clomipramine / Generic mfg. - LARVOL DELTA

Retrospective Analysis of Compulsive-like Long-Standing Unacceptable Urination in Cats. (PubMed, Vet Sci) - "Follow-up completion was also consistently higher in group C across all time points. These findings might suggest a pattern of compulsive-like elimination, with the observed response to clomipramine providing further support for this conceptual framework."

Journal • Retrospective data

Pharmacological treatment of obsessive-compulsive disorder in children and adolescents: An overview. (PubMed, World J Clin Pediatr) - "Clomipramine is also an effective medication option, but its use is limited by tolerability concerns...Newer treatments for pediatric OCD that are effective, safe, and well-tolerated are needed. This comprehensive review outlines the approach to pharmacological treatment of pediatric OCD and the evidence supporting their use."

Journal • Review • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Pediatrics • Psychiatry

Targeting of Itch by clomipramine or gene therapy improves cognitive defects related to Alzheimer's disease. (PubMed, iScience) - "Clomipramine was able to inhibit Itch in neurons and prevent their apoptosis in response to Aβ42. Given that clomipramine is being used against psychiatric disorders, this drug may be repurposed for use against AD."

Journal • Alzheimer's Disease • CNS Disorders • Gene Therapies • Mental Retardation • Psychiatry • Targeted Protein Degradation • Aβ42

Trouble obsessionnel compulsif au Maroc - Évaluation des pratiques thérapeutiques (PubMed, Sante Ment Que) - "After the failure of an initial SSRI, 35.3% recommended trying another SSRI, while others suggested adding an antipsychotic or trying clomipramine (37.9% and 14.7%, respectively)...Conclusion This study highlights marked trends in OCD treatment practices in our context, revealing both concordances and discrepancies with international recommendations. The dissemination and adoption of best prescribing practices, as well as regular monitoring of therapeutic regimens, are crucial to improving the management of patients with OCD and ensuring a more guideline-conformant approach."

Journal • CNS Disorders • Mental Retardation • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Clinical trial to evaluate the effectiveness and efficiency of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT clinical trial. (clinicaltrialsregister.eu) - P4 | N=240 | Not yet recruiting | Sponsor: Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz

Biomarker • New P4 trial • CNS Disorders • Depression • Mood Disorders • Psychiatry • HTR2A • SLC6A4

Current options for the treatment of anxiety in adults with autism spectrum disorder. (PubMed, Expert Rev Neurother) - "Pharmacological treatments show mixed fluvoxamine and clomipramine have shown promise, while citalopram, propranolol, and intranasal oxytocin yielded limited efficacy. Equity in care critical to improving access for this underserved population and requires comprehensive education in neurodevelopmental disorders for researchers and clinicians. Further research and innovation are needed to validate tools and optimize treatment strategies for this often-excluded population."

Journal • Review • Autism Spectrum Disorder • CNS Disorders • Critical care • Depression • Developmental Disorders • General Anxiety Disorder • Genetic Disorders • Mood Disorders • Psychiatry

Neonatal Clomipramine Exposure Disrupts Epididymal Serotonin Signaling and Programs Sperm Dysfunction in Adult Rats. (PubMed, Int J Mol Sci) - "This reprogramming of the local serotonergic milieu was associated with reduced sperm concentration, viability, normal morphology, and motility, alongside increased mitochondrial activity and reactive oxygen species. This study reveals, for the first time, that the epididymal serotonergic system is a key target for neonatal SSRI programming, providing a mechanistic link (altered 5-HT homeostasis) between early-life exposure and persistent sperm defects in adulthood."

Journal • Preclinical

Disruption in Access to Essential Drugs: The Anafranil Shortage in Spain. (PubMed, Span J Psychiatry Ment Health) - No abstract available

Journal

Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study. (PubMed, Iran J Basic Med Sci) - "Ciprofloxacin (CPX) was administered orally to adult male Wistar albino rats at a dose of 50 mg/kg for 14 days to induce depression. Clomipramine-loaded NC via intranasal routes returned the brain content of 5-HT and EAAT 2 to its normal level and has effect superior than oral route. Clomipramine-loaded NC administered via intranasal route showed an enhanced effect and a higher antidepressant activity than the traditional oral route through alleviating CPX neurological toxicity."

Journal • CNS Disorders • Depression • Psychiatry

Identifying and Managing Obsessive-Compulsive Disorder in Primary Care. (PubMed, Pediatr Ann) - "For treatment-resistant cases, augmentation with clomipramine or low-dose antipsychotics may be considered under specialist guidance. Sustained therapy and relapse prevention strategies are critical to maintaining remission. Early recognition and coordinated care can substantially improve prognosis for youth with OCD."

