relacatib (GSK-462795) / GSK - LARVOL DELTA

Unravelling the Relacatib activity against the CTSK proteins causing pycnodysostosis: a molecular docking and dynamics approach. (PubMed, J Biomol Struct Dyn) - "Finally, Molecular dynamics simulations were done in duplicates to recognize the variant (Y283C) activity of the protein structure against Relacatib for 100 ns. This study assists in comprehending the most pathogenic amino-acid variant, the ligand interaction with the protein structure, and paves the way for understanding the steadiness of the ligand with the native and selected significant amino-acid variant.Communicated by Ramaswamy H. Sarma."

Journal • Immunology • Lysosomal Storage Diseases • Metabolic Disorders • Osteoarthritis • Osteoporosis • Pain • Rare Diseases • Rheumatology • CTSK