lithium carbonate ER / Generic mfg. - LARVOL DELTA

Clinical Predictors of Lithium Response in Patients with Bipolar Disorder: Potential Predictive Role of Chronotype, Rumination and Traumatic Events. (PubMed, Curr Neuropharmacol) - "Our findings support the development of personalized treatment strategies for BD."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

A Rare Case of Amphetamine-Induced Acute Pancreatitis (ACG 2026) - "Laboratory values on presentation Figure: Figure. CT abdomen and pelvis without contrast demonstrating acute pancreatitis"

Clinical • Bipolar Disorder • Cardiovascular • CNS Disorders • Diabetes • Gastroenterology • Gestational Diabetes • Metabolic Disorders • Mood Disorders • Pancreatitis

Enhanced axonal mitochondrial motility and neural activity-induced energy deficits destabilize synaptic transmission in models of bipolar disorder. (PubMed, Nat Commun) - "Lithium restored presynaptic mitochondrial retention, improved ATP maintenance, rescued synaptic variability, and reversed behavioral phenotypes. These findings support impaired presynaptic mitochondrial retention and activity-induced synaptoenergetic deficits as cellular mechanisms contributing to bipolar disorder."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Protective Effect of Moderate-Intensity Training and MgSo4 Against Lithium-Induced Renal and Oxidative Damages in Rat Kidney. (PubMed, Adv Biomed Res) - "Treatment with Li10 mg/kg and Li40 mg/kg decreased the TAC, SOD, and GPx and increased the MDA in kidney tissue significantly, which improved after administration of MgSo4 and MIT in comparison with the Li10 and Li40 groups. The findings of this study indicated that exercise and MgSo4 reduced the nephrotoxicity caused by Li via reducing oxidative stress."

Journal • Preclinical • Bipolar Disorder • CNS Disorders • Psychiatry

Liver Structure after Administration of Autophagy-Modifying Drugs in Mice with Experimental Skin Melanoma. (PubMed, Bull Exp Biol Med) - "Morphological changes in the liver were evaluated in mice with implanted B16 skin melanoma after chloroquine and lithium carbonate administration. Chloroquine, a well-known autophagy blocker, did not affect the development of hepatocyte degeneration and necrosis, but stimulated the cell regeneration. Collagen deposits were found in all studied groups."

Journal • Preclinical • Melanoma • Oncology • Solid Tumor

The Three-Component Problem: Deconvoluting Electrolyte Component Roles in Solvation Structure and Silicon Calendar Aging. (PubMed, ACS Appl Mater Interfaces) - "Li+-EMC coordination structures decompose to form insoluble alkanes, C-O species, and lithium carbonate (Li2CO3), while the anion coordination complex decomposes into LiF and LixPOyFz...However, the inorganic lithium species (LiF, LixPOyFz, and Li2CO3) remain constant, suggesting the dissolution of nonpolar organolithium species due to EMC's low dielectric constant and high coordination number. This triggers continuous electrolyte decomposition to reform the SEI, which lowers the silicon anode's calendar lifetime."

Journal

Comparing lithium and valproate in reducing suicide risk: A territory-wide retrospective cohort study with pairwise and network meta-analysis. (PubMed, Psychol Med) - "Lithium and valproate showed comparable effectiveness in reducing suicide risk, while both were associated with lower risk than no treatment. The choice between these two mood stabilizers should be guided by individual patient characteristics and safety considerations."

Clinical • Journal • Retrospective data • Review • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Losartan's regulation of PI3K/AKT signaling underlies its combined anti-seizure and antidepressant effects in epileptic rats. (PubMed, Epilepsy Res) - "Losartan may attenuate both seizures and depression-like behaviors in epileptic rats by activating the hippocampal PI3K/AKT signaling pathway and inhibiting neuronal apoptosis. These results highlight its potential as an adjunctive therapy for epilepsy with comorbid depression."

IO biomarker • Journal • Preclinical • CNS Disorders • Depression • Epilepsy • Psychiatry • BCL2 • CASP3

Perspectives on the use of lithium as a therapeutic option for bipolar disorder in 2026. (PubMed, Expert Rev Neurother) - "Nevertheless, it is with hope that perspectives on Li like these will help to drive increased and appropriate use in bipolar disorder. That said, it is of this author's opinion that, without major new educational and public health approaches, there is unlikely to be any change in usage, at least in l the near future."

