influenza vaccine (FLU-v) / ConserV Biosci, Imutex, SEEK Group - LARVOL DELTA

FLU-v, a Broad-Spectrum Peptide-Based Influenza Vaccine, Induces NK Cell Activating IgG1 and IgG3 Subclass Antibodies in Humans. (PubMed, Vaccines (Basel)) - "A correlation between levels of FLU-v-specific IgG, IgG1, or IgG3 and their ability to induce NK cell activation was demonstrated. A single dose of adjuvanted FLU-v induced high levels of long-lasting antigen-specific IgG1 and IgG3 antibodies with NK cell-mediated effector functions relevant to protection against influenza disease."

Journal • Infectious Disease • Influenza • Respiratory Diseases • LAMP1

Increase in IFNgamma secretion by PBMCs as correlate of cellular protection against influenza infection (ISIRV-FLU 2023) - P2b | "Conclusion Quantification of the IFNgamma secretion by ELISA is a simple assay with the potential to become a correlate of protection for FLU-v. It is likely that different broad-spectrum influenza vaccines will require different correlates of protection and thresholds specific for their target and mode of action."

Infectious Disease • Influenza • Respiratory Diseases • CD4 • CD8 • GZMB • IFNG • IL2 • LAMP1 • TNFA

FLU-v, a Broad-Spectrum Influenza Vaccine, Induces Cross-Reactive Cellular Immune Responses in Humans Measured by Dual IFN-γ and Granzyme B ELISpot Assay. (PubMed, Vaccines (Basel)) - "The correlation observed between number of cells secreting IFN-γ or granzyme B in response to FLU-v and to the influenza strains supported vaccine-induced cross-reactivity. In conclusion, adjuvanted FLU-v vaccination induced cross-reactive cellular responses with cytotoxic capacity, further supporting the development of FLU-v as a broad-spectrum influenza vaccine."

Journal • Infectious Disease • Respiratory Diseases • GZMB • IFNG