Journal • Review • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Pediatrics • Psychiatry

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and CYP2C19 and tricyclic antidepressants. (PubMed, Eur J Hum Genet) - "For CYP2D6 poor metabolisers (PM), dose reductions are advised for amitriptyline (reduction to 60% of the normal dose), clomipramine (reduction to 50% of the normal dose for the indication depression or in case of side effects at the normal dose for the other indications), doxepin (reduction to 40% of normal dose), imipramine (30% of the normal dose), and nortriptyline (40%)...The DPWG classifies CYP2D6 genotyping for all five TCAs and CYP2C19 genotyping for clomipramine in patients with anxiety disorders or OCD, and for imipramine as being "potentially beneficial". Genotyping prior to treatment can be considered on an individual patient basis."

Biomarker • Journal • CNS Disorders • Depression • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry • CYP2C19

Middle meningeal artery lidocaine infusion for refractory migraine: First case report in Portugal (EHF-EHC 2025) - "Various pharmacologic classes were tried without benefit: antihypertensives and calcium channel blockers (propranolol, candesartan, flunarizine), antiepileptics (valproic acid, topiramate, oxcarbazepine), antidepressants (amitriptyline, nortriptyline, venlafaxine, fluvoxamine, sertraline, clomipramine), other preventives (prednisolone, oxitriptan, melatonin), cycles of botulinum toxin (PREEMPT protocol), monoclonal antibodies (galcanezumab, fremanezumab, erenumab), and atogepant. At the time of the procedure, the patient was on eptinezumab 100 mg and botulinum toxin every three months but continued to have daily headaches, with severe intensity and reliance on eletriptan for acute relief... MMA lidocaine infusion has been described in few cases, and this is, to our knowledge, the first reported in Portugal. It constitutes an invasive therapeutic approach that should be considered only as a rescue option for carefully selected patients with severely refractory migraine...."

Case report • Clinical • Anorexia • CNS Disorders • Migraine • Pain

Analgesic Efficacy and Subacute Toxicity of Moroccan Aqueous Moringa oleifera Leaf Extract in a Chronic Constriction Injury Mouse Model of Neuropathic Pain. (PubMed, J Ethnopharmacol) - "AEMO is rich in bioactive compounds, safe for subacute use, and demonstrates significant antinociceptive activity with preservation of nerve histology, supporting its traditional use and potential as a natural analgesic."

Journal • Preclinical • Neuralgia • Pain

Severe Neurocognitive Manifestations in Healthy Young Individuals With COVID-19: A Case Series. (PubMed, Clin Med Insights Case Rep) - "Clomipramine, Zolpidem and Clonazepam were effective in treating these patients. Even in healthy young individuals with COVID-19, severe neurocognitive manifestations could appear with possible long-term consequences. Further research is needed to expand the knowledge on mechanisms, targeted therapeutic strategies and predictors identifying at-risk groups."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Depression • Fatigue • Infectious Disease • Mental Retardation • Mood Disorders • Novel Coronavirus Disease • Psychiatry • Sleep Disorder

Delirium Induced by Rapid Titration of Osilodrostat in a Patient With Cushing's Disease: A Case Report. (PubMed, Cureus) - "We report a woman in her early 40s with a history of major depressive disorder treated with clomipramine. The episode suggests that abrupt cortisol fluctuations may induce psychiatric symptoms even under hydrocortisone supplementation. Clinicians should avoid rapid titration and ensure close collaboration between endocrinology and psychiatry when psychiatric symptoms arise during treatment."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Cushing’s Disease • Depression • Endocrine Disorders • Infectious Disease • Major Depressive Disorder • Nephrology • Psychiatry • Renal Disease • Suicidal Ideation

New-Onset Psychotic Symptoms Associated With Neuromodulation in a Patient With Severe OCD: A Case Report. (PubMed, J ECT) - "He had a longstanding history of contamination obsessions, "just-right" phenomena, repeating compulsions, and severe avoidance, with minimal response to multiple trials of Serotonin Reuptake Inhibitors (SRIs) including clomipramine...Symptoms resolved with antipsychotic treatment. We describe the clinical course and discuss putative mechanisms underlying the emergence of psychosis with neuromodulation in OCD."

Journal • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

The ABC:s of obsessive-compulsive disorder (PubMed, Lakartidningen) - "If treatment response is inadequate, low-dose antipsychotics can be added, followed by a switch to clomipramine. Deep transcranial magnetic stimulation (dTMS) and deep brain stimulation (DBS) may be considered for severe, treatment-resistant OCD."

Journal • Review • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Comparative gastrointestinal effects of antidepressants for the acute treatment of adults with major depressive disorder: a network and dose‒response meta-analysis. (PubMed, Transl Psychiatry) - "Commonly used antidepressants have different gastrointestinal effects. Duloxetine, levomilnacipran, and vilazodone carry a higher risk of inducing nausea and vomiting, whereas trazodone, amitriptyline, agomelatine, and mirtazapine tend to be better tolerated. Amitriptyline, clomipramine, and reboxetine are more prone to induce constipation. Diarrhoea is more commonly associated with vilazodone, fluvoxamine, and sertraline. Amitriptyline, reboxetine, and duloxetine are more likely to cause anorexia. Amitriptyline, reboxetine, and trazodone are related to causing dry mouth. Compared with the placebo, amitriptyline, fluoxetine, and paroxetine were associated with a greater incidence of dyspepsia."