Journal • Bipolar Disorder • CNS Disorders • Dementia • Endocrine Disorders • Mood Disorders • Psychiatry

Lithium-associated peripheral transcriptional signatures correlate with brain white matter microstructure in bipolar disorder. (PubMed, Int Clin Psychopharmacol) - "These genes are widely expressed in the brain, and their peripheral expression correlates with white matter microstructure measures associated with lithium treatment. This observation supports the potential usefulness of peripheral transcriptomic signatures to mark the individual biological impact of lithium treatment on the brain."

Journal • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

Prolonged Post-Electroconvulsive Therapy Delirium in Treatment-Resistant Depression With Central Nervous System Risk Factors Under Programmed Cell Death Protein 1 Inhibitor Therapy: A Case Report. (PubMed, J ECT) - "Following relapse, maintenance ECT was resumed using a modified protocol without recurrence of prolonged delirium. This case highlights that ECT may remain an option in carefully selected complex patients when accompanied by structured diagnostic work-up and interdisciplinary monitoring."

Journal • CNS Disorders • Depression • Epilepsy • Immunology • Mood Disorders • Oncology • Psychiatry

Chronic Pain as a Precision-Weighting Disorder: A Predictive-Processing Framework and Open-Shape-Stabilize Hypothesis (PAINWeek 2026) - "Open: subanesthetic ketamine transiently destabilizes maladaptive precision weighting via cortical interneuron disinhibition and a thalamic burst-to-tonic shift; the framework is pharmacologically agnostic, with serotonergic psychedelics (5-HT2A-mediated hierarchy flattening) as a mechanistically orthogonal opener generating overlapping biomarker predictions. Shape: top-down rTMS and individual-alpha-matched tACS combined with bottom-up short-course NaV1.8 blockade (suzetrigine); sustained low-magnitude nociceptive input during the plasticity window is predicted to bias the system toward a body-safe inference, yielding a dose-response prediction in which the duration of afferent reduction within the window, not merely its presence, should matter... The framework yields an integrated account comprising three central claims and a structured intervention hypothesis. First, the convergence claim: if the precision-assignment mechanism is broadly dysregulated, chronic pain,..."

CNS Disorders • Depression • Mood Disorders • Pain • NAV1

Predicting early psychiatric readmission among people with major depressive disorder: A machine learning analysis from the prospective multicentre DEEP READ study. (PubMed, J Affect Disord) - "A ML model based on routinely collected data showed moderate discrimination for 90-day readmission in MDD. These findings suggest that standard clinical variables may hold predictive value for early readmission. However, external validation, assessment of model calibration, and clinical utility are needed prior to clinical implementation."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Personality Disorder • Psychiatry

Lithium isotope effects and magnetic interactions in flavin-ascorbyl radical pairs. (PubMed, PLoS One) - "For decades, lithium carbonate has been a cornerstone treatment for bipolar disorder and related conditions, yet its mechanism of action remains poorly understood...We propose that lithium's nuclear spin modulates triplet yields in flavin-ascorbyl radical pairs, offering a quantum-based explanation for isotope-dependent effects. Whether these spin interactions play a clinical role remains to be determined, but the possibility is exciting and points toward a promising line of inquiry."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Clinical Consequences of Inadvertent Intramuscular Administration of Subcutaneous Risperidone Formulation. (PubMed, Case Rep Psychiatry) - "She complained of mild pain at the injection site, but no other adverse consequences were noted. When a SC formulation is administered IM, it results in mild muscle pain, and unpredictable release of risperidone, but no other notable clinical problems."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Musculoskeletal Pain • Pain • Psychiatry

Association Between Lithium Use and Suicide-Related Behaviors in Bipolar Disorder: A Multicenter Study. (PubMed, Bipolar Disord) - "In this multicenter clinical sample, lithium exposure was consistently associated with lower odds of suicide-related behaviors across multiple analytic approaches. Aggression was independently associated with suicide-related risk and statistically accounted for part of the observed association between lithium exposure and suicide-related outcomes. However, causal inference is limited by the cross-sectional design, and residual confounding-particularly confounding by indication-remains a key concern. Prospective longitudinal studies are required to clarify temporal relationships and disentangle treatment effects from selection processes."

Clinical • Journal • Bipolar Disorder • CNS Disorders • Psychiatry • Suicidal Ideation

Correlation Analysis of Blood Lithium Metabolism Kinetics and Concentration-to-Dose Ratio in Patients With Hypertension and Manic Episodes. (PubMed, Hum Psychopharmacol) - "Hypertension can reduce renal lithium excretion and elevate both the C/D ratio and the risk of toxicity; therefore, in clinical practice, the initial lithium dose should be reduced and therapeutic drug monitoring should be intensified for patients with comorbid hypertension, while elderly patients should receive stratified management with lower serum concentration ranges."

