clomipramine / Generic mfg. - LARVOL DELTA

Determination of six psychotropic drug metabolites in human plasma by LC-MS/MS method (PubMed, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) - "Objective: To establish a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of N-desalkylquetiapine, hydroxybupropion, N-desmethyl clozapine, N-desmethyl clomipramine, O-desmethyvenlafaxine and dehydro aripiprazole in human plasma. The linear correlation coefficients were 0.9971-0.9999, the limits of quantification of the method were 0.10-6.00 μg/L, and the inter-and intra-day precision were 4.6%-9.8% and 1.5%-8.6%, with the recoveries of the spiked standards ranged from 90.0% to 106.1%. The LC-MS/MS method for the determination of metabolites of six psychotropic drugs in human plasma is simple, rapid and sensitive, and can be used for the qualitative and quantitative determination of metabolites in plasma samples of patients suspected of psychotropic drug poisoning."

Journal

A novel case of aripiprazole and clomipramine-induced toxic megacolon: enough to drive anyone mad. (PubMed, J Surg Case Rep) - "Scattered cases of antipsychotic-induced toxic megacolon have been described in the literature, but to the author's knowledge, none related to aripiprazole or clomipramine. This case highlights the importance of diligent clinical monitoring for patients on psychiatric medications."

Journal • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Psychiatry

Repurposing Tricyclic Antidepressants for Glioblastoma Treatment (EACR 2025) - "Our lab has previously proposed a successful novel combinatorial regimen, including the tricyclic antidepressant (TCA) imipramine, the vascular endothelial growth factor (VEGF) inhibitor bevacizumab, and the immune checkpoint inhibitor anti-PD-L1, which demonstrated significant therapeutic benefit in GBM mouse models (Chryplewicz et al.; Cancer Cell, 2022)...Motivated by these results and encouraged by the clinical support, we aim to further improve this therapeutic regimen by disrupting various capabilities of tumors required for their growth and therapeutic resistance.Material and To optimize this regimen for clinical translation, we screened multiple TCAs - trimipramine, clomipramine, and amitriptyline - alongside imipramine in mouse and human GBM cell lines to evaluate their impact on cell viability... This study aims to delve deeper into TCA mechanisms of action, assess potential synergies with VEGF pathway inhibitors and immune checkpoint blockade, and ultimately..."

IO biomarker • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Update on obsessive-compulsive and related disorders (PubMed, Nervenarzt) - "Pharmacotherapy is primarily carried out with serotonin reuptake inhibitors (SSRIs or clomipramine)...Finally, a short summary delineates other OCD-related disorders. New diagnostic and treatment options to reduce the treatment resistance rates seem promising."

Journal • CNS Disorders • Immunology • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Evidence Based Management of OCD through NbN Lens (CINP-AsCNP 2025) - "Aims & Objectives: SRI dosing is typically constrained by toxicity (e.g., clomipramine) or standard dose ranges proven effective for conditions like depression and anxiety. We will also discuss the medical precautions required when exceeding FDA/EMA-recommended doses and conclude with the clinical and legal implications of super-dosing in OCD treatment."

CNS Disorders • Depression • Mood Disorders • Psychiatry • NBN

A rapid clinical response to etifoxine in treatment-resistant obsessive-compulsive disorder: A case report and literature review (CINP-AsCNP 2025) - "He had received numerous psychotropics, including maximum dosages of SSRIs (escitalopram, sertraline), SNRIs (venlafaxine), and TCAs (clomipramine, imipramine), and several previous augmentations (lithium, risperidone, aripiprazole, quetiapine), but failed to respond...His latest regimen included venlafaxine 375 mg/d, clomipramine 150 mg/d, aripiprazole 15 mg/d, and clonazepam 4 mg/d... This is the first report of the use of a TSPO ligand in OCD treatment. This case illustrates the potential therapeutic option of etifoxine for treatment-resistant OCD. There are at least 2 possible mechanisms of the rapid response to etifoxine: (1) Increase endogenous neurosteroidogenesis."

