RediTrex (methotrexate) / Cumberland, Nordic Group - LARVOL DELTA

Could Methotrexate Work in Hand Osteoarthritis? Save (RheumNow) - "Lancet reports the results of the METHODS study from Australia where hand osteoarthritis (HOA) patients benefitted from 6 months of methotrexate (MTX) - as long as there was MRI synovitis!"

Online posting

High-Dose MTX Does Not Reduce CNS Relapse in Pediatric ALL (Medscape) - "'As researchers in hematology, we look at it as our duty to question the standard approaches that we use to treat patients, even those that we thought of as tried-and-true,' said briefing moderator Mikkael Sekeres....This is one of the abstracts that 'challenge some of those standards and in fact reveal that in many cases, giving less therapy and being less restrictive is actually better for patients, or at least no worse.'"

Media quote

More than 60% of patients with RA, PsA report side effects in days after methotrexate dose (Healio) - "Recent Healio Honoree Jack Cush, MD, has discussed the 'blahs' with methotrexate for years. Patients often tell me that they have to take methotrexate on the weekend because they feel so bad for several days afterwards. Cush offered these suggestions for combating methotrexate toxicity: Use lower doses; higher dose equals more toxicity and oral ulcerations respond to lower methotrexate doses, folate, or vitamin A 8,000 units/day. For the post-MTX funk, use dextromethorphan 20-50 mg weekly, and give with methotrexate and then 8-12 hours later (as Mucinex DM)."

Expanded Table: Some conventional DMARDs for rheumatoid arthritis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Cumberland Pharmaceuticals Launches RediTrex Product Line For Active Rheumatoid, Juvenile Idiopathic And Severe Psoriatic Arthritis (PRNewswire) - "Cumberland Pharmaceuticals Inc...announced today the national launch of its RediTrex® (methotrexate) line of pre-filled syringes designed for the safe and simple treatment of active rheumatoid, juvenile idiopathic and severe psoriatic arthritis."

Launch US • Immunology • Psoriasis

Cumberland Pharmaceuticals Reports 9% Revenue Growth In 2020 (PRNewswire) - "The Company implemented a soft launch of its newly FDA-approved RediTrex product line during the fourth quarter. Cumberland is now preparing for a full national launch during the second half of 2021...Net revenue by product for the three months ended December 31, 2020...$0.9 million for the Company's newest brand, RediTrex®."

Commercial • Launch • Immunology • Psoriasis

Two-Drug Combo Starves Bone Cancer Cells To Death (Futurity) - "'In the future, we would like to add more metabolic therapies so that one day we might be able to eliminate the remaining chemotherapy drugs that these patients will still receive,' says Brian Van Tine. 'The ultimate goal is to transform therapy by going after the metabolic properties that are inherent to osteosarcoma and move away from the classic drugs that damage the whole body.'"

Media quote

Introducing RediTrex, A New Methotrexate Delivery System (PRNewswire) - "Cumberland Pharmaceuticals...announced today the launch of RediTrex® (methotrexate) injection. RediTrex is a new line of pre-filled syringes specifically designed for ease of handling and dosing accuracy for the subcutaneous administration of methotrexate in patients with arthritis and psoriasis...RediTrex will be launched in two phases...During the first quarter of 2021, the second phase will expand activities to a full national launch to the Rheumatology market."

Launch • Psoriasis