Journal • Retrospective data • Review • Anorexia • CNS Disorders • Constipation • Depression • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Major Depressive Disorder • Mood Disorders • Psychiatry • Xerostomia

From Genes to Lifestyle: A Multi-Dimensional Framework for Alzheimer's Disease Prevention and Therapy. (PubMed, Ageing Res Rev) - "Drug repurposing analyses using DrugBank have identified promising therapeutic candidates, including FDA-approved agents (e.g., valproic acid, raloxifene, and clomipramine) and naturally derived compounds (e.g., quercetin and fisetin), which may modulate key AD-related pathways. Collectively, these integrative insights advocated for a multidimensional precision medicine framework that spans genetic, cellular,network, and lifestyle levels of regulation. This shift from single-target therapeutics to an integrated "gene-cell-network-lifestyle" paradigm open new theoretical and translational avenues for delaying or mitigating AD progression."

Journal • Review • Alzheimer's Disease • CNS Disorders • Inflammation

Exploring the therapeutic potential of psilocybin for Obsessive-Compulsive Disorder - A translational approach (Neuroscience 2025) - "Our preclinical model will evaluate psilocybin's effects in a disease-relevant context, allowing for a deeper understanding of the underlying neurobiological mechanisms of psilocybin's therapeutic effects. To generate a developmental model of OCD, Sprague-Dawley rat pups were administered clomipramine or saline control from postnatal days 9 to 16... This study employs a translational approach to evaluate the therapeutic potential of psilocybin in OCD aiming to improve understanding of psilocybin's effects and inform future research directions in the treatment of OCD."

CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry • FOS

Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS. (PubMed, Neurotherapeutics) - "Current Food and Drug Administration-approved drugs -riluzole, edaravone, and tofersen - offer limited clinical benefit due to ALS multifactorial etiology and high heterogeneity...Leveraging the SAveRUNNER algorithm, we identified several potentially repurposable candidates, including clomipramine (Anafranil®), mianserin (Lantanon®/Tolvon®), and modafinil (Provigil®)...Our results demonstrate that clomipramine is the most promising candidate, ameliorating lifespan reduction, improving climbing abilities, and mitigating both genomic instability and inflammation, key pathological hallmarks of these SOD1-ALS models. Despite needing further validation in higher organisms, our Drosophila findings represent preliminary yet significant support for clomipramine's action as an add-on treatment for SOD1-ALS."

Journal • Amyotrophic Lateral Sclerosis • CNS Disorders • Inflammation • Respiratory Diseases

Sertraline-Induced Urine Incontinence. (PubMed, Eur J Case Rep Intern Med) - "Sertraline can rarely cause urinary incontinence, with symptoms showing a dose-response relationship that improves after dose reduction.Recognition and management of this adverse effect (through dose adjustment, switching or adjunctive therapy) allows clinicians to maintain psychiatric remission while minimising distressing urinary symptoms."

Journal • CNS Disorders • General Anxiety Disorder • Mood Disorders • Psychiatry • Urinary Incontinence • Urology

Approach to Treatment-Refractory OCD in Partial Hospital and Residential Treatment (AACAP 2025) - "The presentation will also provide an overview of evidence-based treatment modalities in treatment-resistant cases, and common pitfalls that interfere with treatment effectiveness. Treatment-refractory OCD is defined as failure to respond to 2 adequate SSRIs, or an SSRI and clomipramine, in addition to failure of adequately delivered high-fidelity CBT with exposure and response prevention (ERP). OCD can be a chronic and debilitating illness for children and adolescents. Understanding treatment-refractory patient characteristics and treatment approaches in specialized residential and partial programs is important to improve treatment response and reduce the duration of untreated illness.OCD, RTX, OTH"

Clinical • Pediatrics

When Treatments Stall: The Need for Outside-the-Box Thinking in Residential OCD Treatment (AACAP 2025) - "By the end of this talk, the audience members will be able to workshop creative solutions when refractory OCD patients present to their clinical practice.OCD, TREAT, RTX"

CNS Disorders • Depression • Pediatrics • Psychiatry

Clomipramine Induced Oxidative Stress and Morphological Alterations in the Prefrontal Cortex and Limbic System of Neonatal Rats. (PubMed, Brain Sci) - "Early exposure to CLO can cause long-lasting neurochemical and structural alterations in the brain regions associated with the regulation of emotions and some behavioral responses that can persist over time and affect behavior in adulthood."

Journal • Preclinical • Inflammation