lithium carbonate ER / Generic mfg. - LARVOL DELTA

ROLE OF GDF15 IN LITHIUM-INDUCED COLLECTING DUCT REMODELING (ISN-WCN 2026) - "Finally, V2 receptor antagonism by tolvaptan was performed in wild-type mice under control or lithium-enriched diet, and GDF15 levels (ELISA, qPCR) as well as collecting duct remodeling were analyzed.Results The urinary GDF15-to-creatinine ratio was increased in lithium-treated patients with partial vasopressin (AVP) resistance, and further elevated in those with overt diabetes insipidus, but remained unchanged in patients without renal involvement or with primary polydipsia...Ongoing experiments involving V2R antagonism will help refine the mechanisms linking GDF15 expression to epithelial plasticity. The V2R–GDF15 signaling axis may define a novel adaptive pathway and represent both a biomarker and a potential therapeutic target to mitigate lithium-associated kidney injury."

Bipolar Disorder • Chronic Kidney Disease • CNS Disorders • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • GDF15

The nucleation and surface properties of lithium carbonate were explored based on first-principles methods. (PubMed, J Mol Model) - "Based on classical nucleation theory, the free energy change during nucleus formation was analyzed. Electronic properties (band structure, density of states) and optical properties (dielectric function, absorption coefficient, reflection coefficient) were subsequently calculated for the optimized structures."

Journal

Elevations in serum lithium levels postcystectomy and ileal conduit. (PubMed, BMJ Case Rep) - "Currently, limited guidance exists from urological and psychiatric associations regarding pharmacokinetic interactions in patients with urinary diversion taking lithium. Based on this case, we recommend: increased lithium monitoring in the postoperative period, consideration of prophylactic dose reduction in the acute postoperative period and close psychiatric follow-up for safe re-titration."

Journal • Bipolar Disorder • Bladder Cancer • CNS Disorders • Genito-urinary Cancer • Oncology • Psychiatry • Solid Tumor

Recognising and treating depression - a practical overview of current treatment algorithms and evidence-based recommendations (PubMed, Ther Umsch) - "In conclusion, guideline-based multimodal care for patients starting in primary care improves outcome and prognosis for patients with depression and can reduce the risk of chronification and relapses. Key elements are structured diagnostics, early initiation of evidence-based therapy with regular valid monitoring within a strong doctor-patient-relationship."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Prediction of self-harm in people with newly-diagnosed depression: development and validation of risk prediction models. (PubMed, Mol Psychiatry) - "Performance remained robust in age, sex-stratified subgroups and 1-year vs. 3-year self-harm prediction windows. This validated model leverages EHR data to accurately identified individuals at elevated self-harm risk post-depression diagnosis, may tailor individual-level risk estimates and facilitate timely interventions, thereby potentially averting risk escalation, in the critical window of heightened self-harm risk."

Journal • CNS Disorders • Depression • Psychiatry • Psychosomatic Disorders

Efficacy of Lithium Carbonate Combined with Olanzapine, Risperidone, or Quetiapine in Bipolar Disorder Treatment and Effects on Glycolipid Metabolism. (PubMed, J Vis Exp) - "No marked difference in adverse reactions was observed among the three groups (P > 0.05). All three treatment modalities have therapeutic effects on BD, among which LR has remarkable efficacy, significantly improving the patient's condition and having a relatively small impact on glycolipid metabolism, thus warranting clinical popularization and application."

Journal • Retrospective data • Bipolar Disorder • Cardiovascular • CNS Disorders • Dyslipidemia • Mental Retardation • Metabolic Disorders • Mood Disorders • Psychiatry

Controllable Synthesis and VLS Growth Mechanism of Boron Nitride Nanotubes Catalyzed by Lithium Carbonate. (PubMed, ACS Omega) - "A refined VLS growth mechanism is proposed, in which the size, shape, and spatial distribution of Li-containing liquid droplets govern BNNT diameter, crystallinity, and nucleation density. This work establishes a mechanistic framework for Li2CO3-assisted BNNT synthesis, clarifying the precursor role of Li2CO3 in generating active lithium borate species, and provides a controllable strategy for achieving BNNTs with uniform morphology and well-defined crystalline structures through liquid-phase-mediated growth."

Journal

Co-Administration Treatment in Drug-Naïve Major Depression: Exploratory Real-World Patterns and Predictors in China. (PubMed, Neuropsychiatr Dis Treat) - "The most prescribed adjunctive antidepressants were SNRIs, NaSSAs, bupropion, and trazodone; the most common antipsychotics were quetiapine, olanzapine, aripiprazole, and risperidone...This practice appears to be a symptom-driven approach, targeting specific features like sympathetic arousal and leaden paralysis, which may reflect a pragmatic adaptation to local clinical realities beyond standard guidelines. Due to exploratory nature of the study, these findings are just hypothesis-generating, warranting further validation through more robust, longitudinal studies."

