufentanil in Clinical Application for Painless Gastrointestinal Endoscopy (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Qingdao Binhai University Affiliated Hospital; Qingdao Binhai University Affiliated Hospital

New trial • Pain

The optimal interval time for programmed intermittent epidural bolus of 0.075% ropivacaine hydrochloride and 4 μg/ml alfentanil hydrochloride for labor epidural analgesia: A biased coin up-and-down sequential allocation trial (ChiCTR) - P=N/A | N=40 | Not yet recruiting | Sponsor: The General Hospital of the Northern Theater Command of the People's Liberation Army of China; The General Hospital of the Northern Theater Command of

New trial • Pain

The use of Fospropofol disodium and Propofol Combined with Low-Dose Alfentanil in Gastrointestinal Endoscopy: A Randomized Controlled Study (ChiCTR) - P=N/A | N=156 | Not yet recruiting | Sponsor: The People's Hospital of Fengqing; The People's Hospital of Fengqing

New trial • Pain

Study on the effective dose of alfentanil combined with ciprofol in inhibiting intraoperative body movement responses in patients undergoing breast lump resection. (PubMed, Front Med (Lausanne)) - P1 | "The ED50 of alfentanil combined with ciprofol for intravenous anesthesia to suppress movement during breast lumpectomy is 13.396 μg/kg, and the ED₉₅ is 15.752 μg/kg. http://www.chictr.org.cn, ChiCTR2500109829."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Psychiatry

RAA-TS: A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (clinicaltrials.gov) - P4 | N=50 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xinxiang Medical College

New P4 trial • Anesthesia