lithium carbonate ER / Generic mfg. - LARVOL DELTA

Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study. (PubMed, Int J Bipolar Disord) - "The results indicate that Ramadan fasting did not significantly alter serum lithium levels, renal function, or electrolyte balance across all time points. These findings suggest that fasting during Ramadan can be safely practiced by patients with bipolar disorder receiving lithium therapy, provided they maintain adequate hydration and adhere to their prescribed medication regimen."

Journal • Observational data • PK/PD data • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Effects of an Emotion Regulation Training Programme Combined With Medication Therapy on Mania Severity, Depression and Emotion Regulation Strategies of Adults With Bipolar Disorder Type 1: A Randomized Clinical Trial. (PubMed, Clin Psychol Psychother) - "The augmentation of medication therapy with the Gross model-based ERT can lead to a higher decrease in mania and depression and an increase in emotion regulation (cognitive reappraisal) of depressed adults with BD type 1."

Clinical • Journal • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial. (PubMed, Health Technol Assess) - "12. See the NIHR Funding and Awards website for further award information."

Clinical • HEOR • Journal • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry

Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) - a scoping review. (PubMed, Reprod Biol Endocrinol) - "Evidence on the use of psychopharmacotherapy in ART primarily concerns women. Available literature indicates that psychopharmacotherapy for individuals undergoing ART frequently involves medications commonly used in general psychiatric practice, with a tendency toward lower dosing and a preference for serotonin reuptake inhibitors. However, this observation should be interpreted cautiously, as current evidence remains limited and further research is warranted to establish treatment patterns more conclusively. The variability in study designs and reporting standards further highlights the need for standardized methodologies and improved adherence to reporting guidelines to enhance the quality and applicability of future research."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Gynecology • Infertility • Mental Retardation • Mood Disorders • Psychiatry • Sexual Disorders • NBN

FAMILIAL HYPERPARATHYROIDISM DUE TO GCM2 GENE ALTERATION: A CASE REPORT (ESPE-ESE 2025) - "Few cases of GCM2-related familial PHPT have been documented, underscoring the need for further research into its pathophysiology and optimal management. This case emphasizes the necessity of a comprehensive approach in evaluating hypercalcemia, particularly in patients on long-term lithium therapy, to differentiate between drug-induced and primary hyperparathyroidism and to consider potential genetic contributions when the clinical course is atypical."

Case report • Clinical • Bipolar Disorder • CNS Disorders • Endocrine Disorders • Metabolic Disorders • Mood Disorders • Psychiatry

Demystifying an Unusual Culprit and Analyzing Implications for Management: A Case of Lithium-Induced Parathyroid Hyperplasia Presenting as Severe Symptomatic Hypercalcemia (ESPE-ESE 2025) - "The endocrinology team was consulted, and the patient was started on fluids, calcitonin, cinacalcet, and pamidronate, which lowered her calcium level... Lithium-induced hyperparathyroidism is a rare complication of long-term lithium therapy. Individualized patient education regarding the risks and benefits of Lithium continuation, medical and surgical options, and the importance of a multidisciplinary follow-up with regular calcium and PTH monitoring at least every 6 months."

Clinical • Bipolar Disorder • CNS Disorders • Constipation • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Metabolic Disorders • Movement Disorders • Pain • Psychiatry

Lithium Induces Oxidative Stress, Apoptotic Cell Death, and G2/M Phase Cell Cycle Arrest in A549 Lung Cancer Cells. (PubMed, Molecules) - "The induction of cell death by lithium in A549 cells is accompanied by increased ROS and nitric oxide production. This study shows that lithium chloride possesses some immunomodulatory cytotoxic effects on A549 lung cancer cells and can be further investigated for use in lung cancer treatment."

Journal • Bipolar Disorder • CNS Disorders • Depression • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Psychiatry • Solid Tumor

Alcohol-Induced Neuroleptic Malignant Syndrome Complicated by Severe Acute Rhabdomyolysis. (PubMed, Cureus) - "The patient's medical history of bipolar disorder, managed with lithium, and recent alcohol intake suggest alcohol's role as a trigger for NMS in the context of lithium treatment, compounded by severe rhabdomyolysis. This case underscores the need for heightened clinical awareness of such complex interactions and highlights the critical importance of early recognition and multidisciplinary management to prevent potentially fatal complications."

Journal • Bipolar Disorder • Cardiovascular • CNS Disorders • Hypertension • Mood Disorders • Psychiatry

Lithium in cardiovascular health and disease: Pharmacological and clinical implications. (PubMed, Eur J Pharmacol) - "However, conflicting evidence persists, particularly regarding dose specificity and long-term outcomes. Future research should focus on high-quality clinical trials to clarify the balance between therapeutic benefits and adverse effects of lithium to ensure its safe and effective use in clinical practice."

