Undisclosed p53 Y220C reactivator / Antares Therapeutics - LARVOL DELTA

Highly potent and mutant-selective p53 Y220C reactivators with best-in-class potential (AACR 2026) - "Background: The tumor suppressor p53, encoded by the TP53 gene, is a transcription factor that regulates genes involved in DNA repair, cell cycle arrest, senescence, and apoptosis. The significantly improved potency of the novel p53 reactivators described here offers the opportunity to restore p53 function in less sensitive patient populations and meaningfully improve upon the clinical response profile of rezatapopt."

Oncology • Solid Tumor • KRAS