Journal • Real-world evidence • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Improving Cognition in Bipolar Disorder: A Systematic Review of Current Pharmacological and Nutraceutical Approaches. (PubMed, Neuropsychobiology) - "These results suggest possible approaches for improving cognitive functioning in individuals with BD. Nevertheless, the inconsistency in outcomes and differences in study methodologies highlight the need for larger, rigorously controlled trials with uniform cognitive evaluations to confirm these findings and to assess their clinical relevance."

Journal • Review • Alzheimer's Disease • Bipolar Disorder • CNS Disorders • Cognitive Disorders • Mood Disorders • Psychiatry

Response and Adverse Effects to Lithium Treatment in Patients With Bipolar Disorder at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. (PubMed, Biomed Res Int) - "Age, tobacco use, and treatment duration were associated with lithium adverse effects, with younger age and tobacco use linked to higher risk, whereas older age and longer treatment were associated with fewer adverse effects. In conclusion, the findings highlight the importance of monitoring use of psychiatric concomitant medications and plasma lithium levels to improve outcomes in BD patients on lithium."

Adverse events • Journal • Retrospective data • Bipolar Disorder • CNS Disorders • Mood Disorders • Movement Disorders • Psychiatry

Predicting lithium-associated thyroid dysfunction through dimension reduction to establish a practical machine learning model: A retrospective multicenter study. (PubMed, J Affect Disord) - "This study developed a simplified, clinically applicable XGBoost model for predicting lithium-associated thyroid dysfunction using 7 clinical features. SHAP analysis successfully helped the clinician identify feature contributions and take interventions to prevent thyroid dysfunctions. Future studies on different populations are warranted to extrapolate the models for clinical use."

Clinical • Journal • Retrospective data • CNS Disorders • Endocrine Disorders • Mood Disorders • Psychiatry

In Situ FBRM Analysis of Additive-Controlled Reactive Crystallization of Lithium Carbonate. (PubMed, Molecules) - "Scanning electron microscopy observations confirm the formation of spherulitic Li2CO3 aggregates in all cases, with compactness and radial organization dependent on the additive. These results demonstrate that targeted additive selection allows for precise control of population dynamics and solid properties in reactive crystallization systems, within the investigated high-supersaturation concentration window, with useful mechanistic guidance for the design and control of Li2CO3 precipitation processes."

Journal

Crohn's disease and Lithium use as possible triggers of Chronic Interstitial Nephritis. A case report (NKF-SCM 2026) - "Lithium was discontinued and changed to oxcarbazepine. Cronh’s disease remained under control with Adalimumab and Methotrexate...Like in most cases, our patient had a bland urinalysis remarkable only for proteinuria. Prompt biopsy is critical for an accurate diagnosis and management."

Case report • Clinical • Bipolar Disorder • Chronic Kidney Disease • CNS Disorders • Crohn's disease • Fibrosis • Focal Segmental Glomerulosclerosis • Gastroenterology • Glomerulonephritis • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Nephrology • Renal Disease

A Global Delphi-Based Expert Consensus on Relapse Prevention Strategies Following Successful Electroconvulsive Therapy for Major Depressive Disorder. (PubMed, Am J Psychiatry) - "An essential relapse prevention strategy, namely, pharmacotherapy with lithium and an antidepressant (a tricyclic antidepressant, venlafaxine, or a prior effective antidepressant), was endorsed for all patients...While pharmacotherapy and continuation ECT are core strategies, personalized adjustments based on clinical risk factors remain essential. Further empirical research is needed to refine guidelines and improve long-term outcomes."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Lithium prescription patterns for bipolar disorder at a psychiatric hospital in KwaZulu-Natal. (PubMed, S Afr J Psychiatr) - "This highlights the need to remind clinicians about the South African BD guidelines. The results of this study expand the existing literature on lithium prescribing patterns in BD internationally by contributing data on the prescription of lithium for BD in Africa."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Lithium-induced hypokalemic periodic paralysis: A rare and life-threatening complication in bipolar disorder management. (PubMed, Indian J Psychiatry) - No abstract available

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds. (PubMed, Neuropsychopharmacology) - "We also observed genetic support for commonly used psychotropics for psychiatric treatment (e.g., clozapine, duloxetine, and lithium)...Finally, enrichment and molecular trait results are combined to generate a ranked list of prioritized drugs for each GWAS trait based on supporting genetic evidence. ADHD = Attention deficit hyperactivity disorder, BIP = Bipolar disorder, DEP = Depression, SCZ = Schizophrenia, DBP = Diastolic blood pressure, T2D = Type 2 diabetes, RNA = ribonucleic acid, XWAS = both transcriptome and proteome-wide association studies, MR = Mendelian randomization, coloc = colocalization."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • CNS Disorders • Depression • Diabetes • Mental Retardation • Metabolic Disorders • Mood Disorders • Psychiatry • Schizophrenia • Type 2 Diabetes Mellitus • CYP2D6