Case report • Clinical • Review • Dermatology • Obsessive-Compulsive Disorder • Pruritus • Psychiatry • Suicidal Ideation

Evaluation of the Effect of Aldehyde Oxidase Inhibitors on 6-Mercaptopurine Metabolism. (PubMed, Biol Pharm Bull) - "Thiopurines, such as 6-mercaptopurine (6-MP) and azathioprine, are converted to the inactive metabolites 6-thioxanthin (6-TX) and 6-thiouric acid (6-TUA)...The metabolism of 6-MP to 6-TX was strongly inhibited by AOX inhibitors (amitriptyline, chlorpromazine, clomipramine, clozapine, hydralazine, quetiapine, and raloxifene) in a reaction mixture containing human liver cytosol. The inhibition of 6-TX production rate by each AOX inhibitor was 60-70% at high concentrations, although the XO inhibitor febuxostat showed an inhibition rate of 10-30%...However, because of the lower activity of AOX in rats than that in humans, the contribution of AOX could not be assessed using in vivo experiments. Further studies are needed to evaluate the contribution of AOX to the therapeutic and adverse effects of thiopurines, both in clinical studies and in animal models of liver humanization."

Journal • Hematological Disorders

An Overview of the Systematic Reviews About the Efficacy of Fluvoxamine on Depression. (PubMed, Pharmaceuticals (Basel)) - "Comparisons with imipramine, clomipramine, amitriptyline, dothiepin, paroxetine, fluoxetine, citalopram, mianserin, nortriptyline, and moclobemide generally revealed no significant differences in efficacy. However, some reviews indicated that venlafaxine and mirtazapine were superior to fluvoxamine in certain outcomes, while fluvoxamine demonstrated greater efficacy than desipramine in one review. Sertraline and milnacipran showed mixed or review-quality-dependent results, with one low-quality review favoring milnacipran...While no single antidepressant was universally superior, fluvoxamine's unique pharmacological profile and favourable safety characteristics support its clinical utility. Further research is needed to explore its role in personalized treatment strategies and emerging therapeutic contexts, such as comorbid anxiety and post-traumatic stress disorder."

Journal • Review • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

The Efficacy of Memantine Augmentation in Adult Patients With Treatment-Resistant Obsessive-Compulsive Disorder: An Analysis of Short-Term Studies (APA 2025) - "Description Background: Obsessive-compulsive disorder (OCD) is a distressing condition and many patients are often treatment-resistant despite the use of selective serotonin reuptake inhibitors (SSRIs), clomipramine or adjunctive antipsychotics. Memantine augmentation for a period of at least eight weeks appears to be an effective and well-tolerated option for patients with moderate to severe refractory OCD. This intervention is clinically relevant, particularly in patients with treatment-resistant OCD and a history of mania or those intolerant to supratherapeutic doses of SSRIs (an often-used strategy in refractory cases). Future research over a period much greater than 12 weeks and with a larger sample size is indicated to explore the long-term efficacy and safety of memantine to better guide clinical decision-making."

Clinical • Bipolar Disorder • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Pain • Psychiatry

Practical Management With "Scary" Meds: How to Impress Your Attending After APA (APA 2025) - "Whether they have always been the gold standard for a specific illness (e.g., tricyclic antidepressants such as clomipramine for OCD), gained renewed attention based on recent research and guidelines (e.g., monoamine oxidase inhibitors such as phenelzine for depression), or offer unique benefits for patients with certain symptom profiles (e.g., clozapine and lithium for suicidal ideation), these medications remain important tools in psychiatry's armamentarium...Finally, an audience question and answer session will provide trainees the opportunity to seek advice and provide feedback about their training in the use of these medications. Instructional Level Intermediate; Learning Objectives Objective One: IDENTIFY clinical situations in which clozapine, lithium, tricyclic antidepressants, and monoamine oxidase inhibitors would be indicated Objective Two: DISCUSS how racial disparities impact prescription of effective psychiatric treatments like clozapine and lithium,..."

