isosorbide mononitrate / Generic mfg. - LARVOL DELTA

Use of drug information resources, knowledge, and competence for managing medication related problems: results of a community pharmacy survey in Egypt. (PubMed, Int J Pharm Pract) - "Community pharmacists and pharmacy students/trainees in Egypt reported frequent use of digital DI resources; however, their knowledge and performance remained moderate. Formal training was associated with better performance, highlighting the need to strengthen education and continuing professional development through collaboration between educational institutions and professional bodies."

Journal

Isosorbide Mononitrate/Cilostazol for Lacunar Cerebral Small Vessel Disease-Outcomes at 6 Months in the LACI-2 Randomized Controlled Trial. (PubMed, J Am Heart Assoc) - "A reduction in the composite outcome, cognitive impairment, dependency, and stroke impact was seen within 6 months of starting ISMN or cilostazol."

Journal • Alzheimer's Disease • Cardiovascular • Cognitive Disorders • Ischemic stroke • Myocardial Infarction

Retraction of: Isosorbide Mononitrate Increases Bone Formation and Decreases Bone Resorption in Postmenopausal Women: A Randomized Trial. (PubMed, J Bone Miner Res) - No abstract available

Journal

Heterogeneous Treatment Effects in HFpEF: Distinguishing Drug-Specific Response from Prognostic Phenotypes Across Randomized Trials. (PubMed, medRxiv) - "In contrast, the ITE model identified distinct, drug-specific effect modifiers across trials (cardiorenal-inflammatory for spironolactone (TOPCAT), NO-mediated anti-inflammatory for isosorbide mononitrate (NEAT-HFpEF), afterload-reducing for inorganic nitrite (INDIE-HFpEF), and anti-volume-overload for sildenafil (RELAX). The proposed method identifies mechanism-specific effect modifiers, and uncovers clinically meaningful heterogeneity in treatment response, which is not captured by conventional MCID-based approaches. Although exploratory, these findings support phenotype-guided therapy in HFpEF and argue for phenotype-informed trial design to enhance treatment-effect detection and therapy targeting."

Heterogeneity • Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Implementation Aspects of a Medicines Shortage Policy Tool: Evidence from Australia's Serious Scarcity Substitution Instruments. (PubMed, Drug Saf) - "While product shortages led to decreases in medicines consumption, SSSIs appeared to be successful in limiting decreases. However, SSSIs were less likely to be successful when many of the permitted substitute products were also scarce."

Journal

Acute Microvascular Effects Of Cilostazol And Isosorbide Mononitrate Reveal Redistribution Of Cerebral Blood Supply In Wild-type Mice (AAIC 2026) - No abstract available

Preclinical

Acute Microvascular Effects Of Cilostazol And Isosorbide Mononitrate Reveal Redistribution Of Cerebral Blood Supply In Wild-type Mice (AAIC 2026) - No abstract available

Preclinical • Alzheimer's Disease • CNS Disorders

Repurposed drug prioritization pipeline for a multi-arm platform trial in clinical Alzheimer's disease. (PubMed, Alzheimers Dement) - "This robust drug prioritization pipeline will speed the identification and progression of promising candidates for therapeutic evaluation."

Journal • Alzheimer's Disease • CNS Disorders

Trabectedin-Associated Myocardial Infarction With Nonobstructive Coronary Arteries. (PubMed, JACC Case Rep) - "Patients who develop trabectedin-associated MINOCA may benefit from pretreatment with anti-vasospastic antianginals to allow for safe continuation of therapy."

Journal • Acute Coronary Syndrome • Cardiovascular • Liposarcoma • Myocardial Infarction • Oncology • Sarcoma • Soft Tissue Sarcoma • Solid Tumor

Primary prevention in liver cirrhosis patients with esophageal varicesa: a systematic review and network meta-analysis. (PubMed, Front Gastroenterol (Lausanne)) - "For reducing bleeding incidence, the combinations Midodrine + Propranolol (Mido+PPL), Carvedilol + Endoscopic Variceal Band Ligation (Carv+EVBL), and Fuzheng Huayu Capsule + Propranolol (FZHYJN+PPL) were superior...Regarding safety, Mido+PPL, Nadolol (Nado), and Carvedilol (Carv) had fewer general adverse events, while Isosorbide Mononitrate (ISMN), Mido+PPL, and Carv had lower rates of other decompensation events...Carvedilol and Propranolol showed superior net clinical benefit over Nadolol and Timolol. Although Nadolol (alone or with ISMN) may reduce mortality, its higher adverse event rate precludes it as a first-line strategy. FZHYJN, while effective, may increase the risk of other decompensation events."