Journal • Review • Bipolar Disorder • Cardiovascular • CNS Disorders • Fibrosis • Immunology • Metabolic Disorders • Mood Disorders • Nephrology • Psychiatry • Renal Disease

Designing and characterizing first Iranian study evaluating serum levels of lithium in patients for population pharmacokinetics (FIRELOLIPOP): baseline and first report. (PubMed, Sci Rep) - "Sodium valproate was the most frequently co-prescribed medication (n = 553), followed by lorazepam (n = 468) and risperidone (n = 458)...The findings highlight the necessity of personalized dosing approaches to enhance efficacy and reduce adverse effects. Future research should incorporate pharmacokinetic modeling and machine learning to refine lithium therapy."

Journal • PK/PD data • Bipolar Disorder • CNS Disorders • Depression • Diabetes • Endocrine Disorders • Mental Retardation • Metabolic Disorders • Mood Disorders • Psychiatry

Unmasking Lithium: The Thyroid Storm That Caught Us Off Guard (ATS 2025) - "Based on the BWPS score of 70, she was empirically started on methimazole 20 mg Q8H and hydrocortisone 50 mg Q6H...The current scale used in the diagnostic criteria captures symptoms that overlap with patients already diagnosed with pre-existing liver disease, cardiac conditions, or underlying psychiatric illnesses. This case illustrates the importance of maintaining wide clinical vigilance when treating these patients."

Alzheimer's Disease • Bipolar Disorder • Cardiovascular • CNS Disorders • Cognitive Disorders • Congestive Heart Failure • Developmental Disorders • Endocrine Disorders • Heart Failure • Hepatology • Hypertension • Hypotension • Mental Retardation • Mood Disorders • Psychiatry • Respiratory Diseases

Lithium Treatment Increases FKBP5 Protein but Not mRNA Expression in the Pituitary Gland of Depressive-like Rats. (PubMed, Brain Sci) - "The corticosterone levels were significantly higher in CMS-exposed rats compared to the control, with no significant changes found between lithium-treated and control rats. FKBP5 protein expression in the brain may be regulated by long-term lithium treatment, thus affecting GR signaling in the rat depression model."

Journal • Preclinical • CNS Disorders • Depression • Mental Retardation • Psychiatry • FKBP5

Reasons for discontinuing and restarting lithium multiple times: a case-register study based on the South London and Maudsley NHS Foundation Trust Clinical Record Interactive Search system. (PubMed, Ther Adv Psychopharmacol) - "Lithium was mainly restarted due to relapse. This warrants a better understanding of the reasons for repeatedly discontinuing lithium and the best way to promote lithium adherence to prevent a perpetual cycle of remitting when on lithium and relapsing when off lithium."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry • Schizophrenia

Characteristics of deaths related to lithium toxicity in Australia, 2000-2024. (PubMed, Aust N Z J Psychiatry) - "Toxicity remains a rare event compared to exposure to lithium, with intentional cases comprising a fifth of the series. Deaths were not the sole preserve of the middle-aged or elderly."

Journal • Atherosclerosis • Bipolar Disorder • Cardiovascular • CNS Disorders • Mood Disorders • Psychiatry

Comparative efficacy and safety of alternatives to sodium valproate in the management of bipolar affective disorder in people of child-bearing age: a narrative review by the European Society of Clinical Pharmacy's mental health specialist interest group. (PubMed, Int J Clin Pharm) - "Specific recommendations are made regarding alternatives to valproate in managing bipolar disorder."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Developmental Disorders • Mood Disorders • Psychiatry

Lithium and lamotrigine for the treatment of bipolar II disorder - a systematic review and meta-analysis of randomized trials. (PubMed, J Affect Disord) - "The evidence for lithium and lamotrigine in treating BDII is scarce, and the certainty of the evidence is very low. Large, well-conducted RCTs of patients with BDII are needed."

Journal • Retrospective data • Review • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

An Overview of the Effects of Lithium on Alzheimer's Disease: A Historical Perspective. (PubMed, Pharmaceuticals (Basel)) - "This article will discuss the historical background, discovery, and early experimentation of lithium in psychiatry. We will also review its mechanisms of action and discuss its potential in the treatment and prevention of neurodegenerative disorders, focusing on Alzheimer's disease."