CNS Disorders • Depression • Psychiatry • Suicidal Ideation

High performance thin layer chromatography with eluents containing SDS aided by UV- and Raman spectroscopy. (PubMed, Sci Rep) - "The effect of sodium dodecyl sulphate, SDS, concentration on the chosen drug used in neurodegenerative disorder (sulpiride, olanzapine, carbamazepine, trazodone, clomipramine, and pridinol) retention has been investigated. The new method has better or comparable concentration ranges regarding some of investigated compounds to those presented previously. Additionally, for the first time, a strategy involving various techniques (TLC chromatography supported by UV- and Raman spectroscopy and conductometry) for complex analysis of the separation system was presented, inspiring potential future research directions."

Journal • CNS Disorders

Carbon Materials in Voltammetry: An Overview of Versatile Platforms for Antidepressant Drug Detection. (PubMed, Micromachines (Basel)) - "Moreover, the combination of voltammetric approaches with the unique characteristics of carbon and its derivatives has led to the development of powerful electrochemical sensing tools for detecting antidepressant drugs, which are highly desirable in healthcare, environmental monitoring, and the pharmaceutical industry. In this review, carbon-based materials, such as glassy carbon and boron-doped diamond, and a wide spectrum of carbon nanoparticles, including graphene, graphene oxides, reduced graphene oxides, single-walled carbon nanotubes, and multi-walled carbon nanotubes were described in terms of the sensing performance of agomelatine, alprazolam, amitriptyline, aripiprazole, carbamazepine, citalopram, clomipramine, clozapine, clonazepam, desipramine, desvenlafaxine, doxepin, duloxetine, flunitrazepam, fluoxetine, fluvoxamine, imipramine, nifedipine, olanzapine, opipramol, paroxetine, quetiapine, serotonin, sertraline, sulpiride, thioridazine, trazodone, venlafaxine,..."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Personality Disorder • Psychiatry

Treatment with antidepressant drugs and hyponatremia: a network meta-analysis. (PubMed, J Endocrinol Invest) - "These data appear useful on clinical grounds, in order to increase the awareness regarding the possibility that antidepressants induce hyponatremia and to encourage regular serum sodium monitoring."

Journal • Retrospective data • Review • Cardiovascular • Heart Failure

High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring. (PubMed, Front Pharmacol) - "In this paper, we developed a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method to study simultaneously TDM and clinical pharmacokinetics of 23 antidepressants and active metabolites: sertraline, escitalopram, fluvoxamine, paroxetine, duloxetine, milnacipran, fluoxetine, venlafaxine, O-desmethylvenlafaxine, mirtazapine, trazodone, bupropion, hydroxybupropione, norfluoxetine, vortioxetine, agomelatine, mianserin, doxepine, desmethyldoxepin, clomipramine, desmethylclomipramine, amitriptyline and nortriptyline hydrochloride...Validation of the developed method was carried out based on the Chinese Pharmacopoeia guidelines for bioanalytical method validation, including assessment of specificity, calibration curves, carryover, accuracy, crosstalk, precision, stability, recovery, dilution integrity and matrix effect. The results showed that a simple, fast, reliable and specific HPLC'MS/MS method was developed and validated, and all the..."

Journal • CNS Disorders • Depression • Psychiatry

Global burden of antidepressant-associated seizures from 1967 to 2023: A comparative analysis of the international pharmacovigilance database. (PubMed, J Affect Disord) - "Our findings align with earlier studies indicating that SNRIs and SSRIs carry a lower risk of seizures, whereas bupropion and clomipramine are linked to a higher risk. Agomelatine, vortioxetine, and SNRIs like desvenlafaxine and duloxetine may potentially be safe alternatives."