Journal • Retrospective data • Review • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis

Bioanalytical method development and validation of isosorbide mononitrate in human plasma by using LC-MS/MS. (PubMed, Sci Rep) - No abstract available

Journal

ANI Pharmaceuticals, Inc…announced that following final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA), the Company launched Isosorbide Mononitrate Tablet USP, 10 mg and 20 mg (The Manila Times)

ANDA • Generic launch • Cardiovascular

Intraductal digestive enzyme accumulation drives lethal hemorrhagic necrotizing pancreatitis and enables therapeutic intervention. (PubMed, Res Sq) - "We tested a repurposed strategy using clinically approved agents for other indications: secretin to stimulate ductal fluid secretion and isosorbide mononitrate (ISMN) to promote ductal outflow via sphincter of Oddi relaxation... Pancreatitis severity is determined not only by the magnitude of enzyme activation but also by where enzyme activity is exerted, implicating intraductal enzyme accumulation as a mechanistic determinant and therapeutic target in HNP. Coordinated enhancement of ductal secretion and outflow with clinically approved agents prevents HNP in vivo, supporting a translatable prevention strategy."

Journal • Hematological Disorders • Pancreatitis • GRP-10

CORONARY VASOSPASM AND GASTROENTERITIS IN SETTING OF IMMUNE CHECKPOINT INHIBITOR TREATMENT - CASE REPORT (ACC 2026) - "Case: The patient is a 58-year-old male with history of metastatic renal cell carcinoma, treated with ipilimumab and nivolumab, who presented with several weeks of progressive diarrhea...He required high dose steroids and infliximab, followed by upadacitinib and vedolizumab, with only limited response to therapy...Patient was started on amlodipine and isosorbide mononitrate with good symptom control and resolution of echocardiographic wall motion abnormalities... Our case highlights that coronary involvement can represent a form of ICI-related toxicity, potentially occurring in conjunction with other organ system adverse effects."

Case report • Checkpoint inhibition • Clinical • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Immunology • Oncology • Renal Cell Carcinoma • Solid Tumor

EXPLORING INTERVENTIONAL THERAPIES IN RESISTANT HYPERTENSION: DUAL RENAL REVASCULARIZATION AND DENERVATION (ACC 2026) - "Case: A 62 year old woman with a 20-year history of resistant hypertension on five antihypertensive agents (including amlodipine, doxazosin, hydralazine, isosorbide mononitrate, and torsemide) followed with hypertension clinic due to ongoing difficulty controlling blood pressures at home. Our case presents a unique application of dual renal therapy with renal artery stenting and renal sympathetic denervation."

Atherosclerosis • Cardiovascular • Hypertension • Nephrology • Renal Disease • Respiratory Diseases

A SHOCKING DECISION: REASSESSING ICD NECESSITY IN HIGH-RISK VASOSPASM-INDUCED VF (ACC 2026) - "He was treated with isosorbide mononitrate and diltiazem, alongside lifestyle modifications, though he continued to smoke...After intracoronary nitroglycerin, he developed VF requiring defibrillation... Refined validated risk stratification methods to guide ICD management in vasospasm-induced VF. Strict adherence to vasodilators and lifestyle changes may reduce recurrence risk and could influence long-term ICD decision-making in select patients."

Cardiovascular • Myocardial Infarction • Myocardial Ischemia • Ventricular Tachycardia

A TOXIC TRIGGER: 5-FLUOROURACIL INDUCED STEMI (ACC 2026) - "Decision-Making: Intra-coronary nitroglycerin was given, leading to complete reversal, thereby confirming vasospasm...The patient was treated with verapamil and isosorbide mononitrate... 5-FU induced STEMI is a rare but serious complication arising from coronary vasospasm due to endothelial dysfunction. Prompt recognition is essential, as management differs from atherothrombotic STEMI and relies on discontinuation of 5-FU with vasodilator therapy, thereby avoiding unnecessary percutaneous coronary interventions."