Journal • Review • Alzheimer's Disease • Bipolar Disorder • CNS Disorders • Mental Retardation • Mood Disorders • Psychiatry

The Mechanisms of Lithium Action: The Old and New Findings. (PubMed, Pharmaceuticals (Basel)) - "It was also observed that many seemingly "old" mechanisms have experienced a resurgence in research conducted during the 21st century. Additionally, many studies converged on the previously postulated mechanisms of lithium inhibiting GSK-3β and PI."

Journal • Review • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry • BDNF

Stable Isotope Reference Materials and Scale Definitions-Outcomes of the 2024 IAEA Experts Meeting. (PubMed, Rapid Commun Mass Spectrom) - "The participants of the 12th International Atomic Energy Agency (IAEA) meeting on stable isotope reference materials reached a consensus, acknowledging the existence and use of two carbon isotope delta scales: the VPDB (Vienna Peedee belemnite) scale and the VPDB-LSVEC (LSVEC - lithium carbonate prepared by H. J. Svec)...Efforts are encouraged to improve consistency among laboratories in the isotopic analysis of "non-exchangeable hydrogen" in bulk organic materials and oxygen in carbonates using the phosphoric acid reaction. Additional topics discussed include (1) need for improvement in reference materials for accurate greenhouse gas isotopic analyses; (2) reference materials under production by the IAEA, the US Geological Survey (USGS), and the US National Institute of Standards and Technology (NIST); (3) methods for value and uncertainty assignment of reference materials; and (4) calculation of carbon-13 isotope delta and oxygen-18 isotope delta of CO2..."

Journal

Acute myasthenia caused by lithium: a case report. (PubMed, Front Psychiatry) - "Unlike previously reported cases of lithium-induced chronic and mild myasthenia symptoms, this case involved acute and widespread myasthenia with falls as the primary manifestation. The mechanism may be related to the effect of lithium on acetylcholine receptor (AChR) metabolism, neurotransmitter release, and neuromuscular junction (NMJ) stability."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Transcription-Driven Repurposing of Cardiotonic Steroids for Lithium Treatment of Severe Depression. (PubMed, Cells) - "Our transcriptional and epidemiological observations point towards cardiotonic steroids as possible repurposing candidates for lithium. These observations motivate a controlled trial to establish a causal connection and genuine therapeutic benefit in the context of depression."

Journal • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Assessing bias in AI-driven psychiatric recommendations: A comparative cross-sectional study of chatbot-classified and CANMAT 2023 guideline for adjunctive therapy in difficult-to-treat depression. (PubMed, Psychiatry Res) - "Notable discrepancies were observed in the overestimation of medications such as quetiapine and lithium and the underestimation of modafinil and ketamine. Additionally, a distinct bias pattern was observed in OpenAI's chatbots, which demonstrated a tendency to over-recommend lithium and bupropion. Our study highlights both the promise and the challenges of employing AI tools in psychiatric practice, and advocates for multi-model approaches to mitigate bias and improve clinical reliability."

Journal • Observational data • CNS Disorders • Depression • Mood Disorders • Psychiatry

From Cradle to Clinic: The Evolution of Pediatric Psychiatry (PAS 2025) - "New medications like Lexapro and Prozac better resolve symptoms of depression and anxiety without the more harmful side effects, supplemented with cognitive behavioral therapy, a mainstay of psychiatric treatment in the present day... Initially, barbaric procedures such as lobotomies were employed by Dr. Walter Jackson Freeman, alongside excessive restraint equipment such as straitjackets; used to restrain “violent” and “unruly” patients who were institutionalized. In the 20th century, sedatives like Methylphenidate and mood stabilizers like Lithium were also used as a way to silence children and make them “easier to deal with”."

Clinical • Depression • Mental Retardation • Mood Disorders • Pediatrics • Psychiatry

Emotion regulation difficulties are associated with psychosocial functioning via trait anxiety levels in remitted bipolar disorder patients. (PubMed, Int J Psychiatry Clin Pract) - "Patients on lithium treatment had less difficulty in regulating their emotions than those on valproic acid treatment. In light of these findings, planning interventions for emotion regulation difficulties during the management of patients would reduce anxiety levels and contribute to improving patients' psychosocial functionality."

Journal • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

Minimizing neonatal hypothyroidism induced by lithium exposure through breast milk. (PubMed, J Trace Elem Med Biol) - "In future, supplementing iodine may be potentially useful in clinical practices to address the neonate concerns of lactating mothers and their infants either caused by prolonged lithium medication or maternal iodine deficiency."

Journal • Bipolar Disorder • CNS Disorders • Endocrine Disorders • Mood Disorders • Psychiatry