Adverse events • Journal • CNS Disorders • Epilepsy

Drug treatment for myotonia. (PubMed, Cochrane Database Syst Rev) - "More-recent trials are more robust, and well-conducted RCTs demonstrate moderate-certainty evidence for the efficacy of symptomatic treatments in non-dystrophic myotonias. Additionally, the data suggest that not all patients respond to therapy and research into aetiology and treatment options for non-responders is needed. Other agents that have not been tested in RCTs, such as acetazolamide, flecainide, ranolazine, and lacosamide, will need to be considered when planning future clinical trials. Moreover, the RCTs, in particular the small numbers of most trials, highlight the challenges in recruitment and design of robust trials in rare diseases, and research into trial design to improve recruitment in rare diseases will be important for future trials."

Journal • Review • Cardiovascular • Cataract • CNS Disorders • Fatigue • Gastrointestinal Disorder • Genetic Disorders • Muscular Dystrophy • Myositis • Myotonic Dystrophy • Ophthalmology • Pain • Rare Diseases

The Efficacy of Fluvoxamine in Anxiety Disorders and Obsessive-Compulsive Disorder: An Overview of Systematic Reviews and Meta-Analyses. (PubMed, Pharmaceuticals (Basel)) - "Three meta-analyses comparing fluvoxamine to clomipramine in OCD found no significant differences in efficacy regarding symptom improvement. Overall, the efficacy of fluvoxamine in the treatment of OCD and SAD was demonstrated. While some reviews highlighted its potential in alleviating GAD, its impact on panic-specific outcomes remained inconsistent."

Journal • Review • CNS Disorders • General Anxiety Disorder • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry • Social Anxiety Disorder

AI One-Click Processing-Assisted Nanozyme-Based Fluorescence Capillary Imprinted Sensor Array for Microvolume Rapid Discrimination Antidepressants. (PubMed, Anal Chem) - "In this study, a nanozyme fluorescence capillary imprinted sensor array combined with fluorescence mode and artificial intelligence (AI) one-click processing fluorescence image mode was developed for the rapid visual discrimination and quantification of five ADs (imipramine, citalopram, clomipramine, amitriptyline, and sertraline). With the lower detection limit for identification of five ADs, the nanozyme fluorescence capillary imprinted sensor array was successfully employed for the discrimination of unknown samples in lake water and hospital sewage and freeze-dried with an accuracy of 90.5%. With the advantage of high sensitivity and low reagent consumption, the nanozyme fluorescence capillary imprinted sensor array provides a new strategy for the rapid detection of ADs in trace multipollutant environmental samples."

Journal

Real-world data on behavioral practices for dogs in primary care veterinary hospitals in the United States (2010-2020). (PubMed, J Am Vet Med Assoc) - "Information retrieved included prescription of clomipramine, fluoxetine, or trazodone; patient signalment; and common behavior problem labels (aggression, separation anxiety, and fear or anxiety unrelated to separation anxiety). Furthermore, about 70% of cases prescribed psychoactive medications lacked target behavior problem labels. These findings highlight a critical need to bridge the knowledge gap between identifying behavior problems and effectively addressing them in behavioral practice within primary care veterinary settings."

Journal • Real-world evidence • Mood Disorders • Psychiatry

Systematic review of pharmacotherapy for atypical facial pain: evaluation of pain reduction, depression, anxiety and quality of life. (PubMed, Ann Med) - "Antidepressants such as dothiepin and clomipramine demonstrated significant pain reduction, whereas venlafaxine showed limited efficacy. However, onabotulinum toxin A and sumatriptan exhibited inconsistent or minimal effects on AFP pain intensity...Given the variability in response and adverse events, a multimodal approach combining pharmacological and non-pharmacological therapies may offer the most effective management strategy. Future research should focus on standardized treatment protocols, long-term efficacy, and personalized treatment plans to optimize patient care."

