TP-0413 / Sumitomo Pharma - LARVOL DELTA

LIVER AND SKELETAL MUSCLE MIR-34A CONTRIBUTES TO MITOCHONDRIAL DYSFUNCTION AND INSULIN RESISTANCE IN EXPERIMENTAL NAFLD (UEGW 2016) - "In conclusion, activation of the miR-34a/SIRT1 pathway in experimental NAFLD correlates with the development of IR and mitochondrial dysfunction in both liver and skeletal muscle. A better understanding of the overlapping roles of miR-34a in different tissues during NAFLD may help in establishing new therapeutic options (PTDC/BIM-MEC/0873/2012, UID/DTP/04138/2013, SFRH/BD/104160/2014, FCT, Portugal)."

Preclinical • Biosimilar • Diabetes • Fibrosis • Immunology