Bipolar disorder, from violence to drug therapy (PubMed, Soins Psychiatr) - "Although the social determinants of this issue have been widely described, they remain beyond the reach of mental health professionals. Psychopharmacological interventions, which are equally essential, are largely underutilized."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Association Between Accelerated Atherosclerosis and High-Sensitivity C-Reactive Protein Levels in Bipolar Disorder and Schizophrenia. (PubMed, Acta Psychiatr Scand) - "Even physically healthy patients with BPD and SCZ exhibit accelerated atherosclerosis before geriatric age, reflected by increased cIMT. The association between hs-CRP and cIMT is observed in BPD, but not in SCZ, suggesting a greater role of chronic low-grade inflammation in BPD-related early vascular changes."

Journal • Atherosclerosis • Bipolar Disorder • Cardiovascular • CNS Disorders • Inflammation • Mood Disorders • Psychiatry • Schizophrenia • CRP

POPULATION PHARMACOKINETIC MODELING OF A NOVEL ONCE-DAILY LITHIUM CARBONATE EXTENDED RELEASE (XR) BI-LAYER MATRIX FORMULATION TO SUPPORT FORMULATION SWITCHING AND PEDIATRIC DOSING (ISPOR 2026) - "This popPK model supports QD lithium carbonate XR dosing in adults and pediatric patients and predicts negligible changes in systemic exposure when switching from currently available IR or ER formulations to XR formulation at steady state across approved adult dose ranges."

Clinical • PK/PD data • Pediatrics

Wildfire Smoke and the Brain: Mechanistic Insights and Implications for Disaster Response (AAN 2026) - "The neurological consequences of wildfires disproportionately affect vulnerable populations, amplifying existing health disparities. Disaster medicine frameworks—including resource allocation, evacuation planning, clinical management, and long-term recovery—should be adapted to incorporate neurological risk mitigation. Integrating neuroscience perspectives into disaster preparedness is essential to promote more equitable and effective health outcomes in an era of escalating climate-driven wildfires."

Alzheimer's Disease • Ataxia • Cardiovascular • CNS Disorders • Dementia • Depression • Inflammation • Insomnia • Mood Disorders • Movement Disorders • Post-traumatic Stress Disorder • Sleep Disorder • CXCL8

Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial. (PubMed, JAMA Neurol) - P4 | "To examine the feasibility, safety, and preliminary efficacy of lithium carbonate for delaying cognitive decline in older adults with MCI...None of the coprimary outcomes met the prespecified significance threshold. ClinicalTrials.gov Identifier: NCT03185208."

Clinical • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Movement Disorders • Psychiatry • BDNF

Effect of psychotropic medications on suicide-related outcomes: a systematic review and meta-analysis of observational studies. (PubMed, EClinicalMedicine) - "Across the main diagnostic categories and 70 individual medications examined, associations with reducing risk of suicide mortality were found for second generation antipsychotics in schizophrenia spectrum disorders: clozapine (OR = 0.40; 0.36-0.60; I2 = 60%, moderate certainty), olanzapine (OR = 0.53; 0.39-0.71; I2 = 34%, high certainty), quetiapine (OR = 0.75; 0.58-0.96; I2 = 0%, high certainty), and zuclopenthixol (OR = 0.44; 0.30-0.63; I2 = 0%, high certainty). In schizophrenia, second generation antipsychotics were also associated with reduced risks of suicide attempts: olanzapine (OR = 0.76; 0.60-0.98; I2 = 84%, moderate certainty) and risperidone (OR = 0.61; 0.52-0.72; I2 = 57%, moderate certainty)...Findings are not causal, and limitations include the observational nature of included studies, risk of residual confounding, high heterogeneity for some outcomes, and moderate quality of the evidence. University of Oxford (Hill Foundation), NIHR Oxford Health..."

Journal • Observational data • Retrospective data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Personality Disorder • Psychiatry • Schizophrenia

The anxiolytic effects of quetiapine and lithium and anxiety as a moderator of the antidepressant effect: a secondary analysis of the lithium versus quetiapine in depression (LQD)trial. (PubMed, Psychopharmacology (Berl)) - No abstract available

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Sequenced treatment alternatives to relieve adolescent depression: A pragmatic clinical trial. (PubMed, J Affect Disord) - "In this study, fluoxetine combined with CBT showed no significant advantage over fluoxetine monotherapy. All strategies in step 2 were feasible and acceptable. Our findings supported the feasibility of th sequential treatment pathway for adolescent MDD and provided insights for future adequately powered trials."

Journal • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry