CRD-733
/ Cardurion, Astellas
- LARVOL DELTA
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January 20, 2021
CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure.
(PubMed, Circ Heart Fail)
- "The PDE9 inhibitor, CRD-733, improves key hallmarks of HF including LV hypertrophy, LV dysfunction, left atrial dilation, and pulmonary edema after pressure overload in the mouse transverse aortic constriction HF model. Additionally, elevated plasma cGMP may be used as a biomarker of target engagement. These findings support future investigation into the therapeutic potential of CRD-733 in human HF."
Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Respiratory Diseases
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