Colon Cancer • Colorectal Cancer • Myocardial Infarction • Solid Tumor

ONE HEART, THREE DISSECTIONS: A CASE OF MULTIVESSEL SCAD (ACC 2026) - "The patient was started on medical therapy with Aspirin, clopidogrel, statin and isosorbide mononitrate. This case brings into light the management challenges of SCAD particularly when multivessel involvement is identified within a co-dominant coronary system.."

Clinical • Acute Coronary Syndrome • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Hematological Disorders • Thrombosis

DO YOU BELIEVE IN VASOSPASTIC ANGINA? A CASE WITH ST ELEVATIONS AND POLYMORPHIC VENTRICULAR TACHYCARDIA ON RHYTHM MONITOR (ACC 2026) - "Angiography demonstrated diffuse RCA vasospasm that improved after nitroglycerin and a consecutive FFR of the RCA lesion showed no hemodynamically significant stenosis...Decision-Making: Vasodilator therapy with diltiazem and isosorbide mononitrate was initiated... High suspicion is needed to recognize atypical VSA. Vasodilators and ICD in high-risk patients can prevent sudden death."

Clinical • Atherosclerosis • Cardiovascular • Dyslipidemia • Genetic Disorders • Hypertension • Ventricular Tachycardia

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland. (PubMed, Acta Ophthalmol) - "Our large nested case-control study suggests that certain systemic medications may increase the incidence of surgically treated cataract, but with the possibility of residual confounding."

Journal • Cataract • Diabetes • Metabolic Disorders • Ophthalmology

Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED). (PubMed, Alzheimers Dement) - "Web-based PPIE can effectively inform dementia research at scale and provides a reusable resource for other studies."

Journal • Alzheimer's Disease • CNS Disorders • Dementia

Comparative cardioprotective effects of Kuanxiong Aerosol and its individual components in a rat model of acute myocardial infarction. (PubMed, Pharm Biol) - "Animals were pretreated with low-dose (120 µL/kg) or high-dose (200 µL/kg) KXA, its individual components (120 µL/kg), or isosorbide mononitrate (ISMN; 5 mg/kg)...This study provides evidence supporting the cardioprotective potential of low-dose, multi-component KXA, indicating that such balanced formulations may offer broader benefits than high-dose or single-agent approaches. Further research is needed to elucidate the molecular mechanisms and refine the formulation for clinical translation."

Clinical • Journal • Preclinical • Cardiovascular • Fibrosis • Immunology • Inflammation • Myocardial Infarction

Drug Development. (PubMed, Alzheimers Dement) - "We present a practical approach to prioritising repurposed drugs to evaluate in the context of clinical AD. We would like to thank our patient and public contributors and the wider investigator team."

Journal • Alzheimer's Disease • CNS Disorders • Psychiatry

Trends in Out-of-Pocket Spending for Drugs Under Medicare Part D in Coronary Artery Disease and the Impact of the Inflation Reduction Act (AHA 2025) - "C1 included ticagrelor, isosorbide mononitrate, and atorvastatin; C2 is C1 + ezetimibe; C3 is C2 +bempedoic acid; C4 is C2 + evolocumab; and C5 is C3 + icosapent ethyl and ranolazine. From 2020–2024, modest cost reductions were observed ( C5: $5,632 to $4,400). After the IRA cap in 2025, costs approached or reached $2,000 for all regimens. However, C1 and C2, previously low-cost, paradoxically saw significant OOP increases (C1: +$795, p = 0.0068; C2: +$878, p = 0.009), while C5 experienced a significant reduction (–$2,366, p = 0.005)."

Medicare • Reimbursement • US reimbursement • Cardiovascular • Coronary Artery Disease

A DOUBLE-EDGED PILL: ASPIRIN-INDUCED KOUNIS SYNDROME (CHEST 2025) - "Coronary angiography showed vasospasm in the proximal left anterior descending (90%) and distal right coronary artery (50%), completely resolving with intracoronary nitroglycerin.She was admitted to the intensive care unit and started on nitroglycerin, clopidogrel (without aspirin), diltiazem, nifedipine, and isosorbide mononitrate. Kounis syndrome should be considered in patients with acute coronary syndrome in the context of an allergic reaction. Early recognition and avoidance of the causative agent are crucial for improving outcomes."

Acute Coronary Syndrome • Asthma • Atherosclerosis • Cardiovascular • CNS Disorders • Depression • Dermatology • Eosinophilia • Immunology • Migraine • Nasal Polyps • Otorhinolaryngology • Psychiatry • Respiratory Diseases • Sinusitis • Urticaria