Journal • Retrospective data • Bipolar Disorder • Cardiovascular • CNS Disorders • Hypertension • Mood Disorders

Gender Dysphoria in an Adolescent Presenting With Self-Initiated Hormone Therapy and Genital Self-Mutilation: A Case Report From Bangladesh. (PubMed, Cureus) - "We report a 16-year-old transgender girl in Bangladesh who, lacking access to formal services, self-initiated feminising hormone therapy with oestradiol and spironolactone and described substantial improvement over three and a half months...These events occurred against a background of major depressive disorder diagnosed independently by three psychiatrists and suicidal ideation documented more than a year before she obtained any hormone. The case illustrates the absence of any option between unsupervised self-medication and complete cessation, and the limits of bedside means restriction on an open ward when a patient discloses a specific method."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • Suicidal Ideation

Therapeutic strategies after discontinuation of valproate in females of child-bearing potential with bipolar disorder: an insurance claims database study in France and the United Kingdom. (PubMed, Psychiatry Res) - "Valproate discontinuation was maintained in 47.9% (SNDS) and 51.4% (CPRD) of FCBP, especially in young women, with stable disease. Decisions on BD treatment in FCBP should consider both maternal mental health and fetal safety."

Journal • Reimbursement • US reimbursement • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Exploratory CT-Based Assessment of Emphysema Burden in Smokers with Bipolar Disorder Receiving Lithium Treatment. (PubMed, Int J Chron Obstruct Pulmon Dis) - "Given the observational design and potential influence of inspiratory effort during CT acquisition, these findings should be considered hypothesis-generating rather than evidence of a protective effect. Prospective longitudinal and mechanistic studies are warranted to clarify the relationship between lithium exposure and smoking-related parenchymal lung injury."

Journal • Observational data • Retrospective data • Bipolar Disorder • Chronic Obstructive Pulmonary Disease • CNS Disorders • Psychiatry • Pulmonary Disease • Respiratory Diseases

The recognition, diagnosis, and management of late-onset bipolar disorder. (PubMed, Expert Rev Neurother) - "Lithium, with its potential neuroprotective properties, may be the first-choice medication. Future research should focus on clarifying pathophysiological mechanisms and developing tailored management strategies."

Journal • Review • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Lithium-induced electrolyte disturbances and catatonia (PubMed, Ugeskr Laeger) - "Pausing lithium and treating hypercalcemia led to a gradual improvement in catatonia. The case emphasises the importance of considering endocrine and electrolyte disturbances in cases of acute deterioration of psychiatric symptoms during lithium treatment."

Journal • Bipolar Disorder • CNS Disorders • Endocrine Disorders • Metabolic Disorders • Mood Disorders • Psychiatry

Association between lithium treatment and vascular calcification in bipolar disorder: A retrospective cohort study. (PubMed, J Affect Disord) - "Lithium treatment was independently associated with lower odds of AC and CAC in patients with BD. The exploratory prediction models incorporating lithium exposure and other clinical factors may provide preliminary insights into vascular calcification assessment in this population."

Journal • Retrospective data • Bipolar Disorder • Cardiovascular • CNS Disorders • Diabetes • Metabolic Disorders • Mood Disorders • Psychiatry

Serum Lithium Monitoring, Short-Term Outcomes, and Treatment Barriers in Bipolar Disorder: A Real-World Study. (PubMed, Neuropsychiatr Dis Treat) - "The analysis did not evaluate longitudinal exposure or confirmed steady-state trough concentrations, and improvement during comprehensive care cannot be attributed to lithium alone. These findings support an integrated lithium-care pathway that combines interpretable monitoring, accessible testing, early management of adverse effects, clear toxicity education, and suicide-specific safety planning."

Journal • Real-world evidence • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder: A Nationwide Multicenter Retrospective Cohort Study. (PubMed, J Clin Psychiatry) - " Lithium was associated with a 40% lower risk of suicidal ideation and reduced suicidal behaviors in BD. These findings reinforce lithium as a first-line treatment for suicide prevention and highlight its comprehensive antisuicidal role-from lower rates of ideation to fewer behaviors-supporting confident, evidence-based clinical use."

Journal • Retrospective data • Bipolar Disorder • CNS Disorders • Depression • Psychiatry • Suicidal Ideation