HEOR • Journal • Review • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry • Xerostomia

PERIODIC HYPOTHERMIA WITH HYPERHIDROSIS, ADIPSIA, AND BRADYCARDIA AFTER EPENDYMOMA RESECTION (SCCM 2025) - " Clomipramine, clonidine, and cyproheptadine have been reported to prevent future episodes of periodic hypothermia. Since this rare phenomenon can present like other endocrinologic diagnoses following neurosurgery, recognition in the postoperative course is important for informed treatment decisions and improved patient outcomes. This case adds to the small body of literature on this topic."

Cardiovascular • CNS Disorders • Dermatology • Ependymoma • Gastrointestinal Disorder • Metabolic Disorders • Oncology • Pain • Psychiatry • Rare Diseases • Solid Tumor • Ventriculomegaly

The Assessment of the Safety Profile of Selective Serotonin Reuptake Inhibitors Versus Other Antidepressants: Drug-Drug Interaction Insights from EudraVigilance. (PubMed, J Clin Med) - " SSRIs were the focus of 137,369 ICSRs while for the other antidepressants, namely amitriptyline, clomipramine, duloxetine, venlafaxine, mirtazapine, bupropion, trazodone, tianeptine, agomelatine, brexpiprazole, and esketamine, a total of 155,458 reports were registered...Except fluvoxamine (n = 463), the remaining SSRIs had a higher number of DDIs reported (n = 1049 for escitalopram and n = 1549 for sertraline) compared to other antidepressants...Sertraline appears in more reports concerning DDIs than the other antidepressants. Still, further real world studies related to the DDIs of SSRIs are needed to complete the relevant knowledge level."

Journal • CNS Disorders • Depression • Psychiatry

An Exploration of the Interplay Between Caffeine and Antidepressants Through the Lens of Pharmacokinetics and Pharmacodynamics. (PubMed, Eur J Drug Metab Pharmacokinet) - "The interaction between fluvoxamine and caffeine resulted in increased concentrations of caffeine in the body and lowered the renal clearance of fluvoxamine. Other SSRIs such as fluoxetine and escitalopram had augmented antidepressant effects by decreasing their renal clearance and prolonging their effects in the body when coadministered with caffeine. Caffeine may also increase the concentration of paroxetine, potentially affecting its pharmacodynamic effects. TCAs such as clomipramine, imipramine, desipramine, and sertraline, were found to reduce the metabolism of caffeine...The inhibition of caffeine at high doses when used with MAOIs such as tranylcypromine and phenelzine was found to lead to a higher likelihood of experiencing hypertension. Coadministration of caffeine with venlafaxine (SNRIs) suggests minimal interactions between the two substances and the pharmacodynamic effects of venlafaxine were unlikely to be impacted by caffeine consumption. Miscellaneous..."

Journal • PK/PD data • Review • Cardiovascular • CNS Disorders • Hypertension • Psychiatry

Psychotropic Drugs in Dermatology Part 1: Anti-depressants and Mood Stabilisers. (PubMed, Indian J Dermatol) - "These include selective serotonin reuptake inhibitors like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, alongside selective serotonin norepinephrine reuptake inhibitors such as venlafaxine, desvenlafaxine, and duloxetine. Additionally, norepinephrine dopamine reuptake inhibitors like bupropion; tricyclic antidepressants including doxepin, amitriptyline, imipramine, and clomipramine; and tetracyclic antidepressants like mirtazapine are commonly employed. Supplementary medications like anti-convulsants (e.g., gabapentin and pregabalin) further enrich the therapeutic landscape in psycho-dermatology...After screening 2287 records, 26 studies met the inclusion criteria. The findings underscore the potential role of psychotropic drugs in managing dermatological conditions, highlighting the need for further research to strengthen the evidence base in psycho-dermatology."

Journal • Review • CNS Disorders • Dermatology • Mental Retardation • Psychiatry

Clomipramine-Induced Urinary Retention in an Adult Male - A Case Report. (PubMed, Curr Drug Saf) - "Clinicians should be vigilant for urinary retention in patients receiving clomipramine, especially at higher doses. Regular monitoring and dose adjustments are crucial for managing this side effect without compromising the therapeutic benefits for OCD."

Journal • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry